ES2067645T3 - Derivados hidroxialquilfuranilo. - Google Patents

Derivados hidroxialquilfuranilo.

Info

Publication number
ES2067645T3
ES2067645T3 ES90200720T ES90200720T ES2067645T3 ES 2067645 T3 ES2067645 T3 ES 2067645T3 ES 90200720 T ES90200720 T ES 90200720T ES 90200720 T ES90200720 T ES 90200720T ES 2067645 T3 ES2067645 T3 ES 2067645T3
Authority
ES
Spain
Prior art keywords
6alkyl
hydrogen
derivatives
arylc1
alk
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90200720T
Other languages
English (en)
Inventor
Frans Eduard Janssens
Gaston Stanislas Marcell Diels
Joseph Elisabeth Leenaerts
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of ES2067645T3 publication Critical patent/ES2067645T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)
  • Furan Compounds (AREA)

Abstract

DERIVADOS DE HIDROXILOALQUILOFURANILO DE FORMULA EN DONDE -A1 = A2-A3 = A4ES -CH=CH-CH=CH-, -N=CH-CH=CH-, -CH=N-CH=CH-, -CH=CH-N=CH-, -CH=CH-CH=N-, -N=CH-N=CH- O -CH=N-CH=N-; D ES ALCANODIILO C1-4; R1 ES HIDROGENO, ALQUILO C1-6, ARILO C1-6 ALQUILO, O ALQUILOCARBONILO C1-6; R2 Y R3 SON HIDROGENO O ALQUILO C1-6; N ES 0,1 O 2; B ES NR4, O, S, SO2 O CH2; R4 ES HIDROGENO, ALQUILO C1-6, CICLOALQUILO C3-6, ALQUENILO C3-6 OPCIONALMENTE SUSTITUIDO CON ARILO, ALQUILOCARBONILO C1-6, ALQUILOOXILOCARBONILO C1-6, ARILOCARBONILO, ARILO C1-6 ALQUILOOXILOCARBONILO, ALQUILOSULFONILO C1-6, ARILOSULFONILO, O UN RADICAL DE LA FORMULA -ALK-R5, -ALK-Y-R6, -ALK-Z1-C(=X)-Z2-R7, O -CH2-CHOH-CH2-O-R8, LAS SALES DE ADICION ACIDA Y FORMAS ESTEROQUIMICAMENTE ISOMERAS DE ELLAS, TENIENDO DICHOS COMPUESTOS ACTIVIDAD ANTI-ALERGICA. COMPOSICIONES FARMACEUTICAS CONTENIENDO TALES COMPUESTOS COMO UN INGREDIENTE EFECTIVO; METODOS DE PREPARAR DICHOS COMPUESTOS Y COMPOSICIONES FARMACEUTICAS.
ES90200720T 1989-04-07 1990-03-27 Derivados hidroxialquilfuranilo. Expired - Lifetime ES2067645T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US33502289A 1989-04-07 1989-04-07

Publications (1)

Publication Number Publication Date
ES2067645T3 true ES2067645T3 (es) 1995-04-01

Family

ID=23309914

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90200720T Expired - Lifetime ES2067645T3 (es) 1989-04-07 1990-03-27 Derivados hidroxialquilfuranilo.

Country Status (21)

