ES2091012T3 - Preparacion y utilizacion de nuevos sistemas coloidales dispersables a base de ciclodextrina, en forma de nanoesferas. - Google Patents

Preparacion y utilizacion de nuevos sistemas coloidales dispersables a base de ciclodextrina, en forma de nanoesferas.

Info

Publication number
ES2091012T3
ES2091012T3 ES93913149T ES93913149T ES2091012T3 ES 2091012 T3 ES2091012 T3 ES 2091012T3 ES 93913149 T ES93913149 T ES 93913149T ES 93913149 T ES93913149 T ES 93913149T ES 2091012 T3 ES2091012 T3 ES 2091012T3
Authority
ES
Spain
Prior art keywords
pct
cyclodextrin
nanospheres
preparation
optionally
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93913149T
Other languages
English (en)
Inventor
Mohamed Skiba
Denis Wouessidjewe
Antony Coleman
Hatem Fessi
Jean-Philippe Devissaguet
Dominique Duchene
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Centre National de la Recherche Scientifique CNRS
Original Assignee
Centre National de la Recherche Scientifique CNRS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Centre National de la Recherche Scientifique CNRS filed Critical Centre National de la Recherche Scientifique CNRS
Application granted granted Critical
Publication of ES2091012T3 publication Critical patent/ES2091012T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/08—Simple coacervation, i.e. addition of highly hydrophilic material
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0241—Containing particulates characterized by their shape and/or structure
    • A61K8/0279—Porous; Hollow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/738—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5161—Polysaccharides, e.g. alginate, chitosan, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/41—Particular ingredients further characterized by their size
    • A61K2800/413—Nanosized, i.e. having sizes below 100 nm
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/56—Compounds, absorbed onto or entrapped into a solid carrier, e.g. encapsulated perfumes, inclusion compounds, sustained release forms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/14—Layer or component removable to expose adhesive
    • Y10T428/1405—Capsule or particulate matter containing [e.g., sphere, flake, microballoon, etc.]
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2989—Microcapsule with solid core [includes liposome]

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nanotechnology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Optics & Photonics (AREA)
  • Birds (AREA)
  • Biomedical Technology (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • Dispersion Chemistry (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Dermatology (AREA)
  • Medicinal Preparation (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Cosmetics (AREA)
  • Colloid Chemistry (AREA)

Abstract

LA PREPARACION DEL SISTEMA NANOPARTICULADO SE CARACTERIZA, SEGUN EL INVENTO, PORQUE: 1) SE PREPARA UNA FASE LIQUIDA CONSTITUIDA BASICAMENTE DE UNA SOLUCION DE CICLODEXTRINA MODIFICADA POR GRUPOS ACILO EN UN DISOLVENTE O MEZCLA DE DISOLVENTES ORGANICO(S) Y PUDIENDO AÑADIRLE UNA MOLECULA ACTIVA; 2) SE PREPARA UNA SEGUNDA FASE LIQUIDA CONSTITUIDA BASICAMENTE POR AGUA O MEZCLA ACUOSA, PUDIENDO CONTENER UNO O VARIOS AGENTES TENSOACTIVOS Y PUDIENDO AÑADIRLE UNA MOLECULA ACTIVA; 3) SE AÑADE BAJO AGITACION MODERADA UNA DE LAS FASES LIQUIDAS OBTENIDAS POR 1) O 2) EN LA OTRA, DE MODO QUE SE OBTENGA PRACTICAMENTE AL INSTANTE UNA SUSPENSION COLOIDAL DE NANOESFERAS DE CICLODEXTRINA MODIFICADA. EN CASO CONTRARIO, SE ELIMINA TODO O PARTE DEL DISOLVENTE Y DEL AGUA. SE APLICA A VECTORES DE PRODUCTOS QUIMICOS, FARMACEUTICOS, COSMETICOS, ETC.
ES93913149T 1992-06-16 1993-06-16 Preparacion y utilizacion de nuevos sistemas coloidales dispersables a base de ciclodextrina, en forma de nanoesferas. Expired - Lifetime ES2091012T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9207287A FR2692168B1 (fr) 1992-06-16 1992-06-16 Préparation et utilisation de nouveaux systèmes colloïdaux dispersibles à base de cyclodextrine, sous forme de nanosphères.

