ES2062071T3 - Procedimiento de preparacion de ((diarilmetoxi) alcoil)-1 pirrolidinas y piperidinas y medicamentos que las contienen. - Google Patents

Procedimiento de preparacion de ((diarilmetoxi) alcoil)-1 pirrolidinas y piperidinas y medicamentos que las contienen.

Info

Publication number
ES2062071T3
ES2062071T3 ES89402561T ES89402561T ES2062071T3 ES 2062071 T3 ES2062071 T3 ES 2062071T3 ES 89402561 T ES89402561 T ES 89402561T ES 89402561 T ES89402561 T ES 89402561T ES 2062071 T3 ES2062071 T3 ES 2062071T3
Authority
ES
Spain
Prior art keywords
diarilmetoxi
piperidines
pirrolidines
alcoil
products containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89402561T
Other languages
English (en)
Inventor
Gerard Ferrand
Jacques Barbanton
Jean-Claude Depin
Gilles Chavernac
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sante SAS
Original Assignee
LIPHA SAS
LIPHA Liyonnaise Industrielle Pharmaceutique
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by LIPHA SAS, LIPHA Liyonnaise Industrielle Pharmaceutique filed Critical LIPHA SAS
Application granted granted Critical
Publication of ES2062071T3 publication Critical patent/ES2062071T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/10—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms
    • C07D211/14—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with radicals containing only carbon and hydrogen atoms attached to ring carbon atoms with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms
    • H—ELECTRICITY
    • H03—ELECTRONIC CIRCUITRY
    • H03H—IMPEDANCE NETWORKS, e.g. RESONANT CIRCUITS; RESONATORS
    • H03H7/00—Multiple-port networks comprising only passive electrical elements as network components
    • H03H7/01—Frequency selective two-port networks
    • H03H7/09—Filters comprising mutual inductance

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Pyrrole Compounds (AREA)

Abstract

LA PRESENTE INVENCION SE REFIERE A [(DIARILMETOXI)ALCOHIL]-1 PIRROLIDINAS Y PIPERIDINAS REPRESENTADAS POR LA FORMULA: (FIG. A), EN LA QUE X ES HIDROGENO O UN ATOMO DE FLUOR, ALK ES UN GRUPO ALCOHILO LINEAL O RAMIFICADO QUE CONTIENE 2 O 3 ATOMOS DE CARBONO; R1 Y R2 SON HIDROGENO O UN RADICAL ALCOXI LINEAL O RAMIFICADO QUE CONTIENE DE 1-4 ATOMOS DE CARBONO; N ES 4 O 5. APLICACION DE ESTOS COMPUESTOS COMO MEDICAMENTOS CARDIOVASCULARES.
ES89402561T 1988-09-23 1989-09-19 Procedimiento de preparacion de ((diarilmetoxi) alcoil)-1 pirrolidinas y piperidinas y medicamentos que las contienen. Expired - Lifetime ES2062071T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8812430A FR2636946B1 (fr) 1988-09-23 1988-09-23 ((diarylmethoxy)alcoyl)-1 pyrrolidines et piperidines, procedes de preparation et medicaments les contenant

Publications (1)

Publication Number Publication Date
ES2062071T3 true ES2062071T3 (es) 1994-12-16

Family

ID=9370298

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89402561T Expired - Lifetime ES2062071T3 (es) 1988-09-23 1989-09-19 Procedimiento de preparacion de ((diarilmetoxi) alcoil)-1 pirrolidinas y piperidinas y medicamentos que las contienen.

