ES2068800T1 - Preparacion farmaceutica en forma de un comprimido efervescente o de desintegracion o un granulado soluble al instante, y procedimiento para su produccion. - Google Patents

Preparacion farmaceutica en forma de un comprimido efervescente o de desintegracion o un granulado soluble al instante, y procedimiento para su produccion.

Info

Publication number
ES2068800T1
ES2068800T1 ES93902180T ES93902180T ES2068800T1 ES 2068800 T1 ES2068800 T1 ES 2068800T1 ES 93902180 T ES93902180 T ES 93902180T ES 93902180 T ES93902180 T ES 93902180T ES 2068800 T1 ES2068800 T1 ES 2068800T1
Authority
ES
Spain
Prior art keywords
active ingredient
pct
matrix
amount
effervescent
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
ES93902180T
Other languages
English (en)
Other versions
ES2068800T3 (es
Inventor
Gerhard Gergely
Thomas Gergely
Irmgard Gergely
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of ES2068800T1 publication Critical patent/ES2068800T1/es
Application granted granted Critical
Publication of ES2068800T3 publication Critical patent/ES2068800T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0007Effervescent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/167Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
    • A61K9/1676Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)

Abstract

LA PREPARACION FARMACEUTICA EN LA FORMA DE UNA TABLETA EFERVESCENTE Y/O DESINTEGRABLE O EN UN GRANULADO INSTANTANEO CONTIENE AL MENOS UN AGENTE IRRITANTE PARA EL GUSTO Y AL MENOS UNA MATRIZ DE RETRASO DE LIBERACION DEL AGENTE QUE ESTA UNIDO INTIMAMENTE CON LAS PARTICULAS DEL AGENTE O BIEN LAS ENVUELVE Y LAS APLICA A UN SUBSTRATO. LA PREPARACION EN SOLUCION ACUOSA A TEMPERATURA AMBIENTE LIBERA COMO MAXIMO 65 Y CON PREFERENCIA 50 % DEL AGENTE DENTRO DE APROXIMADAMENTE 2 MINUTOS, PERO EN 0,1 N HCI A 38 % DEL AGENTE EN UN TIEMPO COMO MAXIMO DE 20 Y CON PREFERENCIA DE 15 MINUTOS. LA MATRIZ CONTIENE PREFERENTEMENTE AL MENOS UN ESTER DE ACIDO GRASO Y/O UNA CERA, CON PREFERENCIA CON UN PUNTO DE FUSION ENTRE 30 Y 45, ESPECIALMENTE ENTRE 32 Y 35 MENOS UN DERIVADOS DE CELULOSA Y/O Y AL MENOS UN ESTER ACIDO POLIMETACRILATO. LA CANTIDAD DEL AGENTE SE ENCUENTRA POR DEBAJO DE 60 Y CON PREFERENCIA POR DEBAJO DE 10 MG, DE FORMA QUE EN LA MATRIZ SE DISPONE DE 1 HASTA 10, CON PREFERENCIA 3 HASTA 5 VECES DE LACANTIDAD CORRESPONDIENTE AL AGENTE POR TABLETA O DOSIS DE GRANULADO. PARA EL TRATAMIENTO DE DIARREA MEDIANTE AL MENOS LIPERAMIDA, LA MATRIZ CONTIENE TAMBIEN UNA MEZCLA Y CANTIDAD DE SALES ALCALINAS Y/O ALCALINOTERREAS, CON PREFERENCIA SALES ORGANICAS Y CLORUROS QUE COMPENSAN LA PERDIDA DE ELECTROLITOS EN EL CUERPO.
ES93902180T 1992-01-13 1993-01-12 Preparacion farmaceutica en forma de un comprimido efervescente y/o de descomposicion, o de un granulado instantaneo, asi como procedimiento para su fabricacion. Expired - Lifetime ES2068800T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP92100441 1992-01-13

Publications (2)

Publication Number Publication Date
ES2068800T1 true ES2068800T1 (es) 1995-05-01
ES2068800T3 ES2068800T3 (es) 1995-12-16

Family

ID=8209237

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93902180T Expired - Lifetime ES2068800T3 (es) 1992-01-13 1993-01-12 Preparacion farmaceutica en forma de un comprimido efervescente y/o de descomposicion, o de un granulado instantaneo, asi como procedimiento para su fabricacion.

