ES2049700T3 - Sal de la s-carboximetilcisteina lisina monohidratada y procedimiento para su fabricacion. - Google Patents
Sal de la s-carboximetilcisteina lisina monohidratada y procedimiento para su fabricacion.Info
- Publication number
- ES2049700T3 ES2049700T3 ES92117267T ES92117267T ES2049700T3 ES 2049700 T3 ES2049700 T3 ES 2049700T3 ES 92117267 T ES92117267 T ES 92117267T ES 92117267 T ES92117267 T ES 92117267T ES 2049700 T3 ES2049700 T3 ES 2049700T3
- Authority
- ES
- Spain
- Prior art keywords
- monohidratada
- carboximetilcisteina
- lisina
- salt
- procedure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 title abstract 3
- 238000000034 method Methods 0.000 title abstract 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 2
- -1 LYSINE SALT MONOHYDRATE Chemical class 0.000 abstract 1
- 238000013019 agitation Methods 0.000 abstract 1
- 230000002562 anti-bronchospastic effect Effects 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 238000007865 diluting Methods 0.000 abstract 1
- 229940126601 medicinal product Drugs 0.000 abstract 1
- 230000000510 mucolytic effect Effects 0.000 abstract 1
- 239000000243 solution Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
- C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Abstract
MONOHIDRATO DE SAL DE LISINA DE S-CARBOXIMETILCISTEINA PARA LA PREPARACION DE UN MEDICAMENTO QUE TIENE ACTIVIDADES MUCOLITICAS, BROCOSECRETOLITICAS Y ANTIBRONCOESPASTICAS Y UN PROCESO PARA LA PREPARACION DEL MISMO QUE SE CARACTERIZA PORQUE SE HACER REACCIONAR A LA L(R)-S-CARBOXIMETILCISTEINA CON UNA SOLUCION ACUOSA DE L(S)-LISINA, DILUYENDOSE LA SOLUCION OBTENIDA CON ETANOL Y CRISTALIZANDO EL PRODUCTO MEDIANTE AGITACION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI913338A IT1252201B (it) | 1991-12-12 | 1991-12-12 | S-carbossimetilcisteina sale di lisina monoidrato e procedimento per la sua preparazione. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES2049700T1 ES2049700T1 (es) | 1994-05-01 |
ES2049700T3 true ES2049700T3 (es) | 1996-04-16 |
Family
ID=11361322
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92117267T Expired - Lifetime ES2049700T3 (es) | 1991-12-12 | 1992-10-09 | Sal de la s-carboximetilcisteina lisina monohidratada y procedimiento para su fabricacion. |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0546272B1 (es) |
JP (1) | JPH05310686A (es) |
AT (1) | ATE134613T1 (es) |
DE (2) | DE546272T1 (es) |
DK (1) | DK0546272T3 (es) |
ES (1) | ES2049700T3 (es) |
GR (2) | GR930300083T1 (es) |
IT (1) | IT1252201B (es) |
MX (1) | MX9207225A (es) |
Families Citing this family (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101851185A (zh) * | 2009-10-20 | 2010-10-06 | 西华大学 | 一种福多司坦的制备与纯化方法 |
CN102863365B (zh) * | 2011-07-07 | 2014-04-16 | 广州白云山制药股份有限公司广州白云山制药总厂 | 一种结晶药物化合物及其制备方法和用途 |
CN102775334B (zh) * | 2012-06-12 | 2013-12-18 | 宁波市镇海海德生化科技有限公司 | L-赖氨酸-s-羧甲基-l-半胱氨酸盐的生产工艺 |
US10251854B2 (en) * | 2012-07-06 | 2019-04-09 | Guangzhou Baiyunshan Pharmaceutical Holdings Co., Ltd. | S-(carboxymethyl)-cysteine pharmaceutical compound and preparation method and use thereof |
CN108715582A (zh) * | 2018-08-30 | 2018-10-30 | 浙江三门恒康制药有限公司 | 一种赖氨酸羧甲司坦的制备方法 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2147812A1 (en) * | 1971-07-30 | 1973-03-11 | Rech Pharmaceut Scient | Hemisalts of s-carboxymethylcysteine - for treating respiratory infections,hepatic and skin disorders atherosclerosis,and |
DE2530953C2 (de) * | 1975-07-11 | 1994-07-07 | Dr. Madaus & Co, 5000 Köln | Verfahren zur Herstellung von röntgenamorphem Aescin, nach diesem Verfahren erhältliches röntgenamorphes Aescin und dieses enthaltende Arzneimittel |
IT1130972B (it) * | 1980-03-17 | 1986-06-18 | Franco Bolasco | Composizioni farmaceutiche ad attivita' mucolitica,broncosecretolitica e antibroncospastica |
-
1991
- 1991-12-12 IT ITMI913338A patent/IT1252201B/it active IP Right Grant
-
1992
- 1992-10-09 DE DE92117267T patent/DE546272T1/de active Pending
