ES2078190A1 - Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico. - Google Patents
Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico.Info
- Publication number
- ES2078190A1 ES2078190A1 ES09401121A ES9401121A ES2078190A1 ES 2078190 A1 ES2078190 A1 ES 2078190A1 ES 09401121 A ES09401121 A ES 09401121A ES 9401121 A ES9401121 A ES 9401121A ES 2078190 A1 ES2078190 A1 ES 2078190A1
- Authority
- ES
- Spain
- Prior art keywords
- solvent
- polymer
- droplets
- particles
- preparing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/51—Nanocapsules; Nanoparticles
- A61K9/5107—Excipients; Inactive ingredients
- A61K9/513—Organic macromolecular compounds; Dendrimers
- A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
- A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
- B01J13/02—Making microcapsules or microballoons
- B01J13/20—After-treatment of capsule walls, e.g. hardening
- B01J13/22—Coating
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/773—Nanoparticle, i.e. structure having three dimensions of 100 nm or less
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/70—Nanostructure
- Y10S977/788—Of specified organic or carbon-based composition
- Y10S977/795—Composed of biological material
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/84—Manufacture, treatment, or detection of nanostructure
- Y10S977/89—Deposition of materials, e.g. coating, cvd, or ald
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/84—Manufacture, treatment, or detection of nanostructure
- Y10S977/89—Deposition of materials, e.g. coating, cvd, or ald
- Y10S977/891—Vapor phase deposition
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S977/00—Nanotechnology
- Y10S977/902—Specified use of nanostructure
- Y10S977/904—Specified use of nanostructure for medical, immunological, body treatment, or diagnosis
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Nanotechnology (AREA)
- Optics & Photonics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Physics & Mathematics (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Preparation (AREA)
- Manufacturing Of Micro-Capsules (AREA)
- Cosmetics (AREA)
- Luminescent Compositions (AREA)
- Paints Or Removers (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Processes Of Treating Macromolecular Substances (AREA)
- Glanulating (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
PROCEDIMIENTO PARA EL RECUBRIMIENTO DE GOTICULAS O PARTICULAS DE TAMAÑO NANOMETRICO. COMPRENDE: (1) PREPARAR UNA FINA DISPERSION DE GOTICULAS O DE PARTICULAS QUE CONTIENEN O ESTAN FORMADAS POR UNA SUSTANCIA QUIMICA O BIOLOGICAMENTE ACTIVA EN UNA FASE COMPUESTA POR UN SOLVENTE Y UN NO SOLVENTE DEL POLIMERO FORMADOR DE LA CUBIERTA Y OPCIONALMENTE UN TENSIOACTIVO O AGENTE SUSPENSOR (2) PREPARAR UNA FASE QUE CONTIENE DISUELTO EL POLIMERO FORMADOR DE LA CUBIERTA EN UN SOLVENTE MISCIBLE EN CUALQUIER PROPORCION CON LA DISPERSION ANTERIOR, (3) MEZCLAR LAS DOS FASES DE FORMA CONTINUA MANTENIENDO CONSTANTE LA RELACION DE FASES Y EL VOLUMEN DE MEZCLA Y PULVERIZANDO SIMULTANEAMENTE LA MEZCLA RESULTANTE EN UN SISTEMA DE EVAPORACION CON UNAS CONDICIONES DE TEMPERATURA Y DE VACIO QUE PERMITAN LA INSTANTANEA EVAPORACION DEL SOLVENTE DEL POLIMERO, DANDO LUGAR A LA DEPOSICION DEL POLIMERO ALREDEDOR DE LAS PARTICULAS O GOTICULAS. APLICACION EN FARMACIA, MEDICINA, COSMETICA, VETERINARIA, INDUSTRIA QUIMICA, AGRICULTURA, ETC.