Country Status (16)

Country Link
US (1) US5587179A (es)
EP (1) EP0620731B1 (es)
JP (1) JPH07506336A (es)
AT (1) ATE128028T1 (es)
AU (1) AU668375B2 (es)
CA (1) CA2127352C (es)
CZ (1) CZ283351B6 (es)
DE (1) DE59300632D1 (es)
DK (1) DK0620731T3 (es)
ES (1) ES2068800T3 (es)
FI (1) FI110353B (es)
GR (2) GR950300005T1 (es)
MX (1) MX9300110A (es)
PL (1) PL173676B1 (es)
WO (1) WO1993013760A1 (es)
ZA (1) ZA93215B (es)

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US5395627A (en) * 1992-09-04 1995-03-07 Akzo N.V. Pharmaceutical granulate
DE4403943A1 (de) * 1994-02-08 1995-08-10 Hexal Pharma Gmbh Orale Azrneimittelzubereitung mit Diclofenac-Natrium
TW466119B (en) * 1994-02-28 2001-12-01 Janssen Pharmaceutica Nv Film coated tablet of paracetamol and domperidone
GB9421836D0 (en) * 1994-10-28 1994-12-14 Scherer Corp R P Process for preparing solid pharmaceutical dosage forms of hydrophobic substances
US5837287A (en) * 1994-10-28 1998-11-17 R P Scherer Corporation Process for preparing solid pharmaceutical dosage forms
US5807577A (en) * 1995-11-22 1998-09-15 Lab Pharmaceutical Research International Inc. Fast-melt tablet and method of making same
US6974595B1 (en) * 1996-05-17 2005-12-13 Proethic Pharmaceuticals, Inc. Pharmaceutical compositions based on Diclofenae
GB9710767D0 (en) * 1996-06-26 1997-07-23 On Ninh Analgesic and anti-inflamatory compositions comprising domperidone and methods of using same
BE1011045A3 (fr) * 1997-03-14 1999-04-06 Ucb Sa Compositions pharmaceutiques pour la liberation controlee de substances actives.
US5843477A (en) * 1997-09-30 1998-12-01 Bayer Corporation Lubricants for use in tabletting
US5904937A (en) * 1997-10-03 1999-05-18 Fmc Corporation Taste masked pharmaceutical compositions
DE19814257A1 (de) * 1998-03-31 1999-10-07 Asta Medica Ag Brauseformulierungen
DE19814256A1 (de) * 1998-03-31 1999-10-07 Asta Medica Ag Feste, schnellzerfallende Cetirizin-Formulierungen
DE19822036A1 (de) * 1998-05-15 1999-11-18 Bayer Ag Brausezubereitungen
GB9816899D0 (en) 1998-08-05 1998-09-30 Boots Co Plc Therapeutic agents
US7001612B2 (en) 1998-08-26 2006-02-21 All Sun Hsf Company Limited Composition for the relief of heat stress
US6235322B1 (en) * 1999-03-09 2001-05-22 Mintech, Inc. Highly soluble and stable mineral supplements containing calcium and magnesium
AP2002002410A0 (en) * 1999-08-04 2002-03-31 Ranbaxy Laboratories Ltd Hydrodynamically Balancing Oral Drug Delivery System
US6284270B1 (en) 1999-08-04 2001-09-04 Drugtech Corporation Means for creating a mass having structural integrity
DE60133723T2 (de) * 2000-02-28 2009-07-02 PharmaKodex Ltd., Chippenham Verabreichungssystemen für oral anzuwendende arzneimittel
AU2001275043A1 (en) 2000-05-31 2001-12-11 Drugtech Corporation Mineral supplement
GB0222612D0 (en) * 2002-09-30 2002-11-06 Univ Gent Controlled delivery system for bioactive substances
WO2004032906A1 (en) * 2002-10-11 2004-04-22 Depomed Development, Ltd. Gastro-retentive levodopa delivery form
JP4601271B2 (ja) * 2003-08-01 2010-12-22 大洋薬品工業株式会社 圧縮成形製剤およびその製造方法
WO2005021056A1 (en) * 2003-08-21 2005-03-10 Cns, Inc. Effervescent delivery system
US8216610B2 (en) * 2004-05-28 2012-07-10 Imaginot Pty Ltd. Oral paracetamol formulations
JO3352B1 (ar) * 2005-06-17 2019-03-13 Apr Applied Pharma Res Sa صيغ دايكلوفيناك وطرق استخدامه
US7811604B1 (en) 2005-11-14 2010-10-12 Barr Laboratories, Inc. Non-effervescent, orally disintegrating solid pharmaceutical dosage forms comprising clozapine and methods of making and using the same
JP2009517346A (ja) 2005-11-28 2009-04-30 イメイジノット ピーティーワイ エルティーディー 治療用化合物の経口送達系
EP1902708A1 (de) 2006-09-25 2008-03-26 Losan Pharma GmbH Wirkstoff enthaltende stabilisierte feste Arzneimittelformen und Verfahren zu ihrer Herstellung
CN101084881B (zh) * 2007-06-23 2012-08-29 淮北辉克药业有限公司 靶向速释泡腾制剂及其制备方法
CA2704209C (en) 2007-10-31 2017-02-28 Mcneil-Ppc, Inc. Orally disintegrative dosage form
US8313768B2 (en) 2009-09-24 2012-11-20 Mcneil-Ppc, Inc. Manufacture of tablet having immediate release region and sustained release region
US8858210B2 (en) 2009-09-24 2014-10-14 Mcneil-Ppc, Inc. Manufacture of variable density dosage forms utilizing radiofrequency energy
US9610224B2 (en) 2009-09-24 2017-04-04 Johnson & Johnson Consumer Inc. Manufacture of tablet in a die utilizing powder blend containing water-containing material
US9445971B2 (en) 2012-05-01 2016-09-20 Johnson & Johnson Consumer Inc. Method of manufacturing solid dosage form
US9511028B2 (en) 2012-05-01 2016-12-06 Johnson & Johnson Consumer Inc. Orally disintegrating tablet
US20150366823A1 (en) 2013-02-06 2015-12-24 Hermes Arzneimittel Gmbh Pharmaceutical compositions incorporating low-dose drugs
KR20160107254A (ko) 2014-01-10 2016-09-13 존슨 앤드 존슨 컨수머 인코포레이티드 고주파 및 손실 코팅된 입자를 사용하여 정제를 제조하는 방법
WO2015193485A1 (en) 2014-06-20 2015-12-23 Hermes Arzneimittel Gmbh Taste-masked oral pharmaceutical composition
US10493026B2 (en) 2017-03-20 2019-12-03 Johnson & Johnson Consumer Inc. Process for making tablet using radiofrequency and lossy coated particles

