ES2059316T3 - Un procedimiento para la preparacion de un derivado 4-(2-pirimidinil)-1-piperazinil-heterociclil-carbonilico. - Google Patents

Un procedimiento para la preparacion de un derivado 4-(2-pirimidinil)-1-piperazinil-heterociclil-carbonilico.

Info

Publication number
ES2059316T3
ES2059316T3 ES87103079T ES87103079T ES2059316T3 ES 2059316 T3 ES2059316 T3 ES 2059316T3 ES 87103079 T ES87103079 T ES 87103079T ES 87103079 T ES87103079 T ES 87103079T ES 2059316 T3 ES2059316 T3 ES 2059316T3
Authority
ES
Spain
Prior art keywords
procedure
preparation
carbonilico
heterociclil
pirimidinil
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87103079T
Other languages
English (en)
Inventor
Marcel Hibert
Maurice W Gittos
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2059316T3 publication Critical patent/ES2059316T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

ESTA INVENCION SE REFIERE A DERIVADOS CARBONILICOS HETEROCILICOS DE 4-(2-PIRIMIDINIL)-1-PIPERAZINILO, A UN PROCEDIMIENTO PARA SU PREPARACION Y A SU EMPLEO COMO AGENTES ANSIOLITICOS.
ES87103079T 1986-03-05 1987-03-04 Un procedimiento para la preparacion de un derivado 4-(2-pirimidinil)-1-piperazinil-heterociclil-carbonilico. Expired - Lifetime ES2059316T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US83627786A 1986-03-05 1986-03-05

Publications (1)

Publication Number Publication Date
ES2059316T3 true ES2059316T3 (es) 1994-11-16

Family

ID=25271609

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87103079T Expired - Lifetime ES2059316T3 (es) 1986-03-05 1987-03-04 Un procedimiento para la preparacion de un derivado 4-(2-pirimidinil)-1-piperazinil-heterociclil-carbonilico.

Country Status (18)

Country Link
EP (1) EP0238905B1 (es)
JP (1) JPH0778043B2 (es)
KR (1) KR900000413B1 (es)
CN (1) CN1023484C (es)
AR (2) AR242678A1 (es)
AT (1) ATE93523T1 (es)
AU (1) AU588671B2 (es)
CA (1) CA1286667C (es)
DE (1) DE3787109T2 (es)
DK (1) DK111987A (es)
ES (1) ES2059316T3 (es)
FI (1) FI870925A (es)
HU (1) HU197567B (es)
NO (1) NO167390C (es)
NZ (1) NZ219456A (es)
PH (1) PH24912A (es)
PT (1) PT84408B (es)
ZA (1) ZA871450B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU208690B (en) * 1987-10-26 1993-12-28 Pfizer Process for producing 1-hjeterocyclic sulfonyl-3-(pyrimidinyl piperazinyl)-propane derivatives and pharmaceutical compositions comprising same
SE8803429D0 (sv) * 1988-09-28 1988-09-28 Pharmacia Ab Novel pyridyl- and pyrimidyl derivatives
FI895821A0 (fi) * 1988-12-07 1989-12-05 Wellcome Found Farmaceutiskt aktiva cns foereningar.
ATE187718T1 (de) * 1989-04-22 2000-01-15 American Home Prod Tertiäre alkyl funktionalisierte piperazin- derivate

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3398151A (en) * 1966-02-01 1968-08-20 Mead Johnson & Co Azaspirodecanediones and azaspiroundecanediones
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
DE2727469A1 (de) * 1977-06-18 1978-12-21 Hoechst Ag Neue hexahydropyrimidine, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
US4182763A (en) * 1978-05-22 1980-01-08 Mead Johnson & Company Buspirone anti-anxiety method
DE3321969A1 (de) * 1983-06-18 1984-12-20 Troponwerke GmbH & Co KG, 5000 Köln 2-pyrimidinyl-1-piperazin-derivate, verfahren zu ihrer herstellung und diese enthaltende arzneimittel
HU208690B (en) * 1987-10-26 1993-12-28 Pfizer Process for producing 1-hjeterocyclic sulfonyl-3-(pyrimidinyl piperazinyl)-propane derivatives and pharmaceutical compositions comprising same
US4880930A (en) * 1987-11-30 1989-11-14 New James S Psychotropic acyclic amide derivatives

Also Published As

Publication number Publication date
CN87101688A (zh) 1988-03-02
NO167390B (no) 1991-07-22
DK111987D0 (da) 1987-03-04
AR242790A1 (es) 1993-05-31
FI870925A (fi) 1987-09-06
KR900000413B1 (ko) 1990-01-30
DE3787109D1 (de) 1993-09-30
NO870891L (no) 1987-09-07
NO167390C (no) 1991-10-30
AU6960787A (en) 1987-09-10
EP0238905A2 (en) 1987-09-30
KR870008874A (ko) 1987-10-21
CN1023484C (zh) 1994-01-12
DK111987A (da) 1987-09-06
AU588671B2 (en) 1989-09-21
PH24912A (en) 1990-12-26
DE3787109T2 (de) 1994-02-10
HU197567B (en) 1989-04-28
HUT43591A (en) 1987-11-30
ZA871450B (en) 1987-08-20
EP0238905B1 (en) 1993-08-25
PT84408A (en) 1987-04-01
NZ219456A (en) 1989-08-29
JPS62265285A (ja) 1987-11-18
AR242678A1 (es) 1993-04-30
CA1286667C (en) 1991-07-23
PT84408B (pt) 1989-10-04
NO870891D0 (no) 1987-03-04
FI870925A0 (fi) 1987-03-03
JPH0778043B2 (ja) 1995-08-23
ATE93523T1 (de) 1993-09-15
EP0238905A3 (en) 1989-08-09

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