- 1992-10-09 EP EP92117267A patent/EP0546272B1/en not_active Expired - Lifetime
- 1992-10-09 DE DE69208605T patent/DE69208605T2/de not_active Expired - Lifetime
- 1992-10-09 AT AT92117267T patent/ATE134613T1/de active
- 1992-10-09 DK DK92117267.2T patent/DK0546272T3/da active
- 1992-10-09 ES ES92117267T patent/ES2049700T3/es not_active Expired - Lifetime
- 1992-12-10 JP JP4352125A patent/JPH05310686A/ja active Pending
- 1992-12-11 MX MX9207225A patent/MX9207225A/es unknown
-
1993
- 1993-10-31 GR GR930300083T patent/GR930300083T1/el unknown
-
1996
- 1996-04-09 GR GR960400981T patent/GR3019589T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
ES2049700T1 (es) | 1994-05-01 |
EP0546272B1 (en) | 1996-02-28 |
MX9207225A (es) | 1993-07-01 |
EP0546272A1 (en) | 1993-06-16 |
GR930300083T1 (en) | 1993-10-31 |
JPH05310686A (ja) | 1993-11-22 |
ATE134613T1 (de) | 1996-03-15 |
DE69208605T2 (de) | 1996-07-11 |
ITMI913338A1 (it) | 1993-06-12 |
ITMI913338A0 (it) | 1991-12-12 |
IT1252201B (it) | 1995-06-05 |
DE546272T1 (de) | 1993-10-14 |
DE69208605D1 (de) | 1996-04-04 |
GR3019589T3 (en) | 1996-07-31 |
DK0546272T3 (da) | 1996-06-10 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUT64314A (en) | Process for production isoxazole-4-carboxylic acid amides and hydroxi-alkylidene-cyanic-acetic acid amides and pharmaceutical preparations having these compounds | |
AR041472A1 (es) | Complejos de carbohidrato de hierro acuosos su produccion y medicamentos que los contienen | |
AR050737A1 (es) | Procedimiento para producir derivados de amina opticamente activos | |
ES2063499T3 (es) | Procedimiento para la preparacion del acido cis-beta-fenilglicidico-(2r,3r). | |
ES2109412T3 (es) | (-)-cimaterol en esencia opticamente puro y sus sales por adicion de acidos, asi como su empleo como medicamento o favorecedor del rendimiento. | |
ES2049700T3 (es) | Sal de la s-carboximetilcisteina lisina monohidratada y procedimiento para su fabricacion. | |
MX9305902A (es) | Metodo para la preparacion del acido 5-acetamido-2,3,4,5-tetradesoxi-4-guanidino-d-glicero-d-galacto-non-2-eno-piranosonico y producto obtenido del mismo. | |
GB1155549A (en) | A Sulphur-containing Amine and Process for its Manufacture | |
ES2084878T3 (es) | Sal colina de diclofenac, un procedimiento para su preparacion y composiciones farmaceuticas que lo contienen. | |
ES8104789A1 (es) | Procedimiento para la separacion de leucina, isoleucina y valina | |
AR193107A1 (es) | Procedimiento para la producion de a-monohidroxilaminoantraquinona o de a,a'-dihidroxilaminoantraquinona a partir de una mezcla | |
GB967594A (en) | 2-(2,6-dimethyl-3-hydroxy-4-tert-butyl-benzyl)-2-imidazoline,and acid addition salts thereof,and process for their manufacture | |
ES2109595T3 (es) | Procedimiento para la preparacion de un derivado de n-(fenil)-n-(4-piperidinil)amida. | |
GB999252A (en) | A novel ester and a process for the preparation thereof | |
RU94041832A (ru) | Удаление катализатора из хлоропрена путем обработки оксикислотой | |
GB1345991A (en) | Thiocolchicine derivatives | |
GB1031044A (en) | Mixed salts of acylated amino-carboxylic acids | |
ES196573A1 (es) | PROCEDIMIENTO PARA LA OBTENCIoN DE COMBINACIONES ARSENOBENZoLICAS ASIMÉTRICAS | |
GB1318340A (en) | Bicyclic compounds and a process for the manufacture thereof | |
JPS51136620A (en) | Process for preparing inorganic salts of cysteine of high purity. | |
GB1374327A (en) | T-butylation process | |
AU459586B2 (en) | 3-n(fluorodichloromethylthio)-n-(trifluoromethyl)-amino-benzoic acid isopropyl amide, a process for its preparation, and its fungicidal use | |
SE7700644L (sv) | Nytt forfarande for framstellning av vissa metylbensofenon-, metylbensonitril- och antranilsyraderivat | |
JPS5248606A (en) | Process for preparation of olefinchlorohydrin | |
GB1238288A (es) |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
Ref document number: 546272 Country of ref document: ES |