ATE145210T1 - Neue bis-platinkomplexe als chemotherapeutisches mittel - Google Patents
Neue bis-platinkomplexe als chemotherapeutisches mittelInfo
- Publication number
- ATE145210T1 ATE145210T1 AT90913955T AT90913955T ATE145210T1 AT E145210 T1 ATE145210 T1 AT E145210T1 AT 90913955 T AT90913955 T AT 90913955T AT 90913955 T AT90913955 T AT 90913955T AT E145210 T1 ATE145210 T1 AT E145210T1
- Authority
- AT
- Austria
- Prior art keywords
- complexes
- platinum
- sulfoxide
- carboxylate
- substituted
- Prior art date
Links
- 239000002246 antineoplastic agent Substances 0.000 title 1
- 229940127089 cytotoxic agent Drugs 0.000 title 1
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 abstract 7
- 150000007942 carboxylates Chemical class 0.000 abstract 3
- 239000003446 ligand Substances 0.000 abstract 3
- 229910052697 platinum Inorganic materials 0.000 abstract 3
- 150000003462 sulfoxides Chemical class 0.000 abstract 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 2
- 229910002651 NO3 Inorganic materials 0.000 abstract 2
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 abstract 2
- XYFCBTPGUUZFHI-UHFFFAOYSA-N Phosphine Chemical compound P XYFCBTPGUUZFHI-UHFFFAOYSA-N 0.000 abstract 2
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 abstract 2
- SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 abstract 2
- 229910019142 PO4 Inorganic materials 0.000 abstract 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 150000001805 chlorine compounds Chemical group 0.000 abstract 1
- 150000004985 diamines Chemical class 0.000 abstract 1
- 150000004820 halides Chemical class 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000010452 phosphate Substances 0.000 abstract 1
- 229910000073 phosphorus hydride Inorganic materials 0.000 abstract 1
- 150000003057 platinum Chemical class 0.000 abstract 1
- 229920000768 polyamine Polymers 0.000 abstract 1
- 150000003141 primary amines Chemical class 0.000 abstract 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003335 secondary amines Chemical class 0.000 abstract 1
- 229910021653 sulphate ion Inorganic materials 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/401,919 US5107007A (en) | 1989-09-01 | 1989-09-01 | Bis-platinum complexes as chemotherapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE145210T1 true ATE145210T1 (de) | 1996-11-15 |
Family
ID=23589786
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT90913955T ATE145210T1 (de) | 1989-09-01 | 1990-09-04 | Neue bis-platinkomplexe als chemotherapeutisches mittel |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5107007A (de) |
| EP (1) | EP0489850B1 (de) |
| JP (2) | JP3142866B2 (de) |
| AT (1) | ATE145210T1 (de) |
| AU (1) | AU645266B2 (de) |
| CA (1) | CA2065271C (de) |
| DE (1) | DE69029138T2 (de) |
| ES (1) | ES2094758T3 (de) |
| WO (1) | WO1991003482A1 (de) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5206400A (en) * | 1986-07-07 | 1993-04-27 | Ohio State University | Diastereomeric mono- and di-substituted diamino cyclohexane compounds and the method of preparation thereof |
| US5380897A (en) * | 1993-05-25 | 1995-01-10 | Hoeschele; James D. | Tri(platinum) complexes |
| US5409915A (en) * | 1993-09-14 | 1995-04-25 | The University Of Vermont And State Agricultural College | Bis-platinum (IV) complexes as chemotherapeutic agents |
| IT1273391B (it) * | 1994-03-31 | 1997-07-08 | Boehringer Mannheim Italia | Platino complessi cationici trinucleari ad attivita' antitumorale e composizioni farmaceutiche che li contengono |
| AU2163797A (en) * | 1996-03-11 | 1997-10-01 | Debiopharm S.A. | Binuclear platinum complexes, method for preparing same and pharmaceutical compositions containing said complexes |
| ZA976422B (en) * | 1996-07-22 | 1998-01-22 | Boehringer Mannheim Italia | New bis-platinum complexes with polymethylene derivatives as ligands having antitumor activity. |
| ZA976421B (en) * | 1996-07-22 | 1998-01-22 | Boehringer Mannheim Italia | New bis-platinum complexes with polyamine ligands as antitumor agents. |
| EP0870770A1 (de) * | 1997-04-10 | 1998-10-14 | Kreatech Biotechnology B.V. | Trans-Platinverbindung, ein diese enthaltender, diagnostischer Kit, und ein Verfahren zur Markierung von bioorganischen Molekülen |
