ES2052224T3 - Microesferas "core-shell" magnetizables a base de organopolisiloxano reticulado, su procedimiento de preparacion y su aplicacion en biologia. - Google Patents

Microesferas "core-shell" magnetizables a base de organopolisiloxano reticulado, su procedimiento de preparacion y su aplicacion en biologia.

Info

Publication number
ES2052224T3
ES2052224T3 ES90420556T ES90420556T ES2052224T3 ES 2052224 T3 ES2052224 T3 ES 2052224T3 ES 90420556 T ES90420556 T ES 90420556T ES 90420556 T ES90420556 T ES 90420556T ES 2052224 T3 ES2052224 T3 ES 2052224T3
Authority
ES
Spain
Prior art keywords
magnetizable
organopolisiloxane
reticulated
shell
core
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90420556T
Other languages
English (en)
Inventor
Dominique Charmot
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Prolabo SA
Original Assignee
Prolabo SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prolabo SA filed Critical Prolabo SA
Application granted granted Critical
Publication of ES2052224T3 publication Critical patent/ES2052224T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • B01J13/06—Making microcapsules or microballoons by phase separation
    • B01J13/14—Polymerisation; cross-linking
    • B01J13/18—In situ polymerisation with all reactants being present in the same phase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5094—Microcapsules containing magnetic carrier material, e.g. ferrite for drug targeting
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/20—Magnetic particle immunoreagent carriers the magnetic material being present in the particle core
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/30—Magnetic particle immunoreagent carriers the magnetic material being dispersed in the polymer composition before their conversion into particulate form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/60—Magnetic particle immunoreagent carriers the magnetic material being dispersed in a medium other than the main solvent prior to incorporation into the polymer particle
    • G01N2446/64—Magnetic material dispersed in oil drop
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2446/00—Magnetic particle immunoreagent carriers
    • G01N2446/60—Magnetic particle immunoreagent carriers the magnetic material being dispersed in a medium other than the main solvent prior to incorporation into the polymer particle
    • G01N2446/66—Magnetic material dispersed in surfactant
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2993—Silicic or refractory material containing [e.g., tungsten oxide, glass, cement, etc.]
    • Y10T428/2995—Silane, siloxane or silicone coating
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
    • Y10T428/2991—Coated
    • Y10T428/2998—Coated including synthetic resin or polymer

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Dispersion Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Silicon Polymers (AREA)
  • Processes Of Treating Macromolecular Substances (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
  • Soft Magnetic Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

MICROESFERAS "CORE SHELL" MAGNETIZABLES CONSTITUIDAS DE UN NUCLEO DE CARGAS MAGNETIZABLES Y DE UNA CORTEZA DE ORGANOPOLISILOXANO RETICULADO. SE OBTIENEN POR DISPERSION EN UN DISOLVENTE ORGANICO DE UNA SUSPENSION ACUOSA DE CARGAS MAGNETIZABLES NO REVESTIDAS DE AGENTE DISPERSANTE, DISOLUCION EN LA FASE ORGANICA DE UN ORGANOPOLISILOXANO SIVI Y DE UN ORGANOHIDROGENOPOLISILOXANO SIH, RETICULACION, ELIMINACION DEL AGUA, SEPARACION Y EVENTUALMENTE REDISPERSION DE LAS MICROESFERAS MAGNETIZABLES EN EL AGUA.
ES90420556T 1989-12-27 1990-12-20 Microesferas "core-shell" magnetizables a base de organopolisiloxano reticulado, su procedimiento de preparacion y su aplicacion en biologia. Expired - Lifetime ES2052224T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8917232A FR2656318B1 (fr) 1989-12-27 1989-12-27 Microspheres "core-shell" magnetisables a base d'organopolysiloxane reticule, leur procede de preparation et leur application en biologie.

Publications (1)

Publication Number Publication Date
ES2052224T3 true ES2052224T3 (es) 1994-07-01

Family

ID=9388997

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90420556T Expired - Lifetime ES2052224T3 (es) 1989-12-27 1990-12-20 Microesferas "core-shell" magnetizables a base de organopolisiloxano reticulado, su procedimiento de preparacion y su aplicacion en biologia.

Country Status (14)

Country Link
US (1) US5232782A (es)
EP (1) EP0436450B1 (es)
JP (1) JPH0737572B2 (es)
AT (1) ATE102823T1 (es)
AU (1) AU6849490A (es)
CA (1) CA2033145A1 (es)
DE (1) DE69007456T2 (es)
DK (1) DK0436450T3 (es)
ES (1) ES2052224T3 (es)
FI (1) FI906383L (es)
FR (1) FR2656318B1 (es)
IE (1) IE904372A1 (es)
NO (1) NO178549C (es)
PT (1) PT96327A (es)

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US6423410B1 (en) 1998-09-04 2002-07-23 Mds Proteomics, Inc. Ultrasonically generated paramagnetic polymer particles
US5973138A (en) * 1998-10-30 1999-10-26 Becton Dickinson And Company Method for purification and manipulation of nucleic acids using paramagnetic particles
CA2377946A1 (en) * 1999-06-25 2001-01-04 Shigeru Matsumori Carrier for immunoassay and solid phase for immunoassay containing the same
GB2355012B (en) * 1999-10-05 2004-01-14 Solid Phase Sciences Corp Paramagnetic polymer practice
WO2001099127A2 (en) * 2000-06-19 2001-12-27 The University Of Iowa Research Foundation Coated metallic particles, methods and applications
DE10044635A1 (de) * 2000-09-08 2002-04-04 Henkel Kgaa Transparente Wirkstoffkapseln
AU2003215402A1 (en) 2002-02-22 2003-09-09 Purdue Research Foundation Fe/au nanoparticles and methods
CA2491093A1 (en) * 2002-06-28 2004-01-08 Purdue Research Foundation Magnetic nanomaterials and methods for detection of biological materials
US20040157219A1 (en) * 2003-02-06 2004-08-12 Jianrong Lou Chemical treatment of biological samples for nucleic acid extraction and kits therefor
CN100439515C (zh) * 2003-03-03 2008-12-03 清华大学 一种核酸分析芯片实验室系统与应用
CN1280428C (zh) * 2003-05-19 2006-10-18 清华大学 一种基于微小颗粒的生物芯片系统及其应用
CN100494399C (zh) * 2003-06-30 2009-06-03 清华大学 一种基于dna芯片的基因分型方法及其应用
GB0414159D0 (en) * 2004-06-23 2004-07-28 Smith Adrian Process for manufacture of microbeads
JP4811565B2 (ja) * 2005-03-31 2011-11-09 Ｊｓｒ株式会社 多孔質表面を有する磁性粒子およびその製造方法、生化学用担体、ならびにビオチン類結合用粒子
ES2761937T3 (es) * 2005-10-24 2020-05-21 Magsense Life Sciences Inc Método para preparar micropartículas recubiertas con polímero
FR2910345A1 (fr) * 2006-12-20 2008-06-27 Oreal Particules coeur/ecorce a base de composes silicones
FR2910284B1 (fr) * 2006-12-20 2009-04-17 Oreal Produit cosmetique comprenant des composes silicones et un polymere amphiphile
DE102007031689A1 (de) * 2007-07-06 2009-01-08 Evonik Goldschmidt Gmbh Enzympräparate
WO2013030240A1 (en) * 2011-08-29 2013-03-07 The Provost, Fellows, Foundation Scholars, And The Other Members Of Board, Of The College Of The Holy And Undivided Trinity Of Queen Elizabeth Near Dublin Phase transfer reactions
CN103933903B (zh) * 2014-03-31 2017-01-04 清华大学 制备空心结构纳米有机硅微球的方法
JP6182520B2 (ja) * 2014-12-01 2017-08-16 三洋化成工業株式会社 磁性シリカ粒子、該磁性シリカ粒子を用いた測定対象物質測定方法及び測定対象物質測定用試薬
JP6994021B2 (ja) 2016-08-26 2022-01-14 ジュノー セラピューティクス インコーポレイテッド 細胞組成物中に存在する粒子を計数する方法
KR20200064060A (ko) 2017-07-29 2020-06-05 주노 쎄러퓨티크스 인코퍼레이티드 재조합 수용체를 발현하는 세포 증폭용 시약
JP7335883B2 (ja) 2018-02-28 2023-08-30 ジュノー セラピューティクス インコーポレイテッド 細胞組成物中に存在する粒子を検出するための方法
US20200041518A1 (en) 2018-08-03 2020-02-06 CellMax Life, Inc. Lipid vesicle-coated magnetic beads and uses of the same
KR20230159851A (ko) 2021-03-22 2023-11-22 주노 쎄러퓨티크스 인코퍼레이티드 치료 세포 조성물의 효력을 결정하는 방법
KR20230158573A (ko) 2021-03-22 2023-11-20 주노 쎄러퓨티크스 인코퍼레이티드 바이러스 벡터 입자의 효력을 평가하는 방법
WO2026020055A2 (en) 2024-07-18 2026-01-22 Juno Therapeutics, Inc. Methods for assessing exosomes in a cell composition and related uses

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Also Published As

Publication number Publication date
FR2656318A1 (fr) 1991-06-28
IE904372A1 (en) 1991-07-03
FI906383A7 (fi) 1991-06-28
FI906383L (fi) 1991-06-28
JPH04279664A (ja) 1992-10-05
NO178549B (no) 1996-01-08
AU6849490A (en) 1991-07-04
DK0436450T3 (da) 1994-07-18
EP0436450A1 (fr) 1991-07-10
PT96327A (pt) 1991-09-30
NO905503L (no) 1991-06-28
NO905503D0 (no) 1990-12-20
EP0436450B1 (fr) 1994-03-16
FR2656318B1 (fr) 1994-02-04
DE69007456T2 (de) 1994-10-20
DE69007456D1 (de) 1994-04-21
JPH0737572B2 (ja) 1995-04-26
NO178549C (no) 1996-04-17
CA2033145A1 (fr) 1991-06-28
FI906383A0 (fi) 1990-12-21
US5232782A (en) 1993-08-03
ATE102823T1 (de) 1994-04-15

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