ES2061451T3 - Derivados de trans-6-(2-(n-heteroaril-3,5-disubstituido)pirazol-4-il)-etil)- o etenil)tetrahidro-4-hidroxipiran-2-ona, un proceso para su preparacion y uso de los mismos. - Google Patents

Derivados de trans-6-(2-(n-heteroaril-3,5-disubstituido)pirazol-4-il)-etil)- o etenil)tetrahidro-4-hidroxipiran-2-ona, un proceso para su preparacion y uso de los mismos.

Info

Publication number
ES2061451T3
ES2061451T3 ES87109726T ES87109726T ES2061451T3 ES 2061451 T3 ES2061451 T3 ES 2061451T3 ES 87109726 T ES87109726 T ES 87109726T ES 87109726 T ES87109726 T ES 87109726T ES 2061451 T3 ES2061451 T3 ES 2061451T3
Authority
ES
Spain
Prior art keywords
tetrahidro
heteroaril
pirazol
etil
ona
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87109726T
Other languages
English (en)
Inventor
Bruce David Roth
Drago Robert Sliskovic
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Warner Lambert Co LLC
Original Assignee
Warner Lambert Co LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Warner Lambert Co LLC filed Critical Warner Lambert Co LLC
Application granted granted Critical
Publication of ES2061451T3 publication Critical patent/ES2061451T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

SE PRESENTAN DERIVADOS DE TRANS-6-[2-(N-HETEROARIL-3,5DISUSTITUIDO) PIRAZOL-4-ILO)-ETIL] O ETENIL] TETRAHIDRO-4HIDROXI-2H-PIRANO-2-ONA DE FORMULA (I) Y LOS CORRESPONDIENTES ACIDOS DE ANILLO ABIERTO DERIVADOS DE LOS MISMOS. SON POTENTES INHIBIDORES DE LA ENZIMA 3-HIDROXI-3-METILGLUTARIL-COENZIMA A REDUCTASA (HMG CO A REDUCTASA) Y SON, POR LO TANTO, AGENTES HIPOLIMIDEMICOS O HIPOCOLESTEREMICOS. TAMBIEN SE PRESENTA UN PROCEDIMIENTO PARA SU FABRICACION, COMPOSICIONES FARMACOLOGICAS QUE CONTIENEN DICHOS COMPUESTOS Y UN METODO PARA INHIBIR LA BIOSINTESIS DEL COLESTEROL EMPLEANDO DICHAS COMPOSICIONES FARMACOLOGICAS.
ES87109726T 1986-07-07 1987-07-06 Derivados de trans-6-(2-(n-heteroaril-3,5-disubstituido)pirazol-4-il)-etil)- o etenil)tetrahidro-4-hidroxipiran-2-ona, un proceso para su preparacion y uso de los mismos. Expired - Lifetime ES2061451T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US88232786A 1986-07-07 1986-07-07
US07/048,473 US4808621A (en) 1986-07-07 1987-05-18 Trans-6-[2-(N-heteroaryl-3,5-disubstituted)pyrazol-4-yl)-ethyl]- or ethenyl]tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis

Publications (1)

Publication Number Publication Date
ES2061451T3 true ES2061451T3 (es) 1994-12-16

Family

ID=26726151

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87109726T Expired - Lifetime ES2061451T3 (es) 1986-07-07 1987-07-06 Derivados de trans-6-(2-(n-heteroaril-3,5-disubstituido)pirazol-4-il)-etil)- o etenil)tetrahidro-4-hidroxipiran-2-ona, un proceso para su preparacion y uso de los mismos.

Country Status (6)

Country Link
US (1) US4808621A (es)
EP (1) EP0252476B1 (es)
JP (1) JPH07116182B2 (es)
CA (1) CA1286671C (es)
DE (1) DE3788982T2 (es)
ES (1) ES2061451T3 (es)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO881411L (no) * 1987-04-14 1988-10-17 Bayer Ag Substituerte pyrroler.
US4824959A (en) * 1988-02-18 1989-04-25 Bristol-Myers Company Intermediates for antihypercholesterolemic tetrazole compounds
US5026698A (en) * 1988-11-02 1991-06-25 Nissan Chemical Industries, Ltd. Thienopyridine type mevalonolactones
GB8907656D0 (en) * 1989-04-05 1989-05-17 May & Baker Ltd New compositions of matter
JP2966592B2 (ja) * 1991-07-20 1999-10-25 萩原 義秀 安定化されたヒトモノクローナル抗体製剤
US6169086B1 (en) 1997-01-27 2001-01-02 Daiichi Pharmaceutical Co., Ltd. Pyrazole derivatives
AU724394B2 (en) * 1997-01-27 2000-09-21 Daiichi Pharmaceutical Co., Ltd. Pyrazole derivatives
FR2795726A1 (fr) * 1999-06-30 2001-01-05 Aventis Cropscience Sa Nouveaux pyrazoles fongicides
DK1417180T3 (da) 2001-07-13 2007-04-10 Astrazeneca Uk Ltd Fremstilling af aminopyrimidinforbindelser
CA2455842A1 (en) * 2001-08-22 2003-03-06 Ciba Specialty Chemicals Holding Inc. Process for the preparation of indole derivatives
US7199126B2 (en) * 2004-04-29 2007-04-03 Pharmix Corporation Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
US7163945B2 (en) * 2004-04-29 2007-01-16 Pharmix Corp. Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
US20050282883A1 (en) * 2004-04-29 2005-12-22 John Griffin Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
US20050272770A1 (en) * 2004-04-29 2005-12-08 John Griffin Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
US7183285B2 (en) * 2004-04-29 2007-02-27 Pharmix Corp. Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
US20060084695A1 (en) * 2004-04-29 2006-04-20 John Griffin Compositions and treatments for inhibiting kinase and/or HMG-CoA reductase
KR20070084455A (ko) 2004-11-23 2007-08-24 워너-램버트 캄파니 엘엘씨 지질혈증 치료용 ｈｍｇ ｃｏ-ａ 환원효소 억제제로서의7-(2ｈ-피라졸-3-일)-3,5-디히드록시-헵탄산 유도체
US20060111436A1 (en) * 2004-11-23 2006-05-25 John Griffin Compositions and treatments for modulating kinase and/or HMG-CoA reductase
GB0428328D0 (en) * 2004-12-24 2005-02-02 Astrazeneca Uk Ltd Chemical process
WO2006087630A2 (en) * 2005-02-16 2006-08-24 Warner-Lambert Company Llc OXYPYRAZOLE HMG Co-A REDUCTASE INHIBITORS
US8734705B2 (en) * 2008-06-13 2014-05-27 Tindall Corporation Method for fabrication of structures used in construction of tower base supports
EP2308866A1 (de) * 2009-10-09 2011-04-13 Bayer CropScience AG Phenylpyri(mi)dinylpyrazole und ihre Verwendung als Fungizide

