DE69117762D1 - Stimulierung des haarwuchses mit kaliumchannelöffnern und 5-alpha-reduktase-inhibitoren - Google Patents

Stimulierung des haarwuchses mit kaliumchannelöffnern und 5-alpha-reduktase-inhibitoren

Info

Publication number
DE69117762D1
DE69117762D1 DE69117762T DE69117762T DE69117762D1 DE 69117762 D1 DE69117762 D1 DE 69117762D1 DE 69117762 T DE69117762 T DE 69117762T DE 69117762 T DE69117762 T DE 69117762T DE 69117762 D1 DE69117762 D1 DE 69117762D1
Authority
DE
Germany
Prior art keywords
potassium channel
hair growth
alpha
reductase inhibitors
channel openers
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69117762T
Other languages
English (en)
Other versions
DE69117762T2 (de
Inventor
Arthur Robert Diani
Allen Edwin Buhl
Heinrich Josef Schostarez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co LLC
Original Assignee
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Upjohn Co filed Critical Upjohn Co
Application granted granted Critical
Publication of DE69117762D1 publication Critical patent/DE69117762D1/de
Publication of DE69117762T2 publication Critical patent/DE69117762T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/494—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom
    • A61K8/4953—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with more than one nitrogen as the only hetero atom containing pyrimidine ring derivatives, e.g. minoxidil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74—Biological properties of particular ingredients
    • A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782—Enzyme inhibitors; Enzyme antagonists

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Birds (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69117762T 1990-08-10 1991-07-29 Stimulierung des haarwuchses mit kaliumchannelöffnern und 5-alpha-reduktase-inhibitoren Expired - Fee Related DE69117762T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US56577790A 1990-08-10 1990-08-10
PCT/US1991/005170 WO1992002225A1 (en) 1990-08-10 1991-07-29 STIMULATION OF HAIR GROWTH WITH POTASSIUM CHANNEL OPENERS AND 5α-REDUCTASE INHIBITORS

Publications (2)

Publication Number Publication Date
DE69117762D1 true DE69117762D1 (de) 1996-04-11
DE69117762T2 DE69117762T2 (de) 1996-08-08

Family

ID=24260045

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69117762T Expired - Fee Related DE69117762T2 (de) 1990-08-10 1991-07-29 Stimulierung des haarwuchses mit kaliumchannelöffnern und 5-alpha-reduktase-inhibitoren

Country Status (12)

Country Link
US (1) US5578599A (de)
EP (1) EP0542802B1 (de)
JP (1) JP3004718B2 (de)
KR (1) KR100192734B1 (de)
AT (1) ATE134877T1 (de)
AU (1) AU646069B2 (de)
CA (1) CA2085605C (de)
DE (1) DE69117762T2 (de)
DK (1) DK0542802T3 (de)
ES (1) ES2084175T3 (de)
GR (1) GR3019789T3 (de)
WO (1) WO1992002225A1 (de)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5516768A (en) * 1990-03-16 1996-05-14 Smithkline Beecham Corporation Uncompetitive inhibition of steroid and 5α-reductose
AU6083494A (en) * 1993-01-07 1994-08-15 Merck & Co., Inc. Combination method for treating patterned alopecia with 17beta -n-substituted-carbamoyl-4-aza-5alpha-androst-1-en-3- ones and minoxidil
GB2274060A (en) * 1993-01-07 1994-07-13 Merck & Co Inc Treatment of patterned alopecia with 17ß-acyl-4-aza-5-androst-1-ene-3-ones and minoxidil
US5407944A (en) * 1993-02-19 1995-04-18 Goldman; Boris E. Compositions and methods for promoting hair growth
CA2165077A1 (en) * 1993-06-28 1995-01-05 Philippe L. Durette 4-aza-pregnane 5.alpha.-reductase isozyme 1 inhibitors
US5547957A (en) * 1993-10-15 1996-08-20 Merck & Co., Inc. Method of treating androgenic alopecia with 5-α reductase inhibitors
TW382595B (en) * 1993-10-15 2000-02-21 Merck & Co Inc Pharmaceutical composition for use in arresting and reversing androgenic alopecia
WO1995013815A1 (en) * 1993-11-18 1995-05-26 Merck & Co., Inc. Combination method for the treatment of patterned alopecia
FR2717381B1 (fr) * 1994-03-15 1996-04-19 Oreal Compositions à base d'alpha-pyrones pour induire et stimuler la croissance des cheveux et/ou freiner leur chute et utilisation.
US5886005A (en) * 1995-01-17 1999-03-23 Merck & Co., Inc. 4-Aza-19-norandrostane derivatives
AU704933B2 (en) * 1995-10-19 1999-05-06 Merck & Co., Inc. 16-substituted-6-aza-steroid 5-alpha-reductase inhibitors
JPH10203933A (ja) * 1997-01-27 1998-08-04 Kao Corp 養毛・育毛料
US6013668A (en) * 1997-08-13 2000-01-11 Bristol-Myers Squibb Company Enantiomers of 4-[[(cyanoimino) [(1,2,2-trimethylpropyl) amino]methyl]amino]benzonitrile
US6458835B2 (en) 1997-08-13 2002-10-01 Bristol-Myers Squibb Company Method of inhibiting or treating chemotherapy-induced hair loss
AUPO983897A0 (en) * 1997-10-17 1997-11-06 Soltec Research Pty Ltd Topical antifungal composition
AUPP310798A0 (en) * 1998-04-22 1998-05-14 Soltec Research Pty Ltd Vehicle system for a composition comprising a piperidinopyrimidine derivative
GB9909792D0 (en) 1998-12-04 1999-06-23 Cambridge Bioclinical Limited Potassium channel activators and their use
US7018979B1 (en) 2000-01-26 2006-03-28 Cedars-Sinai Medical Center Method for using potassium channel agonists for delivering a medicant to an abnormal brain region and/or a malignant tumor
US20050153940A1 (en) * 2000-01-26 2005-07-14 Cedars-Sinai Medical Center Method for using potassium channel activation for delivering a medicant to an abnormal brain region and/or a malignant tumor
US6596266B2 (en) 2000-02-18 2003-07-22 Natural Science, Inc. Compositions containing minoxidil and saw palmetto for treating baldness
KR20020005332A (ko) * 2000-07-10 2002-01-17 정상훈 탈모증 치료용 키트
DE10036799A1 (de) * 2000-07-28 2002-02-07 Beiersdorf Ag Neues Mittel zur Behandlung der Haare und der Kopfhaut
SE0100374D0 (sv) * 2001-02-07 2001-02-07 Pharmacia Ab Novel compositions of potassium channel openers and protein kinase c inhibitors and use thereof
US7211561B2 (en) * 2001-10-12 2007-05-01 Cedars-Sinai Medical Center Method for inducing selective cell death of malignant cells by activation of calcium-activated potassium channels (KCa)
SE0104421D0 (sv) * 2001-12-21 2001-12-21 Ponsus Pharma Ab New composition
WO2006091542A2 (en) * 2005-02-22 2006-08-31 Cedars-Sinai Medical Center Use of sildenafil, vardenafil and other 5-phosphodiesterase inhibitors to enhance permeability of the abnormal blood-brain barrier
US7914548B2 (en) * 2006-04-17 2011-03-29 Ustuner E Tuncay Prevention or treatment of male pattern baldness method and device
EP2343061A1 (de) 2009-12-28 2011-07-13 Lipofoods, S.L. Verwendung eines Tallölpechextrakts und dieses enthaltende Zusammensetzungen
KR101205209B1 (ko) * 2011-04-25 2012-11-27 박준형 탈모방지 및 발모촉진용 외용제 조성물
WO2015155609A2 (en) * 2014-04-11 2015-10-15 Bcs Business Consulting Services Pte Ltd Eyebrow and eyelash enhancing formulation

