ES2073028T3 - Anticuerpos y peptidos inmunoactivos y su utilizacion en tratamiento anti-alergico. - Google Patents

Anticuerpos y peptidos inmunoactivos y su utilizacion en tratamiento anti-alergico.

Info

Publication number
ES2073028T3
ES2073028T3 ES90909180T ES90909180T ES2073028T3 ES 2073028 T3 ES2073028 T3 ES 2073028T3 ES 90909180 T ES90909180 T ES 90909180T ES 90909180 T ES90909180 T ES 90909180T ES 2073028 T3 ES2073028 T3 ES 2073028T3
Authority
ES
Spain
Prior art keywords
antibodies
histamine
peptide
phe
terminal
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90909180T
Other languages
English (en)
Inventor
Denis Raymond Stanworth
Ian Victor Lewin
Sarita Nayyar
Valerie Bryn Celyn Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BTG International Ltd
Original Assignee
British Technology Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by British Technology Group Ltd filed Critical British Technology Group Ltd
Application granted granted Critical
Publication of ES2073028T3 publication Critical patent/ES2073028T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
    • C07K16/4283—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig
    • C07K16/4291—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an allotypic or isotypic determinant on Ig against IgE
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/807—Hapten conjugated with peptide or protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

UN INMUNOGEN QUE COMPRENDE UN RESIDUO DE UN PEPTIDO LIBERADOR DE HISTAMINA , QUE INCLUYE UNA CABEZA TERMINAL-N CATIONICA Y UNA EXTREMIDAD TERMINAL-C HIDROFOBICA, JUNTO CON UN RESIDUO CAPAZ DE PRODUCIR ANTICUERPOS CONTRA DICHO PEPTIDO; MIENTRAS INHIBE LA LIBERACION DE LA HISTAMINA POR DICHO PEPTIDO, ES UTIL EN EL TRATAMIENTO ANTIALERGICO. PREFERENTEMENTE, EL PEPTIDO LIBERADOR DE LA HISTAMINA ES DE FORMULA: LYS-THR-LYS-GLY-SER-GLY -PHE-PHE-VAL-PHE, OPCIONALMENTE AMIDADO EN LA TERMINAL C. LOS ANTICUERPOS PARA EL PEPTIDO LIBERADOR DE HISTAMINA, SON UTILES PARA LA INMUNIZACION PASIVA.
ES90909180T 1989-06-15 1990-06-15 Anticuerpos y peptidos inmunoactivos y su utilizacion en tratamiento anti-alergico. Expired - Lifetime ES2073028T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB898913737A GB8913737D0 (en) 1989-06-15 1989-06-15 A novel anti-allergy treatment

Publications (1)

Publication Number Publication Date
ES2073028T3 true ES2073028T3 (es) 1995-08-01

Family

ID=10658467

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90909180T Expired - Lifetime ES2073028T3 (es) 1989-06-15 1990-06-15 Anticuerpos y peptidos inmunoactivos y su utilizacion en tratamiento anti-alergico.

Country Status (18)

Country Link
US (1) US5601821A (es)
EP (2) EP0477231B1 (es)
JP (2) JPH04505922A (es)
KR (1) KR0181313B1 (es)
AT (1) ATE122401T1 (es)
CA (1) CA2057860C (es)
DE (1) DE69019348T2 (es)
DK (1) DK0477231T3 (es)
ES (1) ES2073028T3 (es)
FI (1) FI104723B (es)
GB (2) GB8913737D0 (es)
IE (1) IE71677B1 (es)
NO (1) NO914937L (es)
NZ (1) NZ234085A (es)
PH (1) PH30233A (es)
PT (1) PT94381B (es)
WO (1) WO1990015878A1 (es)
ZA (1) ZA904670B (es)

Families Citing this family (37)

