ES2066309T3 - Nuevos derivados del acido p-oxibenzoico, procedimiento para su fabricacion y su aplicacion como medicamento. - Google Patents

Nuevos derivados del acido p-oxibenzoico, procedimiento para su fabricacion y su aplicacion como medicamento.

Info

Publication number
ES2066309T3
ES2066309T3 ES91116325T ES91116325T ES2066309T3 ES 2066309 T3 ES2066309 T3 ES 2066309T3 ES 91116325 T ES91116325 T ES 91116325T ES 91116325 T ES91116325 T ES 91116325T ES 2066309 T3 ES2066309 T3 ES 2066309T3
Authority
ES
Spain
Prior art keywords
procedure
manufacture
application
medicinal product
new derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES91116325T
Other languages
English (en)
Inventor
Friedemann Dr Reiter
Peter Dr Jank
Michael Schliack
Kaisli Kaipainen-Reiter
Gerhard Lang
Anke Schink
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Astellas Deutschland GmbH
Original Assignee
Klinge Pharma GmbH and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Klinge Pharma GmbH and Co filed Critical Klinge Pharma GmbH and Co
Application granted granted Critical
Publication of ES2066309T3 publication Critical patent/ES2066309T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/04—Monocyclic monocarboxylic acids
    • C07C63/06—Benzoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/235—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids having an aromatic ring attached to a carboxyl group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
    • C07C69/84—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring
    • C07C69/92—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring of monocyclic hydroxy carboxylic acids, the hydroxy groups and the carboxyl groups of which are bound to carbon atoms of a six-membered aromatic ring with etherified hydroxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Emergency Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LOS DERIVADOS DE ACIDO DE OXIBENZOICO-P DE LA FORMULA GENERAL (I) DONDE SIGNIFICAN: SUS SALES TOLERANTES FISOLOGICAMENTE, ASI COMO SUS FORMAS ENANTIOMERAS COMO DIASTOMERAS POSEEN CUALIDADES HIPOLIPEMICAS Y SIRVEN PARA SU ELABORACION DE MEDICAMENTOS CON EFECTOS HIPOLIPEMICOS.
ES91116325T 1990-10-09 1991-09-25 Nuevos derivados del acido p-oxibenzoico, procedimiento para su fabricacion y su aplicacion como medicamento. Expired - Lifetime ES2066309T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE4032037A DE4032037A1 (de) 1990-10-09 1990-10-09 Neue p-oxibenzoesaeurederivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
ES2066309T3 true ES2066309T3 (es) 1995-03-01

Family

ID=6415946

Family Applications (1)

Application Number Title Priority Date Filing Date
ES91116325T Expired - Lifetime ES2066309T3 (es) 1990-10-09 1991-09-25 Nuevos derivados del acido p-oxibenzoico, procedimiento para su fabricacion y su aplicacion como medicamento.

Country Status (15)

Country Link
US (1) US5153353A (es)
EP (1) EP0481253B1 (es)
JP (1) JPH0791221B2 (es)
KR (1) KR950004034B1 (es)
AT (1) ATE116281T1 (es)
AU (1) AU640810B2 (es)
CA (1) CA2048355C (es)
DE (2) DE4032037A1 (es)
DK (1) DK0481253T3 (es)
EE (1) EE02938B1 (es)
ES (1) ES2066309T3 (es)
GR (1) GR3015480T3 (es)
IE (1) IE65962B1 (es)
PT (1) PT98614B (es)
ZA (1) ZA918023B (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4314175C2 (de) * 1993-04-29 1995-03-30 Klinge Co Chem Pharm Fab Modifikation II von Lifibrol
DE4414537A1 (de) * 1994-04-26 1995-11-02 Klinge Co Chem Pharm Fab Kombinationspräparate mit einem Gehalt an einem p-Oxybenzoesäurederivat und einem HMG-CoA-Reduktase-Hemmer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4109013A (en) * 1974-12-20 1978-08-22 Klinge Pharma Gmbh & Co. Substituted propanol-(2) derivatives of hydroxamic acids and the use thereof as hypolipemic drugs
DE2460689C3 (de) * 1974-12-20 1980-06-26 Klinge Pharma Gmbh & Co, 8000 Muenchen 13-disubstituierte Propanol-(2)-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
DE2735856A1 (de) * 1977-08-09 1979-02-22 Klinge Co Chem Pharm Fab Neue 1,3-diphenoxypropan-2-on-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
DE3326164A1 (de) * 1983-07-20 1985-01-31 Klinge Pharma GmbH, 8000 München Neue p-oxibenzoesaeure-derivate, sowie verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
EP0286703A1 (de) * 1987-04-14 1988-10-19 Klinge Pharma GmbH Neue Benzoesäure-Derivate, sowie Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel

Also Published As

Publication number Publication date
AU640810B2 (en) 1993-09-02
IE913453A1 (en) 1992-04-22
GR3015480T3 (en) 1995-06-30
JPH04273846A (ja) 1992-09-30
KR950004034B1 (ko) 1995-04-22
JPH0791221B2 (ja) 1995-10-04
IE65962B1 (en) 1995-11-29
PT98614A (pt) 1992-06-30
CA2048355C (en) 1997-11-18
ATE116281T1 (de) 1995-01-15
EP0481253B1 (de) 1994-12-28
DK0481253T3 (da) 1995-05-22
AU8241691A (en) 1992-06-11
US5153353A (en) 1992-10-06
KR920007977A (ko) 1992-05-27
EE02938B1 (et) 1996-08-15
CA2048355A1 (en) 1992-04-10
DE59104058D1 (de) 1995-02-09
ZA918023B (en) 1992-07-29
EP0481253A3 (en) 1992-10-21
EP0481253A2 (de) 1992-04-22
DE4032037A1 (de) 1992-04-16
PT98614B (pt) 1999-01-29

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