DE19775088I2 - Dipyridoxyl-phosphat als magnetisches Kernresonanz-Bildgebungsmittel - Google Patents

Dipyridoxyl-phosphat als magnetisches Kernresonanz-Bildgebungsmittel

Info

Publication number
DE19775088I2
DE19775088I2 DE1997175088 DE19775088C DE19775088I2 DE 19775088 I2 DE19775088 I2 DE 19775088I2 DE 1997175088 DE1997175088 DE 1997175088 DE 19775088 C DE19775088 C DE 19775088C DE 19775088 I2 DE19775088 I2 DE 19775088I2
Authority
DE
Germany
Prior art keywords
magnetic resonance
resonance imaging
imaging agent
dipyridoxyl
phosphate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE1997175088
Other languages
English (en)
Inventor
Scott Rocklage
Steven Quay
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Amersham Health Salutar Inc
Original Assignee
Nycomed Salutar Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nycomed Salutar Inc filed Critical Nycomed Salutar Inc
Application granted granted Critical
Publication of DE19775088I2 publication Critical patent/DE19775088I2/de
Active legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01R—MEASURING ELECTRIC VARIABLES; MEASURING MAGNETIC VARIABLES
    • G01R33/00—Arrangements or instruments for measuring magnetic variables
    • G01R33/20—Arrangements or instruments for measuring magnetic variables involving magnetic resonance
    • G01R33/44—Arrangements or instruments for measuring magnetic variables involving magnetic resonance using nuclear magnetic resonance [NMR]
    • G01R33/48—NMR imaging systems
    • G01R33/54—Signal processing systems, e.g. using pulse sequences ; Generation or control of pulse sequences; Operator console
    • G01R33/56—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution
    • G01R33/5601—Image enhancement or correction, e.g. subtraction or averaging techniques, e.g. improvement of signal-to-noise ratio and resolution involving use of a contrast agent for contrast manipulation, e.g. a paramagnetic, super-paramagnetic, ferromagnetic or hyperpolarised contrast agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F13/00—Compounds containing elements of Groups 7 or 17 of the Periodic Table
    • C07F13/005—Compounds without a metal-carbon linkage
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/576—Six-membered rings
    • C07F9/58—Pyridine rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Condensed Matter Physics & Semiconductors (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Signal Processing (AREA)
  • Epidemiology (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Public Health (AREA)
  • General Physics & Mathematics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Magnetic Resonance Imaging Apparatus (AREA)
  • Measurement And Recording Of Electrical Phenomena And Electrical Characteristics Of The Living Body (AREA)
  • Measuring And Recording Apparatus For Diagnosis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE1997175088 1987-05-08 1988-05-06 Dipyridoxyl-phosphat als magnetisches Kernresonanz-Bildgebungsmittel Active DE19775088I2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/047,614 US4933456A (en) 1987-05-08 1987-05-08 Dipyridoxyl phosphate NMRI contrast agents

Publications (1)

Publication Number Publication Date
DE19775088I2 true DE19775088I2 (de) 2001-05-23

Family

ID=21949962

Family Applications (2)

Application Number Title Priority Date Filing Date
DE1997175088 Active DE19775088I2 (de) 1987-05-08 1988-05-06 Dipyridoxyl-phosphat als magnetisches Kernresonanz-Bildgebungsmittel
DE3852906T Expired - Lifetime DE3852906T2 (de) 1987-05-08 1988-05-06 Dipyridoxyl-Phosphat als magnetisches Kernresonanz-Bildgebungsmittel.

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE3852906T Expired - Lifetime DE3852906T2 (de) 1987-05-08 1988-05-06 Dipyridoxyl-Phosphat als magnetisches Kernresonanz-Bildgebungsmittel.

Country Status (20)

