ES2091758T3 - Particulas de soporte artificiales y metodo para su preparacion. - Google Patents

Particulas de soporte artificiales y metodo para su preparacion.

Info

Publication number
ES2091758T3
ES2091758T3 ES89118879T ES89118879T ES2091758T3 ES 2091758 T3 ES2091758 T3 ES 2091758T3 ES 89118879 T ES89118879 T ES 89118879T ES 89118879 T ES89118879 T ES 89118879T ES 2091758 T3 ES2091758 T3 ES 2091758T3
Authority
ES
Spain
Prior art keywords
particles
particle
artificial carrier
immunoassays
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89118879T
Other languages
English (en)
Inventor
Takenori Hirai
Hirotaka Ihara
Chuichi Hirayama
Haruo Fuzita
Munehiro Saisho
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Chemo Sero Therapeutic Research Institute Kaketsuken
Original Assignee
Chemo Sero Therapeutic Research Institute Kaketsuken
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chemo Sero Therapeutic Research Institute Kaketsuken filed Critical Chemo Sero Therapeutic Research Institute Kaketsuken
Application granted granted Critical
Publication of ES2091758T3 publication Critical patent/ES2091758T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
    • C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
    • C08G69/36—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino acids, polyamines and polycarboxylic acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pathology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Polymers & Plastics (AREA)
  • Organic Chemistry (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)

Abstract

UNA PARTICULA PORTADORA ARTIFICIAL QUE COMPRENDE UN POLIMERO ANIONICO Y UN ACIDO POLIAMINO SINTETICO PROVISTO DE POR LO MENOS UN GRUPO CARBOXILICO Y POR LO MENOS UN GRUPO AMINO EN SU CADENA LATERAL, INSOLUBILIZANDOSE EL COMPLEJO MEDIANTE UN AGENTE ALDEHIDICO DE ESLABONAMIENTO CRUZADO. LA PARTICULA PORTADORA ARTIFICIAL ES UTIL PARA INMUNOENSAYOS, EN PARTICULAR, INMUNOENSAYOS DE PARTICULA. LAS PARTICULAS PORTADORAS ARTIFICIALES SE OBTIENEN PREPARANDO UNA SOLUCION ACUOSA QUE CONTIENE UN POLIMERO ANIONICO Y UN ACIDO POLIAMINO SINTETICO QUE INCLUYE POR LO MENOS UN GRUPO CARBOXILICO LIBRE Y POR LO MENOS UN GRUPO AMINO LIBRE EN SU CADENA LATERAL, AJUSTANDO EL PH DE LA SOLUCION A 3,5 - 9,5 A TEMPERATURA AMBIENTE O A UNA TEMPERATURA QUE AUMENTA PAULATINAMENTE CON LA AGITACION PARA FORMAR UNA SOLUCION DE PARTICULAS DE UN TAMAÑO DE PARTICULA DESEADO, E INSOLUBILIZANDO LAS PARTICULAS MEDIANTE UN AGENTE ALDEHIDICO DE ESLABONAMIENTO CRUZADO.
ES89118879T 1988-10-12 1989-10-11 Particulas de soporte artificiales y metodo para su preparacion. Expired - Lifetime ES2091758T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP63258004A JPH079429B2 (ja) 1988-10-12 1988-10-12 人工担体およびその製造方法

Publications (1)

Publication Number Publication Date
ES2091758T3 true ES2091758T3 (es) 1996-11-16

Family

ID=17314200

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89118879T Expired - Lifetime ES2091758T3 (es) 1988-10-12 1989-10-11 Particulas de soporte artificiales y metodo para su preparacion.

Country Status (8)