Priority Applications (22)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09401121A ES2078190B1 (es) | 1994-05-20 | 1994-05-20 | Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico. |
HU9600386A HU9600386D0 (en) | 1994-05-20 | 1994-09-07 | Process for coating droplets or nanometric particles |
AT94925490T ATE198548T1 (de) | 1994-05-20 | 1994-09-30 | Verfahren zur umhüllung von nanopartikeln oder - tröpfchen |
BR9407333A BR9407333A (pt) | 1994-05-20 | 1994-09-30 | Processo para revestir goticulas ou particulas sólidas |
DK94925490T DK0717989T3 (da) | 1994-05-20 | 1994-09-30 | Fremgangsmåde til overtrækning af smådråber eller nanopartikler |
AU75379/94A AU696400B2 (en) | 1994-05-20 | 1994-09-30 | Process for coating droplets or nanometric particles |
US08/586,731 US5851452A (en) | 1994-05-20 | 1994-09-30 | Process for coating droplets or nanometric particles |
DE69426568T DE69426568T2 (de) | 1994-05-20 | 1994-09-30 | Verfahren zur umhüllung von nanopartikeln oder -tröpfchen |
CN94193333A CN1130868A (zh) | 1994-05-20 | 1994-09-30 | 用于包覆纳米级微滴或颗粒的方法 |
EP94925490A EP0717989B1 (en) | 1994-05-20 | 1994-09-30 | Process for coating droplets or nanometric particles |
PL94312666A PL312666A1 (en) | 1994-05-20 | 1994-09-30 | Method of coating droplets or particles of nanometer size |
KR1019960700306A KR960703577A (ko) | 1994-05-20 | 1994-09-30 | 비말이나 극미립자의 코팅공정(process for coating droplets or nanometric particles) |
JP7530066A JPH09501101A (ja) | 1994-05-20 | 1994-09-30 | 液滴またはナノメータ粒子の被覆方法 |
PT94925490T PT717989E (pt) | 1994-05-20 | 1994-09-30 | Processo para o revestimento de gpticulas ou particulas nanometricas |
CA002167681A CA2167681A1 (en) | 1994-05-20 | 1994-09-30 | Process for coating droplets or nanometric particles |
PCT/ES1994/000085 WO1995031975A1 (es) | 1994-05-20 | 1994-09-30 | Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico |
NO960232A NO960232L (no) | 1994-05-20 | 1996-01-19 | Fremgangsmåte for belegging av dråper eller nanopartikler |
OA60769A OA10257A (en) | 1994-05-20 | 1996-01-19 | Process for coating droplets or nanometric particles |
BG100372A BG100372A (en) | 1994-05-20 | 1996-02-20 | Process for coating droplets or nanometric particles |
FI961348A FI961348A0 (fi) | 1994-05-20 | 1996-03-25 | Menetelmä pienten pisaroiden tai nanometristen hiukkasten päällystämiseksi |
HK98113202A HK1017807A1 (en) | 1994-05-20 | 1998-12-11 | Process for coating droplets or nanometric particles |
GR20010400505T GR3035655T3 (en) | 1994-05-20 | 2001-03-29 | Process for coating droplets or nanometric particles |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES09401121A ES2078190B1 (es) | 1994-05-20 | 1994-05-20 | Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2078190A1 true ES2078190A1 (es) | 1995-12-01 |
ES2078190B1 ES2078190B1 (es) | 1996-08-01 |
Family
ID=8286348
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09401121A Expired - Lifetime ES2078190B1 (es) | 1994-05-20 | 1994-05-20 | Procedimiento para el recubrimiento de goticulas o particulas de tamaño nanometrico. |
Country Status (22)
Country | Link |
---|---|
US (1) | US5851452A (es) |
EP (1) | EP0717989B1 (es) |
JP (1) | JPH09501101A (es) |
KR (1) | KR960703577A (es) |
CN (1) | CN1130868A (es) |
AT (1) | ATE198548T1 (es) |
AU (1) | AU696400B2 (es) |
BG (1) | BG100372A (es) |
BR (1) | BR9407333A (es) |
CA (1) | CA2167681A1 (es) |
DE (1) | DE69426568T2 (es) |
DK (1) | DK0717989T3 (es) |
ES (1) | ES2078190B1 (es) |
FI (1) | FI961348A0 (es) |
GR (1) | GR3035655T3 (es) |
HK (1) | HK1017807A1 (es) |
HU (1) | HU9600386D0 (es) |
NO (1) | NO960232L (es) |
OA (1) | OA10257A (es) |
PL (1) | PL312666A1 (es) |
PT (1) | PT717989E (es) |
WO (1) | WO1995031975A1 (es) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5922403A (en) * | 1996-03-12 | 1999-07-13 | Tecle; Berhan | Method for isolating ultrafine and fine particles |
