ES2085001T3 - Combinacion de igf-i y igfbp para el anabolismo. - Google Patents
Combinacion de igf-i y igfbp para el anabolismo.Info
- Publication number
- ES2085001T3 ES2085001T3 ES92903897T ES92903897T ES2085001T3 ES 2085001 T3 ES2085001 T3 ES 2085001T3 ES 92903897 T ES92903897 T ES 92903897T ES 92903897 T ES92903897 T ES 92903897T ES 2085001 T3 ES2085001 T3 ES 2085001T3
- Authority
- ES
- Spain
- Prior art keywords
- igf
- combination
- mammal
- igfbp
- human
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 108090000723 Insulin-Like Growth Factor I Proteins 0.000 title abstract 5
- 102000004218 Insulin-Like Growth Factor I Human genes 0.000 title abstract 5
- 102000028416 insulin-like growth factor binding Human genes 0.000 title abstract 2
- 108091022911 insulin-like growth factor binding Proteins 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 241000124008 Mammalia Species 0.000 abstract 3
- 230000001195 anabolic effect Effects 0.000 abstract 2
- 102000018997 Growth Hormone Human genes 0.000 abstract 1
- 108010051696 Growth Hormone Proteins 0.000 abstract 1
- 101000599951 Homo sapiens Insulin-like growth factor I Proteins 0.000 abstract 1
- 102000004374 Insulin-like growth factor binding protein 3 Human genes 0.000 abstract 1
- 108090000965 Insulin-like growth factor binding protein 3 Proteins 0.000 abstract 1
- 102000023732 binding proteins Human genes 0.000 abstract 1
- 108091008324 binding proteins Proteins 0.000 abstract 1
- 238000011260 co-administration Methods 0.000 abstract 1
- 239000000122 growth hormone Substances 0.000 abstract 1
- 102000044162 human IGF1 Human genes 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000010254 subcutaneous injection Methods 0.000 abstract 1
- 239000007929 subcutaneous injection Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4743—Insulin-like growth factor binding protein
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/30—Insulin-like growth factors, i.e. somatomedins, e.g. IGF-1, IGF-2
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Organic Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Immunology (AREA)
- Endocrinology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
SE DESCRIBE UN METODO PARA PRODUCIR UN ESTADO ANABOLICO EN UN MAMIFERO COADMINISTRANDO POR INYECCION SUBCUTANEA DE UNA COMBINACION DE UNA CANTIDAD EFECTIVA DE IGF-I Y UNA PROTEINA DE ENLACE EN UNA RELACION MOLAR DEFINIDA EN LA AUSENCIA DE HORMONA DE CRECIMIENTO DE MANERA A PRODUCIR UNA MAYOR RESPUESTA ANABOLICA EN EL MAMIFERO QUE EL LLEVADO A CABO UTILIZANDO IGF-I EN UNA CANTIDAD IGUAL A LA USADA PARA IGF-I EN LA COMBINACION.PREFERENTEMENTE, LA IGF-I ES UNA SECUENCIA ORIGINARIA, IGF-I DE UN HUMANO MADURO. LA PROTEINA DE ENLACE ES IGFBP-3, Y EL MAMIFERO ES HUMANO O UN ANIMAL NO HUMANO DE IMPORTANCIA ECONOMICA TALES COMO UNA VACA O UN CERDO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/654,436 US5187151A (en) | 1991-02-12 | 1991-02-12 | Use of binding protein with igf-i as an anabolic growth promoting agent |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2085001T3 true ES2085001T3 (es) | 1996-05-16 |
Family
ID=24624851
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92903897T Expired - Lifetime ES2085001T3 (es) | 1991-02-12 | 1992-01-13 | Combinacion de igf-i y igfbp para el anabolismo. |
