ES2051774T3 - Ciertos derivados de cicloalca-(b)-pirazol-(3,4-d)-piridin-3-ona. - Google Patents
Ciertos derivados de cicloalca-(b)-pirazol-(3,4-d)-piridin-3-ona.Info
- Publication number
- ES2051774T3 ES2051774T3 ES87810678T ES87810678T ES2051774T3 ES 2051774 T3 ES2051774 T3 ES 2051774T3 ES 87810678 T ES87810678 T ES 87810678T ES 87810678 T ES87810678 T ES 87810678T ES 2051774 T3 ES2051774 T3 ES 2051774T3
- Authority
- ES
- Spain
- Prior art keywords
- lower alkyl
- radical containing
- unsubstituted
- fused
- aryl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Neurosurgery (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
COMPUESTOS DE LA FORMULA IA O IB, EN LA QUE A REPRESENTA UN AGRUPAMIENTO DIVALENTE SATURADO, OPCIONALMENTE SUSTITUIDO, QUE JUNTO CON LOS DOS ATOMOS DE CARBONO A LOS QUE ESTA UNIDO REPRESENTA UN ANILLO CARBOCICLICO CONDENSADO DE 8, 9, 10 O 11 MIEMBROS, ELEGIDO DE ENTRE CICLOOCTENO, CICLONONENO, CICLODECENO, CICLOUNDECENO Y CICLODODECENO; CADA UNO SIN SUSTITUIR O MONO-, DI, TRI- O TETRASUSTITUIDO EN ATOMOS DE CARBONO EN A POR ALQUILO INFERIOR, ALQUILENO INFERIOR, CICLOALQUILO C3-C7, HIDROXI, ACILOXI, OXO, ALCOXI INFERIOR, ARILO O ARILALCOXI INFERIOR; Y CUANDO SE SUSTITUYE EN EL MISMO ATOMO DE CARBONO EN A, DICHO ATOMO DE CARBONO ESTA SUSTITUIDO POR DOS GRUPOS ALQUILO INFERIORES O DOS GRUPOS ALQUILARILO INFERIORES, O POR UN GRUPO ALQUILO INFERIOR O ARILALQUILO INFERIOR Y UN GRUPO ELEGIDO DE HIDROXI, ALCOXI INFERIOR, ARILALCOXI INFERIOR Y ACILOXI; O CADA UNO DISUSTITUIDO EN EL MISMO ATOMO DE CARBONO EN A POR ALQUILENO DE CADENA RECTA DE 2 A 6 ATOMOS DE CARBONO AL CUAL ESTA UNIDA LA CADENA DE ALQUILENO UN ANILLO ESPIRO CONDENSADO DE 3 A 7 MIEMBROS; O CADA UNO ANILLO A ANILLO; R1 REPRESENTA ALQUILO INFERIOR FENILO O FENILO SUSTITUIDO POR UNO O DOS RADICALES ELEGIDOS DE ALQUILO INFERIOR, ALCOXI INFERIOR, HALOGENO Y TRIFLUOROMETILO; O R1 REPRESENTA UN RADICAL HETEROCICLICO NO SATURADO DE 5 MIEMBROS, QUE CONTIENE UN HETEROATOMO ELEGIDO DE O O S, NITROGENO AMINICO NO SUSTITUIDO O SUSTITUIDO POR ALQUILO INFERIOR, O UN RADICAL QUE CONTIENE DOS HETEROATOMOS QUE CONSTAN DE UN NITROGENO IMINO Y UN MIEMBRO ELEGIDO DE NITROGENO AMINICO NO SUSTITUIDO O SUSTITUIDO POR ALQUILO INFEROR, O Y S; O R1 REPRESENTA UN RADICAL HETEROCICLICO INSATURADO DE 6 MIEMBROS QUE CONTIENE 1 O 2 ATOMOS DE N; O R1 REPRESNTA UN RADICAL BICICLICO CONDENSADO, BENZO-HETEROCICLICO INSATURADO DE 5 MIEMBROS QUE CONTIENE UN HETEROATOMO ELEGIDO DE O, S, N AMINICO NO SUSTITUIDO O SUSTITUIDO POR UN ALQUILO INFERIOR; O R1 REPRESENTA UN RADICAL BICICLICO CONDENSADO BENZO-HETEROCICLICO INSATURADO DE 5 MIEMBROS, QUE CONTIENE2 HETEROATOMOS QUE CONSTAN DE N IMINO Y UN MIEMBRO ELEGIDO ENTRE N AMINICO NO SUSTITUIDO O SUSTITUIDO POR ALQUILO INFERIOR, O Y S; O R1 REPRESENTA UN RADICAL BICICLICO CONDENSADO BENZO-HETEROCICLICO INSATURADO DE 6 MIEMBROS; O R1 REPRESENTA CUALQUIERA DE DICHOS RADICALES HETEROCICLICOS MONO- O DI-SUSTITUIDOS EN EL CARBONO POR ALCOXI INFERIOR, ALQUILO INFERIOR O HALOGENO; R2, R3 Y R''3 INDEPENDIENTEMENTE REPRESENTAN H O ALQUILO INFERIOR; O SUS TAUTOMEROS; O UNA DE SUS SALES FARMACEUTICAMENTE ACEPTABLES; SON UTILES COMO MODULADORES DE RECEPTOR DE BENZODIAZEPINA PARA TRATAMIENTO DE DESORDENES DEL SISTEMA NERVIOSO. TAMBIEN SE DESCRIBEN COMPOSICIONES FARNMACEUTICAS, METODOS DE PREPARACION Y CIERTOS INTERMEDIOS UTILES COMO MODULADORES DE RECEPTOR DE BENZODIAZEPINA. SE PUEDEN OBTENER POR EJEMPLO POR REACCION DE UN COMPUESTO DE PIRDIN-4-ONA-3-CARBOXILATO (III) CON UN COMPUESTO DE FORMULA R''3-NH-NH-R1 (IV).