Country Link
US (1) US4933456A (de)
EP (1) EP0290047B1 (de)
JP (1) JP2512524B2 (de)
AR (1) AR246956A1 (de)
AT (1) ATE118010T1 (de)
AU (1) AU613363B2 (de)
BR (1) BR1100623A (de)
CA (1) CA1322003C (de)
DE (2) DE19775088I2 (de)
DK (1) DK173849B1 (de)
ES (1) ES2066768T3 (de)
FI (1) FI88164C (de)
GR (1) GR3015884T3 (de)
HK (1) HK55195A (de)
IE (1) IE66368B1 (de)
IL (1) IL86298A (de)
NL (1) NL970040I2 (de)
NO (2) NO177462C (de)
NZ (1) NZ224537A (de)
SG (1) SG30569G (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5250285A (en) * 1985-05-08 1993-10-05 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
US5422096A (en) * 1985-05-08 1995-06-06 The General Hospital Corporation Hydroxy-aryl metal chelates for diagnostic NMR imaging
US4994259A (en) * 1987-05-08 1991-02-19 Salutar, Inc. Improvement in the method of NMR imaging employing a manganese II chelates of N,N'-bis[pyridoxal-alkylene (or cycloalkylene) (or arylene)]-N,N'-diacetic acid derivatives
US4827426A (en) * 1987-05-18 1989-05-02 The Coca-Cola Company Data acquisition and processing system for post-mix beverage dispensers
US5087440A (en) * 1989-07-31 1992-02-11 Salutar, Inc. Heterocyclic derivatives of DTPA used for magnetic resonance imaging
AU7346091A (en) * 1990-03-02 1991-09-18 Byk Gulden Lomberg Chemische Fabrik Gmbh Preparations for mr diagnosis
DE4026103A1 (de) * 1990-08-17 1992-02-20 Byk Gulden Lomberg Chem Fab Neue verwendung von komplexsalzen
WO1992003168A1 (de) * 1990-08-15 1992-03-05 Byk Gulden Lomberg Chemische Fabrik Gmbh Neue verwendung von komplexsalzen
WO1992011840A1 (de) * 1991-01-07 1992-07-23 Byk Gulden Lomberg Chemische Fabrik Gmbh Kontrastmittel für die mr-diagnostik
DE4107570A1 (de) * 1991-03-07 1992-11-19 Diagnostikforschung Inst Chelate, deren metallkomplexe sowie ihre verwendung in diagnostik und therapie
EP0594640A4 (en) * 1991-05-23 1998-06-03 Evan C Unger Liposoluble compounds for magnetic resonance imaging
US5385719A (en) * 1991-09-24 1995-01-31 Unger; Evan C. Copolymers and their use as contrast agents in magnetic resonance imaging and in other applications
US5582814A (en) * 1994-04-15 1996-12-10 Metasyn, Inc. 1-(p-n-butylbenzyl) DTPA for magnetic resonance imaging
CA2190727C (en) * 1994-05-19 2006-07-18 Sudhakar Kasina Aromatic amine substituted bridged nitrogen and sulfur donor atom ligands for imaging
TW319763B (de) 1995-02-01 1997-11-11 Epix Medical Inc
SG81898A1 (en) * 1995-08-11 2001-07-24 Sumitomo Chemical Co Olefin polymerization catalyst component, olefin polymerization catalyst and process for producing olefin polymer
US6005083A (en) 1997-03-28 1999-12-21 Neorx Corporation Bridged aromatic substituted amine ligands with donor atoms
DE69838873T2 (de) * 1997-07-01 2008-12-04 Ge Healthcare As Diagnostisches verfahren zum nachweis von myokard-ischämie
EP1060174B1 (de) * 1997-12-23 2004-09-22 Amersham Health AS Stickstoffoxid freisetzende chelatbildner und ihre therapeutische verwendung
FR2867473B1 (fr) 2004-03-12 2006-06-23 Guerbet Sa Compose de porphyrines et utilisation a haut champ en irm
EP2800755B1 (de) * 2012-01-05 2018-05-30 Pledpharma AB Calmangafodipir, eine neue chemische einheit und andere gemischte metallkomplexe, verfahren zur herstellung, zusammensetzungen und verfahren zur behandlung

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3632637A (en) * 1968-02-13 1972-01-04 Arthur E Martell Hydroxyaryl-containing aminocarboxylic chelating agents
AU485693B2 (en) * 1973-08-24 1976-02-05 The Council Ofthe Institute Of Medical And Veterinary Science, Andthe Universityof Adelaide Gariti Cancer Foundation New radiopharmaceuticals for cholescintigraphy
JPS5569517A (en) * 1978-11-20 1980-05-26 Nippon Mejifuijitsukusu Kk Labelling preparation for labelling of erythrocytes with radio-active technetium
JPS5791927A (en) * 1980-11-27 1982-06-08 Nippon Mejifuijitsukusu Kk Technetium-99m labelled diagnosticum
US4647447A (en) * 1981-07-24 1987-03-03 Schering Aktiengesellschaft Diagnostic media
JPS5896031A (ja) * 1981-12-03 1983-06-07 Nippon Mejifuijitsukusu Kk 放射性診断剤およびその製造用組成物
US4637929A (en) * 1985-01-04 1987-01-20 Salutar, Inc. Ferrioxamine-paramagnetic contrast agents for MR imaging, composition, apparatus and use
US4842845A (en) * 1987-05-08 1989-06-27 Salutar, Inc. Radioactive metal chelates for dipyridoxyl phosphate
US4935518A (en) 1987-05-08 1990-06-19 Salutar, Inc. Manganese(II), chelate contrast agents derived from N,N'-bis-(pyridoxal ethylene diamine-N,N')-diacetic acid and derivatives thereof

Also Published As

Publication number Publication date
EP0290047A3 (en) 1990-04-25
SG30569G (en) 1995-09-18
EP0290047A2 (de) 1988-11-09
NL970040I2 (nl) 1998-06-02
DE3852906T2 (de) 1995-06-22
JPS63280087A (ja) 1988-11-17
ATE118010T1 (de) 1995-02-15
IL86298A0 (en) 1988-11-15
AU1568088A (en) 1988-11-10
FI88164B (fi) 1992-12-31
DK251688D0 (da) 1988-05-06
FI882125A0 (fi) 1988-05-06
AR246956A1 (es) 1994-10-31
FI88164C (fi) 1993-04-13
NL970040I1 (nl) 1998-02-02
DK173849B1 (da) 2001-12-27
NZ224537A (en) 1991-06-25
US4933456A (en) 1990-06-12
NO177462B (no) 1995-06-12
BR1100623A (pt) 1999-12-07
NO1998004I1 (no) 1998-01-19
HK55195A (en) 1995-04-21
DE3852906D1 (de) 1995-03-16
CA1322003C (en) 1993-09-07
DK251688A (da) 1988-11-09
NO882004D0 (no) 1988-05-06
NO882004L (no) 1988-11-09
NO177462C (no) 1995-09-20
JP2512524B2 (ja) 1996-07-03
IE881366L (en) 1988-11-08
EP0290047B1 (de) 1995-02-01
IL86298A (en) 1992-11-15
AU613363B2 (en) 1991-08-01
FI882125A (fi) 1988-11-09
GR3015884T3 (en) 1995-07-31
IE66368B1 (en) 1995-12-27
ES2066768T3 (es) 1995-03-16

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