Country Status (25)

Country Link
US (1) US4957927A (es)
EP (1) EP0360685B1 (es)
JP (1) JPH02121964A (es)
AR (1) AR246255A1 (es)
AT (1) ATE101132T1 (es)
AU (1) AU617530B2 (es)
CA (1) CA1327364C (es)
CZ (1) CZ279282B6 (es)
DD (1) DD284875A5 (es)
DE (1) DE68912860T2 (es)
DK (1) DK468389A (es)
ES (1) ES2062071T3 (es)
FR (1) FR2636946B1 (es)
HU (1) HU208422B (es)
IE (1) IE63648B1 (es)
IL (1) IL91689A0 (es)
MA (1) MA21631A1 (es)
NO (1) NO893764L (es)
NZ (1) NZ230744A (es)
OA (1) OA09135A (es)
PT (1) PT91783B (es)
SU (1) SU1757462A3 (es)
TN (1) TNSN89103A1 (es)
YU (1) YU170189A (es)
ZA (1) ZA897212B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9100517A (es) * 1990-08-06 1992-04-01 Smith Kline French Lab Compuestos
MX9100513A (es) * 1990-08-06 1992-04-01 Smith Kline French Lab Compuestos
CA2038066A1 (en) * 1990-08-09 1992-02-10 Hiroshi Fukumi (benzhydryloxyethylpiperidyl) aliphatic acid derivatives and their use in the treatment of allergies and asthma
GB9113031D0 (en) * 1991-06-17 1991-08-07 Smithkline Beecham Plc Compounds
US5578639A (en) * 1994-07-01 1996-11-26 Warner-Lambert Company PLA2 inhibitors and their use for inhibition of intestinal cholesterol absorption
US6153754A (en) * 1995-12-21 2000-11-28 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US6201124B1 (en) * 1995-12-21 2001-03-13 Albany Molecular Research, Inc. Process for production of piperidine derivatives
US5747523A (en) * 1996-01-24 1998-05-05 Guilford Pharmaceuticals Inc. Substituted ethyl α,α-diarylmethyl ether derivatives
US6011035A (en) * 1998-06-30 2000-01-04 Neuromed Technologies Inc. Calcium channel blockers
JP4932994B2 (ja) * 1999-04-07 2012-05-16 ユニバーシテイ・オブ・バージニア・パテント・フアウンデーシヨン 抗癌性カルシウムチャンネル遮断薬
US6946475B1 (en) 1999-04-07 2005-09-20 University Of Virginia Patent Foundation Anticancer calcium channel blockers
WO2002100829A2 (en) * 2001-06-13 2002-12-19 Teva Pharmaceutical Industries Ltd. Process for the preparation of paroxetine substantially free of alkoxy impurities
JP6017964B2 (ja) 2010-03-01 2016-11-02 ティーエーユー・セラピューティクス・エルエルシー 癌診断および撮像

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1545094A (en) * 1976-12-14 1979-05-02 Gist Brocades Nv Piperazine derivatives

Also Published As

Publication number Publication date
TNSN89103A1 (fr) 1991-02-04
FR2636946B1 (fr) 1990-11-02
OA09135A (fr) 1991-10-31
DK468389D0 (da) 1989-09-22
ATE101132T1 (de) 1994-02-15
AU4169089A (en) 1990-03-29
CZ279282B6 (cs) 1995-04-12
PT91783B (pt) 1995-08-09
US4957927A (en) 1990-09-18
ZA897212B (en) 1991-03-27
FR2636946A1 (fr) 1990-03-30
IL91689A0 (en) 1990-06-10
CA1327364C (fr) 1994-03-01
DK468389A (da) 1990-03-24
AR246255A1 (es) 1994-07-29
IE893050L (en) 1990-03-23
AU617530B2 (en) 1991-11-28
YU170189A (en) 1991-02-28
DE68912860D1 (de) 1994-03-17
HU208422B (en) 1993-10-28
DE68912860T2 (de) 1994-08-11
DD284875A5 (de) 1990-11-28
CZ540989A3 (en) 1994-11-16
EP0360685B1 (fr) 1994-02-02
NO893764D0 (no) 1989-09-22
PT91783A (pt) 1990-03-30
JPH02121964A (ja) 1990-05-09
IE63648B1 (en) 1995-05-31
SU1757462A3 (ru) 1992-08-23
HUT52049A (en) 1990-06-28
MA21631A1 (fr) 1990-04-01
NZ230744A (en) 1991-06-25
EP0360685A1 (fr) 1990-03-28
NO893764L (no) 1990-03-26

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