Publications (1)

Publication Number Publication Date
ES2091012T3 true ES2091012T3 (es) 1996-10-16

Family

ID=9430801

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93913149T Expired - Lifetime ES2091012T3 (es) 1992-06-16 1993-06-16 Preparacion y utilizacion de nuevos sistemas coloidales dispersables a base de ciclodextrina, en forma de nanoesferas.

Country Status (8)

Country Link
US (1) US5718905A (es)
EP (1) EP0646003B1 (es)
JP (1) JPH07507784A (es)
AT (1) ATE141161T1 (es)
DE (1) DE69304065T2 (es)
ES (1) ES2091012T3 (es)
FR (1) FR2692168B1 (es)
WO (1) WO1993025195A1 (es)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070117863A1 (en) * 1993-02-22 2007-05-24 Desai Neil P Novel formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
US6090925A (en) 1993-03-09 2000-07-18 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
US5981719A (en) 1993-03-09 1999-11-09 Epic Therapeutics, Inc. Macromolecular microparticles and methods of production and use
ES2070076B1 (es) * 1993-04-20 1996-04-16 Cusi Lab Metodo para aumentar la estabilidad de las nanocapsulas durante su almacenamiento.
US5576311A (en) * 1994-11-30 1996-11-19 Pharmos Corporation Cyclodextrins as suspending agents for pharmaceutical suspensions
DE69618938T2 (de) * 1995-03-28 2002-10-31 Fidia Advanced Biopolymers, S.R.L. Nanosphären mit einem biokompatiblen polysaccharid
FR2742677B1 (fr) 1995-12-21 1998-01-16 Oreal Nanoparticules enrobees d'une phase lamellaire a base de tensioactif silicone et compositions les contenant
US8137684B2 (en) 1996-10-01 2012-03-20 Abraxis Bioscience, Llc Formulations of pharmacological agents, methods for the preparation thereof and methods for the use thereof
KR101180181B1 (ko) * 1997-06-27 2012-09-05 아브락시스 바이오사이언스, 엘엘씨 나노 입자 및 그의 제조 방법
KR100789008B1 (ko) * 1997-06-27 2007-12-26 아브락시스 바이오사이언스 인크. 신규 약물 제제
US20030199425A1 (en) * 1997-06-27 2003-10-23 Desai Neil P. Compositions and methods for treatment of hyperplasia
FR2775435B1 (fr) * 1998-02-27 2000-05-26 Bioalliance Pharma Nanoparticules comprenant au moins un polymere et au moins un compose apte a complexer un ou plusieurs principes actifs
GB9805417D0 (en) * 1998-03-14 1998-05-06 Core Technologies Limited Production of microparticles
US6344218B1 (en) 1998-11-23 2002-02-05 The Procter & Gamble Company Skin deodorizing and santizing compositions
US6177088B1 (en) 1999-01-07 2001-01-23 Fayette Environmental Services, Inc. Surface-functionalized, probe-containing nanospheres
US6653524B2 (en) 1999-12-23 2003-11-25 Kimberly-Clark Worldwide, Inc. Nonwoven materials with time release additives
JP2003531930A (ja) * 2000-04-28 2003-10-28 ユニバーシティ・カレッジ・ダブリン 両親媒性大環状誘導体およびそれらの類似体
ATE319480T1 (de) * 2000-05-11 2006-03-15 Eastman Chem Co Acylierte zyklodextrin guest-inklusion komplexe
FR2808691B1 (fr) * 2000-05-12 2005-06-24 Coletica Cyclodextrines substituees preferentiellement sur leur face primaire par des fonctions acide ou amine
ES2306684T3 (es) * 2001-09-17 2008-11-16 Nanopart-C S.A. Nuevo sistema coloidal dispersable a base de calixareno en forma de nanoparticulas.
US7879820B2 (en) * 2002-04-22 2011-02-01 L'oreal S.A. Use of a cyclodextrin as pearlescent agent and pearlescent compositions
WO2004006959A1 (en) * 2002-07-16 2004-01-22 Elan Pharma International, Ltd Liquid dosage compositions of stable nanoparticulate active agents