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4289751A (en) * 1979-06-29 1981-09-15 Merck & Co., Inc. Effervescent enteric-coated formulation of soluble form of erythromycin and therapeutic use thereof
US4704284A (en) * 1982-08-12 1987-11-03 Pfizer Inc. Long-acting matrix tablet formulations
US4539198A (en) * 1983-07-07 1985-09-03 Rowell Laboratories, Inc. Solid pharmaceutical formulations for slow, zero order release via controlled surface erosion: expanded range
HU198844B (en) * 1984-06-14 1989-12-28 Sandoz Ag Process for producing new galenic pharmaceutical composition ensuring retarded release of active ingredient
DE3440288A1 (de) * 1984-11-05 1986-05-07 Gergely, Gerhard, Dr.-Ing., Wien Pharmazeutische zubereitung mit einem gehalt an mindestens einer schleimhautreizenden substanz oder dergleichen, insbesondere profen, sowie verfahren zu ihrer herstellung
DE3524003A1 (de) * 1985-07-04 1987-01-08 Heumann Ludwig & Co Gmbh Arzneimittelgranulat mit verzoegerter wirkstofffreisetzung und verfahren zu seiner herstellung
US4832956A (en) * 1985-09-25 1989-05-23 Gerhard Gergely Disintegrating tablet and process for its preparation
US4753800A (en) * 1985-10-04 1988-06-28 Warner-Lambert Company Medicament adsorbates and their preparation
NZ231281A (en) * 1988-11-08 1991-01-29 Takeda Chemical Industries Ltd Sustained release pharmaceutical preparations comprising the active agent dispersed in a solid matrix of a fatty acid ester of a polyglycerol
GB8908361D0 (en) * 1989-04-13 1989-06-01 Beecham Group Plc Composition

Also Published As

Publication number Publication date
GR950300005T1 (en) 1995-02-28
US5587179A (en) 1996-12-24
WO1993013760A1 (de) 1993-07-22
AU3349293A (en) 1993-08-03
CZ283351B6 (cs) 1998-03-18
FI110353B (fi) 2002-12-31
FI943315A0 (fi) 1994-07-12
ATE128028T1 (de) 1995-10-15
DE59300632D1 (de) 1995-10-26
EP0620731B1 (de) 1995-09-20
JPH07506336A (ja) 1995-07-13
CA2127352A1 (en) 1993-07-22
DK0620731T3 (da) 1996-04-09
FI943315A (fi) 1994-07-12
GR3017806T3 (en) 1996-01-31
EP0620731A1 (de) 1994-10-26
ES2068800T3 (es) 1995-12-16
AU668375B2 (en) 1996-05-02
CZ160594A3 (en) 1994-12-15
MX9300110A (es) 1994-07-29
ZA93215B (en) 1993-08-19
PL173676B1 (pl) 1998-04-30
CA2127352C (en) 2005-05-31

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