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4596812A (en) * 1976-05-24 1986-06-24 The Upjohn Company Methods and solutions for treating male pattern alopecia
US4139619A (en) * 1976-05-24 1979-02-13 The Upjohn Company 6-Amino-4-(substituted amino)-1,2-dihydro-1-hydroxy-2-iminopyrimidine, topical compositions and process for hair growth
AU584070B2 (en) * 1983-12-12 1989-05-18 Edwin G. Kaszynski Hair growth modification
US4684635A (en) * 1984-05-11 1987-08-04 Norman Orentreich Compositions and methods for inhibiting the action of androgens
AU6131686A (en) * 1985-07-18 1987-02-10 Proctor, P.H. Topical composition and method for stimulating hair growth
DE3615396A1 (de) * 1986-05-07 1987-11-12 Wella Ag Mittel zur behandlung der haare und der kopfhaut
ATE122873T1 (de) * 1987-03-30 1995-06-15 Upjohn Co Kombination aus minoxidil und einer antiinflammatorischen substanz zur behandlung der alopezie.
US5026691A (en) * 1987-03-30 1991-06-25 The Upjohn Company Combination of minoxidil and an antiinflammatory agent for treating patterned alopecia
DE3888994T2 (de) * 1987-04-03 1994-11-03 Merck & Co Inc Behandlung von androgener Alopecia mit 17-beta-n-mono-substituierten-carbamoyl-4-aza-5-alpha-androst-1-en-3-onen.
JPH01305017A (ja) * 1988-05-31 1989-12-08 Yakurigaku Chuo Kenkyusho:Kk 脱毛症治療剤
EP0451156A1 (de) * 1988-12-02 1991-10-16 The Upjohn Company Minoxidil und vasokonstriktorzusammensetzungen zur behandlung von alopecia

Also Published As

Publication number Publication date
ES2084175T3 (es) 1996-05-01
DE69117762T2 (de) 1996-08-08
EP0542802B1 (de) 1996-03-06
AU646069B2 (en) 1994-02-03
KR100192734B1 (ko) 1999-06-15
JP3004718B2 (ja) 2000-01-31
CA2085605A1 (en) 1992-02-11
WO1992002225A1 (en) 1992-02-20
EP0542802A1 (de) 1993-05-26
DK0542802T3 (da) 1996-07-22
JPH06500081A (ja) 1994-01-06
GR3019789T3 (en) 1996-07-31
ATE134877T1 (de) 1996-03-15
US5578599A (en) 1996-11-26
CA2085605C (en) 2003-03-11
AU8301091A (en) 1992-03-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: PHARMACIA & UPJOHN CO., KALAMAZOO, MICH., US

8327 Change in the person/name/address of the patent owner

Owner name: PHARMACIA & UPJOHN CO. LLC, WILMINGTON, DEL., US

8339 Ceased/non-payment of the annual fee