Country Link
EP (1) EP0393738B1 (es)
JP (1) JPH02290874A (es)
KR (1) KR900016193A (es)
CN (1) CN1031403C (es)
AT (1) ATE114653T1 (es)
AU (1) AU615612B2 (es)
CA (1) CA2013892A1 (es)
DE (1) DE69014385T2 (es)
DK (1) DK0393738T3 (es)
ES (1) ES2067645T3 (es)
FI (1) FI95702C (es)
GR (1) GR3015154T3 (es)
HU (1) HUT58324A (es)
IE (1) IE65460B1 (es)
IL (1) IL94008A (es)
NO (1) NO174851C (es)
NZ (1) NZ233088A (es)
PH (1) PH30434A (es)
PT (1) PT93671B (es)
RU (1) RU2030415C1 (es)
ZA (1) ZA902664B (es)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2043564A1 (en) * 1990-07-06 1992-01-07 Alfons G. M. De Knaep 3-[(5-methyl-2-furanyl)methyl]-n-(4-piperidinyl)-3h-imidazo [4,5-b]-pyridin-2-amine 2-hydroxy-1,2,3-propanetricarboxylate
FR2668150B1 (fr) * 1990-10-17 1994-11-18 Theramex Nouveaux derives du terbutylphenyl 1-amino 4-hydroxybutane, leurs procedes de preparation et les compositions pharmaceutiques en renfermant.
BR9206353A (pt) * 1991-08-14 1995-11-07 Procter & Gamble Pharma Uretanos cíclicos utilizáveis como agentes antiarrítmicos e antifibrilatórios
AU3258293A (en) * 1992-01-09 1993-08-03 Janssen Pharmaceutica N.V. Antihistaminic piperazinyl derivatives
US5521183A (en) * 1994-08-30 1996-05-28 Allergan Use of 5-HT ligands as anti-pruritic agents
JP4601175B2 (ja) * 1998-12-19 2010-12-22 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ 抗ヒスタミン性スピロ化合物
EP1418175A1 (en) * 1999-06-28 2004-05-12 Janssen Pharmaceutica N.V. Respiratory syncytial virus replication inhibitors
EP3233799B1 (en) 2014-12-19 2021-05-19 The Broad Institute, Inc. Dopamine d2 receptor ligands
EP3233077A4 (en) 2014-12-19 2018-08-08 The Broad Institute Inc. Dopamine d2 receptor ligands

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4556660A (en) * 1982-07-12 1985-12-03 Janssen Pharmaceutica N.V. N-(Bicyclic heterocyclyl)-4-piperidinamines
US4634704A (en) * 1983-10-06 1987-01-06 Janssen Pharmaceutica, N.V. Anti-allergic five membered heterocyclic ring containing N-(bicyclic heterocycyl)-4-piperidinamines
PH23995A (en) * 1984-01-09 1990-02-09 Janssen Pharmaceutica Nv 4((bicycle heterocyclyl)-methyl and hetero)piperidines
US4695575A (en) * 1984-11-13 1987-09-22 Janssen Pharmaceutica, N.V. 4-[(bicycle heterocyclyl)-methyl and -hetero]-piperidines
US4588722A (en) * 1984-01-09 1986-05-13 Janssen Pharmaceutica N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives
GB8515934D0 (en) * 1985-06-24 1985-07-24 Janssen Pharmaceutica Nv (4-piperidinomethyl and-hetero)purines
DE3781173T2 (de) * 1986-02-03 1992-12-17 Janssen Pharmaceutica Nv N-heterozyklische-4-piperidinamine enthaltende anti-histaminische zusammensetzungen.
US4897401A (en) * 1987-06-19 1990-01-30 Janssen Pharmaceutical N.V. N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases
CA1317939C (en) * 1987-07-01 1993-05-18 Janssen Pharmaceutica Naamloze Vennootschap ¬(bicyclic heterocyclyl)methyl and -hetero| substituted hexahydro-1h-azepines and pyrrolidines

Also Published As

Publication number Publication date
CN1046161A (zh) 1990-10-17
AU5295190A (en) 1990-10-11
HUT58324A (en) 1992-02-28
ZA902664B (en) 1991-12-24
NO901580L (no) 1990-10-08
NZ233088A (en) 1991-10-25
CA2013892A1 (en) 1990-10-07
NO901580D0 (no) 1990-04-06
IE901257L (en) 1990-10-07
KR900016193A (ko) 1990-11-12
DE69014385T2 (de) 1995-04-20
IE65460B1 (en) 1995-11-01
DE69014385D1 (de) 1995-01-12
JPH02290874A (ja) 1990-11-30
FI95702B (fi) 1995-11-30
IL94008A (en) 1997-02-18
EP0393738A1 (en) 1990-10-24
FI95702C (fi) 1996-03-11
AU615612B2 (en) 1991-10-03
EP0393738B1 (en) 1994-11-30
IL94008A0 (en) 1991-01-31
RU2030415C1 (ru) 1995-03-10
DK0393738T3 (da) 1995-01-16
ATE114653T1 (de) 1994-12-15
PH30434A (en) 1997-05-09
PT93671B (pt) 1996-06-28
NO174851B (no) 1994-04-11
FI901755A0 (fi) 1990-04-06
CN1031403C (zh) 1996-03-27
GR3015154T3 (en) 1995-05-31
NO174851C (no) 1994-07-20
PT93671A (pt) 1990-11-20
HU902107D0 (en) 1990-07-28

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