JPS6440499A - Folic acid-analog derivative and production thereof - Google Patents

Folic acid-analog derivative and production thereof

Info

Publication number
JPS6440499A
JPS6440499A JP62195262A JP19526287A JPS6440499A JP S6440499 A JPS6440499 A JP S6440499A JP 62195262 A JP62195262 A JP 62195262A JP 19526287 A JP19526287 A JP 19526287A JP S6440499 A JPS6440499 A JP S6440499A
Authority
JP
Japan
Prior art keywords
leucyl
alanyl
folic acid
derivative
formula
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP62195262A
Other languages
Japanese (ja)
Other versions
JPH0689026B2 (en
Inventor
Yoshinori Kato
Takeshi Hara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Teijin Ltd
Original Assignee
Teijin Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Teijin Ltd filed Critical Teijin Ltd
Priority to JP62195262A priority Critical patent/JPH0689026B2/en
Publication of JPS6440499A publication Critical patent/JPS6440499A/en
Publication of JPH0689026B2 publication Critical patent/JPH0689026B2/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

NEW MATERIAL:The compound of formula I (R is univalent organic group forming a folic acid antagonistic folic acid-analog residue together with adjacent carbonyl; Y is L-leucyl-L-alanyl-L-leucyl, L-leucyl-L-alanyl-L-leucyl-L-alanyl or L-alanyl-L-leucyl-L-ananyl-L-leucyl; X is halogen). EXAMPLE:10-Ethyl-1-deazaaminopterin derivative. USE:A selective antitumor agent. PREPARATION:A hydrazide compound of formula II is made to react with an active derivative of a carboxylic acid of formula III (Z is univalent organic group forming an activated derivative group of carboxyl group together with adjacent carbonyl).
JP62195262A 1987-08-06 1987-08-06 Methotrexate derivative and method for producing the same Expired - Lifetime JPH0689026B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP62195262A JPH0689026B2 (en) 1987-08-06 1987-08-06 Methotrexate derivative and method for producing the same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62195262A JPH0689026B2 (en) 1987-08-06 1987-08-06 Methotrexate derivative and method for producing the same

Publications (2)

Publication Number Publication Date
JPS6440499A true JPS6440499A (en) 1989-02-10
JPH0689026B2 JPH0689026B2 (en) 1994-11-09

Family

ID=16338217

Family Applications (1)

Application Number Title Priority Date Filing Date
JP62195262A Expired - Lifetime JPH0689026B2 (en) 1987-08-06 1987-08-06 Methotrexate derivative and method for producing the same

Country Status (1)

Country Link
JP (1) JPH0689026B2 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58139445A (en) * 1982-02-15 1983-08-18 Nec Corp Semiconductor integrated circuit device
JPS595646A (en) * 1982-07-01 1984-01-12 Nec Corp Semiconductor device
JP2005502592A (en) * 2001-04-04 2005-01-27 バイオニューメリック・ファーマスーティカルズ・インコーポレイテッド Methods for coupling amino acids to the folic acid antagonist backbone
WO2005085294A1 (en) * 2004-03-05 2005-09-15 Denki Kagaku Kogyo Kabushiki Kaisha Hyaluronic acid/methotrexate compound
WO2005095464A1 (en) * 2004-04-02 2005-10-13 Denki Kagaku Kogyo Kabushiki Kaisha Hyaluronic acid/methotrexate compound

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS58139445A (en) * 1982-02-15 1983-08-18 Nec Corp Semiconductor integrated circuit device
JPS595646A (en) * 1982-07-01 1984-01-12 Nec Corp Semiconductor device
JP2005502592A (en) * 2001-04-04 2005-01-27 バイオニューメリック・ファーマスーティカルズ・インコーポレイテッド Methods for coupling amino acids to the folic acid antagonist backbone
WO2005085294A1 (en) * 2004-03-05 2005-09-15 Denki Kagaku Kogyo Kabushiki Kaisha Hyaluronic acid/methotrexate compound
JPWO2005085294A1 (en) * 2004-03-05 2007-12-13 電気化学工業株式会社 Hyaluronic acid-methotrexate conjugate
WO2005095464A1 (en) * 2004-04-02 2005-10-13 Denki Kagaku Kogyo Kabushiki Kaisha Hyaluronic acid/methotrexate compound

Also Published As

Publication number Publication date
JPH0689026B2 (en) 1994-11-09

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