ES2070961T3 - Oxadiazolil-fenoxialquilisoxazoles y su uso como agentes antiviricos. - Google Patents

Oxadiazolil-fenoxialquilisoxazoles y su uso como agentes antiviricos.

Info

Publication number
ES2070961T3
ES2070961T3 ES90115525T ES90115525T ES2070961T3 ES 2070961 T3 ES2070961 T3 ES 2070961T3 ES 90115525 T ES90115525 T ES 90115525T ES 90115525 T ES90115525 T ES 90115525T ES 2070961 T3 ES2070961 T3 ES 2070961T3
Authority
ES
Spain
Prior art keywords
alkyl
agents
oxadiazolil
fenoxialquilisoxazoles
antiviric
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90115525T
Other languages
English (en)
Inventor
Guy Dominic Diana
Thomas Robert Bailey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
STWB Inc
Original Assignee
Sterling Winthrop Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/396,419 external-priority patent/US4945164A/en
Priority claimed from US07/396,414 external-priority patent/US4942241A/en
Priority claimed from US07/532,480 external-priority patent/US5175178A/en
Priority claimed from US07/534,917 external-priority patent/US5110821A/en
Application filed by Sterling Winthrop Inc filed Critical Sterling Winthrop Inc
Application granted granted Critical
Publication of ES2070961T3 publication Critical patent/ES2070961T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Detergent Compositions (AREA)

Abstract

COMPUESTOS DE LAS FORMULAS Y EN DONDE: Y ES UN PUENTE ALQUILENO DE 3 A 9 ATOMOS DE CARBONO; R'' ES ALQUILO INFERIOR O HIDROXI HIDROGENO, HALOGENO, ALQUILO INFERIOR, ALCOXILO INFERIOR, NITROGENO, ALCOXICARBONILO INFERIOR O TRIFLUOROMETILO; Y R8 ES HIDROGENO O ALQUILO INFERIOR DE 1 A 5 ATOMOS DE CARBONO, CON LA PROVISION DE QUE CUANDO R8 ES HIDROGENO R'' ES HIDROXIINFERIOR, SE USAN COMO AGENTES ANTIVIRICOS, PARTICULARMENTE CONTRA UNA DIVERSIDAD DE VIROSIS DEL MAIZ, INCLUYENDO NUMEROSAS CEPAS DE RINOVIRUS.
ES90115525T 1989-08-18 1990-08-13 Oxadiazolil-fenoxialquilisoxazoles y su uso como agentes antiviricos. Expired - Lifetime ES2070961T3 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US07/396,419 US4945164A (en) 1989-08-18 1989-08-18 1,3,4-Oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents and intermediates thereof
US07/396,414 US4942241A (en) 1989-08-21 1989-08-21 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US07/532,480 US5175178A (en) 1989-08-21 1990-06-04 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US07/534,917 US5110821A (en) 1989-08-18 1990-06-07 1,3,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents

Publications (1)

Publication Number Publication Date
ES2070961T3 true ES2070961T3 (es) 1995-06-16

Family

ID=27503394

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90115525T Expired - Lifetime ES2070961T3 (es) 1989-08-18 1990-08-13 Oxadiazolil-fenoxialquilisoxazoles y su uso como agentes antiviricos.

Country Status (14)

Country Link
EP (1) EP0413289B1 (es)
JP (1) JP3125793B2 (es)
KR (1) KR100197853B1 (es)
AT (1) ATE118005T1 (es)
AU (1) AU634567B2 (es)
DE (1) DE69016528T2 (es)
DK (1) DK0413289T3 (es)
ES (1) ES2070961T3 (es)
FI (1) FI96862C (es)
IE (1) IE68848B1 (es)
IL (1) IL95275A (es)
MY (1) MY106979A (es)
NO (1) NO180487C (es)
NZ (1) NZ234760A (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175177A (en) * 1991-07-17 1992-12-29 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5349068A (en) * 1992-04-15 1994-09-20 Sterling Winthrop Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents
US5453433A (en) * 1994-05-13 1995-09-26 Sterling Winthrop Inc. Thiadiazoles and antipicornaviral compositions
DE19643037A1 (de) * 1996-10-18 1998-04-23 Boehringer Ingelheim Kg Neue Oxadiazole, Verfahren zu ihrer Herstellung sowie deren Verwendung als Arzneimittel
BRPI0716996B8 (pt) * 2006-09-08 2021-05-25 Ptc Therapeutics Inc processo para preparar um composto

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1023383A (es) *
DE2722331A1 (de) * 1976-05-18 1977-11-24 Ricoh Kk 1,3,4-oxadiazolderivate sowie diese enthaltende elektrophotographische aufzeichnungsmaterialien
US4451476A (en) * 1982-12-13 1984-05-29 Sterling Drug Inc. Isoxazoles as antiviral agents
CA1299176C (en) * 1985-07-02 1992-04-21 Guy Dominic Diana Process for preparing isoxazole and furan derivatives
NZ209209A (en) * 1983-08-29 1988-02-12 Sterling Drug Inc Substituted phenyl-aliphatic isoxazole derivatives and pharmaceutical compositions
AU587802B2 (en) * 1985-03-08 1989-08-31 Ferrosan A/S Novel oxadiazolyl imidazobenzodiazepine derivatives and methods of preparing such compounds
US4945164A (en) * 1989-08-18 1990-07-31 Sterling Drug Inc. 1,3,4-Oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents and intermediates thereof
US4942241A (en) * 1989-08-21 1990-07-17 Sterling Drug Inc. 1,2,4-oxadiazolyl-phenoxyalkylisoxazoles and their use as antiviral agents

Also Published As

Publication number Publication date
FI96862B (fi) 1996-05-31
IE68848B1 (en) 1996-07-24
EP0413289A3 (en) 1991-08-07
JP3125793B2 (ja) 2001-01-22
NO180487B (no) 1997-01-20
DE69016528D1 (de) 1995-03-16
KR100197853B1 (ko) 1999-06-15
FI96862C (fi) 1996-09-10
IL95275A0 (en) 1991-06-30
IE902973A1 (en) 1991-02-27
ATE118005T1 (de) 1995-02-15
KR910004612A (ko) 1991-03-29
AU634567B2 (en) 1993-02-25
MY106979A (en) 1995-08-30
FI903886A0 (fi) 1990-08-06
IL95275A (en) 1995-08-31
NO903613D0 (no) 1990-08-16
EP0413289A2 (en) 1991-02-20
NZ234760A (en) 1991-09-25
NO903613L (no) 1991-02-19
NO180487C (no) 1997-04-30
JPH03130283A (ja) 1991-06-04
DE69016528T2 (de) 1995-08-24
AU6104190A (en) 1991-02-21
EP0413289B1 (en) 1995-02-01
DK0413289T3 (da) 1995-03-27

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