WO2005044224A2 (en) * 2003-05-02 2005-05-19 Case Western Reserve University Drug delivery system based on polymer nanoshells
SE0303179D0 (sv) * 2003-11-26 2003-11-26 Astrazeneca Ab Novel compounds
WO2005102248A2 (en) * 2004-04-20 2005-11-03 Dow Corning Corporation Silicone vesicles containing actives
CA2580529A1 (en) * 2004-10-01 2006-04-13 Eisai R & D Management Co., Ltd. Fine particle-containing composition and manufacturing method therefor
FR2895257A1 (fr) * 2005-12-22 2007-06-29 Oreal Actif pour le traitement du contour des yeux.
FR2898817B1 (fr) * 2006-03-23 2008-08-08 Univ Rouen Association de substance oleagineuse avec un melange d'au moins deux cyclodextrines
BRPI0720035A2 (pt) 2006-12-06 2019-05-07 Medimmune, Llc métodos para tratar um paciente tendo uma doença ou distúrbio, para tratar um paciente com doença autoimune, para neutralizar um perfil de expressão do marcador pd indutível por ifn do tipo 1 ou ifnalfa em um paciente, para monitorar ou prognosticar progressão de doença autoimune de um paciente, para monitorar a progressão da doença de um paciente que recebe o tratamento com um agente terapêutico que liga-se a e modula a atividade de ifnalfa, para identificar um paciente como um candidato para um agente terapêutico que liga-se a e modula a atividade de ifnalfa, para diagnosticar um paciente como tendo um distùrbio associado com níveis aumentados de ifnalfa, para identificar um terapêutico candidato para o tratamento de distùrbios mediados por ifnalfa e para detectar atividade de ifn em uma amostra, conjunto de sondas, e, kit
FR2910345A1 (fr) 2006-12-20 2008-06-27 Oreal Particules coeur/ecorce a base de composes silicones
JP2010526107A (ja) 2007-05-03 2010-07-29 メディミューン，エルエルシー 自己免疫疾患の自己抗体マーカー
ITMI20081056A1 (it) * 2008-06-10 2009-12-11 Sea Marconi Technologies Sas Nanospugne a base di ciclodestrine come supporto per catalizzatori biologici e nella veicolazione e rilascio di enzimi, proteine, vaccini ed anticorpi
US11020363B2 (en) 2009-05-29 2021-06-01 Cydex Pharmaceuticals, Inc. Injectable nitrogen mustard compositions comprising a cyclodextrin derivative and methods of making and using the same
US20100311838A1 (en) 2009-05-29 2010-12-09 Pipkin James D Injectable Melphalan Compositions Comprising a Cyclodextrin Derivative and Methods of Making and Using the Same
ITTO20110884A1 (it) * 2011-10-04 2013-04-05 Univ Degli Studi Torino Membrana per nanocapsula, nanocapsula comprendente la stessa e suo uso
EP2838653A4 (en) 2012-04-18 2015-11-25 Cerulean Pharma Inc METHODS AND SYSTEMS FOR POLYMER PRECIPITATION AND PARTICLE GENERATION
US11406595B2 (en) * 2012-05-21 2022-08-09 University Of Maryland, College Park Highly stable colloid from aqueous solutions of small organic molecules
AU2013292636A1 (en) 2012-07-18 2015-02-05 Onyx Therapeutics, Inc. Liposomal compositions of epoxyketone-based proteasome inhibitors
CN116508750B (zh) * 2023-03-31 2024-09-20 南宁师范大学 环糊精酯的应用和方法、含环糊精酯的农药制剂及其制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8204244L (sv) * 1982-07-09 1984-01-10 Ulf Schroder Kristalliserad kolhydratsmatris for biologiskt aktiva substanser
CH656884A5 (de) * 1983-08-26 1986-07-31 Sandoz Ag Polyolester, deren herstellung und verwendung.
FR2608942B1 (fr) * 1986-12-31 1991-01-11 Centre Nat Rech Scient Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanocapsules

Also Published As

Publication number Publication date
FR2692168B1 (fr) 1995-03-24
FR2692168A1 (fr) 1993-12-17
EP0646003A1 (fr) 1995-04-05
DE69304065T2 (de) 1997-03-20
US5718905A (en) 1998-02-17
WO1993025195A1 (fr) 1993-12-23
DE69304065D1 (de) 1996-09-19
EP0646003B1 (fr) 1996-08-14
ATE141161T1 (de) 1996-08-15
JPH07507784A (ja) 1995-08-31

Similar Documents

Publication Publication Date Title
ES2091012T3 (es) Preparacion y utilizacion de nuevos sistemas coloidales dispersables a base de ciclodextrina, en forma de nanoesferas.
GB9126209D0 (en) Drug formulations for parenteral use
DK0670713T3 (da) Farmaceutisk formulering
KR960703316A (ko) 작물 보호 활성 화합물의 다상의 안정한 수성 가공 제제 및 이의 제조 방법(Aqueous, Multiphase, Stable Finished Formulation for Crop Protection Active Compounds and Its Preparation)
ATE181087T1 (de) Superporöse polysaccharidgele
DK0695171T3 (da) Lyosfærer indeholdende gonadotropin
FR2608988B1 (fr) Procede de preparation de systemes colloidaux dispersibles d'une substance, sous forme de nanoparticules
MY100199A (en) Lamella type single phase liquid crystal composition and oil-base cosmetic compositions using the same
BR0111054A (pt) Microesferas e processo de preparação das mesmas
ATE141784T1 (de) Haarshampoo-formulierung mit silikon, kationischem polymer und flüssigen, öligen konditionierungsmitteln
RU95114376A (ru) Нитроэфиры, обладающие фармакологической активностью, и способ их получения
KR930016090A (ko) 화장제 조성물
Islam et al. Thermodynamic study on surface adsorption and micelle formation of poly (ethylene glycol) mono-n-tetradecyl ethers
ES2083291T3 (es) Preparacion y aplicacion de nuevos sistemas coloidales nanovesiculares dispersables a base de ciclodextrina, en forma de nanocapsulas.
PT994727E (pt) Processo para solubilizar ingredientes farmaceuticamente activos em agua e noutros veiculos aquosos
KR920002758A (ko) 샴푸 시스템
BR0013012A (pt) Composição contendo substância ativa, sua produção e seu uso
BR9611343A (pt) Processo de solubilização d eum agente em um anfifìlico, composição, e, uso da mesma.
FI934569A0 (fi) Foerbaettrade retardsystem foer foerdroejd frigoering av medicinskt och/eller biologiskt verkande aemnen fraon depotbaerarmaterial
DK0488142T3 (da) Fremgangsmåde til indkapsling af faste eller flydende, lipofile virksomme stoffer i phospholipid-liposomer samt lægemidler indeholdende disse liposomer
DE59600039D1 (de) Verfahren zur Herstellung von hochaktiven, stabilen Metallocen-Katalysatorsystemen und gemäss diesem Verfahren hergestellte Formulierungen
KR960013361A (ko) 실리마린(Silymarin)의 용해방법
JUNI et al. Controlled Release of Butamben (Buryl p-aminobenzoate) through Silicone Membrane by Means of Complexation and Micellar Solubilization
DE59711745D1 (de) Schaumförmige Zubereitungen mit einem Gehalt an grenzflächenaktiven Substanzen und Elektrolyten
BG105852A (en) Dermatological compositions containing a liquid crystal vehicle and method of preparing same

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 646003

Country of ref document: ES

FG2A Definitive protection

Ref document number: 646003

Country of ref document: ES