DE69124110D1 - Retrovirale protease inhibitoren - Google Patents

Retrovirale protease inhibitoren

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Publication number
DE69124110D1
DE69124110D1 DE69124110T DE69124110T DE69124110D1 DE 69124110 D1 DE69124110 D1 DE 69124110D1 DE 69124110 T DE69124110 T DE 69124110T DE 69124110 T DE69124110 T DE 69124110T DE 69124110 D1 DE69124110 D1 DE 69124110D1
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Germany
Prior art keywords
protease inhibitors
retroviral protease
inhibitors
retroviral
protease
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69124110T
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English (en)
Other versions
DE69124110T2 (de
Inventor
Kathryn Reed
John Talley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Monsanto Co
Original Assignee
Monsanto Co
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Filing date
Publication date
Application filed by Monsanto Co filed Critical Monsanto Co
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Publication of DE69124110D1 publication Critical patent/DE69124110D1/de
Publication of DE69124110T2 publication Critical patent/DE69124110T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
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    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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    • C07C271/20—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by nitrogen atoms not being part of nitro or nitroso groups
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    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
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DE69124110T 1990-11-19 1991-11-18 Retrovirale protease inhibitoren Expired - Fee Related DE69124110T2 (de)

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US61521090A 1990-11-19 1990-11-19
US78964391A 1991-11-14 1991-11-14
PCT/US1991/008596 WO1992008700A1 (en) 1990-11-19 1991-11-18 Retroviral protease inhibitors

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DE69132439T Expired - Fee Related DE69132439T2 (de) 1990-11-19 1991-11-18 Inhibitoren retroviraler Proteasen
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US5830888A (en) * 1993-04-16 1998-11-03 Monsanto Company Macrocyclic retroviral protease inhibitors
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EP0558657A1 (de) 1993-09-08
DE69124110T2 (de) 1997-06-05
DE69132439D1 (de) 2000-11-09
EP0735019A2 (de) 1996-10-02
IE914019A1 (en) 1992-05-20
DK0558657T3 (da) 1997-07-07
ATE147378T1 (de) 1997-01-15
WO1992008700A1 (en) 1992-05-29
AU662309B2 (en) 1995-08-31
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ATE196466T1 (de) 2000-10-15
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DE69132423D1 (de) 2000-10-26
EP0735019A3 (de) 1997-05-14
ES2059294T1 (es) 1994-11-16
DE69132423T2 (de) 2001-04-26
CA2096528A1 (en) 1992-05-20
MX9102138A (es) 1994-05-31
CA2096528C (en) 2005-12-06
AU9133291A (en) 1992-06-11
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ES2151618T3 (es) 2001-01-01
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DK0731088T3 (da) 2000-10-16
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ES2059294T3 (es) 1997-04-01
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