ES2084629T3 - Procedimiento y aparato automatizados para realizar analisis de diagnostico en fase solida. - Google Patents

Procedimiento y aparato automatizados para realizar analisis de diagnostico en fase solida.

Info

Publication number
ES2084629T3
ES2084629T3 ES90116379T ES90116379T ES2084629T3 ES 2084629 T3 ES2084629 T3 ES 2084629T3 ES 90116379 T ES90116379 T ES 90116379T ES 90116379 T ES90116379 T ES 90116379T ES 2084629 T3 ES2084629 T3 ES 2084629T3
Authority
ES
Spain
Prior art keywords
sample
fibrous matrix
well
microparticles
analyte
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90116379T
Other languages
English (en)
Inventor
Omar S Khalil
Denise G Huff
Charles F Hanna
Thomas F Zurek
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Laboratories
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Application granted granted Critical
Publication of ES2084629T3 publication Critical patent/ES2084629T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5025—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures for parallel transport of multiple samples
    • B01L3/50255—Multi-well filtration
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/54366—Apparatus specially adapted for solid-phase testing
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/576—Immunoassay; Biospecific binding assay; Materials therefor for hepatitis
    • G01N33/5761—Hepatitis B
    • G01N33/5762—Hepatitis B core antigen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
    • G01N35/1002—Reagent dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/069—Absorbents; Gels to retain a fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0829—Multi-well plates; Microtitration plates
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/805—Test papers
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/25375—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.]
    • Y10T436/255—Liberation or purification of sample or separation of material from a sample [e.g., filtering, centrifuging, etc.] including use of a solid sorbent, semipermeable membrane, or liquid extraction
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/25—Chemistry: analytical and immunological testing including sample preparation
    • Y10T436/2575—Volumetric liquid transfer

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Cell Biology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Investigating Or Analyzing Materials By The Use Of Magnetic Means (AREA)

Abstract

UN DISPOSITIVO DESECHABLE, UTIL PARA LLEVAR A CABO PRUEBAS DE DIAGNOSTICOS EN FASE SOLIDA QUE EMPLEA MICROPARTICULAS PARA ACOMPLEJAR UN ANALITO Y DONDE EL COMPLEJO DE MICROPARTICULA SE RETIENE E INMOVILIZA EN UNA MATRIZ FIBROSA DE TAL MANERA QUE LA PRESENCIA DE ANALITO EN LAS MICROPARTICULAS PUEDE DETECTARSE POR MEDIOS OPTICOS. SE PRESENTA UN DISPOSITIVO CON UNA CUBETA DE MUESTRA PARA RECIBIR UNA MUESTRA Y REACTIVOS PARA FORMAR UNA MEZCLA DE REACCION, UNA CUBETA DE LECTURA QUE INCLUYE (A) UNA ENTRADA Y ELEMENTOS DE SOPORTE PARA RECIBIR Y RETENER UNA CANTIDAD DE MUESTRA Y REACTIVOS DE ENSAYO, (B) UNA MATRIZ FIBROSA PARA RETENER E INMOVILIZAR COMPLEJOS DE MICROPARTICULAS/ANALITO PARA SU DETECCION, DICHA MATRIZ FIBROSA SE COLOCA BAJO LOS ELEMENTOS DE SOPORTE MENCIONADOS, Y CON UNA SEPARACION ESPACIAL MEDIA DE FIBRAS MAYOR QUE EL DIAMETRO MEDIO DE LAS MICROPARTICULAS MENCIONADAS, (C) ELEMENTOS COLOCADOS BAJO DICHA MATRIZ PARA AYUDAR AL FLUJO DE MUESTRA Y REACTIVOS DE ENSAYO A TRAVES DE DICHA MATRIZ FIBROSA, COMO UN MATERIAL ABSORBENTE O VACIO BAJO ESA MATRIZ FIBROSA, (D) ELEMENTO PARA IMPERMEABILIZAR A LA LUZ ALREDEDOR DE LA CUBETA, (E) ELEMENTO PARA DESCARGAR EL AIRE ATRAPADO EN EL MATERIAL ABSORBENTE Y QUE ES DESPLAZADO POR FLUIDOS ABSORBIDOS EN EL, Y (F) ELEMENTO DE PASO QUE COMUNICA LA CUBETA DE MUESTRA CON LA CUBETA DE LECTURA POR DONDE LA MUESTRA Y LAS MEZCLAS DE REACCION PUEDEN TRANSFERIRSE Y LAVARSE DESDE DICHA CUBETA DE MUESTRA A DICHA CUBETA DE LECTURA SIN SER PUESTAS EN CONTACTO POR NINGUN APARATO.
ES90116379T 1989-10-23 1990-08-27 Procedimiento y aparato automatizados para realizar analisis de diagnostico en fase solida. Expired - Lifetime ES2084629T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/425,651 US5244630A (en) 1988-04-22 1989-10-23 Device for performing solid-phase diagnostic assay

Publications (1)

Publication Number Publication Date
ES2084629T3 true ES2084629T3 (es) 1996-05-16

Family

ID=23687468

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90116379T Expired - Lifetime ES2084629T3 (es) 1989-10-23 1990-08-27 Procedimiento y aparato automatizados para realizar analisis de diagnostico en fase solida.

Country Status (9)

Country Link
US (1) US5244630A (es)
EP (1) EP0424633B1 (es)
JP (1) JP2515428B2 (es)
KR (1) KR910008408A (es)
AT (1) ATE133263T1 (es)
AU (1) AU639703B2 (es)
CA (1) CA2021587C (es)
DE (1) DE69024905T2 (es)
ES (1) ES2084629T3 (es)

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AU5984890A (en) 1991-04-26
EP0424633B1 (en) 1996-01-17
EP0424633A2 (en) 1991-05-02
KR910008408A (ko) 1991-05-31
DE69024905D1 (de) 1996-02-29
DE69024905T2 (de) 1996-09-05
AU639703B2 (en) 1993-08-05
JP2515428B2 (ja) 1996-07-10
CA2021587C (en) 2003-04-08
CA2021587A1 (en) 1991-04-24
ATE133263T1 (de) 1996-02-15
US5244630A (en) 1993-09-14
JPH03160981A (ja) 1991-07-10
EP0424633A3 (en) 1992-09-23

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