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US5955076A (en) * 1989-06-15 1999-09-21 Peptide Therapeutics Limited Immunoactive peptides and antibodies and their use in anti-allergy treatment
SE9102808L (sv) * 1991-09-26 1993-03-27 Lars T Hellman Inst F Immunolo Vaccin, foer humant bruk, vars avsedda effekt aer att lindra symptomen eller foerhindra uppkomsten av ige-medierade allergiska reaktioner
JP3156237B2 (ja) * 1991-12-24 2001-04-16 雪印乳業株式会社 抗ヒトＩｇＥ モノクローナル抗体
US6066718A (en) * 1992-09-25 2000-05-23 Novartis Corporation Reshaped monoclonal antibodies against an immunoglobulin isotype
US5958708A (en) * 1992-09-25 1999-09-28 Novartis Corporation Reshaped monoclonal antibodies against an immunoglobulin isotype
JPH06113881A (ja) * 1992-10-07 1994-04-26 Snow Brand Milk Prod Co Ltd ヒト型モノクローナル抗ペプチド抗体及びこれをコードするｄｎａ
AU5957794A (en) * 1992-12-21 1994-07-19 Uab Research Foundation, The Compositions and method for the inhibition of phagocytes
US5759551A (en) * 1993-04-27 1998-06-02 United Biomedical, Inc. Immunogenic LHRH peptide constructs and synthetic universal immune stimulators for vaccines
ATE221387T1 (de) * 1993-04-27 2002-08-15 United Biomedical Inc Immunogene lhrh peptidkonstrukion und synthetische, universale immunstimulatoren als impfstoffe
WO1995026365A1 (en) * 1994-03-28 1995-10-05 United Biomedical, Inc. Synthetic peptide based immunogens for the treatment of allergy
GB9412714D0 (en) * 1994-06-24 1994-08-17 Lewin Ian V T cill epitopes
GB9416321D0 (en) * 1994-08-12 1994-10-05 Peptide Therapeutics Ltd Peptides and antibodies and their use in treatment of carcinomas
GB9417086D0 (en) * 1994-08-24 1994-10-12 Peptide Therapeutrics Limited Screen for potential therapeutic compounds
GB9422294D0 (en) * 1994-11-04 1994-12-21 Peptide Therapeutics Ltd Peptides for anti-allergy treatment
GB2304347A (en) 1995-08-11 1997-03-19 Boeringer Ingelheim Vetmedica Antigenic preparations
IL125590A (en) * 1996-03-01 2001-08-26 Novartis Ag Peptide immunogens, process for their preparation and use thereof as vaccines against allergies
CA2256900A1 (en) * 1996-05-29 1997-12-04 Xiao-Ying Meng Cationic polymer/lipid nucleic acid delivery vehicles
GB9724531D0 (en) 1997-11-19 1998-01-21 Smithkline Biolog Novel compounds
US6913749B2 (en) 1998-11-02 2005-07-05 Resistentia Pharmaceuticals Ab Immunogenic polypeptides for inducing anti-self IgE responses
US6573372B2 (en) 1999-01-07 2003-06-03 Heska Corporation Feline immunoglobulin E molecules and compositions there of
EP1195161A3 (en) 2000-08-30 2002-07-24 Pfizer Products Inc. Anti-IgE vaccines
US7320793B2 (en) 2001-01-19 2008-01-22 Cytos Biotechnology Ag Molecular antigen array
GB0109297D0 (en) 2001-04-12 2001-05-30 Glaxosmithkline Biolog Sa Vaccine
JP2003047482A (ja) * 2001-05-22 2003-02-18 Pfizer Prod Inc 非アナフィラキシー誘発性ＩｇＥワクチン
DE60234375D1 (de) 2001-09-14 2009-12-24 Cytos Biotechnology Ag VERPACKUNG VON IMMUNSTIMULIERENDEM CpG IN VIRUSÄHNLICHEN PARTIKELN: HERSTELLUNGSVERFAHREN UND VERWENDUNG
RU2450827C2 (ru) 2002-07-19 2012-05-20 Цитос Биотехнологи Аг Композиции вакцин, содержащие наборы антигенов в виде амилоида бета 1-6
JP4459810B2 (ja) 2002-08-14 2010-04-28 マクロジェニクス，インコーポレーテッド ＦｃγＲＩＩＢ特異的抗体とその利用法
US20070218086A1 (en) 2004-04-26 2007-09-20 Innate Pharma, S.A. Adjuvant Composition and Methods for Its Use
GB0424563D0 (en) 2004-11-05 2004-12-08 Novartis Ag Organic compounds
TWI457133B (zh) 2005-12-13 2014-10-21 Glaxosmithkline Biolog Sa 新穎組合物
WO2007144150A1 (en) 2006-06-12 2007-12-21 Cytos Biotechnology Ag Processes for packaging oligonucleotides into virus-like particles of rna bacteriophages
HUE030269T2 (en) 2006-06-26 2017-04-28 Macrogenics Inc FC RIIB-specific antibodies and methods for their use
CN102482351B (zh) * 2009-02-25 2015-03-18 中央研究院 能与人B淋巴细胞上的mIgE结合的抗CεmX抗体
EP2838919A4 (en) 2012-04-20 2016-03-23 Academia Sinica ANTIBLE ANTIBODIES BINDING TO THE TRANSITION BETWEEN CH4 AND C EPSILON MX DOMAINS
WO2017158202A1 (en) * 2016-03-18 2017-09-21 Genclis Molecular origin of allergy
EP3703753A4 (en) 2017-10-31 2021-08-18 Oneness Biotech Co., Ltd. TREATMENT OF IGE-MEDIATED ALLERGIC DISEASES
JP7503857B2 (ja) * 2022-04-11 2024-06-21 緑茵生技股▲ふん▼有限公司 抗アレルギー性ペプチド及びその免疫調節と抗アレルギーに用いられる用途

