ES8104199A1 - Procedimiento de preparacion de nuevos derivados de benzoil-2 nitro-4 anilidas y sus sales - Google Patents

Procedimiento de preparacion de nuevos derivados de benzoil-2 nitro-4 anilidas y sus sales

Info

Publication number
ES8104199A1
ES8104199A1 ES493256A ES493256A ES8104199A1 ES 8104199 A1 ES8104199 A1 ES 8104199A1 ES 493256 A ES493256 A ES 493256A ES 493256 A ES493256 A ES 493256A ES 8104199 A1 ES8104199 A1 ES 8104199A1
Authority
ES
Spain
Prior art keywords
group
nitrogen
anilides
benzoyl
nitro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES493256A
Other languages
English (en)
Other versions
ES493256A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pierre Fabre SA
Original Assignee
Pierre Fabre SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pierre Fabre SA filed Critical Pierre Fabre SA
Publication of ES493256A0 publication Critical patent/ES493256A0/es
Publication of ES8104199A1 publication Critical patent/ES8104199A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/14—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D295/145—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/15—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE BENZOIL-2-NITRO-4 ANILIDAS Y SUS SALES DE FORMULA (I), EN LA QUE R, R1 Y R2 PUEDEN SER, CADA UNO, VARIOS TIPOS DE RADICALES, Y ADEMAS, R1 Y R2 PUEDEN FORMAR CON EL ATOMO DE NITROGENO AL QUE ESTAN UNIDOS UN HETEROCICLO QUE CONTIENE EVENTUALMENTE OTRO HETEROATOMO NITROGENO U OXIGENO. EL PROCEDIMIENTO CONSISTE SUSTANCIALMENTE EN LA CONDENSACION DE UNA HALO-ACETAMIDA DE FORMULA (II), EN LA QUE R ES LO MISMO QUE EN LA FORMULA (I) Y X ES UN HALOGENO, CON UNA AMINA, *FORMULA*, EN LA QUE R1 Y R2 SON LOS MISMOS QUE EN LA FORMULA (I). LA MEZCLA DE REACCION, OBTENIDA POR TRATAMIENTO A REFLUJO, SE EXTRAE DE MODO CONVENCIONAL UTILIZANDO ACETATO DE ETILO COMO DISOLVENTE, SE EVAPORA EL DISOLVENTE Y RECRISTALIZA EL PRODUCTO. ESTOS COMPUESTOS TIENEN APLICACION FARMACOLOGICA POR SU ACTIVIDAD SOBRE EL SISTEMA NERVIOSOS CENTRAL.
ES493256A 1979-06-25 1980-06-23 Procedimiento de preparacion de nuevos derivados de benzoil-2 nitro-4 anilidas y sus sales Expired ES8104199A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7916213A FR2459793A1 (fr) 1979-06-25 1979-06-25 Nouveaux derives de benzoyl-2 nitro-4 anilides, leur preparation et leur application en tant que medicaments

Publications (2)

Publication Number Publication Date
ES493256A0 ES493256A0 (es) 1981-04-16
ES8104199A1 true ES8104199A1 (es) 1981-04-16

Family

ID=9227028

Family Applications (1)

Application Number Title Priority Date Filing Date
ES493256A Expired ES8104199A1 (es) 1979-06-25 1980-06-23 Procedimiento de preparacion de nuevos derivados de benzoil-2 nitro-4 anilidas y sus sales

Country Status (10)

Country Link
US (1) USRE31237E (es)
EP (1) EP0022017B1 (es)
JP (1) JPS568353A (es)
AT (1) ATE960T1 (es)
AU (1) AU536228B2 (es)
CA (1) CA1141380A (es)
DE (1) DE3060367D1 (es)
ES (1) ES8104199A1 (es)
FR (1) FR2459793A1 (es)
ZA (1) ZA803721B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2436776A1 (fr) 1978-09-25 1980-04-18 Fabre Sa Pierre Nouveaux derives d'ortho chloro benzoyl-2 chloro-4 glycylanilide, leur preparation et leur application en tant que medicaments
FR2525214B1 (fr) * 1982-04-16 1986-02-07 Fabre Sa Pierre Nouveaux derives d'halogeno benzoyl-2 nitro-4 glycylanilides, leur procede de preparation et leur application en therapeutique
FR2528424A1 (fr) * 1982-06-11 1983-12-16 Fabre Sa Pierre Nouveaux derives d'alpha-hydroxybenzylglycylanilides, leur procede de preparation et leur application en tant que medicaments anxiolytiques
JP2711034B2 (ja) * 1991-09-25 1998-02-10 大日本スクリーン製造株式会社 感光板貯蔵・搬送装置
US6063921A (en) 1997-11-20 2000-05-16 Pharm-Eco Laboratories, Inc. Synthesis of 11-aryl-5,6-dihydro-11H-dibenz[b,e]azepines
US6500411B2 (en) 2001-02-05 2002-12-31 Amcol International Corporation Multifunctional particulate additive for personal care and cosmetic compositions, and the process of making the same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1462887A (fr) * 1966-01-06 1966-12-16 Hoffmann La Roche Procédé pour la préparation de dérivés de benzodiazépine
US3914215A (en) * 1967-11-27 1975-10-21 Sankyo Co Benzodiazepine derivatives and process for preparing the same
BG19177A3 (es) * 1968-07-01 1975-04-30 Sankyo Co
US3799928A (en) * 1970-09-18 1974-03-26 L Schlager 3-amino alkyl-4-phenyl-2(1h)-quinolone derivatives
AT314541B (de) * 1970-10-19 1974-04-10 Sumitomo Chemical Co Verfahren zur Herstellung von neuen Benzodiazepinen und ihren Salzen
LU65340A1 (es) * 1972-05-12 1973-11-22
DE2356239A1 (de) * 1973-11-10 1975-05-15 Cassella Farbwerke Mainkur Ag Benzophenon-derivate und verfahren zu ihrer herstellung
JPS52113952A (en) * 1976-03-19 1977-09-24 Shionogi & Co Ltd Aminobenzophenone derivatives
FR2403330A1 (fr) * 1977-06-16 1979-04-13 Fabre Sa Pierre Nouveaux derives de benzoyl-2-chloro-4-glycinanilides substitues, leur procede de preparation et leur application en tant que medicaments

Also Published As

Publication number Publication date
USRE31237E (en) 1983-05-10
ES493256A0 (es) 1981-04-16
EP0022017A1 (fr) 1981-01-07
EP0022017B1 (fr) 1982-05-05
AU5953180A (en) 1981-01-08
ATE960T1 (de) 1982-05-15
AU536228B2 (en) 1984-05-03
CA1141380A (fr) 1983-02-15
DE3060367D1 (en) 1982-06-24
JPS568353A (en) 1981-01-28
ZA803721B (en) 1981-07-29
FR2459793A1 (fr) 1981-01-16
FR2459793B1 (es) 1983-09-09

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