ES2084175T3 - Estimulacion del crecimiento del cabello con activadores de los canales del potasio e inhibidores de la 5-alfa-reductasa. - Google Patents

Estimulacion del crecimiento del cabello con activadores de los canales del potasio e inhibidores de la 5-alfa-reductasa.

Info

Publication number
ES2084175T3
ES2084175T3 ES91913987T ES91913987T ES2084175T3 ES 2084175 T3 ES2084175 T3 ES 2084175T3 ES 91913987 T ES91913987 T ES 91913987T ES 91913987 T ES91913987 T ES 91913987T ES 2084175 T3 ES2084175 T3 ES 2084175T3
Authority
ES
Spain
Prior art keywords
alpha
potassium channel
hair growth
reductase inhibitors
stimulation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91913987T
Other languages
English (en)
Inventor
Arthur Robert Diani
Allen Edwin Buhl
Heinrich Josef Schostarez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of ES2084175T3 publication Critical patent/ES2084175T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

UN METODO MEJORADO Y LA COMPOSICION PARA FAVORECER EL CRECIMIENRTO DEL PELO EN MAMIFEROS PARA TRATAR VARIOS TIPOS DE ALOPECIA O CALVICIE NORMAL MASCULINA COMPRENDE LA ADMINISTRACION CONCOMITANTE DE ABRIDORES DE CANALES DE POTASIO, COMO EL MINOXIDIL, EL CROMOCALIM, PINACIDIL, O UN COMPUESTO SELECCIONADO DE ENTRE LAS CLASES DE S-TRIACINA, TIAN-1-OXIDO, COMPUESTOS DE BENZOPIRANO Y PIRIDINOPIRANO; E INHIBIDORES DE LA 5(ALFA)-REDUCTASA, 17(BETA)-(N-TEREBUTILCARBAMAIL)-4-AZO-5-(ALFA)-ANDROST-1-EN-3-ONA. EL METODO COMPRENDE LA ADMINISTRACION DE UNA CANTIDAD EFECTIVA DE UN ABRIDOR DE UN CANAL DE POTASIO Y LA ADMINISTRACION DE UNA CANTIDAD EFECTIVA DE LA 17(BETA)-(N-TEREBUTILCARBAMAIL)-4-AZO-5-(ALFA)ANDROST-1-EN-3-ONA, POR LO CUAL EL FAVORECIMIENTO DEL CRECIMIENTO DEL PELO SE AUMENTA POR ENCIMA DE LA ADMINISTRACION UNICA DEL INHIBIDOR DEL CANAL DE POTASIO.
ES91913987T 1990-08-10 1991-07-29 Estimulacion del crecimiento del cabello con activadores de los canales del potasio e inhibidores de la 5-alfa-reductasa. Expired - Lifetime ES2084175T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US56577790A 1990-08-10 1990-08-10

Publications (1)

Publication Number Publication Date
ES2084175T3 true ES2084175T3 (es) 1996-05-01

Family

ID=24260045

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91913987T Expired - Lifetime ES2084175T3 (es) 1990-08-10 1991-07-29 Estimulacion del crecimiento del cabello con activadores de los canales del potasio e inhibidores de la 5-alfa-reductasa.

Country Status (12)

