ES2066768T3 - Agentes de contraste en la formacion de imagenes por resonancia magnetica nuclear del tipo dipiridoxil-fosfato. - Google Patents

Agentes de contraste en la formacion de imagenes por resonancia magnetica nuclear del tipo dipiridoxil-fosfato.

Info

Publication number
ES2066768T3
ES2066768T3 ES88107346T ES88107346T ES2066768T3 ES 2066768 T3 ES2066768 T3 ES 2066768T3 ES 88107346 T ES88107346 T ES 88107346T ES 88107346 T ES88107346 T ES 88107346T ES 2066768 T3 ES2066768 T3 ES 2066768T3
Authority
ES
Spain
Prior art keywords
contrast agents
phosphate
dipiridoxil
formation
magnetic resonance
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88107346T
Other languages
English (en)
Inventor
Scott M Rocklage
Steven C Quay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amersham Health Salutar Inc
Original Assignee
Nycomed Salutar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Salutar Inc filed Critical Nycomed Salutar Inc
Application granted granted Critical
Publication of ES2066768T3 publication Critical patent/ES2066768T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • General Physics & Mathematics (AREA)
  • Signal Processing (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

LOS ACIDOS N,N''-BIS-(PIRIDOXAL-5-FOSFATO)-ALQUILENDIAMINA-N, N''-DIACETICOS, N, N''-BIS-(PIRIDOXAL-5-FOSFATO)-1,2CICLOALQUILENDIAMINA-N,N''-DIACETICO, Y N, N''-BIS (PIRIDOXAL-5-FOSFATO)-1,2-ARILENDIAMINA-N,N''-DIACETICO, LOS CORRESPONDIENTES COMPUESTOS DE MONOFOSFATO Y DE LOS ACIDOS MONOACETICOS, ASI COMO SUS SALES Y ESTERES FORMAN QUELATOS ESTABLES MUY SOLUBLES CON IONES METALICOS PARAMAGNETICOS, Y SON AGENTES DE CONTRASTE RAIOLOGICO PARA RMN ALTAMENTE EFICACES. LOS AGENTES DE CONTRASTE PREFERIDO SON LOS YA CITADOS DE ACIDOS DIACETICOS Y SUS SALES CALCICAS SOLUBLES. LA INVENCION SE REFIERE TAMBIEN A NUEVOS COMPUESTOS INTERMEDIOS PARA FORMAR ESTOS COMPUESTOS.
ES88107346T 1987-05-08 1988-05-06 Agentes de contraste en la formacion de imagenes por resonancia magnetica nuclear del tipo dipiridoxil-fosfato. Expired - Lifetime ES2066768T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/047,614 US4933456A (en) 1987-05-08 1987-05-08 Dipyridoxyl phosphate NMRI contrast agents

Publications (1)

Publication Number Publication Date
ES2066768T3 true ES2066768T3 (es) 1995-03-16

Family

ID=21949962

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88107346T Expired - Lifetime ES2066768T3 (es) 1987-05-08 1988-05-06 Agentes de contraste en la formacion de imagenes por resonancia magnetica nuclear del tipo dipiridoxil-fosfato.

Country Status (20)

