ES2094148T3 - Procedimientos y composiciones para el tratamiento del cancer con la ayuda de oligonucleotidos. - Google Patents

Procedimientos y composiciones para el tratamiento del cancer con la ayuda de oligonucleotidos.

Info

Publication number
ES2094148T3
ES2094148T3 ES90903093T ES90903093T ES2094148T3 ES 2094148 T3 ES2094148 T3 ES 2094148T3 ES 90903093 T ES90903093 T ES 90903093T ES 90903093 T ES90903093 T ES 90903093T ES 2094148 T3 ES2094148 T3 ES 2094148T3
Authority
ES
Spain
Prior art keywords
cancer
bone marrow
oligonucleotides
procedures
help
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90903093T
Other languages
English (en)
Inventor
Larry J Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Texas System
Original Assignee
University of Texas System
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Texas System filed Critical University of Texas System
Application granted granted Critical
Publication of ES2094148T3 publication Critical patent/ES2094148T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1135—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against oncogenes or tumor suppressor genes

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Public Health (AREA)
  • General Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

LA PRESENTE INVENCION DESARROLLA METODOS PRACTICOS EN EL TRANSPLANTE AUTOLOGO DE MEDULA OSEA Y TERAPIA DEL CANCER. CONFORME A UN ASPECTO DE LA INVENCION, LAS CELULAS DE MEDULA OSEA DE UN PACIENTE CON DOLENCIA CANCERIGENA PUEDEN SER TRATADAS CON OLIGONUCLEOTIDOS SELECTIVOS ANTISENSIBLES AL OBJETO DE AGOTAR DE CELULAS MALIGNAS LA MEDULA OSEA ANTES DE VOLVER A INSTALARLAS EN LA MEDULA OSEA DEL DONANTE. PARA UNA TERAPIA ANTICANCERIGENA, SE ADMINISTRAN OLIGONUCLEOTIDOS SELECTIVOS ANTISENSIBLES EN INCORPORACION POR SEPARADO.
ES90903093T 1989-02-15 1990-01-24 Procedimientos y composiciones para el tratamiento del cancer con la ayuda de oligonucleotidos. Expired - Lifetime ES2094148T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/311,096 US5087617A (en) 1989-02-15 1989-02-15 Methods and compositions for treatment of cancer using oligonucleotides

Publications (1)

Publication Number Publication Date
ES2094148T3 true ES2094148T3 (es) 1997-01-16

Family

ID=23205390

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90903093T Expired - Lifetime ES2094148T3 (es) 1989-02-15 1990-01-24 Procedimientos y composiciones para el tratamiento del cancer con la ayuda de oligonucleotidos.

Country Status (10)

Country Link
US (1) US5087617A (es)
EP (1) EP0458829B1 (es)
JP (1) JPH04505752A (es)
AT (1) ATE143265T1 (es)
AU (1) AU635002B2 (es)
CA (1) CA2046916C (es)
DE (1) DE69028694T2 (es)
DK (1) DK0458829T3 (es)
ES (1) ES2094148T3 (es)
WO (1) WO1990009180A1 (es)

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DK0458829T3 (es) 1997-02-10
AU635002B2 (en) 1993-03-11
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DE69028694T2 (de) 1997-05-15
ATE143265T1 (de) 1996-10-15

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