ES2059814T3 - Agentes de contraste por ultrasonidos a base de burbujas de gas y microparticulas que contienen acidos grasos. - Google Patents

Agentes de contraste por ultrasonidos a base de burbujas de gas y microparticulas que contienen acidos grasos.

Info

Publication number
ES2059814T3
ES2059814T3 ES89730095T ES89730095T ES2059814T3 ES 2059814 T3 ES2059814 T3 ES 2059814T3 ES 89730095 T ES89730095 T ES 89730095T ES 89730095 T ES89730095 T ES 89730095T ES 2059814 T3 ES2059814 T3 ES 2059814T3
Authority
ES
Spain
Prior art keywords
gas bubbles
contrast agents
ultrasonics
fatty acids
containing fatty
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES89730095T
Other languages
English (en)
Inventor
Lothar Prof Lange
Jurgen Hilmann
Thomas Dr Fritzsch
Joachim Dr Siegert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer Pharma AG
Original Assignee
Schering AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering AG filed Critical Schering AG
Application granted granted Critical
Publication of ES2059814T3 publication Critical patent/ES2059814T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/223—Microbubbles, hollow microspheres, free gas bubbles, gas microspheres
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/39—Markers, e.g. radio-opaque or breast lesions markers
    • A61B2090/3925—Markers, e.g. radio-opaque or breast lesions markers ultrasonic

Abstract

EL INVENTO DESCRIBE UN MEDIO DE CONTRASTE PARA LA DIAGNOSIS DEL ULTRASONIDO A BASE DE BURBUJAS DE GAS Y MICROPARTICULAS Y SE CARACTERIZA PORQUE COMO MICROPARTICULAS CONTIENEN UNA MEZCLA DE ACIDO GRASO DE C10 A 20 CON UNA SUSTANCIA SOLIDA NO ACTIVADORA DE SUPERFICIES LIMITES SUSPENDIDA EN UN SOPORTE FLUIDO. SE CONFIGURA EN EL SOPORTE DE CONTRASTE SEGUN APLICACION INTRAVENOSA LA EMISION DE CONTRASTE DE LA PARTE DERECHA E IZQUIERDA DEL CORAZON, EL MIOCARDIO Y OTRROS ORGANOS COMO HIGADO, BAZO O RIÑON.
ES89730095T 1988-10-07 1989-04-06 Agentes de contraste por ultrasonidos a base de burbujas de gas y microparticulas que contienen acidos grasos. Expired - Lifetime ES2059814T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3834705A DE3834705A1 (de) 1988-10-07 1988-10-07 Ultraschallkontrastmittel aus gasblaeschen und fettsaeure enthaltenden mikropartikeln

Publications (1)

Publication Number Publication Date
ES2059814T3 true ES2059814T3 (es) 1994-11-16

Family

ID=6364930

Family Applications (1)

Application Number Title Priority Date Filing Date
ES89730095T Expired - Lifetime ES2059814T3 (es) 1988-10-07 1989-04-06 Agentes de contraste por ultrasonidos a base de burbujas de gas y microparticulas que contienen acidos grasos.

Country Status (19)

Country Link
EP (1) EP0365467B1 (es)
JP (1) JPH0737394B2 (es)
KR (1) KR970001433B1 (es)
CN (1) CN1027575C (es)
AT (1) ATE93145T1 (es)
AU (1) AU627456B2 (es)
CA (1) CA1338507C (es)
DE (2) DE3834705A1 (es)
DK (1) DK99789A (es)
ES (1) ES2059814T3 (es)
FI (1) FI100170B (es)
IE (1) IE65243B1 (es)
IL (1) IL90028A (es)
LU (1) LU90004I2 (es)
NL (1) NL970009I2 (es)
NO (2) NO178139C (es)
NZ (1) NZ228781A (es)
PT (1) PT91523B (es)
ZA (1) ZA892885B (es)

