ES2092120T3 - Resolucion de ibuprofeno. - Google Patents

Resolucion de ibuprofeno.

Info

Publication number
ES2092120T3
ES2092120T3 ES92913362T ES92913362T ES2092120T3 ES 2092120 T3 ES2092120 T3 ES 2092120T3 ES 92913362 T ES92913362 T ES 92913362T ES 92913362 T ES92913362 T ES 92913362T ES 2092120 T3 ES2092120 T3 ES 2092120T3
Authority
ES
Spain
Prior art keywords
enriched
ibuprophen
solvent
ibuprofen
enantiomer
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92913362T
Other languages
English (en)
Inventor
Glenn Patrick Stahly
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Albemarle Corp
Original Assignee
Albemarle Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albemarle Corp filed Critical Albemarle Corp
Application granted granted Critical
Publication of ES2092120T3 publication Critical patent/ES2092120T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/42—Separation; Purification; Stabilisation; Use of additives
    • C07C51/487—Separation; Purification; Stabilisation; Use of additives by treatment giving rise to chemical modification

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

SE EXPONE UN PROCESO PARA OBTENER UN ENANTIOMERO SUSTANCIALMENTE PURO DE IBUPROFENO. EL PROCESO UTILIZA PRIMERO UNA MEZCLA ENANTIOMERICAMENTE ENRIQUECIDA DE IBUPROFENO OBTENIDA A PARTIR DE PROCESOS DE REDISOLUCION QUINETICA, CRISTALIZACION DIASTEREOMERICA O SINTESIS ASIMETRICA. ESTA MEZCLA ENRIQUECIDA SE DISUELVE EN UN DISOLVENTE Y RESULTA SEPARADO IBUPROFENO RACEMICO SOLIDO, DEJANDO UN LICOR MADRE QUE COMPRENDE EL DISOLVENTE Y EL ENANTIOMERO ENRIQUECIDO SUSTANCIALMENTE LIBRE DEL OTRO ENANTIOMERO.
ES92913362T 1991-07-01 1992-06-16 Resolucion de ibuprofeno. Expired - Lifetime ES2092120T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/724,166 US5189208A (en) 1991-07-01 1991-07-01 Ibuprofen resolution

Publications (1)

Publication Number Publication Date
ES2092120T3 true ES2092120T3 (es) 1996-11-16

Family

ID=24909296

Family Applications (1)

Application Number Title Priority Date Filing Date
ES92913362T Expired - Lifetime ES2092120T3 (es) 1991-07-01 1992-06-16 Resolucion de ibuprofeno.

Country Status (8)

Country Link
US (1) US5189208A (es)
EP (1) EP0592491B1 (es)
JP (1) JP3195346B2 (es)
CA (1) CA2111971A1 (es)
DE (1) DE69213742T2 (es)
DK (1) DK0592491T3 (es)
ES (1) ES2092120T3 (es)
WO (1) WO1993001156A1 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2145219C1 (ru) * 1991-05-13 2000-02-10 Дзе Бутс Компани ПЛС Фармацевтическая композиция, содержащая s(-)-2-(4-изобутилфенил)пропионат натрия, способ получения натриевой соли энантиомера 2-(4-изобутилфенил)пропионовой кислоты, s(-)-2-(4-изобутилфенил)пропионат натрия дигидрат
US5360938A (en) * 1991-08-21 1994-11-01 Union Carbide Chemicals & Plastics Technology Corporation Asymmetric syntheses
US5300301A (en) * 1992-12-02 1994-04-05 Hoechst Celanese Corporation Isolation of ibuprofen from tablets
US5380867A (en) * 1992-12-02 1995-01-10 Hoechst Celanese Corporation Selective precipitation of α-aryl carboxylic acid salts
US5223640A (en) * 1992-12-23 1993-06-29 Hoechst Celanese Corporation Preparation of optically active α-aryl propionic acids
IN189741B (es) * 1998-11-09 2003-04-19 Council Scient Ind Res
KR20030002955A (ko) * 2001-07-03 2003-01-09 (주)국전약품 이부프로펜의 에난티오머 제조 방법
FR2863609A1 (fr) * 2003-12-15 2005-06-17 Isochem Sa Procede d'enrichissement enantiomerique d'un melange d'enantiomeres d'alpha-aminoacides
BR112012030787A2 (pt) * 2010-06-04 2020-09-01 Kowa Company Ltd. derivado opticamente de dibenzilamina para preparar o mesmo

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3405159A (en) * 1964-11-17 1968-10-08 Merck & Co Inc Process for resolving racemic mixtures of optically-active enantiomorphs
IT987071B (it) * 1973-04-13 1975-02-20 Snam Progetti Idrogenazione asimmetrica a mez zo di derivati otticamente atti vi dell idroro di alluminio
JPS57171938A (en) * 1981-04-15 1982-10-22 Nissan Chem Ind Ltd Preparation of optically active naphthylpropionic acid ester
IT1222013B (it) * 1987-07-10 1990-08-31 Chimica Profarmaco Spa Ind Processo di risoluzione ottica di acido 2 (6 metossi 2 naftil) propionico
US4786731A (en) * 1987-08-05 1988-11-22 The Dow Chemical Company Resolution of enantiomers of 2-(phenyl or phenoxy/propionic acids using optically active alkanolamines
DE3824353A1 (de) * 1988-07-19 1990-01-25 Paz Arzneimittelentwicklung Verfahren zur trennung von gemischen enantiomerer arylpropionsaeuren

Also Published As

Publication number Publication date
US5189208A (en) 1993-02-23
DK0592491T3 (da) 1996-12-30
EP0592491B1 (en) 1996-09-11
DE69213742T2 (de) 1997-01-30
EP0592491A1 (en) 1994-04-20
JPH06509096A (ja) 1994-10-13
CA2111971A1 (en) 1993-01-21
WO1993001156A1 (en) 1993-01-21
DE69213742D1 (de) 1996-10-17
JP3195346B2 (ja) 2001-08-06

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