DE3852906D1 - Dipyridoxyl-Phosphat als magnetisches Kernresonanz-Bildgebungsmittel. - Google Patents

Dipyridoxyl-Phosphat als magnetisches Kernresonanz-Bildgebungsmittel.

Info

Publication number
DE3852906D1
DE3852906D1 DE3852906T DE3852906T DE3852906D1 DE 3852906 D1 DE3852906 D1 DE 3852906D1 DE 3852906 T DE3852906 T DE 3852906T DE 3852906 T DE3852906 T DE 3852906T DE 3852906 D1 DE3852906 D1 DE 3852906D1
Authority
DE
Germany
Prior art keywords
magnetic resonance
resonance imaging
imaging agent
dipyridoxyl
phosphate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE3852906T
Other languages
English (en)
Other versions
DE3852906T2 (de
Inventor
Scott M Rocklage
Steven C Quay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amersham Health Salutar Inc
Original Assignee
Nycomed Salutar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Salutar Inc filed Critical Nycomed Salutar Inc
Publication of DE3852906D1 publication Critical patent/DE3852906D1/de
Application granted granted Critical
Publication of DE3852906T2 publication Critical patent/DE3852906T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic System
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings
DE3852906T 1987-05-08 1988-05-06 Dipyridoxyl-Phosphat als magnetisches Kernresonanz-Bildgebungsmittel. Expired - Lifetime DE3852906T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/047,614 US4933456A (en) 1987-05-08 1987-05-08 Dipyridoxyl phosphate NMRI contrast agents

Publications (2)

Publication Number Publication Date
DE3852906D1 true DE3852906D1 (de) 1995-03-16
DE3852906T2 DE3852906T2 (de) 1995-06-22

Family

ID=21949962

Family Applications (2)

Application Number Title Priority Date Filing Date
DE3852906T Expired - Lifetime DE3852906T2 (de) 1987-05-08 1988-05-06 Dipyridoxyl-Phosphat als magnetisches Kernresonanz-Bildgebungsmittel.
DE1997175088 Active DE19775088I2 (de) 1987-05-08 1988-05-06 Dipyridoxyl-phosphat als magnetisches Kernresonanz-Bildgebungsmittel

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE1997175088 Active DE19775088I2 (de) 1987-05-08 1988-05-06 Dipyridoxyl-phosphat als magnetisches Kernresonanz-Bildgebungsmittel

Country Status (20)

Country Link
US (1) US4933456A (de)
EP (1) EP0290047B1 (de)
JP (1) JP2512524B2 (de)
AR (1) AR246956A1 (de)
AT (1) ATE118010T1 (de)
AU (1) AU613363B2 (de)
BR (1) BR1100623A (de)
CA (1) CA1322003C (de)
DE (2) DE3852906T2 (de)
DK (1) DK173849B1 (de)
ES (1) ES2066768T3 (de)
FI (1) FI88164C (de)
GR (1) GR3015884T3 (de)
HK (1) HK55195A (de)
IE (1) IE66368B1 (de)
IL (1) IL86298A (de)
NL (1) NL970040I2 (de)
NO (2) NO177462C (de)
NZ (1) NZ224537A (de)
SG (1) SG30569G (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5422096A (en) * 1985-05-08 1995-06-06 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
US5250285A (en) * 1985-05-08 1993-10-05 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
US4994259A (en) * 1987-05-08 1991-02-19 Salutar, Inc. Improvement in the method of NMR imaging employing a manganese II chelates of N,N'-bis[pyridoxal-alkylene (or cycloalkylene) (or arylene)]-N,N'-diacetic acid derivatives
US4827426A (en) * 1987-05-18 1989-05-02 The Coca-Cola Company Data acquisition and processing system for post-mix beverage dispensers
US5087440A (en) * 1989-07-31 1992-02-11 Salutar, Inc. Heterocyclic derivatives of DTPA used for magnetic resonance imaging
AU7346091A (en) * 1990-03-02 1991-09-18 Byk Gulden Lomberg Chemische Fabrik Gmbh Preparations for mr diagnosis
JPH06500090A (ja) * 1990-08-15 1994-01-06 ビイク　グルデン　ロンベルク　ヒエーミツシエ　フアブリーク　ゲゼルシヤフト　ミツト　ベシユレンクテル　ハフツング 錯塩の新規使用
DE4026103A1 (de) * 1990-08-17 1992-02-20 Byk Gulden Lomberg Chem Fab Neue verwendung von komplexsalzen
WO1992011840A1 (de) * 1991-01-07 1992-07-23 Byk Gulden Lomberg Chemische Fabrik Gmbh Kontrastmittel für die mr-diagnostik
DE4107570A1 (de) * 1991-03-07 1992-11-19 Diagnostikforschung Inst Chelate, deren metallkomplexe sowie ihre verwendung in diagnostik und therapie
AU660033B2 (en) * 1991-05-23 1995-06-08 Imarx Pharmaceutical Corp. Liposoluble compounds for magnetic resonance imaging
US5385719A (en) * 1991-09-24 1995-01-31 Unger; Evan C. Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
CA2190727C (en) * 1994-05-19 2006-07-18 Sudhakar Kasina Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging
TW319763B (de) 1995-02-01 1997-11-11 Epix Medical Inc
SG81898A1 (en) * 1995-08-11 2001-07-24 Sumitomo Chemical Co Olefin polymerization catalyst component, olefin polymerization catalyst and process for producing olefin polymer
US6005083A (en) 1997-03-28 1999-12-21 Neorx Corporation Bridged aromatic substituted amine ligands with donor atoms
ES2297888T3 (es) * 1997-07-01 2008-05-01 Ge Healthcare As Procedimiento diagnostico para la deteccion de isquemia miocardica.
WO1999033823A1 (en) * 1997-12-23 1999-07-08 Nycomed Imaging As Nitric oxide releasing chelating agents and their therapeutic use
FR2867473B1 (fr) 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
MX2014008247A (es) * 2012-01-05 2015-03-09 Pledpharma Ab Calmangafodipir, una nueva entidad quimica, y otros complejos de metal mezclados, metodos de preparacion, composiciones y metodos de tratamiento.

