ES2070500T3 - Inhibidores de la enzima convertidora de la angiotensina. - Google Patents
Inhibidores de la enzima convertidora de la angiotensina.Info
- Publication number
- ES2070500T3 ES2070500T3 ES91910962T ES91910962T ES2070500T3 ES 2070500 T3 ES2070500 T3 ES 2070500T3 ES 91910962 T ES91910962 T ES 91910962T ES 91910962 T ES91910962 T ES 91910962T ES 2070500 T3 ES2070500 T3 ES 2070500T3
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- alkyl
- phenyl
- different
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 102000015427 Angiotensins Human genes 0.000 title 1
- 108010064733 Angiotensins Proteins 0.000 title 1
- 239000002532 enzyme inhibitor Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 239000001257 hydrogen Substances 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 5
- 125000005037 alkyl phenyl group Chemical group 0.000 abstract 3
- 150000002431 hydrogen Chemical group 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000001589 carboacyl group Chemical group 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 125000001054 5 membered carbocyclic group Chemical group 0.000 abstract 1
- 125000004008 6 membered carbocyclic group Chemical group 0.000 abstract 1
- 239000005541 ACE inhibitor Substances 0.000 abstract 1
- 101100516572 Caenorhabditis elegans nhr-8 gene Proteins 0.000 abstract 1
- 101100160255 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) YLR154C-H gene Chemical group 0.000 abstract 1
- 229940044094 angiotensin-converting-enzyme inhibitor Drugs 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical group 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229940124549 vasodilator Drugs 0.000 abstract 1
- 239000003071 vasodilator agent Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
- C07D339/02—Five-membered rings
- C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C229/36—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings with at least one amino group and one carboxyl group bound to the same carbon atom of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/64—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings
- C07C233/81—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
- C07C233/82—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/83—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/56—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/34—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/28—Phosphorus compounds with one or more P—C bonds
- C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
- C07F9/40—Esters thereof
- C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
- C07F9/4075—Esters with hydroxyalkyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2603/00—Systems containing at least three condensed rings
- C07C2603/56—Ring systems containing bridged rings
- C07C2603/58—Ring systems containing bridged rings containing three rings
- C07C2603/70—Ring systems containing bridged rings containing three rings containing only six-membered rings
- C07C2603/74—Adamantanes
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
SE PRESENTAN COMPUESTOS DE LA FORMULA (I): Z(CH2)NCHR1COOCHR2COOH, EN LA QUE Z ES -SR3, -COCHR4NHCOR5, (A) O -NHCHR7COOH; R4, R5. R6 Y R7, QUE PUEDEN SER IGUALES O DIFERENTES, SON CADA UNA FENIL O ALQUILFENIL C7-C12; R1 ES HIDROGENO, ALQUIL C1-C6, NHR8 O (CH2)PR9; R2 ES (CH2)MXR10, ALQUIL C1-C6 OPCIONALMENTE SUBSTITUIDO POR UN ANILLO HETEROCICLICO O CARBOCICLICO DE 5 O 6 MIEMBROS SATURADO, ALQUILHALO C1-C6, ALQUILCIANO C1-C6 O ALQUILFENIL C7-C12, EL FENIL ESTA OPCIONALMENTE SUBSTITUIDO POR NO2 O NH2; X ES O, S(O)Q, C=O O NR11, Y R10 ES ALQUIL C1-C6, ALQUILHALO C1-C6, ALCOXIDO C1-C6, ALCOXIDO C1-C6 SUBSTITUIDO POR HALOGENO, ALCANOIL C1-CV6, S(O)RR12, NR13R14, FENIL, ALQUILFENIL C7-C12, NAFTALENIL O UN ANILLO HETEROCICLICO INSATURDO DE 5 MIEMBROS; N ES UN ENTERO ENTRE 0 Y 6; M Y P, QUE PUEDEN SER LO MISMO O DIFERENTES, SON CADA UNA DE ELLAS UN ENTERO ENTRE 1 Y 6; R9 ES HIDROGENO, SR15 O FENIL OPCIONALMENTE SUBSTITUIDO POR OR16; R3 Y R15, CADA UNA PUEDEN SER LO MISMO O DIFERENTES, SON CADA UNAHIDROGENO O ALCANOIL C1-C6; R8 ES HIDROGENO O COOR17; Q Y R, QUE PUEDEN SER IGUALES O DIFERENTES, SON CADA UNA 0, 1 O 2, Y R11, R12, R13, R14, R16 Y R17. QUE PUEDEN SER IGUALES O DIFERENTES SON CADA UNA HIDROGENO O ALQUIL C1-C6; ASIMISMO SE PRESENTAN LAS SALES FARMACEUTICAMENTE ACEPTABLES DE LOS COMPUESTOS, CON CIERTAS SALVEDADES. TAMBIEN SE DESCRIBEN PROCESOS PARA LA PREPARACION DE LOS COMPUESTOS, COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN Y METODOS DE TRATAMIENTO QUE COMPRENDEN SU USO.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB909013994A GB9013994D0 (en) | 1990-06-22 | 1990-06-22 | Compounds |
