DE69211406T2 - Verwendung von Rapamycin zur Behandlung des Diabetes - Google Patents

Verwendung von Rapamycin zur Behandlung des Diabetes

Info

Publication number
DE69211406T2
DE69211406T2 DE69211406T DE69211406T DE69211406T2 DE 69211406 T2 DE69211406 T2 DE 69211406T2 DE 69211406 T DE69211406 T DE 69211406T DE 69211406 T DE69211406 T DE 69211406T DE 69211406 T2 DE69211406 T2 DE 69211406T2
Authority
DE
Germany
Prior art keywords
rapamycin
treat diabetes
insulin
arresting
retarding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69211406T
Other languages
English (en)
Other versions
DE69211406D1 (de
Inventor
William Lee Baeder
Surendra Nath Sehgal
Laurel Moore Adams
Thomas Joseph Caggiano
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth LLC
Original Assignee
American Home Products Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/792,105 external-priority patent/US5321009A/en
Application filed by American Home Products Corp filed Critical American Home Products Corp
Publication of DE69211406D1 publication Critical patent/DE69211406D1/de
Application granted granted Critical
Publication of DE69211406T2 publication Critical patent/DE69211406T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
DE69211406T 1991-04-03 1992-03-31 Verwendung von Rapamycin zur Behandlung des Diabetes Expired - Fee Related DE69211406T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US67970691A 1991-04-03 1991-04-03
US07/792,105 US5321009A (en) 1991-04-03 1991-11-14 Method of treating diabetes

Publications (2)

Publication Number Publication Date
DE69211406D1 DE69211406D1 (de) 1996-07-18
DE69211406T2 true DE69211406T2 (de) 1996-11-28

Family

ID=27102296

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69211406T Expired - Fee Related DE69211406T2 (de) 1991-04-03 1992-03-31 Verwendung von Rapamycin zur Behandlung des Diabetes

Country Status (19)