Country Link
US (1) US5059542A (es)
EP (1) EP0363921B1 (es)
JP (1) JPH079429B2 (es)
AT (1) ATE143388T1 (es)
CA (1) CA2000547C (es)
DE (1) DE68927247T2 (es)
ES (1) ES2091758T3 (es)
GR (1) GR3021815T3 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2896174B2 (ja) * 1989-10-27 1999-05-31 富士レビオ株式会社 人工担体
US5484584A (en) * 1990-10-02 1996-01-16 Board Of Regents, The University Of Texas System Therapeutic and diagnostic use of modified polymeric microcapsules
JP2836009B2 (ja) * 1994-05-24 1998-12-14 株式会社第一ラジオアイソトープ研究所 生化学用微粒子およびその製法ならびにそれを使用する免疫学的測定法
DE19725766B4 (de) * 1997-06-18 2005-06-30 Elvira Schecklies Formulierung zur Herstellung von Testsystemen und Herstellung der Formulierung
WO1998058258A1 (de) * 1997-06-18 1998-12-23 Elvira Schecklies Formulierung für immunologische reaktionssysteme
US6251409B1 (en) 1997-11-11 2001-06-26 Clarigen, Inc. Use of particles in the composition of cosmetic products
FR2774311B1 (fr) * 1998-02-02 2000-03-17 Rhodia Chimie Sa Granules dispersables dans l'eau comprenant une matiere active hydrophobe
FR2849043B1 (fr) * 2002-12-24 2005-07-08 Gemac Procede de fabrication d'un vecteur de molecules actives applicable dans le domaine de la diffusion de principes actifs et vecteur obtenu
CN104774329B (zh) * 2015-01-30 2017-01-25 华东师范大学 用于抗肿瘤药物递送的酸敏感高分子载体及制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342739A (en) * 1979-01-09 1982-08-03 Fuji Photo Film Co., Ltd. Novel material for immunological assay of biochemical components and a process for the determination of said components
US4276206A (en) * 1979-01-18 1981-06-30 Scripps Clinic & Research Foundation Immunochemical conjugates: method and composition
DE3267499D1 (en) * 1981-03-18 1986-01-02 Fujirebio Kk Support material for use in serological testing and process for the production thereof
EP0062968B2 (en) * 1981-03-18 1991-07-10 FUJIREBIO KABUSHIKI KAISHA also trading as FUJIREBIO INC. Support material for use in serological testing and process for the production thereof
US4452886A (en) * 1981-09-21 1984-06-05 Henry Robert P Novel photon absorbing or emitting polymers and their use as reagents in immunoassay systems
JPS5951355A (ja) * 1982-09-17 1984-03-24 Fujirebio Inc 抗ウイルス抗体検出用試薬
GB8430252D0 (en) * 1984-11-30 1985-01-09 Beecham Group Plc Compounds
JPS61205865A (ja) * 1985-03-09 1986-09-12 Meidensha Electric Mfg Co Ltd 免疫学的な測定試薬の調製法とこれによつて得た試薬
JPS621728A (ja) * 1985-06-27 1987-01-07 Chuichi Hirayama ポリアミノ酸の球状粒子とその製造方法

Also Published As

Publication number Publication date
EP0363921B1 (en) 1996-09-25
JPH079429B2 (ja) 1995-02-01
ATE143388T1 (de) 1996-10-15
CA2000547A1 (en) 1990-04-12
CA2000547C (en) 1996-11-05
JPH02103470A (ja) 1990-04-16
EP0363921A2 (en) 1990-04-18
DE68927247D1 (de) 1996-10-31
GR3021815T3 (en) 1997-02-28
US5059542A (en) 1991-10-22
DE68927247T2 (de) 1997-03-06
EP0363921A3 (en) 1991-11-27

Similar Documents

Publication Publication Date Title
ATE138388T1 (de) Enzymatisches hydrolysat von einem cellulosederivat
ATE52857T1 (de) Lumineszenz immunoassay fuer haptene und hierfuer verwendbares chemilumineszent-markiertes haptenkonjugat sowie verfahren zur herstellung derselben.
ES2091758T3 (es) Particulas de soporte artificiales y metodo para su preparacion.
ATE70455T1 (de) Verfahren zur reinigung von serumalbumin.
ATE290405T1 (de) Verfahren zur herstellung von diagnostica
EP0401199A3 (de) Verfahren zur Präparierung von biologischem Implantationsmaterial
DE68916048D1 (de) Verfahren zur Herstellung von monodispersen Polymerteilchen mit erhöhter Teilchengrösse.
ZA888396B (en) Process for the production of biodegradable microcapsules of water-soluble peptides and proteins,and microcapsules obtained by this process
EP0325270A3 (en) Anticancer conjugates
EP0330878A3 (en) Anti-ras protein-antibodies
KR870005649A (ko) 고상화항체 및 그 제조방법
ES2056130T3 (es) Proceso para la preparacion de acidos carboxilicos aminopirrolidinilnaftiridinicos y quinolonicos enantiomericamente homogeneos.
ATE90790T1 (de) Verfahren zur herstellung einer festphasenmatrix.
AU8190587A (en) Crosslinked polyacrylamide-sulfhydryl gel and sulfhydryl-functionalized derivatives thereof
EP0255933A3 (en) Dry strength resin of amino/aldehyde acid colloid with acrylamide polymer, process for the production thereof and paper produced therefrom
ATE101026T1 (de) Haarfixierungszusammensetzung.
ES2121587T3 (es) Procedimiento para la obtencion simultanea de acidos dicarboxilicos y diaminas a partir de poliamidas.
ES544175A0 (es) Un procedimiento para preparar un material polimero hidrofilo basado en polisacaridos polipeptidos y -o proteinas y derivados acrilicos hidrofilos.
CA2082647A1 (en) Polymer material and a process for its production
EP0414293A3 (en) Bakers jellies
DE3781254D1 (de) Verfahren zur herstellung von eiweisshydrolysaten, loeslich in einem saeuremilieu und die erhaltenen hydrolysate.
RU1776661C (ru) Способ получени модифицированного полиметилметакрилата
DK90184D0 (da) Fremgangsmade til fremstilling af let resorberbart "isoxicam"
JPS57146583A (en) Preparation of immobilized enzyme
JPS57206693A (en) Protein an-7d

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 363921

Country of ref document: ES