Country Link
US (1) US4933456A (es)
EP (1) EP0290047B1 (es)
JP (1) JP2512524B2 (es)
AR (1) AR246956A1 (es)
AT (1) ATE118010T1 (es)
AU (1) AU613363B2 (es)
BR (1) BR1100623A (es)
CA (1) CA1322003C (es)
DE (2) DE19775088I2 (es)
DK (1) DK173849B1 (es)
ES (1) ES2066768T3 (es)
FI (1) FI88164C (es)
GR (1) GR3015884T3 (es)
HK (1) HK55195A (es)
IE (1) IE66368B1 (es)
IL (1) IL86298A (es)
NL (1) NL970040I2 (es)
NO (2) NO177462C (es)
NZ (1) NZ224537A (es)
SG (1) SG30569G (es)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250285A (en) * 1985-05-08 1993-10-05 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
US5422096A (en) * 1985-05-08 1995-06-06 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
US4994259A (en) * 1987-05-08 1991-02-19 Salutar, Inc. Improvement in the method of NMR imaging employing a manganese II chelates of N,N'-bis[pyridoxal-alkylene (or cycloalkylene) (or arylene)]-N,N'-diacetic acid derivatives
US4827426A (en) * 1987-05-18 1989-05-02 The Coca-Cola Company Data acquisition and processing system for post-mix beverage dispensers
US5087440A (en) * 1989-07-31 1992-02-11 Salutar, Inc. Heterocyclic derivatives of DTPA used for magnetic resonance imaging
AU7346091A (en) * 1990-03-02 1991-09-18 Byk Gulden Lomberg Chemische Fabrik Gmbh Preparations for mr diagnosis
DE4026103A1 (de) * 1990-08-17 1992-02-20 Byk Gulden Lomberg Chem Fab Neue verwendung von komplexsalzen
WO1992003168A1 (de) * 1990-08-15 1992-03-05 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue verwendung von komplexsalzen
WO1992011840A1 (de) * 1991-01-07 1992-07-23 Byk Gulden Lomberg Chemische Fabrik Gmbh Kontrastmittel für die mr-diagnostik
DE4107570A1 (de) * 1991-03-07 1992-11-19 Diagnostikforschung Inst Chelate, deren metallkomplexe sowie ihre verwendung in diagnostik und therapie
EP0594640A4 (en) * 1991-05-23 1998-06-03 Evan C Unger Liposoluble compounds for magnetic resonance imaging
US5385719A (en) * 1991-09-24 1995-01-31 Unger; Evan C. Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
CA2190727C (en) * 1994-05-19 2006-07-18 Sudhakar Kasina Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging
TW319763B (es) 1995-02-01 1997-11-11 Epix Medical Inc
SG81898A1 (en) * 1995-08-11 2001-07-24 Sumitomo Chemical Co Olefin polymerization catalyst component, olefin polymerization catalyst and process for producing olefin polymer
US6005083A (en) 1997-03-28 1999-12-21 Neorx Corporation Bridged aromatic substituted amine ligands with donor atoms
DE69838873T2 (de) * 1997-07-01 2008-12-04 Ge Healthcare As Diagnostisches verfahren zum nachweis von myokard-ischämie
EP1060174B1 (en) * 1997-12-23 2004-09-22 Amersham Health AS Nitric oxide releasing chelating agents and their therapeutic use
FR2867473B1 (fr) 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
EP2800755B1 (en) * 2012-01-05 2018-05-30 Pledpharma AB Calmangafodipir, a new chemical entity, and other mixed metal complexes, methods of preparation, compositions, and methods of treatment

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3632637A (en) * 1968-02-13 1972-01-04 Arthur E Martell Hydroxyaryl-containing aminocarboxylic chelating agents
AU485693B2 (en) * 1973-08-24 1976-02-05 The Council Ofthe Institute Of Medical And Veterinary Science, Andthe Universityof Adelaide Gariti Cancer Foundation New radiopharmaceuticals for cholescintigraphy
JPS5569517A (en) * 1978-11-20 1980-05-26 Nippon Mejifuijitsukusu Kk Labelling preparation for labelling of erythrocytes with radio-active technetium
JPS5791927A (en) * 1980-11-27 1982-06-08 Nippon Mejifuijitsukusu Kk Technetium-99m labelled diagnosticum
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
JPS5896031A (ja) * 1981-12-03 1983-06-07 Nippon Mejifuijitsukusu Kk 放射性診断剤およびその製造用組成物
US4637929A (en) * 1985-01-04 1987-01-20 Salutar, Inc. Ferrioxamine-paramagnetic contrast agents for MR imaging, composition, apparatus and use
US4842845A (en) * 1987-05-08 1989-06-27 Salutar, Inc. Radioactive metal chelates for dipyridoxyl phosphate
US4935518A (en) 1987-05-08 1990-06-19 Salutar, Inc. Manganese(II), chelate contrast agents derived from N,N'-bis-(pyridoxal ethylene diamine-N,N')-diacetic acid and derivatives thereof

Also Published As

Publication number Publication date
EP0290047A3 (en) 1990-04-25
SG30569G (en) 1995-09-18
EP0290047A2 (en) 1988-11-09
NL970040I2 (nl) 1998-06-02
DE3852906T2 (de) 1995-06-22
JPS63280087A (ja) 1988-11-17
ATE118010T1 (de) 1995-02-15
IL86298A0 (en) 1988-11-15
AU1568088A (en) 1988-11-10
FI88164B (fi) 1992-12-31
DK251688D0 (da) 1988-05-06
FI882125A0 (fi) 1988-05-06
AR246956A1 (es) 1994-10-31
FI88164C (fi) 1993-04-13
NL970040I1 (nl) 1998-02-02
DK173849B1 (da) 2001-12-27
NZ224537A (en) 1991-06-25
US4933456A (en) 1990-06-12
DE19775088I2 (de) 2001-05-23
NO177462B (no) 1995-06-12
BR1100623A (pt) 1999-12-07
NO1998004I1 (no) 1998-01-19
HK55195A (en) 1995-04-21
DE3852906D1 (de) 1995-03-16
CA1322003C (en) 1993-09-07
DK251688A (da) 1988-11-09
NO882004D0 (no) 1988-05-06
NO882004L (no) 1988-11-09
NO177462C (no) 1995-09-20
JP2512524B2 (ja) 1996-07-03
IE881366L (en) 1988-11-08
EP0290047B1 (en) 1995-02-01
IL86298A (en) 1992-11-15
AU613363B2 (en) 1991-08-01
FI882125A (fi) 1988-11-09
GR3015884T3 (en) 1995-07-31
IE66368B1 (en) 1995-12-27

