ES2053411T3 - Sistemas efervescentes dotados de reaccion. - Google Patents
Sistemas efervescentes dotados de reaccion.Info
- Publication number
- ES2053411T3 ES2053411T3 ES92912980T ES92912980T ES2053411T3 ES 2053411 T3 ES2053411 T3 ES 2053411T3 ES 92912980 T ES92912980 T ES 92912980T ES 92912980 T ES92912980 T ES 92912980T ES 2053411 T3 ES2053411 T3 ES 2053411T3
- Authority
- ES
- Spain
- Prior art keywords
- acid
- pct
- layer
- gas
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
- General Preparation And Processing Of Foods (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Superconductors And Manufacturing Methods Therefor (AREA)
- Gas Separation By Absorption (AREA)
- Saccharide Compounds (AREA)
Abstract
LA TABLETA EFERVESCENTE CONTIENE UN SISTEMA EFERVESCENTE DE CRISTALES PORTADORES, POR LO MENOS UN ACIDO ORGANICO COMESTIBLE SOLIDO, POR LO MENOS UN COMPONENTE DESPRENDIENDO GAS BAJO FORMACION DE SAL A TRAVES DE LA REACCION CON EL ACIDO Y POR LO MENOS UNA SAL FORMADA POR EL COMPONENTE DESPRENDIENDO GAS Y EL ACIDO. SOBRE EL CRISTAL PORTADOR SE APLICA UNA PRIMERA CAPA DE OTRO ACIDO Y UNA SEGUNDA CAPA DE UNA SAL PREFERENTEMENTE ACIDO POR LO MENOS UNO DE AMBOS ACIDOS. A PARTIR DE LA CANTIDAD TOTAL DEL ACIDO O DE LOS ACIDOS EMPLEADOS Y DEL COMPONENTE DESPRENDIENDO GAS, ESTA PRESENTE UN 10 A 40 PARTICULARMENTE 10 A 20% EN FORMA DE SAL, PREFERENTEMENTE EN FORMA DE SAL ACIDA. LOS CRISTALES PORTADORES SON ACIDO CITRONICO, ACIDO MALICO, ACIDO TARTARICO, CITRATO MONOSODICO Y/O ACIDO ASCORBINICO. LA PRIMERA CAPA PUEDE CONTENER GLUCONICO-DELTA-LACTONA Y SE RECUBRE PREFERENTEMENTE CON ACIDO CITRONICO, MALICO Y/O ACIDO TARTARICO. PERMANECE UNA CAPA FORMADA COMO MONOSAL EN UNA FRACCION DE LA CANTIDAD TOTALDEL COMPONENTE DESPRENDIENDO GAS A TRAVES DE LA REACCION CON UNO DE LOS ACIDOS EMPLEADOS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH194291 | 1991-07-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2053411T1 ES2053411T1 (es) | 1994-08-01 |
ES2053411T3 true ES2053411T3 (es) | 1995-05-01 |
Family
ID=4222201
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92912980T Expired - Lifetime ES2053411T3 (es) | 1991-07-01 | 1992-06-24 | Sistemas efervescentes dotados de reaccion. |
Country Status (9)
Country | Link |
---|---|
US (1) | US5415870A (es) |
EP (1) | EP0592484B1 (es) |
JP (1) | JP3517233B2 (es) |
AT (1) | ATE117199T1 (es) |
CA (1) | CA2112663C (es) |
DE (1) | DE59201238D1 (es) |
DK (1) | DK0592484T3 (es) |
ES (1) | ES2053411T3 (es) |
WO (1) | WO1993000886A1 (es) |
Families Citing this family (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4027927A1 (de) * | 1990-09-04 | 1992-03-05 | Bayer Ag | Brausekomponente und verfahren zu ihrer herstellung |
US5503846A (en) * | 1993-03-17 | 1996-04-02 | Cima Labs, Inc. | Base coated acid particles and effervescent formulation incorporating same |
ATE140621T1 (de) * | 1993-04-15 | 1996-08-15 | Gergely Gerhard | Brausesystem mit einem alkali- und/oder metallempfindlichen, pharmazeutischen wirkstoff, und verfahren zur herstellung |
DE59408273D1 (de) * | 1993-09-07 | 1999-06-24 | Gergely Gerhard | Brausemischung mit Alkalisalzen oder Lysinaten saurer, unlöslicher oder schwer löslicher Wirkstoffe |
DE670160T1 (de) * | 1994-03-01 | 1996-03-14 | Gerhard Gergely | Ein Brausesystem und einen Arzneiwirkstoff enthaltendes granuläres Produkt bzw. Tablette sowie Verfahren zu deren Herstellung. |
IL112779A (en) * | 1994-03-01 | 1999-11-30 | Gergely Gerhard | Granular product or tablet containing an efferescent system and an active pharmaceutical substance and its preparation |
