ES2059294T3 - Inhibidores de proteasas retroviricas. - Google Patents

Inhibidores de proteasas retroviricas.

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Publication number
ES2059294T3
ES2059294T3 ES92901691T ES92901691T ES2059294T3 ES 2059294 T3 ES2059294 T3 ES 2059294T3 ES 92901691 T ES92901691 T ES 92901691T ES 92901691 T ES92901691 T ES 92901691T ES 2059294 T3 ES2059294 T3 ES 2059294T3
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ES
Spain
Prior art keywords
retroviric
proteases inhibitors
inhibitors
proteases
protease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92901691T
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English (en)
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ES2059294T1 (es
Inventor
Kathryn Lea Reed
John Jeffrey Talley
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Monsanto Co
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Monsanto Co
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Publication of ES2059294T3 publication Critical patent/ES2059294T3/es
Anticipated expiration legal-status Critical
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
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    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
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    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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Abstract

COMPUESTOS REPRESENTADOS POR LA FORMULA (I) O UNA SAL ACEPTABLE FARMACEUTICAMENTE, O ESTER CONSIGUIENTE, DONDE A REPRESENTA RADICALES REPRESENTADOS POR LAS FORMULAS (A1,A2,A3) (VALORES PARA LAS VARIABLES AQUI DADAS), SON EFICACES COMO INHIBIDORES DE PROTEASA RETROVIRAL, EN PARTICULAR COMO INHIBIDORES DE PROTEASA HIV.
ES92901691T 1990-11-19 1991-11-18 Inhibidores de proteasas retroviricas. Expired - Lifetime ES2059294T3 (es)

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US61521090A 1990-11-19 1990-11-19
US78964391A 1991-11-14 1991-11-14

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ES96107359T Expired - Lifetime ES2151975T3 (es) 1990-11-19 1991-11-18 Inhibidores de proteasas retroviricas.

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US6071895A (en) * 1992-03-11 2000-06-06 Narhex Limited Polar-substituted hydrocarbons
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US5830888A (en) * 1993-04-16 1998-11-03 Monsanto Company Macrocyclic retroviral protease inhibitors
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WO1998033795A1 (en) * 1997-02-04 1998-08-06 The Regents Of The University Of California Nanomolar, non-peptide inhibitors of cathepsin d
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GR3034894T3 (en) 2001-02-28
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GR3023051T3 (en) 1997-07-30
EP0558657A1 (en) 1993-09-08
DE69124110T2 (de) 1997-06-05
DE69132439D1 (de) 2000-11-09
EP0735019A2 (en) 1996-10-02
IE914019A1 (en) 1992-05-20
DE69124110D1 (de) 1997-02-20
DK0558657T3 (da) 1997-07-07
ATE147378T1 (de) 1997-01-15
WO1992008700A1 (en) 1992-05-29
AU662309B2 (en) 1995-08-31
JPH06502866A (ja) 1994-03-31
ATE196466T1 (de) 2000-10-15
GR3035176T3 (en) 2001-04-30
EP0731088A2 (en) 1996-09-11
IE914018A1 (en) 1992-05-20
DK0735019T3 (da) 2000-10-23
DE69132423D1 (de) 2000-10-26
EP0735019A3 (en) 1997-05-14
ES2059294T1 (es) 1994-11-16
DE69132423T2 (de) 2001-04-26
CA2096528A1 (en) 1992-05-20
MX9102138A (es) 1994-05-31
CA2096528C (en) 2005-12-06
AU9133291A (en) 1992-06-11
EP0731088B1 (en) 2000-10-04
ES2151618T3 (es) 2001-01-01
EP0731088A3 (en) 1997-05-14
DK0731088T3 (da) 2000-10-16
ES2151975T3 (es) 2001-01-16
EP0558657B1 (en) 1997-01-08
ATE196759T1 (de) 2000-10-15
DE69132439T2 (de) 2001-05-03

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