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3632637A (en) * 1968-02-13 1972-01-04 Arthur E Martell Hydroxyaryl-containing aminocarboxylic chelating agents
AU485693B2 (en) * 1973-08-24 1976-02-05 The Council Ofthe Institute Of Medical And Veterinary Science, Andthe Universityof Adelaide Gariti Cancer Foundation New radiopharmaceuticals for cholescintigraphy
JPS5569517A (en) * 1978-11-20 1980-05-26 Nippon Mejifuijitsukusu Kk Labelling preparation for labelling of erythrocytes with radio-active technetium
JPS5791927A (en) * 1980-11-27 1982-06-08 Nippon Mejifuijitsukusu Kk Technetium-99m labelled diagnosticum
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
JPS5896031A (ja) * 1981-12-03 1983-06-07 Nippon Mejifuijitsukusu Kk 放射性診断剤およびその製造用組成物
US4637929A (en) * 1985-01-04 1987-01-20 Salutar, Inc. Ferrioxamine-paramagnetic contrast agents for MR imaging, composition, apparatus and use
US4935518A (en) 1987-05-08 1990-06-19 Salutar, Inc. Manganese(II), chelate contrast agents derived from N,N'-bis-(pyridoxal ethylene diamine-N,N')-diacetic acid and derivatives thereof
US4842845A (en) * 1987-05-08 1989-06-27 Salutar, Inc. Radioactive metal chelates for dipyridoxyl phosphate

Also Published As

Publication number Publication date
HK55195A (en) 1995-04-21
AU1568088A (en) 1988-11-10
NO882004D0 (no) 1988-05-06
NO882004L (no) 1988-11-09
FI88164B (fi) 1992-12-31
JPS63280087A (ja) 1988-11-17
GR3015884T3 (en) 1995-07-31
EP0290047B1 (de) 1995-02-01
FI882125A0 (fi) 1988-05-06
EP0290047A3 (en) 1990-04-25
NZ224537A (en) 1991-06-25
NO177462B (no) 1995-06-12
DK173849B1 (da) 2001-12-27
ATE118010T1 (de) 1995-02-15
FI882125A (fi) 1988-11-09
DE3852906T2 (de) 1995-06-22
IL86298A0 (en) 1988-11-15
IE66368B1 (en) 1995-12-27
IE881366L (en) 1988-11-08
AR246956A1 (es) 1994-10-31
DK251688D0 (da) 1988-05-06
NL970040I2 (nl) 1998-06-02
BR1100623A (pt) 1999-12-07
NO177462C (no) 1995-09-20
DE19775088I2 (de) 2001-05-23
NO1998004I1 (no) 1998-01-19
ES2066768T3 (es) 1995-03-16
CA1322003C (en) 1993-09-07
NL970040I1 (nl) 1998-02-02
US4933456A (en) 1990-06-12
FI88164C (fi) 1993-04-13
JP2512524B2 (ja) 1996-07-03
DK251688A (da) 1988-11-09
IL86298A (en) 1992-11-15
SG30569G (en) 1995-09-18
AU613363B2 (en) 1991-08-01
EP0290047A2 (de) 1988-11-09

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
V448 Application of spc

Free format text: PRODUCT NAME: MANGAFODIPIR-TRISODIUM (ANHYDROUS); REGISTRATION NO/DATE: EU/1/97/040/001, EU/1/97/040/002; 19970522

Spc suppl protection certif: 197 75 088

Filing date: 19971103

V457 Spc granted

Free format text: PRODUCT NAME: MANGAFODIPIR-TRISODIUM (ANHYDROUS); REGISTRATION NO/DATE: EU/1/97/040/001, EU/1/97/040/002; 19970522

Spc suppl protection certif: 197 75 088

Filing date: 19971103

8327 Change in the person/name/address of the patent owner

Owner name: AMERSHAM HEALTH SALUTAR INC., PRINCETON, N.J., US

R071 Expiry of right

Free format text: PRODUCT NAME: DER WIRKSTOFF DES ARZNEIMITTELS TESLASCAN IN ALLEN DEM SCHUTZ DES GRUNDPATENTS UNTERLIEGENDEN FORMEN; REGISTRATION NO/DATE: EU/1/97/040/001-002 19970522

Spc suppl protection certif: 19775088

Filing date: 19971103

Expiry date: 20080507

Extension date: 20120522

Effective date: 20120523