| GB909021411A GB9021411D0 (en) | 1990-10-02 | 1990-10-02 | Compounds |
| GB919107237A GB9107237D0 (en) | 1991-04-06 | 1991-04-06 | Compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2070500T3 true ES2070500T3 (es) | 1995-06-01 |
Family
ID=27265153
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES91910962T Expired - Lifetime ES2070500T3 (es) | 1990-06-22 | 1991-06-18 | Inhibidores de la enzima convertidora de la angiotensina. |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US5348978A (es) |
| EP (1) | EP0535042B1 (es) |
| JP (1) | JPH05507919A (es) |
| AT (1) | ATE120453T1 (es) |
| CA (1) | CA2085993A1 (es) |
| DE (1) | DE69108553T2 (es) |
| DK (1) | DK0535042T3 (es) |
| ES (1) | ES2070500T3 (es) |
| FI (1) | FI925799A0 (es) |
| IE (1) | IE65893B1 (es) |
| IL (1) | IL98546A (es) |
| NO (1) | NO179902C (es) |
| NZ (1) | NZ238644A (es) |
| PT (1) | PT98057B (es) |
| WO (1) | WO1992000276A2 (es) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ20013453A3 (cs) * | 1999-03-29 | 2002-02-13 | Bristol-Myers Squibb Company | Inhibitor vasopeptidázy a farmaceutický prostředek, který ho obsahuje |
| EP2623605B1 (en) | 2007-04-09 | 2018-11-28 | University of Florida Research Foundation, Inc. | RAAV vector compositions having tyrosine-modified capsid proteins and methods for use |
| RU2018103185A (ru) * | 2015-07-02 | 2019-08-05 | Новас Интернэшнл Инк. | Анионные поверхностно-активные вещества |
| US10584306B2 (en) | 2017-08-11 | 2020-03-10 | Board Of Regents Of The University Of Oklahoma | Surfactant microemulsions |
| JP7169584B2 (ja) * | 2018-01-30 | 2022-11-11 | 公立大学法人横浜市立大学 | オーキシン生合成阻害活性を有する新規化合物、その製造方法及びその用途 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1090354A (en) * | 1977-07-14 | 1980-11-25 | Miguel A. Ondetti | Carboxymethyl esters of mercaptopropanoic acids |
| US4611002A (en) * | 1977-07-14 | 1986-09-09 | E. R. Squibb And Sons, Inc. | Carboxymethyl esters of mercaptopropanoic acids as enkephalinase inhibitors |
| US4242265A (en) * | 1979-01-10 | 1980-12-30 | E. R. Squibb & Sons, Inc. | Indolylalkyl esters of mercaptoalkanoic acids |
-
1991
- 1991-06-18 JP JP91510751A patent/JPH05507919A/ja active Pending
- 1991-06-18 EP EP91910962A patent/EP0535042B1/en not_active Expired - Lifetime
- 1991-06-18 IE IE208891A patent/IE65893B1/en not_active IP Right Cessation
- 1991-06-18 DE DE69108553T patent/DE69108553T2/de not_active Expired - Fee Related
- 1991-06-18 DK DK91910962.9T patent/DK0535042T3/da active
- 1991-06-18 WO PCT/GB1991/000980 patent/WO1992000276A2/en active IP Right Grant
- 1991-06-18 CA CA002085993A patent/CA2085993A1/en not_active Abandoned
- 1991-06-18 IL IL9854691A patent/IL98546A/en not_active IP Right Cessation
- 1991-06-18 AT AT91910962T patent/ATE120453T1/de not_active IP Right Cessation
- 1991-06-18 ES ES91910962T patent/ES2070500T3/es not_active Expired - Lifetime
- 1991-06-18 US US07/956,877 patent/US5348978A/en not_active Expired - Fee Related
- 1991-06-20 PT PT98057A patent/PT98057B/pt not_active IP Right Cessation
- 1991-06-21 NZ NZ238644A patent/NZ238644A/xx unknown
-
1992
- 1992-12-21 FI FI925799A patent/FI925799A0/fi not_active Application Discontinuation
- 1992-12-21 NO NO924953A patent/NO179902C/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL98546A (en) | 1996-05-14 |
| ATE120453T1 (de) | 1995-04-15 |
| EP0535042A1 (en) | 1993-04-07 |
| DK0535042T3 (da) | 1995-07-24 |
| IE912088A1 (en) | 1992-01-01 |
| WO1992000276A3 (en) | 1992-02-20 |
| DE69108553T2 (de) | 1995-08-03 |
| NO924953D0 (no) | 1992-12-21 |
| PT98057B (pt) | 1998-11-30 |
| NZ238644A (en) | 1993-05-26 |
| FI925799A (fi) | 1992-12-21 |
| US5348978A (en) | 1994-09-20 |
| JPH05507919A (ja) | 1993-11-11 |
| EP0535042B1 (en) | 1995-03-29 |
| AU638588B2 (en) | 1993-07-01 |
| WO1992000276A2 (en) | 1992-01-09 |
| DE69108553D1 (de) | 1995-05-04 |
| IE65893B1 (en) | 1995-11-29 |
| IL98546A0 (en) | 1992-07-15 |
| AU8067791A (en) | 1992-01-23 |
| NO179902B (no) | 1996-09-30 |
| FI925799A0 (fi) | 1992-12-21 |
| PT98057A (pt) | 1992-05-29 |
| CA2085993A1 (en) | 1991-12-23 |
| NO179902C (no) | 1997-01-08 |
| NO924953L (no) | 1993-02-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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