DE69419492T2 (de) * | 1994-03-01 | 2000-02-03 | Gerhard Gergely | Ein Brausesystem und einen Arzneiwirkstoff enthaltendes granuläres Produkt bzw. Tablette sowie Verfahren zu deren Herstellung |
US5824339A (en) * | 1995-09-08 | 1998-10-20 | Takeda Chemical Industries, Ltd | Effervescent composition and its production |
US6974595B1 (en) * | 1996-05-17 | 2005-12-13 | Proethic Pharmaceuticals, Inc. | Pharmaceutical compositions based on Diclofenae |
US6077539A (en) * | 1996-11-12 | 2000-06-20 | Pozen, Inc. | Treatment of migraine headache |
US5728401A (en) * | 1997-04-16 | 1998-03-17 | Ranbaxy Laboratories, Ltd. | Effervescent ranitidine formulations |
BR9813873A (pt) * | 1997-10-21 | 2000-09-26 | Gerhard Gergely | Base efervescente |
ATE214285T1 (de) * | 1997-10-27 | 2002-03-15 | Gergely Gerhard | Brausezubereitung mit pflanzenextrakt |
JP3660588B2 (ja) * | 1997-12-03 | 2005-06-15 | 花王株式会社 | 口腔衛生用固形製剤 |
US6235311B1 (en) * | 1998-03-18 | 2001-05-22 | Bristol-Myers Squibb Company | Pharmaceutical composition containing a combination of a statin and aspirin and method |
DE19814257A1 (de) | 1998-03-31 | 1999-10-07 | Asta Medica Ag | Brauseformulierungen |
DE59808063D1 (de) * | 1998-06-03 | 2003-05-28 | Gergely Dr & Co | Mit Alkali- bzw. Erdalkali-Ionen dotierte Zitronensäure |
AT407111B (de) * | 1998-12-22 | 2000-12-27 | Gergely Dr & Co | Zucker- und/oder zuckeralkoholhältiges matrixmaterial und verfahren zu seiner herstellung |
GB9909801D0 (en) * | 1999-04-28 | 1999-06-23 | Btg Int Ltd | Ultrasound detectable instrument |
US6766753B2 (en) * | 2001-03-20 | 2004-07-27 | Hank E Pierson | Pre-feeder for a main sail |
EP1490024B1 (en) | 2002-03-06 | 2012-01-18 | EffRx Pharmaceuticals SA | Effervescent compositions comprising alendronate |
US7488496B2 (en) * | 2002-03-06 | 2009-02-10 | Christer Rosen | Effervescent compositions comprising bisphosphonates and methods related thereto |
CA2528346C (en) * | 2003-06-20 | 2010-02-16 | Intrinsic Therapeutics, Inc. | Implant for intervertebral disc annular defect |
ES2700162T3 (es) | 2006-07-12 | 2019-02-14 | Purac Biochem Bv | Partículas de calidad alimenticia recubiertas de ácido parcialmente neutralizado |
US8431171B2 (en) * | 2006-07-12 | 2013-04-30 | Purac Biochem B.V. | Partially neutralized acid coated food-grade particles |
US8778398B2 (en) | 2008-11-04 | 2014-07-15 | Jazz Pharmaceuticals, Inc. | Immediate release formulations and dosage forms of gamma-hydroxybutyrate |
TR200900881A2 (tr) * | 2009-02-05 | 2010-08-23 | Bi̇lgi̇ç Mahmut | Tadı ve kokusu maskelenmiş stabil farmasötik bileşimler |
CN102917697B (zh) | 2010-03-24 | 2016-01-20 | 爵士制药有限公司 | 用于高剂量的水溶性和吸湿性药物的控释剂型 |
CA2798178C (en) * | 2010-05-04 | 2017-06-13 | Jazz Pharmaceuticals, Inc. | Immediate release formulations and dosage forms of gamma-hydroxybutyrate |
MY166971A (en) * | 2010-12-06 | 2018-07-26 | Effrx Pharmaceuticals Sa | Stable effervescent bisphosphonate formulations with rapid solubilization characteristics |
WO2013115746A1 (en) * | 2012-01-31 | 2013-08-08 | Mahmut Bilgic | A production method for (effervescent) pharmaceutical compositions comprising an alpha - glucosidase inhibitor (miglitol) and metformin |
WO2014065890A1 (en) * | 2012-10-25 | 2014-05-01 | Otc Nutrition Llc | Fast dissolving solid calcium mineral supplement compositions and process of making |
JP5935172B2 (ja) * | 2013-01-22 | 2016-06-15 | 株式会社東洋新薬 | 発泡性皮膚外用剤 |