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US6723303B1 (en) 1991-09-17 2004-04-20 Amersham Health, As Ultrasound contrast agents including protein stabilized microspheres of perfluoropropane, perfluorobutane or perfluoropentane
US5409688A (en) * 1991-09-17 1995-04-25 Sonus Pharmaceuticals, Inc. Gaseous ultrasound contrast media
MX9205298A (es) * 1991-09-17 1993-05-01 Steven Carl Quay Medios gaseosos de contraste de ultrasonido y metodo para seleccionar gases para usarse como medios de contraste de ultrasonido
US5196183A (en) * 1991-12-04 1993-03-23 Sterling Winthrop Inc. Contrast agents for ultrasound imaging
GB9200388D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
GB9200387D0 (en) * 1992-01-09 1992-02-26 Nycomed As Improvements in or relating to contrast agents
IL108416A (en) 1993-01-25 1998-10-30 Sonus Pharma Inc Colloids with phase difference as contrast ultrasound agents
US5558855A (en) * 1993-01-25 1996-09-24 Sonus Pharmaceuticals Phase shift colloids as ultrasound contrast agents
NZ262237A (en) 1993-01-25 1997-06-24 Sonus Pharma Inc Ultrasound contrast agents comprising phase shift colloids having a boiling point below the body temperature of the animal it is used in
GB9402867D0 (en) * 1994-02-15 1994-04-06 Nycomed Imaging As Improvements in or relating to contrast agents
DE4406474A1 (de) * 1994-02-23 1995-08-24 Schering Ag Gas enthaltende Mikropartikel, diese enthaltende Mittel, deren Verwendung in der Ultraschalldiagnostik, sowie Verfahren zur Herstellung der Partikel und Mittel
EP0699445A3 (en) * 1994-08-04 1996-04-17 Gakko Houjin Toin Gakuen Process for the preparation of an ultrasonic microbubble contrast agent with a surfactant
DE19602930A1 (de) * 1996-01-18 1997-07-24 Schering Ag Poröse Matrices aus niedermolekularen Substanzen zur Genierung stabiler Gasblasensuspensionen, deren Verwendung als Ultraschallkontrastmittel sowie Verfahren zu deren Herstellung
GB9808582D0 (en) * 1998-04-22 1998-06-24 Nycomed Imaging As Improvements in or relating to contrast agents
WO2000021578A1 (en) 1998-10-12 2000-04-20 Mallinckrodt Inc. Novel ultrasound contrast agents
DE19950311A1 (de) * 1999-10-13 2001-04-19 Schering Ag Die Verwendung von Trockenstopfen zur Erhöhung der Lagerstabilität von Ultraschallkontrastmitteln
DE19952738A1 (de) * 1999-10-27 2001-05-23 Schering Ag Verbesserte Suspensionen von Ultraschallkontrastmitteln
JP5078212B2 (ja) 2000-06-02 2012-11-21 ブラッコ・スイス・ソシエテ・アノニム 内皮細胞を標的とするための化合物、それを含む組成物およびその使用方法
WO2002080774A2 (en) 2001-04-06 2002-10-17 Bracco Research S.A. Method for improved measurement of local physical parameters in afluid-filled cavity
WO2004065621A1 (en) 2002-03-01 2004-08-05 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US8623822B2 (en) 2002-03-01 2014-01-07 Bracco Suisse Sa KDR and VEGF/KDR binding peptides and their use in diagnosis and therapy
US7211240B2 (en) 2002-03-01 2007-05-01 Bracco International B.V. Multivalent constructs for therapeutic and diagnostic applications
US7261876B2 (en) 2002-03-01 2007-08-28 Bracco International Bv Multivalent constructs for therapeutic and diagnostic applications
WO2003074005A2 (en) 2002-03-01 2003-09-12 Dyax Corp. Kdr and vegf/kdr binding peptides and their use in diagnosis and therapy
US7794693B2 (en) 2002-03-01 2010-09-14 Bracco International B.V. Targeting vector-phospholipid conjugates
US7462366B2 (en) 2002-03-29 2008-12-09 Boston Scientific Scimed, Inc. Drug delivery particle
US7842377B2 (en) 2003-08-08 2010-11-30 Boston Scientific Scimed, Inc. Porous polymeric particle comprising polyvinyl alcohol and having interior to surface porosity-gradient
US8012454B2 (en) 2002-08-30 2011-09-06 Boston Scientific Scimed, Inc. Embolization
US7883490B2 (en) 2002-10-23 2011-02-08 Boston Scientific Scimed, Inc. Mixing and delivery of therapeutic compositions
DK2949658T3 (en) 2003-03-03 2018-10-01 Dyax Corp Peptides that specifically bind HGF receptor (cMet) and uses thereof
US7976823B2 (en) 2003-08-29 2011-07-12 Boston Scientific Scimed, Inc. Ferromagnetic particles and methods
US7901770B2 (en) 2003-11-04 2011-03-08 Boston Scientific Scimed, Inc. Embolic compositions
KR101001547B1 (ko) 2004-01-28 2010-12-17 삼성에스디아이 주식회사 섬유상 태양 전지 및 이의 제조 방법
US7736671B2 (en) 2004-03-02 2010-06-15 Boston Scientific Scimed, Inc. Embolization
US8173176B2 (en) 2004-03-30 2012-05-08 Boston Scientific Scimed, Inc. Embolization
US7311861B2 (en) 2004-06-01 2007-12-25 Boston Scientific Scimed, Inc. Embolization
US8012457B2 (en) 2004-06-04 2011-09-06 Acusphere, Inc. Ultrasound contrast agent dosage formulation
US8425550B2 (en) 2004-12-01 2013-04-23 Boston Scientific Scimed, Inc. Embolic coils
US7858183B2 (en) 2005-03-02 2010-12-28 Boston Scientific Scimed, Inc. Particles
US7727555B2 (en) 2005-03-02 2010-06-01 Boston Scientific Scimed, Inc. Particles
US7963287B2 (en) 2005-04-28 2011-06-21 Boston Scientific Scimed, Inc. Tissue-treatment methods
US9463426B2 (en) 2005-06-24 2016-10-11 Boston Scientific Scimed, Inc. Methods and systems for coating particles
US8007509B2 (en) 2005-10-12 2011-08-30 Boston Scientific Scimed, Inc. Coil assemblies, components and methods
US8152839B2 (en) 2005-12-19 2012-04-10 Boston Scientific Scimed, Inc. Embolic coils
US8101197B2 (en) 2005-12-19 2012-01-24 Stryker Corporation Forming coils
US7947368B2 (en) 2005-12-21 2011-05-24 Boston Scientific Scimed, Inc. Block copolymer particles
US8414927B2 (en) 2006-11-03 2013-04-09 Boston Scientific Scimed, Inc. Cross-linked polymer particles
JP5196896B2 (ja) * 2007-07-13 2013-05-15 花王株式会社 微細気泡前駆体の製造方法
WO2021141595A1 (en) * 2020-01-10 2021-07-15 Advanced Microbubbles Laboratories Llc Preparation and preservation of collagen microbubbles