Country Link
EP (1) EP0507555B1 (de)
JP (1) JP2535119B2 (de)
AT (1) ATE139120T1 (de)
AU (1) AU652037B2 (de)
CA (1) CA2064678A1 (de)
CZ (1) CZ282733B6 (de)
DE (1) DE69211406T2 (de)
DK (1) DK0507555T3 (de)
ES (1) ES2089395T3 (de)
GR (1) GR3020316T3 (de)
HK (1) HK108797A (de)
HU (1) HUT60626A (de)
IE (1) IE74884B1 (de)
IL (1) IL101353A0 (de)
MX (1) MX9201513A (de)
NO (1) NO921279L (de)
NZ (1) NZ242190A (de)
SG (1) SG43075A1 (de)
SK (1) SK279180B6 (de)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378696A (en) * 1990-09-19 1995-01-03 American Home Products Corporation Rapamycin esters
US5177203A (en) * 1992-03-05 1993-01-05 American Home Products Corporation Rapamycin 42-sulfonates and 42-(N-carboalkoxy) sulfamates useful as immunosuppressive agents
US5256790A (en) * 1992-08-13 1993-10-26 American Home Products Corporation 27-hydroxyrapamycin and derivatives thereof
CA2106034A1 (en) * 1992-09-24 1994-03-25 Ralph J. Russo 21-norrapamycin
US5480989A (en) * 1992-10-13 1996-01-02 American Home Products Corporation Carbamates of rapamycin
US5302584A (en) * 1992-10-13 1994-04-12 American Home Products Corporation Carbamates of rapamycin
US5480988A (en) * 1992-10-13 1996-01-02 American Home Products Corporation Carbamates of rapamycin
US5434260A (en) * 1992-10-13 1995-07-18 American Home Products Corporation Carbamates of rapamycin
US5489680A (en) * 1992-10-13 1996-02-06 American Home Products Corporation Carbamates of rapamycin
US5349060A (en) * 1993-01-07 1994-09-20 American Home Products Corporation Rapamycin 31-ester with N,N-dimethylglycine derivatives useful as immunosuppressive agents
US5252579A (en) * 1993-02-16 1993-10-12 American Home Products Corporation Macrocyclic immunomodulators
US7279561B1 (en) 1993-04-23 2007-10-09 Wyeth Anti-rapamycin monoclonal antibodies
ES2295093T3 (es) 1993-04-23 2008-04-16 Wyeth Conjugados y anticuerpos de rapamicina.
US5504091A (en) * 1993-04-23 1996-04-02 American Home Products Corporation Biotin esters of rapamycin
US5387680A (en) * 1993-08-10 1995-02-07 American Home Products Corporation C-22 ring stabilized rapamycin derivatives
US5391730A (en) * 1993-10-08 1995-02-21 American Home Products Corporation Phosphorylcarbamates of rapamycin and oxime derivatives thereof
US5373014A (en) * 1993-10-08 1994-12-13 American Home Products Corporation Rapamycin oximes
US5378836A (en) * 1993-10-08 1995-01-03 American Home Products Corporation Rapamycin oximes and hydrazones
US5385908A (en) * 1993-11-22 1995-01-31 American Home Products Corporation Hindered esters of rapamycin
US5385909A (en) * 1993-11-22 1995-01-31 American Home Products Corporation Heterocyclic esters of rapamycin
US5385910A (en) * 1993-11-22 1995-01-31 American Home Products Corporation Gem-distributed esters of rapamycin
US5389639A (en) * 1993-12-29 1995-02-14 American Home Products Company Amino alkanoic esters of rapamycin
US5525610A (en) * 1994-03-31 1996-06-11 American Home Products Corporation 42-Epi-rapamycin and pharmaceutical compositions thereof
US5362718A (en) 1994-04-18 1994-11-08 American Home Products Corporation Rapamycin hydroxyesters
US5496831A (en) * 1994-05-13 1996-03-05 The General Hospital Corporation Inhibition of insulin-induced adiposis
US5463048A (en) * 1994-06-14 1995-10-31 American Home Products Corporation Rapamycin amidino carbamates
US5491231A (en) * 1994-11-28 1996-02-13 American Home Products Corporation Hindered N-oxide esters of rapamycin
US5563145A (en) * 1994-12-07 1996-10-08 American Home Products Corporation Rapamycin 42-oximes and hydroxylamines
US5561138A (en) * 1994-12-13 1996-10-01 American Home Products Corporation Method of treating anemia
US5496832A (en) * 1995-03-09 1996-03-05 American Home Products Corporation Method of treating cardiac inflammatory disease
FR2736550B1 (fr) 1995-07-14 1998-07-24 Sandoz Sa Composition pharmaceutique sous la forme d'une dispersion solide comprenant un macrolide et un vehicule
TW427904B (en) * 1995-12-07 2001-04-01 American Home Prod Neuroprotective agents
US5780462A (en) * 1995-12-27 1998-07-14 American Home Products Corporation Water soluble rapamycin esters
US5922730A (en) * 1996-09-09 1999-07-13 American Home Products Corporation Alkylated rapamycin derivatives
US6015809A (en) * 1998-08-17 2000-01-18 American Home Products Corporation Photocyclized rapamycin
IL154925A0 (en) * 2000-09-14 2003-10-31 Beth Israel Hospital Modulation of il-2 and il-15-mediated t cell responses
DE60329724D1 (de) 2002-06-07 2009-11-26 Waratah Pharmaceuticals Inc Methoden und Kompositionen um Diabetes zu behandeln

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5100899A (en) * 1989-06-06 1992-03-31 Roy Calne Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof
US5023263A (en) * 1990-08-09 1991-06-11 American Home Products Corporation 42-oxorapamycin

Also Published As

Publication number Publication date
EP0507555A1 (de) 1992-10-07
HK108797A (en) 1997-08-22
ES2089395T3 (es) 1996-10-01
HU9201113D0 (en) 1992-06-29
NO921279L (no) 1992-10-05
NO921279D0 (no) 1992-04-02
SK279180B6 (sk) 1998-07-08
ATE139120T1 (de) 1996-06-15
JP2535119B2 (ja) 1996-09-18
DE69211406D1 (de) 1996-07-18
IE74884B1 (en) 1997-08-13
AU1395792A (en) 1992-10-08
NZ242190A (en) 1997-06-24
GR3020316T3 (en) 1996-09-30
MX9201513A (es) 1993-04-01
CZ97292A3 (en) 1993-09-15
EP0507555B1 (de) 1996-06-12
AU652037B2 (en) 1994-08-11
IL101353A0 (en) 1992-11-15
DK0507555T3 (da) 1996-07-01
IE921055A1 (en) 1992-10-07
CA2064678A1 (en) 1992-10-04
JPH0597688A (ja) 1993-04-20
CZ282733B6 (cs) 1997-09-17
HUT60626A (en) 1992-10-28
SK97292A3 (en) 1994-11-09
SG43075A1 (en) 1997-10-17

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: WYETH (N.D.GES.D. STAATES DELAWARE), MADISON, N.J.

8339 Ceased/non-payment of the annual fee