ES2089395T3 - Utilizacion de rapamicina para tratar la diabetes. - Google Patents
Utilizacion de rapamicina para tratar la diabetes.Info
- Publication number
- ES2089395T3 ES2089395T3 ES92302842T ES92302842T ES2089395T3 ES 2089395 T3 ES2089395 T3 ES 2089395T3 ES 92302842 T ES92302842 T ES 92302842T ES 92302842 T ES92302842 T ES 92302842T ES 2089395 T3 ES2089395 T3 ES 2089395T3
- Authority
- ES
- Spain
- Prior art keywords
- rapamicine
- treat diabetes
- insulin
- arresting
- retarding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
Abstract
USO DE LA RAPAMICINA PARA EL TRATAMIENTO DE LA DIABETES. ESTA INVENCION ESTA RELACIONADA CON EL USO DE LA RAPAMICINA SOLA O EN COMBINACION CON INSULINA EN LA PREVENCION PROFILACTICAMENTE DEL INICIO, DETENIENDO EL DESARROLLO, O RETARDANDO LA PROGRESION DE LA DIABETES MELLITUS DEPENDIENTE DE LA INSULINA EN UN MAMIFERO.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US67970691A | 1991-04-03 | 1991-04-03 | |
US07/792,105 US5321009A (en) | 1991-04-03 | 1991-11-14 | Method of treating diabetes |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2089395T3 true ES2089395T3 (es) | 1996-10-01 |
Family
ID=27102296
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92302842T Expired - Lifetime ES2089395T3 (es) | 1991-04-03 | 1992-03-31 | Utilizacion de rapamicina para tratar la diabetes. |
Country Status (19)
Country | Link |
---|---|
EP (1) | EP0507555B1 (es) |
JP (1) | JP2535119B2 (es) |
AT (1) | ATE139120T1 (es) |
AU (1) | AU652037B2 (es) |
CA (1) | CA2064678A1 (es) |
CZ (1) | CZ282733B6 (es) |
DE (1) | DE69211406T2 (es) |
DK (1) | DK0507555T3 (es) |
ES (1) | ES2089395T3 (es) |
GR (1) | GR3020316T3 (es) |
HK (1) | HK108797A (es) |
HU (1) | HUT60626A (es) |
IE (1) | IE74884B1 (es) |
IL (1) | IL101353A0 (es) |
MX (1) | MX9201513A (es) |
NO (1) | NO921279L (es) |
NZ (1) | NZ242190A (es) |
SG (1) | SG43075A1 (es) |
SK (1) | SK279180B6 (es) |
Families Citing this family (37)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5378696A (en) * | 1990-09-19 | 1995-01-03 | American Home Products Corporation | Rapamycin esters |
US5177203A (en) * | 1992-03-05 | 1993-01-05 | American Home Products Corporation | Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents |
US5256790A (en) * | 1992-08-13 | 1993-10-26 | American Home Products Corporation | 27-hydroxyrapamycin and derivatives thereof |
CA2106034A1 (en) * | 1992-09-24 | 1994-03-25 | Ralph J. Russo | 21-norrapamycin |
US5480989A (en) * | 1992-10-13 | 1996-01-02 | American Home Products Corporation | Carbamates of rapamycin |
US5302584A (en) * | 1992-10-13 | 1994-04-12 | American Home Products Corporation | Carbamates of rapamycin |
US5480988A (en) * | 1992-10-13 | 1996-01-02 | American Home Products Corporation | Carbamates of rapamycin |
US5434260A (en) * | 1992-10-13 | 1995-07-18 | American Home Products Corporation | Carbamates of rapamycin |
US5489680A (en) * | 1992-10-13 | 1996-02-06 | American Home Products Corporation | Carbamates of rapamycin |
US5349060A (en) * | 1993-01-07 | 1994-09-20 | American Home Products Corporation | Rapamycin 31-ester with N,N-dimethylglycine derivatives useful as immunosuppressive agents |
US5252579A (en) * | 1993-02-16 | 1993-10-12 | American Home Products Corporation | Macrocyclic immunomodulators |
US7279561B1 (en) | 1993-04-23 | 2007-10-09 | Wyeth | Anti-rapamycin monoclonal antibodies |
ES2295093T3 (es) | 1993-04-23 | 2008-04-16 | Wyeth | Conjugados y anticuerpos de rapamicina. |
US5504091A (en) * | 1993-04-23 | 1996-04-02 | American Home Products Corporation | Biotin esters of rapamycin |
US5387680A (en) * | 1993-08-10 | 1995-02-07 | American Home Products Corporation | C-22 ring stabilized rapamycin derivatives |
US5391730A (en) * | 1993-10-08 | 1995-02-21 | American Home Products Corporation | Phosphorylcarbamates of rapamycin and oxime derivatives thereof |
US5373014A (en) * | 1993-10-08 | 1994-12-13 | American Home Products Corporation | Rapamycin oximes |
US5378836A (en) * | 1993-10-08 | 1995-01-03 | American Home Products Corporation | Rapamycin oximes and hydrazones |
US5385908A (en) * | 1993-11-22 | 1995-01-31 | American Home Products Corporation | Hindered esters of rapamycin |
US5385909A (en) * | 1993-11-22 | 1995-01-31 | American Home Products Corporation | Heterocyclic esters of rapamycin |
US5385910A (en) * | 1993-11-22 | 1995-01-31 | American Home Products Corporation | Gem-distributed esters of rapamycin |