| EP0973785B1 (de) * | 1997-04-10 | 2003-12-03 | Kreatech Biotechnology B.V. | Trans-platinverbindung und diagnostischer testsatz |
| SE9703396D0 (sv) * | 1997-09-19 | 1997-09-19 | Lincoln | Binuclear complex |
| US6130245A (en) * | 1998-10-26 | 2000-10-10 | Unitech Pharmaceuticals, Inc. | Dinuclear platinum complexes as cisplatin analogs for cancer treatment |
| US6001872A (en) * | 1999-03-05 | 1999-12-14 | Virginia Commonwealth University | Water soluble transplatinum complexes with anti-cancer activity and method of using same |
| US6310047B1 (en) * | 1999-08-24 | 2001-10-30 | Virginia Commonwealth University | High affinity DNA binding compounds as adjuvants in antisense technology |
| US7160908B2 (en) * | 2003-03-04 | 2007-01-09 | Unitech Pharmaceuticals, Inc. | Dynamic anticancer platinum compounds |
| DE602006018299D1 (de) * | 2005-06-30 | 2010-12-30 | Bionumerik Pharmaceuticals Inc | Platinanaloga mit monoazolligand |
| WO2007005056A2 (en) * | 2005-06-30 | 2007-01-11 | Bionumerik Pharmaceuticals, Inc. | Platinum complexes with mononitrile-containing ligands |
| ITMI20052449A1 (it) * | 2005-12-22 | 2007-06-23 | Cell Therapeutics Europe Srl | Nuovi bis-platino complessi ad attivita' antitumorale |
| WO2010005548A2 (en) * | 2008-07-07 | 2010-01-14 | Northwestern University | Functionalization of carbon nanotubes with metallic moieties |
| US20100197890A1 (en) * | 2009-01-31 | 2010-08-05 | Mctavish Hugh | Anti-cancer protein-platinum conjugates |
| WO2011085772A1 (en) | 2010-01-15 | 2011-07-21 | Basf Se | "process for the dmc-catalyzed preparation of polyols" |
| WO2017110669A1 (ja) * | 2015-12-22 | 2017-06-29 | 日本化薬株式会社 | スルホキシド誘導体配位白金（ｉｉ）錯体の高分子結合体 |
| KR102224578B1 (ko) * | 2019-01-30 | 2021-03-05 | 전남대학교산학협력단 | 뱀장어를 비롯한 저서성 어류와 저서생물의 통합어도시스템 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4560782A (en) * | 1982-11-19 | 1985-12-24 | Research Corporation | Anti-tumor diplatinum coordination compounds |
| US4533502A (en) * | 1983-02-22 | 1985-08-06 | Rochon Fernande D | Platinum (II) compounds and their preparation |
| US4565884A (en) * | 1983-05-10 | 1986-01-21 | Andrulis Research Corporation | Bis-platinum complexes as antitumor agents |
| DE3432320A1 (de) * | 1984-09-03 | 1986-03-13 | Behringwerke Ag, 3550 Marburg | Cis-platin-komplexe mit einem pentaerythritderivat als liganden, verfahren zu ihrer herstellung und diese verbindungen enthaltendes pharmazeutisches mittel |
| US4797393A (en) * | 1986-07-25 | 1989-01-10 | University Of Vermont And State Agricultural College | Bis-platinum complexes as chemotherapeutic agents |
| AU2817589A (en) * | 1987-12-18 | 1989-07-19 | Boehringer Biochemia Robin S.P.A | Amino anthracenediones-bis platinum complexes, useful as antitumoral agents |
-
1989
- 1989-09-01 US US07/401,919 patent/US5107007A/en not_active Expired - Lifetime
-
1990
- 1990-09-04 AU AU64050/90A patent/AU645266B2/en not_active Expired
- 1990-09-04 CA CA002065271A patent/CA2065271C/en not_active Expired - Lifetime
- 1990-09-04 DE DE69029138T patent/DE69029138T2/de not_active Expired - Lifetime
- 1990-09-04 ES ES90913955T patent/ES2094758T3/es not_active Expired - Lifetime
- 1990-09-04 AT AT90913955T patent/ATE145210T1/de not_active IP Right Cessation
- 1990-09-04 WO PCT/US1990/004966 patent/WO1991003482A1/en active IP Right Grant
- 1990-09-04 EP EP90913955A patent/EP0489850B1/de not_active Expired - Lifetime
- 1990-09-04 JP JP02513023A patent/JP3142866B2/ja not_active Expired - Lifetime
-
1999
- 1999-05-06 JP JP12559699A patent/JP3200421B2/ja not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| CA2065271C (en) | 1996-02-20 |
| AU645266B2 (en) | 1994-01-13 |
| EP0489850B1 (de) | 1996-11-13 |
| EP0489850A1 (de) | 1992-06-17 |
| JP3142866B2 (ja) | 2001-03-07 |
| AU6405090A (en) | 1991-04-08 |
| WO1991003482A1 (en) | 1991-03-21 |
| JP3200421B2 (ja) | 2001-08-20 |
| CA2065271A1 (en) | 1991-03-02 |
| JP2000001496A (ja) | 2000-01-07 |
| ES2094758T3 (es) | 1997-02-01 |
| DE69029138D1 (de) | 1996-12-19 |
| DE69029138T2 (de) | 1997-03-06 |
| JPH05500218A (ja) | 1993-01-21 |
| EP0489850A4 (en) | 1992-11-04 |
| US5107007A (en) | 1992-04-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification | ||
| EELA | Cancelled due to lapse of time |