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93475486A | 1986-11-25 | 1986-11-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2051774T3 true ES2051774T3 (es) | 1994-07-01 |
Family
ID=25466008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES87810678T Expired - Lifetime ES2051774T3 (es) | 1986-11-25 | 1987-11-19 | Ciertos derivados de cicloalca-(b)-pirazol-(3,4-d)-piridin-3-ona. |
Country Status (17)
| Country | Link |
|---|---|
| EP (1) | EP0270494B1 (es) |
| JP (1) | JPS63141979A (es) |
| AT (1) | ATE79621T1 (es) |
| AU (1) | AU606899B2 (es) |
| CA (1) | CA1306258C (es) |
| DD (1) | DD275244A5 (es) |
| DE (1) | DE3781249T2 (es) |
| DK (1) | DK617087A (es) |
| ES (1) | ES2051774T3 (es) |
| FI (1) | FI86724C (es) |
| GR (1) | GR3006305T3 (es) |
| HU (1) | HU203346B (es) |
| IE (1) | IE59817B1 (es) |
| NO (1) | NO166586C (es) |
| NZ (2) | NZ222644A (es) |
| PT (1) | PT86184B (es) |
| ZA (1) | ZA878798B (es) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4957915A (en) * | 1989-02-27 | 1990-09-18 | Biomeasure, Inc. | Benzodiazepine analogs |
| GB9806102D0 (en) | 1998-03-20 | 1998-05-20 | Merck Sharp & Dohme | Therapeutic agents |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1263651A (en) * | 1984-07-09 | 1989-12-05 | Ciba-Geigy Ag | Certain ring-fused pyrazolo ¬3,4-d|-pyridin-3-one derivatives |
| EP0193329A3 (en) * | 1985-02-22 | 1987-08-19 | Beecham Group Plc | Pyrazolopyridines, their preparation and pharmaceutical compositions containing them |
-
1987
- 1987-11-19 EP EP87810678A patent/EP0270494B1/en not_active Expired - Lifetime
- 1987-11-19 AT AT87810678T patent/ATE79621T1/de not_active IP Right Cessation
- 1987-11-19 DE DE8787810678T patent/DE3781249T2/de not_active Expired - Lifetime
- 1987-11-19 ES ES87810678T patent/ES2051774T3/es not_active Expired - Lifetime
- 1987-11-20 PT PT86184A patent/PT86184B/pt not_active IP Right Cessation
- 1987-11-23 FI FI875169A patent/FI86724C/fi not_active IP Right Cessation
- 1987-11-23 DD DD87309347A patent/DD275244A5/de not_active IP Right Cessation
- 1987-11-23 NZ NZ222644A patent/NZ222644A/xx unknown
- 1987-11-23 NZ NZ222649A patent/NZ222649A/xx unknown
- 1987-11-23 CA CA000552423A patent/CA1306258C/en not_active Expired - Lifetime
- 1987-11-24 AU AU81639/87A patent/AU606899B2/en not_active Ceased
- 1987-11-24 JP JP62294260A patent/JPS63141979A/ja active Granted
- 1987-11-24 NO NO874887A patent/NO166586C/no unknown
- 1987-11-24 HU HU875249A patent/HU203346B/hu not_active IP Right Cessation
- 1987-11-24 ZA ZA878798A patent/ZA878798B/xx unknown
- 1987-11-24 DK DK617087A patent/DK617087A/da not_active Application Discontinuation
- 1987-11-24 IE IE318487A patent/IE59817B1/en not_active IP Right Cessation
-
1992
- 1992-11-20 GR GR920401773T patent/GR3006305T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IE59817B1 (en) | 1994-04-06 |
| DD275244A5 (de) | 1990-01-17 |
| FI86724B (fi) | 1992-06-30 |
| AU8163987A (en) | 1988-05-26 |
| GR3006305T3 (es) | 1993-06-21 |
| CA1306258C (en) | 1992-08-11 |
| FI875169A (fi) | 1988-05-26 |
| FI875169A0 (fi) | 1987-11-23 |
| JPS63141979A (ja) | 1988-06-14 |
| DE3781249T2 (de) | 1992-12-17 |
| ZA878798B (en) | 1988-10-26 |
| NO166586C (no) | 1991-08-14 |
| NZ222649A (en) | 1990-08-28 |
| DE3781249D1 (de) | 1992-09-24 |
| NO166586B (no) | 1991-05-06 |
| IE873184L (en) | 1988-05-25 |
| FI86724C (fi) | 1992-10-12 |
| DK617087A (da) | 1988-05-26 |
| PT86184B (pt) | 1990-08-31 |
| HU203346B (en) | 1991-07-29 |
| NO874887L (no) | 1988-05-26 |
| DK617087D0 (da) | 1987-11-24 |
| NZ222644A (en) | 1989-07-27 |
| JPH0546347B2 (es) | 1993-07-13 |
| EP0270494A3 (en) | 1988-07-06 |
| ATE79621T1 (de) | 1992-09-15 |
| HUT46006A (en) | 1988-09-28 |
| PT86184A (en) | 1987-12-01 |
| EP0270494A2 (en) | 1988-06-08 |
| NO874887D0 (no) | 1987-11-24 |
| AU606899B2 (en) | 1991-02-21 |
| EP0270494B1 (en) | 1992-08-19 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG2A | Definitive protection |
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