ES2076166T3 - Procedimiento para producir 2-amino-4,6-dicloropirimidina. - Google Patents

Procedimiento para producir 2-amino-4,6-dicloropirimidina.

Info

Publication number
ES2076166T3
ES2076166T3 ES89102789T ES89102789T ES2076166T3 ES 2076166 T3 ES2076166 T3 ES 2076166T3 ES 89102789 T ES89102789 T ES 89102789T ES 89102789 T ES89102789 T ES 89102789T ES 2076166 T3 ES2076166 T3 ES 2076166T3
Authority
ES
Spain
Prior art keywords
amino
dichloropyrimidine
procedure
produce
reaction
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89102789T
Other languages
English (en)
Inventor
Takahiro Ishihara Sangyo Haga
Yasuhiro Tsujii
Tatsuo Ishihara Sangyo Isogai
Shigeo Murai
Toshihiro Tanaka
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ishihara Sangyo Kaisha Ltd
Original Assignee
Ishihara Sangyo Kaisha Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ishihara Sangyo Kaisha Ltd filed Critical Ishihara Sangyo Kaisha Ltd
Application granted granted Critical
Publication of ES2076166T3 publication Critical patent/ES2076166T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/30—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A UN PROCESO INDUSTRIALMENTE VENTAJOSO PARA PRODUCIR 2 - AMINO - 4,6 - DICLOROPIRIMIDINA, QUE COMPRENDE LA REACCION DE 2 - AMINO - 4,6 - DIHIDROPIRIMIDINA O SU SAL CON OXICLORURO DE FOSFORO A UNA TEMPERATURA DE 50 A 100 (GRADOS) C EN PRESENCIA DE UN DISOLVENTE Y DE UN AGENTE ELIMINADOR DE ACIDO. EL RENDIMIENTO DE 2 - AMINO - 4,6 - DICLOROPIRIMIDINA PUEDE MEJORARSE MAS HIDROLIZANDO EL DICLORURO 4,6 - DICLORO - 2 - PIRIMIDINILFOSFORAMIDICO PRODUCIDO COMO SUBPRODUCTO DE LA REACCION DE CLORACION PARA FORMAR 2 - AMINO 4,6 - DICLOROPIRIMIDINA, LA CUAL ES UTIL COMO PRODUCTO INTERMEDIO PARA MEDICAMENTOS Y PRODUCTOS QUIMICOS AGRICOLAS.
ES89102789T 1988-02-19 1989-02-17 Procedimiento para producir 2-amino-4,6-dicloropirimidina. Expired - Lifetime ES2076166T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP3702388 1988-02-19

Publications (1)

Publication Number Publication Date
ES2076166T3 true ES2076166T3 (es) 1995-11-01

Family

ID=12486051

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89102789T Expired - Lifetime ES2076166T3 (es) 1988-02-19 1989-02-17 Procedimiento para producir 2-amino-4,6-dicloropirimidina.

Country Status (8)

Country Link
US (1) US4929729A (es)
EP (1) EP0329170B1 (es)
KR (1) KR890012979A (es)
CN (1) CN1019575B (es)
AT (1) ATE124038T1 (es)
CA (1) CA1307272C (es)
DE (1) DE68923103T2 (es)
ES (1) ES2076166T3 (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995007265A1 (en) * 1993-09-10 1995-03-16 E.I. Du Pont De Nemours And Company Improved process for preparing 2-amino-4,6-dichloropyrimidine
AT402924B (de) * 1994-05-13 1997-09-25 Chemie Linz Gmbh Verfahren zur herstellung von 2-amino-4,6-dichloro-pyrimidin
DE4419118A1 (de) * 1994-06-01 1995-12-07 Chemie Linz Deutschland Verfahren zur Herstellung von 2-Amino-4,6-dichloro-pyrimidin
AT402818B (de) * 1995-06-02 1997-09-25 Chemie Linz Gmbh Verfahren zur herstellung von reinem 4,6-dichlorpyrimidin
AT405738B (de) * 1997-09-03 1999-11-25 Chemie Linz Gmbh Verfahren zur reinigung von phosphoroxychlorid
DE59903535D1 (de) * 1998-12-21 2003-01-09 Lonza Ag Verfahren zur Herstellung von N-(Amino-4,6-dihalogenpyrimidin)-formamiden
CN107857734A (zh) * 2017-12-12 2018-03-30 江西开元生物医药科技有限公司 一种2,4‑二氨基‑6‑氯嘧啶的合成方法
CN109796413A (zh) * 2019-01-24 2019-05-24 安徽广信农化股份有限公司 一种用于4,6-二氯嘧啶合成的三乙胺回收工艺
CN113754592B (zh) * 2021-10-26 2023-05-16 江苏睿实生物科技有限公司 一种2,4-二胺基-6-氯嘧啶的制备方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1055560B (it) * 1974-05-02 1982-01-11 Istituto Chemioterapico Derivati pirimidinici e relative composizioni per il trattamento di infezioni virali
DE3642452A1 (de) * 1986-12-12 1988-06-23 Bayer Ag Substituierte 4-amino-pyrimidine

Also Published As

Publication number Publication date
CA1307272C (en) 1992-09-08
ATE124038T1 (de) 1995-07-15
KR890012979A (ko) 1989-09-20
CN1035504A (zh) 1989-09-13
US4929729A (en) 1990-05-29
DE68923103D1 (de) 1995-07-27
EP0329170A2 (en) 1989-08-23
DE68923103T2 (de) 1996-04-04
EP0329170A3 (en) 1990-09-12
CN1019575B (zh) 1992-12-23
EP0329170B1 (en) 1995-06-21

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