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4171299A (en) * 1975-04-04 1979-10-16 The Regents Of The University Of California Polypeptide agents for blocking the human allergic response
DE2602443A1 (de) * 1975-04-04 1976-10-21 Univ California Biologisch aktive polypeptide
DE2861593D1 (en) * 1977-06-29 1982-03-11 Beecham Group Plc Peptides, pharmaceutical compositions containing the peptides and a process for the preparation of the peptides
US4579840A (en) * 1983-08-12 1986-04-01 Immunetech Pharmaceuticals Method of blocking immune complex binding to immunoglobulin Fc receptors
US4683292A (en) * 1983-08-12 1987-07-28 Immunetech, Inc. Immunotherapeutic polypeptide agents which bind to lymphocyte immunoglobulin FC receptors
AU1484688A (en) * 1987-02-20 1988-09-14 Imclone Systems, Inc. Monoclonal antibodies in vaccine formulations
CA1336818C (en) * 1987-04-16 1995-08-29 International Institute Of Cellular And Molecular Pathology Treatment of allergy and composition thereof
GB8727045D0 (en) * 1987-11-19 1987-12-23 Research Corp Ltd Immunoglobulin e competitor
JPH0742313B2 (ja) * 1988-03-28 1995-05-10 日立化成工業株式会社 新規ペプチド、その塩及びペプチド性抗アレルギー剤
EP0605410B1 (en) * 1990-05-25 1995-08-16 Peptide Therapeutics Limited Immunodiagnostic assay for rheumatoid arthritis
DE4037426A1 (de) * 1990-11-24 1992-05-27 Kali Chemie Pharma Gmbh Piperidinoalkylbenzoxazin- und -thiazin-verbindungen sowie verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel

Also Published As

Publication number Publication date
CA2057860C (en) 2000-05-09
EP0403312A1 (en) 1990-12-19
FI915891A0 (fi) 1991-12-13
IE902154A1 (en) 1991-01-02
DE69019348T2 (de) 1995-09-21
CA2057860A1 (en) 1990-12-16
PH30233A (en) 1997-02-05
DE69019348D1 (de) 1995-06-14
US5601821A (en) 1997-02-11
FI104723B (fi) 2000-03-31
PT94381B (pt) 1996-11-29
DK0477231T3 (da) 1995-07-10
KR0181313B1 (ko) 1999-04-01
AU5814890A (en) 1991-01-08
KR920702723A (ko) 1992-10-06
EP0477231A1 (en) 1992-04-01
PT94381A (pt) 1991-02-08
GB8913737D0 (en) 1989-08-02
EP0477231B1 (en) 1995-05-10
ATE122401T1 (de) 1995-05-15
ZA904670B (en) 1992-02-26
NO914937L (no) 1991-12-19
WO1990015878A1 (en) 1990-12-27
IE902154L (en) 1990-12-15
NZ234085A (en) 1991-09-25
NO914937D0 (no) 1991-12-13
GB9013478D0 (en) 1990-08-08
IE71677B1 (en) 1997-02-26
JPH04505922A (ja) 1992-10-15
AU646808B2 (en) 1994-03-10
JP2000152783A (ja) 2000-06-06

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