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US3640271A (en) 1969-06-30 1972-02-08 Ibm Blood flow pressure measurement technique employing injected bubbled and ultrasonic frequency scanning
US4276885A (en) 1979-05-04 1981-07-07 Rasor Associates, Inc Ultrasonic image enhancement
US4265251A (en) 1979-06-28 1981-05-05 Rasor Associates, Inc. Method of determining pressure within liquid containing vessel
CA1170569A (en) 1980-11-17 1984-07-10 Julia S. Rasor Microbubble precursors and methods for their production and use
DE3141641A1 (de) 1981-10-16 1983-04-28 Schering Ag, 1000 Berlin Und 4619 Bergkamen Ultraschall-kontrastmittel und dessen herstellung
JPS5920532A (ja) * 1982-07-23 1984-02-02 Nippon Denso Co Ltd 車載内燃機関の燃料調量制御方法
DE3313946A1 (de) * 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel
DE3313947A1 (de) * 1983-04-15 1984-10-18 Schering AG, 1000 Berlin und 4709 Bergkamen Mikropartikel und gasblaeschen enthaltende ultraschall-kontrastmittel
DE3637926C1 (de) * 1986-11-05 1987-11-26 Schering Ag Ultraschall-Manometrieverfahren in einer Fluessigkeit mittels Mikroblaeschen

Also Published As

Publication number Publication date
KR900005939A (ko) 1990-05-07
LU90004I2 (fr) 1997-03-04
NZ228781A (en) 1992-03-26
NO890609L (no) 1990-04-09
IE891149L (en) 1990-04-07
ZA892885B (en) 1990-12-28
ATE93145T1 (de) 1993-09-15
AU3390089A (en) 1990-04-12
NO178139C (no) 1996-01-31
DK99789D0 (da) 1989-03-01
JPH0737394B2 (ja) 1995-04-26
DE3834705A1 (de) 1990-04-12
KR970001433B1 (ko) 1997-02-06
NO178139B (no) 1995-10-23
NL970009I2 (nl) 1997-08-01
EP0365467B1 (de) 1993-08-18
IE65243B1 (en) 1995-10-04
FI890749A0 (fi) 1989-02-16
CA1338507C (en) 1996-08-06
CN1044225A (zh) 1990-08-01
CN1027575C (zh) 1995-02-08
FI890749A (fi) 1990-04-08
EP0365467A2 (de) 1990-04-25
DE58905318D1 (de) 1993-09-23
IL90028A0 (en) 1989-12-15
DK99789A (da) 1990-04-08
EP0365467A3 (en) 1990-06-06
IL90028A (en) 1993-01-31
FI100170B (fi) 1997-10-15
JPH02145528A (ja) 1990-06-05
AU627456B2 (en) 1992-08-27
NL970009I1 (nl) 1997-05-01
NO1998014I1 (no) 1998-05-05
PT91523A (pt) 1990-04-30
PT91523B (pt) 1995-05-31
NO890609D0 (no) 1989-02-13

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