US20150025025A1 (en) * | 2013-07-19 | 2015-01-22 | Ricky McCullough | Immuno-modulators for treating functional epithelial syndromes |
JP6627485B2 (ja) * | 2015-01-28 | 2020-01-08 | ライオン株式会社 | ゲル組成物及びその製造方法 |
US10398662B1 (en) | 2015-02-18 | 2019-09-03 | Jazz Pharma Ireland Limited | GHB formulation and method for its manufacture |
US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US20180263936A1 (en) | 2017-03-17 | 2018-09-20 | Jazz Pharmaceuticals Ireland Limited | Gamma-hydroxybutyrate compositions and their use for the treatment of disorders |
WO2020106735A1 (en) | 2018-11-19 | 2020-05-28 | Jazz Pharmaceuticals Ireland Limited | Alcohol-resistant drug formulations |
US11400065B2 (en) | 2019-03-01 | 2022-08-02 | Flamel Ireland Limited | Gamma-hydroxybutyrate compositions having improved pharmacokinetics in the fed state |
JP2021014431A (ja) * | 2019-07-12 | 2021-02-12 | ライオン株式会社 | 粉体組成物、粉体組成物を含有する内服固形製剤及びその製造方法 |
CN111184694A (zh) * | 2020-01-19 | 2020-05-22 | 广东青云山药业有限公司 | 一种口腔速溶颗粒的制备方法 |
US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2211485A (en) * | 1940-08-13 | Effervescent acetyl salicylic acid | ||
US3345265A (en) * | 1963-10-09 | 1967-10-03 | Kendall & Co | Multiple layer tablet with calcium salt central core separated from soluble fluoride outer coating |
US3887700A (en) * | 1969-11-28 | 1975-06-03 | Aspro Nicholas Ltd | Analgesic formulations |
US4127645A (en) * | 1976-05-21 | 1978-11-28 | Life Savers, Inc. | Effervescent tablet and method |
AT374348B (de) * | 1980-07-01 | 1984-04-10 | Gergely Gerhard | Verfahren zur herstellung von gewuenschtenfalls zu brausetabletten verarbeitbaren brausegranulaten |
JPS5756434A (en) * | 1980-09-22 | 1982-04-05 | Kao Corp | Stabilized foamable composition |
US4678661A (en) * | 1983-09-28 | 1987-07-07 | Gerhard Gergely | Effervescent composition and method of making same |
FR2593065B1 (fr) * | 1986-01-22 | 1988-09-09 | Smith Kline French Lab | Couples effervescents, compositions effervescentes d'antagonistes h2 de l'histamine les contenant et leur preparation. |
DE3627475A1 (de) * | 1986-06-26 | 1988-01-14 | Gergely Gerhard | Verfahren zum herstellen eines brausegranulates, danach hergestelltes brausegranulat sowie dessen verwendung |
US5064656A (en) * | 1989-11-14 | 1991-11-12 | Dr. Gergely & Co. | Uncoated pharmaceutical reaction tablet |
-
1992
- 1992-06-24 ES ES92912980T patent/ES2053411T3/es not_active Expired - Lifetime
- 1992-06-24 CA CA002112663A patent/CA2112663C/en not_active Expired - Fee Related
- 1992-06-24 US US08/170,262 patent/US5415870A/en not_active Expired - Lifetime
- 1992-06-24 JP JP50191693A patent/JP3517233B2/ja not_active Expired - Fee Related
- 1992-06-24 AT AT92912980T patent/ATE117199T1/de active
- 1992-06-24 DK DK92912980.7T patent/DK0592484T3/da not_active Application Discontinuation
- 1992-06-24 EP EP92912980A patent/EP0592484B1/de not_active Expired - Lifetime
- 1992-06-24 DE DE59201238T patent/DE59201238D1/de not_active Expired - Lifetime
- 1992-06-24 WO PCT/EP1992/001421 patent/WO1993000886A1/de active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
EP0592484A1 (de) | 1994-04-20 |
CA2112663A1 (en) | 1993-01-21 |
JPH06508839A (ja) | 1994-10-06 |
DK0592484T3 (da) | 1995-06-12 |
ES2053411T1 (es) | 1994-08-01 |
EP0592484B1 (de) | 1995-01-18 |
ATE117199T1 (de) | 1995-02-15 |
US5415870A (en) | 1995-05-16 |
DE59201238D1 (de) | 1995-03-02 |
JP3517233B2 (ja) | 2004-04-12 |
CA2112663C (en) | 2002-04-23 |
WO1993000886A1 (de) | 1993-01-21 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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