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4375475A (en) * 1979-08-17 1983-03-01 Merck & Co., Inc. Substituted pyranone inhibitors of cholesterol synthesis
JPS61502467A (ja) * 1984-06-22 1986-10-30 サンド・アクチエンゲゼルシヤフト メバロノラクトンのピラゾ−ル同族体およびその誘導体、それらの製造方法ならびに用途
DE3528753A1 (de) * 1985-08-10 1987-02-19 Bayer Ag Substituierte pyrazolin-5-one

Also Published As

Publication number Publication date
EP0252476A3 (en) 1989-10-18
DE3788982T2 (de) 1994-05-19
CA1286671C (en) 1991-07-23
DE3788982D1 (de) 1994-03-17
US4808621A (en) 1989-02-28
EP0252476B1 (en) 1994-02-02
EP0252476A2 (en) 1988-01-13
JPH07116182B2 (ja) 1995-12-13
JPS6388179A (ja) 1988-04-19

Similar Documents

Publication Publication Date Title
ES2061451T3 (es) Derivados de trans-6-(2-(n-heteroaril-3,5-disubstituido)pirazol-4-il)-etil)- o etenil)tetrahidro-4-hidroxipiran-2-ona, un proceso para su preparacion y uso de los mismos.
ES2019899T4 (es) Procedimiento para preparar trans-6-6(2-3(3-o 4-carboxamido-sustituido-pirrol-1-il)-alquil)-4-hidroxipiran-2-onas con actividad inhibidora de la sintesis de colesterol.
DE69709938D1 (de) N-benzylpiperidin- und tetrahydropyridin-derivate
ES8701756A1 (es) Un metodo de preparacion de 6-2(pirrol-1-il sustituido) alquil piran-2-ona
EE03194B1 (et) Ühendid, nende kasutamine magustavate toimeainetena ja nende valmistamise meetod
PT85109A (en) Process for the preparation of hydroxy-tetrahydropyranone derivatives or corresponding ring opened dihydroxy acids which are hmg-coa reductase inhibitors
ES2061580T3 (es) Compuestos de 3,7-diazabiciclo(3,3,1)nonano, asi como procedimiento para su preparacion y medicamentos que contienen estos compuestos.
ES2029829T3 (es) Un procedimiento para la preparacion de compuestos antihipercolesterolemicos.
PT865498E (pt) Processo para a preparacao de ciclodepsipeptideos com 24 atomos no anel substituidos contendo acido aril-lactico
AR000813A1 (es) Procedimiento para la obtencion de n-aril y n-heteroarilhidroxilaminas
EG19361A (en) A process for the preparation of piperidine compound having local anaesthetica and analgetic
ES2016017A6 (es) Procedimiento para preparar derivados de acido 1,1-dioxocefem-4-carbotiolico.
AU2001235668A1 (en) Xanthine derivatives, intermediates and use for treating osteoporosis
ES2098032T3 (es) Procedimiento de preparacion de inhibidores de ribonucleotido-reductasa.
ES2078370T3 (es) Procedimiento para preparar compuestos de esteres de acidos 2-halogeno-3-hidroxi-3-fenilpropionicos.
ES2070334T3 (es) Procedimiento para la preparacion de derivados de progesterona.
ATE89550T1 (de) Phenylsulfon-derivate.
ES2130392T3 (es) Procedimiento para la preparacion de acido clavulanico.
AU3424899A (en) Method for laminaribiose synthesis
NO994108L (no) Fremgangsmaate ved fremstilling av 4H-4-okso-kinolizin-3-karboksylsyrederivater
FI944967A (fi) Menetelmiä proteolyyttisen entsyymin inhibiittoreina käyttökelpoisten sakkariinijohdannaisten ja niiden välituotteiden valmistamiseksi
PT828848E (pt) Preparacao de compostos hidroxi por bioconversao com dioxigenase
NO911236L (no) Fremgangsmaate for fremstilling av haloethyl-substituerte steroidale enzyminhibitorer.
AR246248A1 (es) Procedimiento de preparacion de metilendi(feniluretano)por transposicion de al menos un bis(n-carboalcoxianilino)metano,dado el caso en presencia de por lo menos un n-fenilcarbamato de alquilo
ES2049652B1 (es) Procedimiento para la preparacion de un acido quinolin carboxilico.

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 252476

Country of ref document: ES