Country Status (10)
Country | Link |
---|---|
US (1) | US5187151A (es) |
EP (1) | EP0571417B1 (es) |
JP (1) | JPH06505235A (es) |
AT (1) | ATE135587T1 (es) |
CA (1) | CA2101340C (es) |
DE (1) | DE69209277T2 (es) |
DK (1) | DK0571417T3 (es) |
ES (1) | ES2085001T3 (es) |
GR (1) | GR3019851T3 (es) |
WO (1) | WO1992013556A1 (es) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5374620A (en) * | 1990-06-07 | 1994-12-20 | Genentech, Inc. | Growth-promoting composition and its use |
US5681814A (en) * | 1990-06-07 | 1997-10-28 | Genentech, Inc. | Formulated IGF-I Composition |
US5126324A (en) * | 1990-06-07 | 1992-06-30 | Genentech, Inc. | Method of enhancing growth in patients using combination therapy |
US5643867A (en) * | 1992-08-26 | 1997-07-01 | Celtrix Pharmaceuticals, Inc. | Method for treating catabolic conditions |
CA2142455A1 (en) * | 1992-08-26 | 1994-03-03 | Andreas Sommer | Method for systemic treatment of catabolic conditions and systemic tissue injury |
US5407913A (en) * | 1992-12-03 | 1995-04-18 | Celtrix Pharmaceuticals, Inc. | Method and composition for systemic treatment of tissue injury |
US5273961A (en) * | 1992-09-22 | 1993-12-28 | Genentech, Inc. | Method of prophylaxis of acute renal failure |
WO1994009815A1 (en) * | 1992-10-29 | 1994-05-11 | Celtrix Pharmaceuticals, Inc. | USES OF TGF-β RECEPTOR FRAGMENT AS A THERAPEUTIC AGENT |
ATE143267T1 (de) * | 1992-10-29 | 1996-10-15 | Genentech Inc | Methode zur behandlung oder verhütung von fettleibigkeit |
US6124259A (en) * | 1993-01-28 | 2000-09-26 | Celtrix Pharmaceuticals, Inc. | Method for treating ophthalmic disorders with IGFBP |
AU6093794A (en) * | 1993-01-29 | 1994-08-15 | Synergen, Inc. | Wound healing composition |
US5459051A (en) * | 1993-03-26 | 1995-10-17 | Celtrix Pharmaceuticals, Inc. | Methods and vectors for over-expression of ubiquitin fusion proteins in host cells |
ES2241906T3 (es) * | 1993-09-20 | 2005-11-01 | Celtrix Pharmaceuticals, Inc. | Tratamiento de trastornos inmunologicos y hematologicos con igfbp solo o asociado con igf. |
JPH09509140A (ja) * | 1993-11-15 | 1997-09-16 | セルトリックス ファーマシューティカルズ,インコーポレイテッド | 神経学的障害の治療方法 |
US6207640B1 (en) * | 1994-04-07 | 2001-03-27 | Genentech, Inc. | Treatment of partial growth hormone insensitivity syndrome |
US5824642A (en) * | 1994-04-07 | 1998-10-20 | Genentech, Inc. | Treatment of partial growth hormone insensitivity syndrome |
JPH10512235A (ja) * | 1994-07-20 | 1998-11-24 | セルトリックス ファーマシューティカルズ,インコーポレイテッド | 骨形成の促進および骨再造形の調節のためのigf/igfbp複合体 |
US5728676A (en) * | 1994-09-08 | 1998-03-17 | Ciba-Geigy Corporation | Use of insulin-like growth factors I and II for inhibition of inflammatory response |
AUPN271195A0 (en) * | 1995-05-02 | 1995-05-25 | Bunge Meat Industries Ltd. | Method of selecting livestock |
US5741776A (en) * | 1995-05-22 | 1998-04-21 | Genentech, Inc. | Method of administration of IGF-I |
US5565428A (en) * | 1995-05-22 | 1996-10-15 | Genentech, Inc. | Method of administration of IGF-I |
EP0766966A3 (en) * | 1995-09-08 | 2001-02-28 | Eli Lilly And Company | Method of treating insulin resistance |
US5948757A (en) * | 1996-03-01 | 1999-09-07 | Celtrix Pharmaceuticals, Inc. | High dose IGF-1 therapy |
US5747273A (en) * | 1996-05-07 | 1998-05-05 | Diagnostic Systems Laboratories, Inc. | Immunoassay of total insulin-like growth factor binding protein-1 |
