ES2070959T3 - Utilizacion de derivados del bis(4-hidroxifeniltio)metano en el tratamiento de la diabetes mellitus. - Google Patents

Utilizacion de derivados del bis(4-hidroxifeniltio)metano en el tratamiento de la diabetes mellitus.

Info

Publication number
ES2070959T3
ES2070959T3 ES90113853T ES90113853T ES2070959T3 ES 2070959 T3 ES2070959 T3 ES 2070959T3 ES 90113853 T ES90113853 T ES 90113853T ES 90113853 T ES90113853 T ES 90113853T ES 2070959 T3 ES2070959 T3 ES 2070959T3
Authority
ES
Spain
Prior art keywords
diabetes mellitus
hydroxyphenyltie
methane
bis
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90113853T
Other languages
English (en)
Inventor
Keith M Robinson
Simon J T Mao
Richard L Jackson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2070959T3 publication Critical patent/ES2070959T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/10—Sulfides; Sulfoxides; Sulfones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Emergency Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Saccharide Compounds (AREA)

Abstract

EL PRESENTE INVENTO SE REFIERE AL USO DE UN COMPUESTO DE LA FORMULA (I) EN LA QUE R1, R2, R3 Y R4 SON CADA UNA INDEPENDIENTEMENTE UN GRUPO ALQUIL C1-C6, DICHO COMPUESTO SIRVE PARA LA PREPARACION DE COMPOSICIONES FARMACEUTICAS PARA HACER DESCENDER LA GLUCOSA EN SANGRE Y TRATAR LA DIABETES.
ES90113853T 1989-07-24 1990-07-19 Utilizacion de derivados del bis(4-hidroxifeniltio)metano en el tratamiento de la diabetes mellitus. Expired - Lifetime ES2070959T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/384,571 US4959392A (en) 1989-07-24 1989-07-24 Method of treating diabetes mellitus

Publications (1)

Publication Number Publication Date
ES2070959T3 true ES2070959T3 (es) 1995-06-16

Family

ID=23517848

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90113853T Expired - Lifetime ES2070959T3 (es) 1989-07-24 1990-07-19 Utilizacion de derivados del bis(4-hidroxifeniltio)metano en el tratamiento de la diabetes mellitus.

Country Status (12)

Country Link
US (1) US4959392A (es)
EP (1) EP0410305B1 (es)
JP (1) JP2889663B2 (es)
KR (1) KR0171188B1 (es)
AT (1) ATE118346T1 (es)
AU (1) AU623543B2 (es)
DE (1) DE69016866T2 (es)
DK (1) DK0410305T3 (es)
ES (1) ES2070959T3 (es)
IE (1) IE65718B1 (es)
PH (1) PH26679A (es)
ZA (1) ZA905650B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5122542A (en) * 1990-06-19 1992-06-16 Merrell Dow Pharmaceuticals Inc. Hypotriglyceridemic use of certain bis (3,5-di-alkyl-4-hydroxyphenylthio)methanes
AU651873B2 (en) * 1991-03-18 1994-08-04 Merrell Dow Pharmaceuticals Inc. Method of inhibiting the progressive development of diabetes mellitus
US5411741A (en) * 1993-07-29 1995-05-02 Zaias; Nardo Method and composition for skin depigmentation
JP4928172B2 (ja) * 2006-06-15 2012-05-09 株式会社クボタ モーア
DE202008009661U1 (de) 2008-07-18 2008-10-16 Phieler, Frank-Michael Sterilisationsbehälter
CN113200894A (zh) * 2020-03-16 2021-08-03 北京中美红格科技有限公司 双硫双丁酚及类似物的合成方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3862332A (en) * 1967-05-11 1975-01-21 Dow Chemical Co Method of lowering serum cholesterol
GB1199871A (en) * 1967-05-11 1970-07-22 Consolidation Coal Co Improvements in or relating to Sulfur-Containing Bisphenols
JPS509041A (es) * 1973-05-30 1975-01-30
US4734527A (en) * 1986-10-17 1988-03-29 Merrell Dow Pharmaceuticals Inc. Process for preparing 2,6-di-tertiarybutyl-4-mercaptophenol
DE3869202D1 (de) * 1987-03-17 1992-04-23 Merrell Dow Pharma Alkylidendithiobis (substituierte) phenolen zur hemmung der freisetzung von interleukin-1 und zur linderung von interleukin-1 vermittelten krankheiten.
US4900757A (en) * 1988-12-08 1990-02-13 Merrell Dow Pharmaceuticals Inc. Hypocholesterolemic and antiatherosclerotic uses of bix(3,5-di-tertiary-butyl-4-hydroxyphenylthio)methane

Also Published As

Publication number Publication date
KR0171188B1 (ko) 1999-02-01
PH26679A (en) 1992-09-15
IE902675A1 (en) 1991-02-27
EP0410305B1 (en) 1995-02-15
EP0410305A2 (en) 1991-01-30
JP2889663B2 (ja) 1999-05-10
DK0410305T3 (da) 1995-04-03
ATE118346T1 (de) 1995-03-15
ZA905650B (en) 1991-05-29
JPH0358923A (ja) 1991-03-14
AU5910690A (en) 1991-01-24
IE65718B1 (en) 1995-11-15
US4959392A (en) 1990-09-25
EP0410305A3 (en) 1992-02-19
AU623543B2 (en) 1992-05-14
KR910002456A (ko) 1991-02-25
DE69016866D1 (de) 1995-03-23
DE69016866T2 (de) 1995-06-08

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