US5389639A (en) * | 1993-12-29 | 1995-02-14 | American Home Products Company | Amino alkanoic esters of rapamycin |
US5525610A (en) * | 1994-03-31 | 1996-06-11 | American Home Products Corporation | 42-Epi-rapamycin and pharmaceutical compositions thereof |
US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
US5496831A (en) * | 1994-05-13 | 1996-03-05 | The General Hospital Corporation | Inhibition of insulin-induced adiposis |
US5463048A (en) * | 1994-06-14 | 1995-10-31 | American Home Products Corporation | Rapamycin amidino carbamates |
US5491231A (en) * | 1994-11-28 | 1996-02-13 | American Home Products Corporation | Hindered N-oxide esters of rapamycin |
US5563145A (en) * | 1994-12-07 | 1996-10-08 | American Home Products Corporation | Rapamycin 42-oximes and hydroxylamines |
US5561138A (en) * | 1994-12-13 | 1996-10-01 | American Home Products Corporation | Method of treating anemia |
US5496832A (en) * | 1995-03-09 | 1996-03-05 | American Home Products Corporation | Method of treating cardiac inflammatory disease |
FR2736550B1 (fr) | 1995-07-14 | 1998-07-24 | Sandoz Sa | Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule |
TW427904B (en) * | 1995-12-07 | 2001-04-01 | American Home Prod | Neuroprotective agents |
US5780462A (en) * | 1995-12-27 | 1998-07-14 | American Home Products Corporation | Water soluble rapamycin esters |
US5922730A (en) * | 1996-09-09 | 1999-07-13 | American Home Products Corporation | Alkylated rapamycin derivatives |
US6015809A (en) * | 1998-08-17 | 2000-01-18 | American Home Products Corporation | Photocyclized rapamycin |
IL154925A0 (en) * | 2000-09-14 | 2003-10-31 | Beth Israel Hospital | Modulation of il-2 and il-15-mediated t cell responses |
DE60329724D1 (de) | 2002-06-07 | 2009-11-26 | Waratah Pharmaceuticals Inc | Methoden und Kompositionen um Diabetes zu behandeln |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5100899A (en) * | 1989-06-06 | 1992-03-31 | Roy Calne | Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof |
US5023263A (en) * | 1990-08-09 | 1991-06-11 | American Home Products Corporation | 42-oxorapamycin |
-
1992
- 1992-03-24 IL IL101353A patent/IL101353A0/xx unknown
- 1992-03-31 JP JP4076664A patent/JP2535119B2/ja not_active Expired - Fee Related
- 1992-03-31 DK DK92302842.7T patent/DK0507555T3/da active
- 1992-03-31 SG SG1996003300A patent/SG43075A1/en unknown
- 1992-03-31 AT AT92302842T patent/ATE139120T1/de not_active IP Right Cessation
- 1992-03-31 EP EP92302842A patent/EP0507555B1/en not_active Expired - Lifetime
- 1992-03-31 DE DE69211406T patent/DE69211406T2/de not_active Expired - Fee Related
- 1992-03-31 ES ES92302842T patent/ES2089395T3/es not_active Expired - Lifetime
- 1992-04-01 SK SK972-92A patent/SK279180B6/sk unknown
- 1992-04-01 CZ CS92972A patent/CZ282733B6/cs not_active IP Right Cessation
- 1992-04-01 NZ NZ242190A patent/NZ242190A/en not_active IP Right Cessation
- 1992-04-01 AU AU13957/92A patent/AU652037B2/en not_active Ceased
- 1992-04-01 CA CA002064678A patent/CA2064678A1/en not_active Abandoned
- 1992-04-02 HU HU9201113A patent/HUT60626A/hu unknown
- 1992-04-02 NO NO92921279A patent/NO921279L/no unknown
- 1992-04-02 IE IE921055A patent/IE74884B1/en not_active IP Right Cessation
- 1992-04-02 MX MX9201513A patent/MX9201513A/es not_active IP Right Cessation
-
1996
- 1996-06-20 GR GR960401686T patent/GR3020316T3/el unknown
-
1997
- 1997-06-26 HK HK108797A patent/HK108797A/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP0507555A1 (en) | 1992-10-07 |
HK108797A (en) | 1997-08-22 |
HU9201113D0 (en) | 1992-06-29 |
NO921279L (no) | 1992-10-05 |
NO921279D0 (no) | 1992-04-02 |
SK279180B6 (sk) | 1998-07-08 |
ATE139120T1 (de) | 1996-06-15 |
JP2535119B2 (ja) | 1996-09-18 |
DE69211406D1 (de) | 1996-07-18 |
IE74884B1 (en) | 1997-08-13 |
AU1395792A (en) | 1992-10-08 |
NZ242190A (en) | 1997-06-24 |
GR3020316T3 (en) | 1996-09-30 |
MX9201513A (es) | 1993-04-01 |
CZ97292A3 (en) | 1993-09-15 |
EP0507555B1 (en) | 1996-06-12 |
AU652037B2 (en) | 1994-08-11 |
IL101353A0 (en) | 1992-11-15 |
DK0507555T3 (da) | 1996-07-01 |
DE69211406T2 (de) | 1996-11-28 |
IE921055A1 (en) | 1992-10-07 |
CA2064678A1 (en) | 1992-10-04 |
JPH0597688A (ja) | 1993-04-20 |
CZ282733B6 (cs) | 1997-09-17 |
HUT60626A (en) | 1992-10-28 |
SK97292A3 (en) | 1994-11-09 |
SG43075A1 (en) | 1997-10-17 |
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Legal Events
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