ES2054665T3 - Derivados de naftiridina y piridopirazina sustituidos con arilo. - Google Patents

Derivados de naftiridina y piridopirazina sustituidos con arilo.

Info

Publication number
ES2054665T3
ES2054665T3 ES87303102T ES87303102T ES2054665T3 ES 2054665 T3 ES2054665 T3 ES 2054665T3 ES 87303102 T ES87303102 T ES 87303102T ES 87303102 T ES87303102 T ES 87303102T ES 2054665 T3 ES2054665 T3 ES 2054665T3
Authority
ES
Spain
Prior art keywords
aryl
piridopyrazine
naftiridine
derivatives replaced
disclosed
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES87303102T
Other languages
English (en)
Inventor
David John Blythin
Marvin Ira Siegel
Ho-Jane Shue
Sidney Randall Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/921,288 external-priority patent/US4882332A/en
Application filed by Schering Corp filed Critical Schering Corp
Application granted granted Critical
Publication of ES2054665T3 publication Critical patent/ES2054665T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
  • Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

LA INVENCION SE REFIERE A NAFTIRIDINAS Y PIRIDOPIRAZINAS ARIL-SUSTITUIDAS, QUE SON UTILES EN EL TRATAMIENTO DE REACCIONES ALERGICAS, INFLAMACION, ULCERAS PEPTICAS, ENFERMEDAD HIPERPROLIFERATIVA DE LA PIEL Y/O RESPUESTAS DE INMUNOSUPRESION EN MAMIFEROS. TAMBIEN SE REFIERE LA INVENCION A COMPOSICIONES Y METODOS DE TRATAMIENTO QUE EMPLEAN DICHOS COMPUESTOS.
ES87303102T 1986-04-11 1987-04-09 Derivados de naftiridina y piridopirazina sustituidos con arilo. Expired - Lifetime ES2054665T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US85106886A 1986-04-11 1986-04-11
US06/921,288 US4882332A (en) 1986-10-20 1986-10-20 Immune suppression method employing arly-substituted naphthyridine and pyridopyrazine derivatives

Publications (1)

Publication Number Publication Date
ES2054665T3 true ES2054665T3 (es) 1994-08-16

Family

ID=27126973

Family Applications (1)

Application Number Title Priority Date Filing Date
ES87303102T Expired - Lifetime ES2054665T3 (es) 1986-04-11 1987-04-09 Derivados de naftiridina y piridopirazina sustituidos con arilo.

Country Status (16)

Country Link
EP (1) EP0241291B1 (es)
JP (1) JPH0774215B2 (es)
KR (1) KR870010049A (es)
AT (1) ATE90096T1 (es)
AU (1) AU609389B2 (es)
CA (1) CA1324381C (es)
DE (1) DE3786036T2 (es)
DK (1) DK186487A (es)
ES (1) ES2054665T3 (es)
FI (1) FI88033C (es)
HU (1) HU200768B (es)
IL (1) IL82150A0 (es)
NO (1) NO165923C (es)
NZ (1) NZ219931A (es)
OA (1) OA08583A (es)
PT (1) PT84658B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK127086A (da) * 1985-03-25 1986-09-26 Schering Corp Substituerede 1,8-naphthyridoner, fremgangsmaader til deres fremstilling og farmaceutiske kompositioner, der indeholder disse forbindelser
US5037826A (en) * 1986-10-15 1991-08-06 Schering Corporation 1-substituted naphthyridine and pyridopyrazine derivatives
EP2367821B1 (en) * 2008-12-17 2015-09-16 Merck Patent GmbH C-ring modified tricyclic benzonaphthiridinone protein kinase inhibitors and use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4680298A (en) * 1983-05-31 1987-07-14 Schering Corporation Tricyclic anti-allergy and use as anti-inflammatory agents
DE3481418D1 (de) * 1983-12-14 1990-04-05 Schering Corp Substituierte spiropyridinderivate, diese enthaltende pharmazeutische zubereitungen, verfahren zu ihrer herstellung und zubereitungen.
DK127086A (da) * 1985-03-25 1986-09-26 Schering Corp Substituerede 1,8-naphthyridoner, fremgangsmaader til deres fremstilling og farmaceutiske kompositioner, der indeholder disse forbindelser
US4596809A (en) * 1985-03-25 1986-06-24 Schering Corporation Substituted 1,8-naphthyridinones, useful as anti-allergic agents

Also Published As

Publication number Publication date
IL82150A0 (en) 1987-10-30
OA08583A (fr) 1988-09-30
JPS62270582A (ja) 1987-11-24
KR870010049A (ko) 1987-11-30
AU609389B2 (en) 1991-05-02
DE3786036D1 (de) 1993-07-08
ATE90096T1 (de) 1993-06-15
EP0241291A3 (en) 1989-05-31
NO871507D0 (no) 1987-04-10
FI88033C (fi) 1993-03-25
EP0241291B1 (en) 1993-06-02
PT84658B (pt) 1989-11-30
AU7135887A (en) 1987-10-15
DK186487D0 (da) 1987-04-10
CA1324381C (en) 1993-11-16
NO871507L (no) 1987-10-12
EP0241291A2 (en) 1987-10-14
HUT43847A (en) 1987-12-28
FI88033B (fi) 1992-12-15
NZ219931A (en) 1989-10-27
JPH0774215B2 (ja) 1995-08-09
FI871568A0 (fi) 1987-04-09
NO165923C (no) 1991-05-02
NO165923B (no) 1991-01-21
DE3786036T2 (de) 1993-09-09
HU200768B (en) 1990-08-28
FI871568A (fi) 1987-10-12
DK186487A (da) 1987-10-12
PT84658A (en) 1987-05-01

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