US5945126A (en) * | 1997-02-13 | 1999-08-31 | Oakwood Laboratories L.L.C. | Continuous microsphere process |
EP1023050B1 (en) * | 1997-06-27 | 2013-09-25 | Abraxis BioScience, LLC | Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof |
CA2352362C (en) * | 1998-11-30 | 2009-02-17 | Nanosphere, Inc. | Nanoparticles with polymer shells |
DE19856432A1 (de) * | 1998-12-08 | 2000-06-15 | Basf Ag | Nanopartikuläre Kern-Schale Systeme sowie deren Verwendung in pharmazeutischen und kosmetischen Zubereitungen |
FR2805761B1 (fr) * | 2000-03-02 | 2002-08-30 | Mainelab | Nanocapsules lipidiques, procede de preparation et utilisation comme medicament |
WO2003037359A1 (fr) * | 2001-10-29 | 2003-05-08 | Chengdu Somo Namotechnology Co., Ltd. | Nanoparticule de composants de medicaments insolubles et procede de production correspondant |
US7053034B2 (en) * | 2002-04-10 | 2006-05-30 | Salvona, Llc | Targeted controlled delivery compositions activated by changes in pH or salt concentration |
DE602004019662D1 (de) | 2003-09-26 | 2009-04-09 | 3M Innovative Properties Co | Nanoskalige goldkatalysatoren, aktivierungsmittel, trägermedien und verwandte methodologien zur herstellung derartiger katalysatorsysteme, insbesondere bei abscheidung des golds auf den trägermedien mittels pvd |
US8058202B2 (en) * | 2005-01-04 | 2011-11-15 | 3M Innovative Properties Company | Heterogeneous, composite, carbonaceous catalyst system and methods that use catalytically active gold |
KR101430767B1 (ko) * | 2005-07-18 | 2014-08-19 | 유니버시티 오브 메사츄세츠 로웰 | 나노에멀젼 조성물 및 이의 제조 및 사용 방법 |
PT3295955T (pt) | 2005-12-01 | 2021-07-12 | Univ Massachusetts Lowell | Nanoemulsões botulínicas |
US9486408B2 (en) | 2005-12-01 | 2016-11-08 | University Of Massachusetts Lowell | Botulinum nanoemulsions |
WO2008070538A2 (en) | 2006-12-01 | 2008-06-12 | Anterios, Inc. | Micellar nanoparticles comprising botulinum toxin |
CN107080703A (zh) | 2006-12-01 | 2017-08-22 | 安特里奥公司 | 肽纳米粒子和其用途 |
EP2162117B1 (en) | 2007-05-31 | 2018-02-21 | Anterios, Inc. | Nucleic acid nanoparticles and uses therefor |
WO2011088273A2 (en) | 2010-01-13 | 2011-07-21 | Dohrmann Daniel R | Ultra-low flow agricultural pump with unobstructed flow path and electronic flow control, tank refill indication, and detection of loss of flow |
BR102015032910B1 (pt) * | 2015-12-29 | 2021-03-09 | Companhia Nitro Química Brasileira | processo de obtenção de uma dispersão coloidal, dispersão coloidal e seu uso |
CA3034527A1 (en) | 2016-08-23 | 2018-03-01 | Emmanuel John Simons | Compositions and methods for treating non-age-associated hearing impairment in a human subject |
MX2019005833A (es) | 2016-11-21 | 2019-10-30 | Eirion Therapeutics Inc | Administracion transdermica de agentes grandes. |
CN110325272A (zh) * | 2017-03-28 | 2019-10-11 | 富士胶片株式会社 | 微胶囊及其制造方法 |
US20200001263A1 (en) * | 2018-06-28 | 2020-01-02 | Cornell University | Encapsulation System and Method |
CN116096905A (zh) | 2020-02-21 | 2023-05-09 | 阿库斯股份有限公司 | 用于治疗人受试者的非年龄相关性听力损伤的组合物和方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2551072A1 (fr) * | 1983-08-26 | 1985-03-01 | Sandoz Sa | Nouveaux esters de polyols, leur preparation et leur utilisation |
FR2608988A1 (fr) * | 1986-12-31 | 1988-07-01 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules |
WO1993025194A1 (fr) * | 1992-06-16 | 1993-12-23 | Centre National De La Recherche Scientifique (Cnrs) | Preparation et application de nouveaux systemes colloidaux nanovesiculaires dispersibles a base de cyclodextrine, sous forme de nanocapsules |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2909906A1 (de) * | 1979-03-14 | 1980-10-02 | Bayer Ag | Verfahren zur kontinuierlichen herstellung von mikrokapseln |
FR2608942B1 (fr) * | 1986-12-31 | 1991-01-11 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules |
US5021248A (en) * | 1988-09-19 | 1991-06-04 | Enzytech, Inc. | Hydrophobic protein microparticles and preparation thereof |
FR2663222A1 (fr) * | 1990-06-13 | 1991-12-20 | Medgenix Group Sa | Microcapsule de liquide huileux. |
KR930006431B1 (ko) * | 1990-10-11 | 1993-07-16 | 재단법인 한국화학연구소 | 약물의 미세캡슐화 방법 |
ES2034891B1 (es) * | 1991-08-08 | 1993-12-16 | Cusi Lab | Procedimiento de elaboracion en continuo de sistemas coloidales dispersos, en forma de nanocapsulas o nanoparticulas. |
US5326488A (en) * | 1992-02-18 | 1994-07-05 | Idemitsu Kosan Co., Ltd. | Mannich reaction product and process for producing the same and use of the product |
ATE170293T1 (de) * | 1992-06-08 | 1998-09-15 | Behring Diagnostics Inc | Flüssigkeitsspendersystem |
-
1994
- 1994-05-20 ES ES09401121A patent/ES2078190B1/es not_active Expired - Lifetime
- 1994-09-07 HU HU9600386A patent/HU9600386D0/hu unknown
- 1994-09-30 WO PCT/ES1994/000085 patent/WO1995031975A1/es active IP Right Grant
- 1994-09-30 EP EP94925490A patent/EP0717989B1/en not_active Expired - Lifetime
- 1994-09-30 DE DE69426568T patent/DE69426568T2/de not_active Expired - Fee Related
- 1994-09-30 US US08/586,731 patent/US5851452A/en not_active Expired - Fee Related
- 1994-09-30 CN CN94193333A patent/CN1130868A/zh active Pending
- 1994-09-30 DK DK94925490T patent/DK0717989T3/da active
- 1994-09-30 JP JP7530066A patent/JPH09501101A/ja active Pending
- 1994-09-30 CA CA002167681A patent/CA2167681A1/en not_active Abandoned
- 1994-09-30 PL PL94312666A patent/PL312666A1/xx unknown
- 1994-09-30 AT AT94925490T patent/ATE198548T1/de not_active IP Right Cessation
- 1994-09-30 BR BR9407333A patent/BR9407333A/pt not_active Application Discontinuation
- 1994-09-30 AU AU75379/94A patent/AU696400B2/en not_active Ceased
- 1994-09-30 KR KR1019960700306A patent/KR960703577A/ko not_active Application Discontinuation
- 1994-09-30 PT PT94925490T patent/PT717989E/pt unknown
-
1996
- 1996-01-19 OA OA60769A patent/OA10257A/en unknown
- 1996-01-19 NO NO960232A patent/NO960232L/no unknown
- 1996-02-20 BG BG100372A patent/BG100372A/xx unknown
- 1996-03-25 FI FI961348A patent/FI961348A0/fi active IP Right Revival
-
1998
- 1998-12-11 HK HK98113202A patent/HK1017807A1/xx not_active IP Right Cessation
-
2001
- 2001-03-29 GR GR20010400505T patent/GR3035655T3/el not_active IP Right Cessation
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2551072A1 (fr) * | 1983-08-26 | 1985-03-01 | Sandoz Sa | Nouveaux esters de polyols, leur preparation et leur utilisation |
FR2608988A1 (fr) * | 1986-12-31 | 1988-07-01 | Centre Nat Rech Scient | Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules |
WO1993025194A1 (fr) * | 1992-06-16 | 1993-12-23 | Centre National De La Recherche Scientifique (Cnrs) | Preparation et application de nouveaux systemes colloidaux nanovesiculaires dispersibles a base de cyclodextrine, sous forme de nanocapsules |
Also Published As
Publication number | Publication date |
---|---|
BG100372A (en) | 1996-12-31 |
GR3035655T3 (en) | 2001-06-29 |
ES2078190B1 (es) | 1996-08-01 |
HK1017807A1 (en) | 1999-11-26 |
HU9600386D0 (en) | 1996-04-29 |
ATE198548T1 (de) | 2001-01-15 |
AU7537994A (en) | 1995-12-18 |
EP0717989B1 (en) | 2001-01-10 |
PL312666A1 (en) | 1996-04-29 |
KR960703577A (ko) | 1996-08-31 |
JPH09501101A (ja) | 1997-02-04 |
NO960232L (no) | 1996-03-19 |
DE69426568T2 (de) | 2001-08-23 |
CA2167681A1 (en) | 1995-11-30 |
CN1130868A (zh) | 1996-09-11 |
AU696400B2 (en) | 1998-09-10 |
DE69426568D1 (de) | 2001-02-15 |
FI961348A (fi) | 1996-03-25 |
DK0717989T3 (da) | 2001-05-21 |
FI961348A0 (fi) | 1996-03-25 |
OA10257A (en) | 1997-10-07 |
WO1995031975A1 (es) | 1995-11-30 |
US5851452A (en) | 1998-12-22 |
NO960232D0 (no) | 1996-01-19 |
PT717989E (pt) | 2001-06-29 |
EP0717989A1 (en) | 1996-06-26 |
BR9407333A (pt) | 1996-06-18 |
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