JPS6440499A - Folic acid-analog derivative and production thereof - Google Patents
Folic acid-analog derivative and production thereofInfo
- Publication number
- JPS6440499A JPS6440499A JP62195262A JP19526287A JPS6440499A JP S6440499 A JPS6440499 A JP S6440499A JP 62195262 A JP62195262 A JP 62195262A JP 19526287 A JP19526287 A JP 19526287A JP S6440499 A JPS6440499 A JP S6440499A
- Authority
- JP
- Japan
- Prior art keywords
- leucyl
- alanyl
- folic acid
- derivative
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Abstract
NEW MATERIAL:The compound of formula I (R is univalent organic group forming a folic acid antagonistic folic acid-analog residue together with adjacent carbonyl; Y is L-leucyl-L-alanyl-L-leucyl, L-leucyl-L-alanyl-L-leucyl-L-alanyl or L-alanyl-L-leucyl-L-ananyl-L-leucyl; X is halogen). EXAMPLE:10-Ethyl-1-deazaaminopterin derivative. USE:A selective antitumor agent. PREPARATION:A hydrazide compound of formula II is made to react with an active derivative of a carboxylic acid of formula III (Z is univalent organic group forming an activated derivative group of carboxyl group together with adjacent carbonyl).
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62195262A JPH0689026B2 (en) | 1987-08-06 | 1987-08-06 | Methotrexate derivative and method for producing the same |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP62195262A JPH0689026B2 (en) | 1987-08-06 | 1987-08-06 | Methotrexate derivative and method for producing the same |
Publications (2)
Publication Number | Publication Date |
---|---|
JPS6440499A true JPS6440499A (en) | 1989-02-10 |
JPH0689026B2 JPH0689026B2 (en) | 1994-11-09 |
Family
ID=16338217
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP62195262A Expired - Lifetime JPH0689026B2 (en) | 1987-08-06 | 1987-08-06 | Methotrexate derivative and method for producing the same |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPH0689026B2 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58139445A (en) * | 1982-02-15 | 1983-08-18 | Nec Corp | Semiconductor integrated circuit device |
JPS595646A (en) * | 1982-07-01 | 1984-01-12 | Nec Corp | Semiconductor device |
JP2005502592A (en) * | 2001-04-04 | 2005-01-27 | バイオニューメリック・ファーマスーティカルズ・インコーポレイテッド | Methods for coupling amino acids to the folic acid antagonist backbone |
WO2005085294A1 (en) * | 2004-03-05 | 2005-09-15 | Denki Kagaku Kogyo Kabushiki Kaisha | Hyaluronic acid/methotrexate compound |
WO2005095464A1 (en) * | 2004-04-02 | 2005-10-13 | Denki Kagaku Kogyo Kabushiki Kaisha | Hyaluronic acid/methotrexate compound |
-
1987
- 1987-08-06 JP JP62195262A patent/JPH0689026B2/en not_active Expired - Lifetime
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS58139445A (en) * | 1982-02-15 | 1983-08-18 | Nec Corp | Semiconductor integrated circuit device |
JPS595646A (en) * | 1982-07-01 | 1984-01-12 | Nec Corp | Semiconductor device |
JP2005502592A (en) * | 2001-04-04 | 2005-01-27 | バイオニューメリック・ファーマスーティカルズ・インコーポレイテッド | Methods for coupling amino acids to the folic acid antagonist backbone |
WO2005085294A1 (en) * | 2004-03-05 | 2005-09-15 | Denki Kagaku Kogyo Kabushiki Kaisha | Hyaluronic acid/methotrexate compound |
JPWO2005085294A1 (en) * | 2004-03-05 | 2007-12-13 | 電気化学工業株式会社 | Hyaluronic acid-methotrexate conjugate |
WO2005095464A1 (en) * | 2004-04-02 | 2005-10-13 | Denki Kagaku Kogyo Kabushiki Kaisha | Hyaluronic acid/methotrexate compound |
Also Published As
Publication number | Publication date |
---|---|
JPH0689026B2 (en) | 1994-11-09 |
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