AUPN999096A0 (en) * | 1996-05-22 | 1996-06-13 | Northstar Biologicals Pty Ltd | Peptides, antibodies, vaccines & uses thereof |
US6156728A (en) | 1996-11-01 | 2000-12-05 | Genentech, Inc. | Treatment of inner ear hair cells |
US6593290B1 (en) | 1996-11-01 | 2003-07-15 | Genentech, Inc. | Treatment of inner ear hair cells |
US6066464A (en) * | 1996-12-10 | 2000-05-23 | Diagnostic Systems Laboratories, Inc. | Immunoassay of IGF family of peptides, their binding proteins and related molecules in dried whole blood filter paper spots |
US6025368A (en) * | 1997-02-25 | 2000-02-15 | Celtrix Pharmaceuticals, Inc. | Method for treating the symptoms of chronic stress-related disorders using IGF |
US6514937B1 (en) * | 1997-02-25 | 2003-02-04 | Celtrix Pharmaceuticals, Inc. | Method of treating psychological and metabolic disorders using IGF or IGF/IGFBP-3 |
US6015786A (en) * | 1997-02-25 | 2000-01-18 | Celtrix Pharmaceuticals, Inc. | Method for increasing sex steroid levels using IGF or IGF/IGFBP-3 |
US5824467A (en) * | 1997-02-25 | 1998-10-20 | Celtrix Pharmaceuticals | Methods for predicting drug response |
US6420518B1 (en) | 1997-04-04 | 2002-07-16 | Genetech, Inc. | Insulin-like growth factor agonist molecules |
US6121416A (en) | 1997-04-04 | 2000-09-19 | Genentech, Inc. | Insulin-like growth factor agonist molecules |
US6916790B2 (en) | 1997-05-05 | 2005-07-12 | Mayo Foundation For Medical Education And Research | Treatment of osteoporosis |
AU746423B2 (en) * | 1997-05-05 | 2002-05-02 | Mayo Foundation For Medical Education And Research | Treatment of osteoporosis |
US6548482B1 (en) | 1997-05-05 | 2003-04-15 | Mayo Foundation For Medical Education And Research | Treatment of osteoporosis |
TW586934B (en) * | 1997-05-19 | 2004-05-11 | Sumitomo Pharma | Immunopotentiating composition |
US6436897B2 (en) * | 1998-06-01 | 2002-08-20 | Celtrix Pharmaceuticals, Inc. | Pharmaceutical formulations for IGF/IGFBP |
US6417330B1 (en) | 1998-06-01 | 2002-07-09 | Celtrix Pharmaceuticals, Inc. | Insulin-like growth factor binding protein variants |
US7288516B1 (en) | 1999-09-20 | 2007-10-30 | Celtrix Pharmaceuticals, Inc. | Null IGF for the treatment of cancer |
JP2002526417A (ja) * | 1998-10-02 | 2002-08-20 | セルトリックス ファーマシューティカルズ,インコーポレイテッド | 非甲状腺性疾患の治療方法 |
JP3971108B2 (ja) * | 1999-01-06 | 2007-09-05 | ジェネンテック・インコーポレーテッド | インシュリン様成長因子(igf)i突然変異体 |
DK1282437T3 (da) * | 2000-05-16 | 2008-06-30 | Genentech Inc | Behandling af brusklidelser |
AU9109001A (en) * | 2000-09-19 | 2002-04-02 | Bioexpertise Llc | Method for use of IGF-binding protein for selective sensitization of target cells in vivo |
AUPR030900A0 (en) * | 2000-09-22 | 2000-10-12 | Queensland University Of Technology | Growth factor complex |
MXPA03007042A (es) * | 2001-02-09 | 2004-05-24 | Genentech Inc | Cristalizacion de igf-1. |
US6914049B2 (en) * | 2001-09-18 | 2005-07-05 | Bioexpertise, Llc | IGF-binding protein-derived peptide or small molecule |
WO2003025121A2 (en) * | 2001-09-18 | 2003-03-27 | Bioexpertise, Llc | Igf-binding protein-derived peptide or small molecule |
US6887851B2 (en) * | 2001-09-18 | 2005-05-03 | Bioexpertise, Llc | IGF-binding protein-derived peptide |
ATE536186T1 (de) | 2003-09-12 | 2011-12-15 | Tercica Inc | Verfahren zur behandlung von igf-1 (insulin-like growth factor 1)-mangel |