Similar Documents

Publication Publication Date Title
ES2066768T3 (es) Agentes de contraste en la formacion de imagenes por resonancia magnetica nuclear del tipo dipiridoxil-fosfato.
ES492316A0 (es) Un metodo para mejorar las propiedades de sales de acidos del fosforo
ES2031832T3 (es) Quelatos paramagneticos.
ES504469A0 (es) Procedimiento para la preparacion de composiciones acuosas de sales polimericas de amonio cuaternario de base acrilica
DE3853027D1 (de) Zwei-Frequenzen NMR Oberflächenspule.
IT1089971B (it) Procedimento per la produzione di sali di n-fosfonometilglicina
AR248140A1 (es) Composicion de 1, 4, 7, 10-tetraazaciclododecano como la fraccion macrolitica, o sales fisiologicamente aceptables del mismo y radionuclidos como agente terapeuticamente activo.
ES2056105T3 (es) Di-t-butilfenoles sustituidos.
SE8404019D0 (sv) Oftalmiskt medel
FR2338039A1 (fr) Composes bis-(meta-amidinophenoxy) et leurs sels d'addition avec des acides pharmacologiquement acceptables
IT1090625B (it) Procedimento per la fabbricazione di nuclei ferromagnetici per macchine dinamo-elettriche
AR227450A1 (es) Procedimiento para producir nuevos 8-arilalquil-3-fenil-3-nortropanoles y sus sales de adicion de acidos
SE8604950D0 (sv) Dementia-improving and therapeutic agents
FR2398072A1 (fr) Acides et sels d'acides (n-carboxyalkyl-amino)-alcane-polyphosphoniques utilisables comme agents complexants
SE7706392L (sv) N-fosfonometylenmonoaminoalkanmono- och -polyfosfonsyror respektive n-fosfonometylendiaminoalkanpolyfosfonsyror samt sett for deras framstellning
ATE26462T1 (de) Fluessige detergenszusammensetzung.
ES502018A0 (es) Un procedimiento para preparar una composicion detergente granular
ATE76076T1 (de) 6,7-disubstituierte 1-cyclopropyl-1,4-dihydro-4oxo-1,8-naphthyridin-3-carbons|uren.
ATE13308T1 (de) Neue saeuren des phosphors und deren derivate.
ES2134409T3 (es) Formulaciones supresoras frente a las metastasis hepaticas de los tumores.
IT7828802A0 (it) Processo per la preparazione di un'amina.
ES2061530T3 (es) 9-amino-1,4-etano-1,2,3,4-tetrahidroacridina y compuestos afines, intermediarios y un procedimiento para la preparacion de los mismos y su uso como medicamentos.
TNSN90153A1 (fr) Procede de preparation de derives du glycerol
AR240814A2 (es) Nuevos derivados de acilamino-s-triazina, procedimiento para su preparacion y composiciones antiparasitarias que los contienen, excluida su actividad terapeutica.
AR225434A1 (es) Procedimiento para la preparacion de sales de metales alcalinoterreos de acidos alcohilbencenosulfonicos

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 290047

Country of ref document: ES

SPCF Request for supplementary protection certificate filed

Free format text: REGISTRY NO/DATE: 668442 19980113, FIRST REGISTRY NO/DATE: UEEU/1/97/040/001 19970522

Spc suppl protection certif: C9800022

Filing date: 19980713

SPCG Supplementary protection certificate granted

Free format text: PRODUCT NAME: MANGAFODIPIR (TELASCAN), REGISTRY NO/DATE: 668442 19980113, FIRST REGISTRY NO/DATE: UEEU/1/97/040/001 19970522

Spc suppl protection certif: C9800022

Filing date: 19980713