ES2056423T3 - Microesferas compuestas magnetizables a base de un polimero organosiliciado reticulado, su procedimiento de preparacion y su aplicacion en biologia. - Google Patents

Microesferas compuestas magnetizables a base de un polimero organosiliciado reticulado, su procedimiento de preparacion y su aplicacion en biologia.

Info

Publication number
ES2056423T3
ES2056423T3 ES90420557T ES90420557T ES2056423T3 ES 2056423 T3 ES2056423 T3 ES 2056423T3 ES 90420557 T ES90420557 T ES 90420557T ES 90420557 T ES90420557 T ES 90420557T ES 2056423 T3 ES2056423 T3 ES 2056423T3
Authority
ES
Spain
Prior art keywords
biology
polymer
sivi
polysilsesquioxane
magnetisable
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90420557T
Other languages
English (en)
Inventor
Dominique Charmot
Andre Thibon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Prolabo SA
Original Assignee
Prolabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prolabo SA filed Critical Prolabo SA
Application granted granted Critical
Publication of ES2056423T3 publication Critical patent/ES2056423T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/12—Powdering or granulating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J3/00—Processes of treating or compounding macromolecular substances
    • C08J3/12—Powdering or granulating
    • C08J3/126—Polymer particles coated by polymer, e.g. core shell structures
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/14—Enzymes or microbial cells immobilised on or in an inorganic carrier
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01F—MAGNETS; INDUCTANCES; TRANSFORMERS; SELECTION OF MATERIALS FOR THEIR MAGNETIC PROPERTIES
    • H01F1/00—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties
    • H01F1/44—Magnets or magnetic bodies characterised by the magnetic materials therefor; Selection of materials for their magnetic properties of magnetic liquids, e.g. ferrofluids
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2383/00—Characterised by the use of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen, or carbon only; Derivatives of such polymers
    • C08J2383/04—Polysiloxanes
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
    • C08J2483/00—Characterised by the use of macromolecular compounds obtained by reactions forming in the main chain of the macromolecule a linkage containing silicon with or without sulfur, nitrogen, oxygen, or carbon only; Derivatives of such polymers
    • C08J2483/02—Polysilicates
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/20—Magnetic particle immunoreagent carriers the magnetic material being present in the particle core
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/30—Magnetic particle immunoreagent carriers the magnetic material being dispersed in the polymer composition before their conversion into particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/60—Magnetic particle immunoreagent carriers the magnetic material being dispersed in a medium other than the main solvent prior to incorporation into the polymer particle
    • G01N2446/64—Magnetic material dispersed in oil drop
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/60—Magnetic particle immunoreagent carriers the magnetic material being dispersed in a medium other than the main solvent prior to incorporation into the polymer particle
    • G01N2446/66—Magnetic material dispersed in surfactant
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
    • Y10T428/2995—Silane, siloxane or silicone coating

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Polymers & Plastics (AREA)
  • Genetics & Genomics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Power Engineering (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Silicon Polymers (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Soft Magnetic Materials (AREA)
  • Hard Magnetic Materials (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

MICROESFERAS COMPOSITAS MAGNETIZABLES FORMADAS DE UN NUCLEO DE CARGAS MAGNETIZABLES REPARTIDAS UNIFORMEMENTE EN UNA RED DE UN POLISILSESQUIOXANO (SIVI) QUE PRESENTA INSATURACIONES ETILENICAS Y DE UNA CORTEZA EN UN POLIMERO ORGANOSILICEADO RETICULADO DERIVADO DE HIDROSILILACION DE UN ORGANOHIDROGENOPOLISIXANO SIH CON LOS GRUPOS ETILEMICAMENTE NO SATURADOS DEL POLISILSESQUIOXANO SIVI. SE OBTIENEN POR DISPERSION EN UN SOLVENTE DE UNA SUSPENSION ACUOSA DE CARGAS MAGNETIZABLES NO REVESTIDAS DE AGENTE DISPERSANTE, DE DISOLUCION DE UN ALCOXISILANO O DE UN ALCOXISILOXANO QUE PRESENTA INSATURACIONES ETILEMICAS, POLICONDENSACION EN UN POLISILSESQUIOXANO SIVI, ELIMINACION DEL AGUA, DISOLUCION EN LA FASE ORGANICA DEL POLIMERO SIH, RETICULACION, ELIMINACION DEL AGUA, SEPARACION DE LAS MICROESFERAS Y EVENTUALMENTE REDISPERSION EN EL AGUA. UTILIZACION COMO SOPORTE ACTIVO EN BIOLOGIA.
ES90420557T 1989-12-27 1990-12-20 Microesferas compuestas magnetizables a base de un polimero organosiliciado reticulado, su procedimiento de preparacion y su aplicacion en biologia. Expired - Lifetime ES2056423T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8917233A FR2656319B1 (fr) 1989-12-27 1989-12-27 Microspheres composites magnetisables a base d'un polymere organosilicie reticule, leur procede de preparation et leur application en biologie.

Publications (1)

Publication Number Publication Date
ES2056423T3 true ES2056423T3 (es) 1994-10-01

Family

ID=9388998

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90420557T Expired - Lifetime ES2056423T3 (es) 1989-12-27 1990-12-20 Microesferas compuestas magnetizables a base de un polimero organosiliciado reticulado, su procedimiento de preparacion y su aplicacion en biologia.

Country Status (13)

Country Link
US (1) US5178947A (es)
EP (1) EP0435785B1 (es)
JP (1) JPH0737529B2 (es)
AT (1) ATE106720T1 (es)
AU (1) AU6849390A (es)
CA (1) CA2033144A1 (es)
DE (1) DE69009721T2 (es)
DK (1) DK0435785T3 (es)
ES (1) ES2056423T3 (es)
FI (1) FI906381A (es)
FR (1) FR2656319B1 (es)
NO (1) NO177999C (es)
PT (1) PT96328A (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2716263B1 (fr) * 1994-02-11 1997-01-17 Pasteur Institut Procédé d'alignement de macromolécules par passage d'un ménisque et applications dans un procédé de mise en évidence, séparation et/ou dosage d'une macromolécule dans un échantillon.
FR2716206B1 (fr) * 1994-02-11 1996-05-10 Pasteur Institut Surfaces hautement spécifiques pour réactions biologiques, procédé pour leur préparation et procédé de dosage d'une molécule utilisant ces surfaces.
US5623030A (en) * 1994-12-01 1997-04-22 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Curable composition and process for producing molded articles using the same
US6248537B1 (en) 1999-05-28 2001-06-19 Institut Pasteur Use of the combing process for the identification of DNA origins of replication
CA2377946A1 (en) * 1999-06-25 2001-01-04 Shigeru Matsumori Carrier for immunoassay and solid phase for immunoassay containing the same
WO2003072830A1 (en) 2002-02-22 2003-09-04 Purdue Research Foundation Magnetic nanomaterials and methods for detection of biological materials
US6646039B2 (en) * 2002-03-05 2003-11-11 Dow Corning Corporation Hydrosilyation cured silicone resin containing colloidal silica and a process for producing the same
US7670623B2 (en) * 2002-05-31 2010-03-02 Materials Modification, Inc. Hemostatic composition
AU2006203585B2 (en) * 2002-05-31 2008-11-06 Materials Modification, Inc. A hemostatic composition
CA2491093A1 (en) * 2002-06-28 2004-01-08 Purdue Research Foundation Magnetic nanomaterials and methods for detection of biological materials
US7560160B2 (en) * 2002-11-25 2009-07-14 Materials Modification, Inc. Multifunctional particulate material, fluid, and composition
FR2848879A1 (fr) * 2002-12-20 2004-06-25 Oreal Nanocapsules comprenant un polymere silicone de type polysilsesquioxane, composition cosmetique ou pharmaceutique les comprenant, et procede de preparation
US7007972B1 (en) 2003-03-10 2006-03-07 Materials Modification, Inc. Method and airbag inflation apparatus employing magnetic fluid
US6982501B1 (en) 2003-05-19 2006-01-03 Materials Modification, Inc. Magnetic fluid power generator device and method for generating power
US7200956B1 (en) 2003-07-23 2007-04-10 Materials Modification, Inc. Magnetic fluid cushioning device for a footwear or shoe
US7448389B1 (en) 2003-10-10 2008-11-11 Materials Modification, Inc. Method and kit for inducing hypoxia in tumors through the use of a magnetic fluid
US7846201B2 (en) * 2004-02-20 2010-12-07 The Children's Hospital Of Philadelphia Magnetically-driven biodegradable gene delivery nanoparticles formulated with surface-attached polycationic complex
US9028829B2 (en) * 2004-02-20 2015-05-12 The Children's Hospital Of Philadelphia Uniform field magnetization and targeting of therapeutic formulations
US8562505B2 (en) 2004-02-20 2013-10-22 The Children's Hospital Of Philadelphia Uniform field magnetization and targeting of therapeutic formulations
JP4706411B2 (ja) * 2005-09-21 2011-06-22 住友電気工業株式会社 軟磁性材料、圧粉磁心、軟磁性材料の製造方法、および圧粉磁心の製造方法
JP4654881B2 (ja) * 2005-11-02 2011-03-23 住友電気工業株式会社 軟磁性材料を用いて製造された圧粉磁心
RU2373957C2 (ru) 2006-10-13 2009-11-27 Александр Метталинович Тишин Носитель для лекарственных средств и биологически активных веществ для лечения и диагностики и применение его для создания лекарственных средств и способа регулируемой управляемой доставки лекарственного средства или биологически активного вещества с регулируемой десорбцией его
JP6197118B2 (ja) 2013-12-09 2017-09-13 スリーエム イノベイティブ プロパティズ カンパニー 硬化性シルセスキオキサンポリマー、組成物、物品、及び方法
US10392538B2 (en) 2014-06-20 2019-08-27 3M Innovative Properties Company Adhesive compositions comprising a silsesquioxane polymer crosslinker, articles and methods
US10370564B2 (en) 2014-06-20 2019-08-06 3M Innovative Properties Company Adhesive compositions comprising a silsesquioxane polymer crosslinker, articles and methods
EP3197966A1 (en) 2014-09-22 2017-08-02 3M Innovative Properties Company Curable polymers comprising silsesquioxane polymer core silsesquioxane polymer outer layer, and reactive groups
US9957416B2 (en) 2014-09-22 2018-05-01 3M Innovative Properties Company Curable end-capped silsesquioxane polymer comprising reactive groups
WO2017151582A1 (en) 2016-02-29 2017-09-08 The University Of North Carolina At Chapel Hill Array of micro-elements for high resolution and high content imaging and sorting of cells

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3220972A (en) * 1962-07-02 1965-11-30 Gen Electric Organosilicon process using a chloroplatinic acid reaction product as the catalyst
US3159662A (en) * 1962-07-02 1964-12-01 Gen Electric Addition reaction
US3159601A (en) * 1962-07-02 1964-12-01 Gen Electric Platinum-olefin complex catalyzed addition of hydrogen- and alkenyl-substituted siloxanes
US3296291A (en) * 1962-07-02 1967-01-03 Gen Electric Reaction of silanes with unsaturated olefinic compounds
US3480555A (en) * 1964-05-11 1969-11-25 Diamond Shamrock Corp Sols of gamma ferric oxide and their preparation
US3436366A (en) * 1965-12-17 1969-04-01 Gen Electric Silicone potting compositions comprising mixtures of organopolysiloxanes containing vinyl groups
US3344111A (en) * 1966-09-28 1967-09-26 Gen Electric Preparation of stable copolymerizable organosilicon compositions containing a platinum catalyst and an acrylonitrile type compound
US3814730A (en) * 1970-08-06 1974-06-04 Gen Electric Platinum complexes of unsaturated siloxanes and platinum containing organopolysiloxanes
US3715334A (en) * 1970-11-27 1973-02-06 Gen Electric Platinum-vinylsiloxanes
US3775452A (en) * 1971-04-28 1973-11-27 Gen Electric Platinum complexes of unsaturated siloxanes and platinum containing organopolysiloxanes
GB1476314A (en) * 1973-06-23 1977-06-10 Dow Corning Ltd Coating process
US4094804A (en) * 1974-08-19 1978-06-13 Junzo Shimoiizaka Method for preparing a water base magnetic fluid and product
US4364377A (en) * 1979-02-02 1982-12-21 Walker Scientific, Inc. Magnetic field hemostasis
DE3002477A1 (de) * 1979-02-02 1980-08-07 Walker Scient Inc Praeparat zur behandlung des magendarmkanals
US4695393A (en) * 1983-05-12 1987-09-22 Advanced Magnetics Inc. Magnetic particles for use in separations
US4695392A (en) * 1983-05-12 1987-09-22 Advanced Magnetics Inc. Magnetic particles for use in separations
US4672040A (en) * 1983-05-12 1987-06-09 Advanced Magnetics, Inc. Magnetic particles for use in separations
US4698302A (en) * 1983-05-12 1987-10-06 Advanced Magnetics, Inc. Enzymatic reactions using magnetic particles
US4554088A (en) * 1983-05-12 1985-11-19 Advanced Magnetics Inc. Magnetic particles for use in separations
US4628037A (en) * 1983-05-12 1986-12-09 Advanced Magnetics, Inc. Binding assays employing magnetic particles
FR2618084B1 (fr) * 1987-07-15 1989-11-10 Rhone Poulenc Chimie Microspheres magnetisables a base de polysiloxane, leur procede de preparation et leur application en biologie
JP2618663B2 (ja) * 1987-11-30 1997-06-11 東レ・ダウコーニング・シリコーン株式会社 磁性シリコーンゴム粉状物の製造方法
FR2624873B1 (fr) * 1987-12-18 1992-01-10 Rhone Poulenc Chimie Particules composites magnetisables a base d'organopolysiloxane reticule, leur procede de preparation et leur application en biologie

Also Published As

Publication number Publication date
EP0435785B1 (fr) 1994-06-08
FR2656319A1 (fr) 1991-06-28
FI906381A (fi) 1991-06-28
JPH04356527A (ja) 1992-12-10
FI906381A0 (fi) 1990-12-21
NO905504L (no) 1991-06-28
CA2033144A1 (fr) 1991-06-28
US5178947A (en) 1993-01-12
NO905504D0 (no) 1990-12-20
EP0435785A1 (fr) 1991-07-03
JPH0737529B2 (ja) 1995-04-26
DE69009721T2 (de) 1994-12-08
PT96328A (pt) 1991-09-30
NO177999C (no) 1996-01-03
ATE106720T1 (de) 1994-06-15
DE69009721D1 (de) 1994-07-14
NO177999B (no) 1995-09-25
DK0435785T3 (da) 1994-08-29
AU6849390A (en) 1991-07-04
FR2656319B1 (fr) 1992-03-20

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