JP2008511838A (ja) * | 2004-08-30 | 2008-04-17 | テルシカ・インク | インシュリン様成長因子欠乏疾患の診断及び治療のための方法及び装置 |
JP5449134B2 (ja) * | 2007-04-18 | 2014-03-19 | プレーマクレ・アクチエボラーグ | 未熟児合併症の治療及び/又は予防の方法と製品 |
JP7077229B2 (ja) * | 2015-12-31 | 2022-05-30 | シーメンス・ヘルスケア・ダイアグノスティックス・インコーポレーテッド | 非組み換えヒトインスリン様成長因子結合タンパク質の濃縮物 |
US20190018025A1 (en) * | 2015-12-31 | 2019-01-17 | Siemens Healthcare Diagnostics Inc. | Non-recombinant human insulin-like growth factor binding protein concentrate |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1163880B (it) * | 1983-07-29 | 1987-04-08 | Guido Vergari | Fascetta di legatura |
ATE81779T1 (de) * | 1985-08-22 | 1992-11-15 | Gropep Pty Ltd | Peptidanalogedes insulinaehnlichen wachstumsfaktors-1 bei saeugetieren. |
EP0308500B1 (en) * | 1987-04-06 | 1993-06-16 | Celtrix Pharmaceuticals, Inc. | Human somatomedin carrier protein subunits and process for producing them |
DK131988A (da) * | 1988-03-11 | 1989-09-12 | Erasmus University | Igf-bindingsprotein, dna-struktur, der koder for igf-bindingsproteinet og vektor indeholdende denne dna-struktur |
US5258287A (en) * | 1988-03-22 | 1993-11-02 | Genentech, Inc. | DNA encoding and methods of production of insulin-like growth factor binding protein BP53 |
AU1955388A (en) * | 1988-04-12 | 1989-11-03 | Synergen, Inc. | Method for potentiating and inhibiting insulin-like growth factor activity |
DE3822646A1 (de) * | 1988-07-05 | 1990-01-11 | Steag Ag | Verfahren zur gewinnung von sphaerischen feststoffteilchen insbesondere solchen zur verwendung als strahlperlen |
ATE125268T1 (de) * | 1988-07-15 | 1995-08-15 | Cent Sydney Area Health Serv | Säureempfindliche subeinheit eines insulinähnlichen wachstumfaktors-bindeprotein- komplexes. |
GB8826451D0 (en) * | 1988-11-11 | 1988-12-14 | Sandoz Ltd | Improvements in/relating to organic compounds |
IL92816A0 (en) * | 1988-12-22 | 1990-09-17 | Biogrowth Inc | Recombinant dna molecules,hosts,processes and human somatomedin carrier protein-like polypeptides |
-
1991
- 1991-02-12 US US07/654,436 patent/US5187151A/en not_active Expired - Lifetime
-
1992
- 1992-01-13 DE DE69209277T patent/DE69209277T2/de not_active Expired - Lifetime
- 1992-01-13 WO PCT/US1992/000345 patent/WO1992013556A1/en active IP Right Grant
- 1992-01-13 EP EP92903897A patent/EP0571417B1/en not_active Expired - Lifetime
- 1992-01-13 JP JP4504577A patent/JPH06505235A/ja active Pending
- 1992-01-13 AT AT92903897T patent/ATE135587T1/de not_active IP Right Cessation
- 1992-01-13 ES ES92903897T patent/ES2085001T3/es not_active Expired - Lifetime
- 1992-01-13 CA CA002101340A patent/CA2101340C/en not_active Expired - Lifetime
- 1992-01-13 DK DK92903897.4T patent/DK0571417T3/da active
-
1996
- 1996-05-07 GR GR960401236T patent/GR3019851T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
DK0571417T3 (da) | 1996-04-15 |
ATE135587T1 (de) | 1996-04-15 |
CA2101340A1 (en) | 1992-08-13 |
DE69209277T2 (de) | 1996-10-31 |
EP0571417B1 (en) | 1996-03-20 |
GR3019851T3 (en) | 1996-08-31 |
WO1992013556A1 (en) | 1992-08-20 |
EP0571417A1 (en) | 1993-12-01 |
DE69209277D1 (de) | 1996-04-25 |
CA2101340C (en) | 2003-05-06 |
JPH06505235A (ja) | 1994-06-16 |
US5187151A (en) | 1993-02-16 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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