ATE145912T1 - Bisplatinum-komplexe als chemotherapeutisches mittel - Google Patents
Bisplatinum-komplexe als chemotherapeutisches mittelInfo
- Publication number
- ATE145912T1 ATE145912T1 AT87905092T AT87905092T ATE145912T1 AT E145912 T1 ATE145912 T1 AT E145912T1 AT 87905092 T AT87905092 T AT 87905092T AT 87905092 T AT87905092 T AT 87905092T AT E145912 T1 ATE145912 T1 AT E145912T1
- Authority
- AT
- Austria
- Prior art keywords
- chemotherapeutic agent
- complexes
- same
- carboxylate
- bisplatinum
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 229940127089 cytotoxic agent Drugs 0.000 title 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 4
- 229910052697 platinum Inorganic materials 0.000 abstract 3
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- 150000007942 carboxylates Chemical class 0.000 abstract 2
- 229910002651 NO3 Inorganic materials 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 1
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 150000004985 diamines Chemical class 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 229920000768 polyamine Polymers 0.000 abstract 1
- 150000003141 primary amines Chemical class 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003335 secondary amines Chemical class 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/889,397 US4797393A (en) | 1986-07-25 | 1986-07-25 | Bis-platinum complexes as chemotherapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE145912T1 true ATE145912T1 (de) | 1996-12-15 |
Family
ID=25395019
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT87905092T ATE145912T1 (de) | 1986-07-25 | 1987-07-24 | Bisplatinum-komplexe als chemotherapeutisches mittel |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4797393A (de) |
| EP (1) | EP0275297B1 (de) |
| JP (1) | JP2537531B2 (de) |
| AT (1) | ATE145912T1 (de) |
| AU (1) | AU609049B2 (de) |
| CA (1) | CA1340892C (de) |
| DE (1) | DE3751967T2 (de) |
| WO (1) | WO1988000947A1 (de) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5107007A (en) * | 1989-09-01 | 1992-04-21 | The University Of Vermont And State Agricultural College | Bis-platinum complexes as chemotherapeutic agents |
| US5770591A (en) * | 1986-07-25 | 1998-06-23 | The University Of Vermont And State Agricultural College | Bis-platinum complexes as chemotherapeutic agents |
| FR2635317B1 (fr) * | 1988-08-11 | 1990-10-19 | Norsolor Sa | Hydrures de platine de structure bimetallique pontee, leur procede de preparation et leur application a la catalyse de reactions chimiques |
| JPH02275891A (ja) * | 1988-12-29 | 1990-11-09 | Tsumura & Co | 新規な複核白金錯体および該錯体を有効成分とする抗腫瘍剤 |
| KR940010295B1 (ko) * | 1991-07-05 | 1994-10-22 | 한국과학기술연구원 | 신규 항암성 백금 착화합물 유도체 및 그 제조방법 |
| US5380897A (en) * | 1993-05-25 | 1995-01-10 | Hoeschele; James D. | Tri(platinum) complexes |
| US5409915A (en) * | 1993-09-14 | 1995-04-25 | The University Of Vermont And State Agricultural College | Bis-platinum (IV) complexes as chemotherapeutic agents |
| ZA976422B (en) * | 1996-07-22 | 1998-01-22 | Boehringer Mannheim Italia | New bis-platinum complexes with polymethylene derivatives as ligands having antitumor activity. |
| ZA976421B (en) * | 1996-07-22 | 1998-01-22 | Boehringer Mannheim Italia | New bis-platinum complexes with polyamine ligands as antitumor agents. |
| WO2000006136A2 (en) * | 1998-07-31 | 2000-02-10 | The Health Research, Inc. | Therapeutic combination of polyamine with an anticancer agent |
| US6130245A (en) * | 1998-10-26 | 2000-10-10 | Unitech Pharmaceuticals, Inc. | Dinuclear platinum complexes as cisplatin analogs for cancer treatment |
| JP2005501123A (ja) * | 2001-08-22 | 2005-01-13 | ヴァージニア コモンウェルス ユニバーシティ | プロドラッグとしての標的ビス白金ポリアミド：白金の選択的放出 |
| US7160908B2 (en) * | 2003-03-04 | 2007-01-09 | Unitech Pharmaceuticals, Inc. | Dynamic anticancer platinum compounds |
| CA2552027A1 (en) * | 2004-01-15 | 2005-07-28 | Newsouth Innovations Pty Limited | Multi-nuclear metal complexes partially encapsulated by cucurbit[7-12]urils |
| US20050256239A1 (en) * | 2004-05-11 | 2005-11-17 | Lee Chun D | White polyolefin compositions having reduced die drool |
| US7897817B2 (en) * | 2005-03-09 | 2011-03-01 | Inter-University Research Institute Corporation National Institutes Of Natural Sciences | Resin-platinum complex and resin-supported platinum cluster catalyst |
| ITMI20052449A1 (it) | 2005-12-22 | 2007-06-23 | Cell Therapeutics Europe Srl | Nuovi bis-platino complessi ad attivita' antitumorale |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE447902B (sv) * | 1977-10-19 | 1986-12-22 | Johnson Matthey Co Ltd | Cis-koordinationsforening av platina och komposition innehallande foreningen |
| SE7903361L (sv) * | 1978-04-20 | 1979-10-21 | Johnson Matthey Co Ltd | Kompositioner innehallande platina |
| US4533502A (en) * | 1983-02-22 | 1985-08-06 | Rochon Fernande D | Platinum (II) compounds and their preparation |
| US4565884A (en) * | 1983-05-10 | 1986-01-21 | Andrulis Research Corporation | Bis-platinum complexes as antitumor agents |
| US4571335A (en) * | 1983-06-17 | 1986-02-18 | Taylor Robert C | Method of inhibiting herpetic lesions by the use of platinum coordination compounds |
| DE3432320A1 (de) * | 1984-09-03 | 1986-03-13 | Behringwerke Ag, 3550 Marburg | Cis-platin-komplexe mit einem pentaerythritderivat als liganden, verfahren zu ihrer herstellung und diese verbindungen enthaltendes pharmazeutisches mittel |
-
1986
- 1986-07-25 US US06/889,397 patent/US4797393A/en not_active Expired - Lifetime
-
1987
- 1987-07-23 CA CA000542812A patent/CA1340892C/en not_active Expired - Lifetime
- 1987-07-24 AT AT87905092T patent/ATE145912T1/de not_active IP Right Cessation
- 1987-07-24 JP JP62504563A patent/JP2537531B2/ja not_active Expired - Lifetime
- 1987-07-24 AU AU76994/87A patent/AU609049B2/en not_active Expired
- 1987-07-24 DE DE3751967T patent/DE3751967T2/de not_active Expired - Lifetime
- 1987-07-24 EP EP87905092A patent/EP0275297B1/de not_active Expired - Lifetime
- 1987-07-24 WO PCT/US1987/001738 patent/WO1988000947A1/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| CA1340892C (en) | 2000-02-08 |
| JPH01501309A (ja) | 1989-05-11 |
| US4797393A (en) | 1989-01-10 |
| DE3751967D1 (de) | 1997-01-16 |
| DE3751967T2 (de) | 1997-05-15 |
| AU609049B2 (en) | 1991-04-26 |
| EP0275297A1 (de) | 1988-07-27 |
| EP0275297B1 (de) | 1996-12-04 |
| AU7699487A (en) | 1988-02-24 |
| WO1988000947A1 (en) | 1988-02-11 |
| JP2537531B2 (ja) | 1996-09-25 |
| EP0275297A4 (en) | 1990-09-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |