ES2055696T3 - Procedimiento para preparar analogos de gonadoliberina. - Google Patents

Procedimiento para preparar analogos de gonadoliberina.

Info

Publication number
ES2055696T3
ES2055696T3 ES87114702T ES87114702T ES2055696T3 ES 2055696 T3 ES2055696 T3 ES 2055696T3 ES 87114702 T ES87114702 T ES 87114702T ES 87114702 T ES87114702 T ES 87114702T ES 2055696 T3 ES2055696 T3 ES 2055696T3
Authority
ES
Spain
Prior art keywords
trp
thi
phe
optionally substituted
gonadoliberin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87114702T
Other languages
English (en)
Inventor
Wolfgang Dr Konig
Jurgen Kurt Dr Sandow
Cenek Dr Kolar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Application granted granted Critical
Publication of ES2055696T3 publication Critical patent/ES2055696T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/59—Follicle-stimulating hormone [FSH]; Chorionic gonadotropins, e.g.hCG [human chorionic gonadotropin]; Luteinising hormone [LH]; Thyroid-stimulating hormone [TSH]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04—Linear peptides containing only normal peptide links
    • C07K7/23—Luteinising hormone-releasing hormone [LHRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Endocrinology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Reproductive Health (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Compounds Of Unknown Constitution (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Cosmetics (AREA)

Abstract

LA INVENCION SE REFIERE A PEPTIDOS DE FORMULA (I) EN LA QUE X ESTA AUSENTE O BIEN REPRESENTA HIDROGENO O ACILO, A REPRESENTA D-NAL(2), D-PHE O D-TRP, EVENTUALMENTE SUSTITUIDOS; B REPRESENTA HIS O D-PHE EVENTUALMENTE SUSTITUIDO; C REPRESENTA TRP, D-THI, D-PAL(3) O D-TRP EVENTUALMENTE SUSTITUIDO; D REPRESENTA TYR, ARG O HIS; E REPRESENTA D-SER (R1), BETA- ASN, BETA- ASP -O ME, D- THI, O BIEN , -NH-CH(CH2R2)-CO-; F REPRESENTA SER (R1), LEU, TRP O PHE; G REPRESENTA GEY-NH2, AZA- GLY- NH2, D- ALA- NH2 O NH ALQUILO; R1 REPRESENTA GLICOSILO Y R2 REPRESENTA HIDROGENO ACILO, ARILO O HETEROARILO. LA INVENCION SE REFIERE ADEMAS A PROCEDIMIENTOS PARA LA OBTENCION DE ESTOS PEPTIDOS, MEDICAMENTOS QUE LOS CONTIENEN Y APLICACIONES DE LOS MISMOS.
ES87114702T 1986-10-09 1987-10-08 Procedimiento para preparar analogos de gonadoliberina. Expired - Lifetime ES2055696T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19863634435 DE3634435A1 (de) 1986-10-09 1986-10-09 Analoga von gonadoliberin mit verbesserter loeslichkeit, verfahren zu deren herstellung, diese enthaltende mittel und ihre verwendung

Publications (1)

Publication Number Publication Date
ES2055696T3 true ES2055696T3 (es) 1994-09-01

Family

ID=6311399

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87114702T Expired - Lifetime ES2055696T3 (es) 1986-10-09 1987-10-08 Procedimiento para preparar analogos de gonadoliberina.

Country Status (20)

Country Link
US (1) US5091367A (es)
EP (1) EP0263521B1 (es)
JP (1) JP2573625B2 (es)
KR (1) KR960013387B1 (es)
AT (1) ATE70278T1 (es)
AU (1) AU595383B2 (es)
CA (1) CA1314656C (es)
CZ (1) CZ408491A3 (es)
DE (2) DE3634435A1 (es)
DK (1) DK171823B1 (es)
ES (1) ES2055696T3 (es)
FI (1) FI86863C (es)
GR (1) GR3003927T3 (es)
IE (1) IE60296B1 (es)
IL (1) IL84121A (es)
NZ (1) NZ222076A (es)
PH (1) PH24731A (es)
PT (1) PT85881B (es)
SK (1) SK408491A3 (es)
ZA (1) ZA877561B (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK163689A (da) * 1988-04-08 1989-10-30 Sandoz Ag Peptidderivater
DE3842010A1 (de) * 1988-12-14 1990-06-21 Hoechst Ag Kompetitive gonadoliberin-antagonisten
DK0477499T3 (da) * 1990-08-04 1994-05-30 Hoechst Ag Gonadoliberin-antagonister
US5760000A (en) * 1994-05-13 1998-06-02 University Technologies International,Inc. Inhibition of liver cancer by the use of GnRH and GnRH analogs
GB2343182A (en) * 1998-10-27 2000-05-03 Ferring Bv Use of GnRH-II and analogues thereof for the treatment of osteoporosis
CN1301771A (zh) * 1999-12-27 2001-07-04 上海博德基因开发有限公司 一种新的多肽——人促性腺释放激素11和编码这种多肽的多核苷酸
CN1315354A (zh) * 2000-03-24 2001-10-03 上海博德基因开发有限公司 一种新的多肽——人促性腺释放激素12和编码这种多肽的多核苷酸
CA2560956A1 (en) * 2004-03-29 2005-10-20 The Arizona Board Of Regents On Behalf Of The University Of Arizona Amphipathic glycopeptides

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ188987A (en) * 1977-11-30 1982-02-23 Salk Inst For Biological Studi Peptide analogues of luteinizing hormone releasing factor
FR2465486A1 (fr) * 1979-09-21 1981-03-27 Roussel Uclaf Nouvelle application utilisant la lh-rh ou des agonistes
US4409208A (en) * 1980-04-15 1983-10-11 The Salk Institute For Biological Studies GnRH antagonists
US4444759A (en) * 1982-07-26 1984-04-24 The Salk Institute For Biological Studies GnRH Antagonists II
EP0145032B1 (en) * 1983-08-16 1987-11-04 Akzo N.V. Lh- rh antagonists

Also Published As

Publication number Publication date
DK527187A (da) 1988-04-10
US5091367A (en) 1992-02-25
FI874401A (fi) 1988-04-10
SK408491A3 (en) 1995-07-11
PT85881B (pt) 1990-07-31
IE872693L (en) 1988-04-09
ZA877561B (en) 1988-05-25
AU595383B2 (en) 1990-03-29
FI86863B (fi) 1992-07-15
IL84121A (en) 1992-06-21
KR960013387B1 (ko) 1996-10-04
PT85881A (de) 1987-11-01
CZ408491A3 (en) 1993-01-13
DE3775156D1 (de) 1992-01-23
FI86863C (fi) 1992-10-26
KR880005149A (ko) 1988-06-28
EP0263521A2 (de) 1988-04-13
DE3634435A1 (de) 1988-04-14
IE60296B1 (en) 1994-06-29
AU7945987A (en) 1988-04-14
EP0263521B1 (de) 1991-12-11
ATE70278T1 (de) 1991-12-15
DK171823B1 (da) 1997-06-23
IL84121A0 (en) 1988-03-31
JPS6396198A (ja) 1988-04-27
CA1314656C (en) 1993-03-16
FI874401A0 (fi) 1987-10-07
JP2573625B2 (ja) 1997-01-22
NZ222076A (en) 1989-09-27
EP0263521A3 (en) 1988-07-06
GR3003927T3 (es) 1993-03-16
PH24731A (en) 1990-10-01
DK527187D0 (da) 1987-10-08

Similar Documents

Publication Publication Date Title
ES2054741T3 (es) Antagonistas de lhrh, su preparacion y preparados farmaceuticos correspondientes.
GB1498048A (en) Decapeptide amides
DK413986A (da) Syntetisk peptid og farmaceutisk middel indeholdende peptidet
ES2055696T3 (es) Procedimiento para preparar analogos de gonadoliberina.
KR860009041A (ko) GnRH길항제 IX의 제조방법
AR009600A1 (es) Secuencia de acido nucleico y aminoacidos relacionados con helicobacter pylori y composiciones de vacuna de la misma.
ES548052A0 (es) Procedimiento para preparar peptidos
DK568281A (da) Fremgangsmaade til fremstilling af peptider
ATE14886T1 (de) Gnrh-antagonisten.
ATE30919T1 (de) Magensekretion hemmende peptidderivate, verfahren zu ihrer herstellung und sie enthaltende arzneimittel.
ES8507474A1 (es) Procedimiento para preparar ciclopeptidos
ES8207510A1 (es) Un metodo de preparacion de un peptido inhibidor de la liberacion de gonadotropinas por la glandula pituitaria en mamiferos.
ATE100822T1 (de) Gonadoliberin-antagonisten.
FI933629A (fi) Antagonistpeptider till hormon som frigoer luteiniserande hormon (lhrh)
IT1256247B (it) Peptidi ciclici
TH1762EX (th) เพพไทด์สังเคราะห์ที่แสดงฤทธิ์ปลดปล่อยฮอร์โมนช่วยการเติบโตของพิทูอิทารี

Legal Events

Date Code Title Description
FG2A Definitive protection

Ref document number: 263521

Country of ref document: ES