Country Link
US (1) US5578599A (es)
EP (1) EP0542802B1 (es)
JP (1) JP3004718B2 (es)
KR (1) KR100192734B1 (es)
AT (1) ATE134877T1 (es)
AU (1) AU646069B2 (es)
CA (1) CA2085605C (es)
DE (1) DE69117762T2 (es)
DK (1) DK0542802T3 (es)
ES (1) ES2084175T3 (es)
GR (1) GR3019789T3 (es)
WO (1) WO1992002225A1 (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516768A (en) * 1990-03-16 1996-05-14 Smithkline Beecham Corporation Uncompetitive inhibition of steroid and 5α-reductose
WO1994015602A1 (en) * 1993-01-07 1994-07-21 Merck & Co., Inc. COMBINATION METHOD FOR TREATING PATTERNED ALOPECIA WITH 17β-N-SUBSTITUTED-CARBAMOYL-4-AZA-5α-ANDROST-1-EN-3-ONES AND MINOXIDIL
GB2274060A (en) * 1993-01-07 1994-07-13 Merck & Co Inc Treatment of patterned alopecia with 17ß-acyl-4-aza-5-androst-1-ene-3-ones and minoxidil
US5407944A (en) * 1993-02-19 1995-04-18 Goldman; Boris E. Compositions and methods for promoting hair growth
CA2165077A1 (en) * 1993-06-28 1995-01-05 Philippe L. Durette 4-aza-pregnane 5.alpha.-reductase isozyme 1 inhibitors
TW382595B (en) * 1993-10-15 2000-02-21 Merck & Co Inc Pharmaceutical composition for use in arresting and reversing androgenic alopecia
US5547957A (en) * 1993-10-15 1996-08-20 Merck & Co., Inc. Method of treating androgenic alopecia with 5-α reductase inhibitors
AU1097995A (en) * 1993-11-18 1995-06-06 Merck & Co., Inc. Combination method for the treatment of patterned alopecia
FR2717381B1 (fr) * 1994-03-15 1996-04-19 Oreal Compositions à base d'alpha-pyrones pour induire et stimuler la croissance des cheveux et/ou freiner leur chute et utilisation.
US5886005A (en) * 1995-01-17 1999-03-23 Merck & Co., Inc. 4-Aza-19-norandrostane derivatives
JPH11513684A (ja) * 1995-10-19 1999-11-24 メルク エンド カンパニー インコーポレーテッド １６−置換−６−アザ−ステロイド５α−レダクターゼ阻害剤
JPH10203933A (ja) * 1997-01-27 1998-08-04 Kao Corp 養毛・育毛料
US6458835B2 (en) 1997-08-13 2002-10-01 Bristol-Myers Squibb Company Method of inhibiting or treating chemotherapy-induced hair loss
US6013668A (en) 1997-08-13 2000-01-11 Bristol-Myers Squibb Company Enantiomers of 4-[[(cyanoimino) [(1,2,2-trimethylpropyl) amino]methyl]amino]benzonitrile
AUPO983897A0 (en) * 1997-10-17 1997-11-06 Soltec Research Pty Ltd Topical antifungal composition
AUPP310798A0 (en) 1998-04-22 1998-05-14 Soltec Research Pty Ltd Vehicle system for a composition comprising a piperidinopyrimidine derivative
GB9909792D0 (en) 1998-12-04 1999-06-23 Cambridge Bioclinical Limited Potassium channel activators and their use
US7018979B1 (en) 2000-01-26 2006-03-28 Cedars-Sinai Medical Center Method for using potassium channel agonists for delivering a medicant to an abnormal brain region and/or a malignant tumor
US20050153940A1 (en) * 2000-01-26 2005-07-14 Cedars-Sinai Medical Center Method for using potassium channel activation for delivering a medicant to an abnormal brain region and/or a malignant tumor
US6596266B2 (en) 2000-02-18 2003-07-22 Natural Science, Inc. Compositions containing minoxidil and saw palmetto for treating baldness
KR20020005332A (ko) * 2000-07-10 2002-01-17 정상훈 탈모증 치료용 키트
DE10036799A1 (de) * 2000-07-28 2002-02-07 Beiersdorf Ag Neues Mittel zur Behandlung der Haare und der Kopfhaut
SE0100374D0 (sv) * 2001-02-07 2001-02-07 Pharmacia Ab Novel compositions of potassium channel openers and protein kinase c inhibitors and use thereof
US7211561B2 (en) * 2001-10-12 2007-05-01 Cedars-Sinai Medical Center Method for inducing selective cell death of malignant cells by activation of calcium-activated potassium channels (KCa)
SE0104421D0 (sv) * 2001-12-21 2001-12-21 Ponsus Pharma Ab New composition
US20080188480A1 (en) * 2005-02-22 2008-08-07 Cedars-Sinai Medical Center Use of Sildenafil, Vardenafil and Other 5-Phosphodiesterase Inhibitors to Enhance Permeability of the Abnormal Blood-Brain Barrier
US7914548B2 (en) * 2006-04-17 2011-03-29 Ustuner E Tuncay Prevention or treatment of male pattern baldness method and device
EP2343061A1 (en) 2009-12-28 2011-07-13 Lipofoods, S.L. Use of tall oil pitch extract and compositions which contain it
KR101205209B1 (ko) * 2011-04-25 2012-11-27 박준형 탈모방지 및 발모촉진용 외용제 조성물
WO2015155609A2 (en) * 2014-04-11 2015-10-15 Bcs Business Consulting Services Pte Ltd Eyebrow and eyelash enhancing formulation
MX2018001546A (es) * 2018-02-06 2019-08-07 Centro Int De Cosmiatria S A P I De C V Formulacion y metodo para el tratamiento de la alopecia androgenica.

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4139619A (en) * 1976-05-24 1979-02-13 The Upjohn Company 6-Amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidine, topical compositions and process for hair growth
US4596812A (en) * 1976-05-24 1986-06-24 The Upjohn Company Methods and solutions for treating male pattern alopecia
DE3486090T2 (de) * 1983-12-12 1993-08-05 Kaszynski Edwin G Haarwuchsmodifikation.
US4684635A (en) * 1984-05-11 1987-08-04 Norman Orentreich Compositions and methods for inhibiting the action of androgens
ATE89159T1 (de) * 1985-07-18 1993-05-15 Peter H Proctor Topische zusammensetzung und verfahren zur anregung des haarwuchses.
DE3615396A1 (de) * 1986-05-07 1987-11-12 Wella Ag Mittel zur behandlung der haare und der kopfhaut
AU1542288A (en) * 1987-03-30 1988-11-02 Upjohn Company, The Combination of minoxidil and an anti-inflammatory agent for treating patterned alopecia
US5026691A (en) * 1987-03-30 1991-06-25 The Upjohn Company Combination of minoxidil and an antiinflammatory agent for treating patterned alopecia
DE3888994T2 (de) * 1987-04-03 1994-11-03 Merck & Co Inc Behandlung von androgener Alopecia mit 17-beta-n-mono-substituierten-carbamoyl-4-aza-5-alpha-androst-1-en-3-onen.
JPH01305017A (ja) * 1988-05-31 1989-12-08 Yakurigaku Chuo Kenkyusho:Kk 脱毛症治療剤
JPH04501851A (ja) * 1988-12-02 1992-04-02 ジ・アップジョン・カンパニー 脱毛症治療のためのミノキシジルおよび血管収縮薬組成物

Also Published As

Publication number Publication date
WO1992002225A1 (en) 1992-02-20
EP0542802B1 (en) 1996-03-06
AU646069B2 (en) 1994-02-03
DE69117762T2 (de) 1996-08-08
JPH06500081A (ja) 1994-01-06
JP3004718B2 (ja) 2000-01-31
DK0542802T3 (da) 1996-07-22
ATE134877T1 (de) 1996-03-15
CA2085605C (en) 2003-03-11
GR3019789T3 (en) 1996-07-31
DE69117762D1 (de) 1996-04-11
KR100192734B1 (ko) 1999-06-15
AU8301091A (en) 1992-03-02
EP0542802A1 (en) 1993-05-26
US5578599A (en) 1996-11-26
CA2085605A1 (en) 1992-02-11

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