IT1252201B - S-carbossimetilcisteina sale di lisina monoidrato e procedimento per la sua preparazione. - Google Patents

S-carbossimetilcisteina sale di lisina monoidrato e procedimento per la sua preparazione.

Info

Publication number
IT1252201B
IT1252201B ITMI913338A ITMI913338A IT1252201B IT 1252201 B IT1252201 B IT 1252201B IT MI913338 A ITMI913338 A IT MI913338A IT MI913338 A ITMI913338 A IT MI913338A IT 1252201 B IT1252201 B IT 1252201B
Authority
IT
Italy
Prior art keywords
preparation
carboxymethylcistein
procedure
lysine salt
salt monohydrate
Prior art date
Application number
ITMI913338A
Other languages
English (en)
Inventor
Maria Argese
Enrico Bosone
Gaetano Clavenna
Roberto Giani
Original Assignee
Dompe Farmaceutici Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=11361322&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=IT1252201(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Dompe Farmaceutici Spa filed Critical Dompe Farmaceutici Spa
Priority to ITMI913338A priority Critical patent/IT1252201B/it
Publication of ITMI913338A0 publication Critical patent/ITMI913338A0/it
Priority to DE69208605T priority patent/DE69208605T2/de
Priority to DE92117267T priority patent/DE546272T1/de
Priority to ES92117267T priority patent/ES2049700T3/es
Priority to EP92117267A priority patent/EP0546272B1/en
Priority to DK92117267.2T priority patent/DK0546272T3/da
Priority to AT92117267T priority patent/ATE134613T1/de
Priority to JP4352125A priority patent/JPH05310686A/ja
Priority to MX9207225A priority patent/MX9207225A/es
Publication of ITMI913338A1 publication Critical patent/ITMI913338A1/it
Priority to GR930300083T priority patent/GR930300083T1/el
Publication of IT1252201B publication Critical patent/IT1252201B/it
Application granted granted Critical
Priority to GR960400981T priority patent/GR3019589T3/el

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/10—Expectorants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

S-carbossimetilcisteina sale di lisina monoidrato e procedimento per la sua preparazione, caratterizzato dal fatto che si fa reagire la L(R)-S-carbossimetilcisteina con una soluzione acquosa di L(S)-lisina, si diluisce la soluzione ottenuta con etanolo e la si cristallizza per agitazione.
ITMI913338A 1991-12-12 1991-12-12 S-carbossimetilcisteina sale di lisina monoidrato e procedimento per la sua preparazione. IT1252201B (it)

Priority Applications (11)

Application Number Priority Date Filing Date Title
ITMI913338A IT1252201B (it) 1991-12-12 1991-12-12 S-carbossimetilcisteina sale di lisina monoidrato e procedimento per la sua preparazione.
AT92117267T ATE134613T1 (de) 1991-12-12 1992-10-09 5-carboxymethylcysteine lysinsalz-monohydrat und verfahren zu seiner herstellung
DK92117267.2T DK0546272T3 (da) 1991-12-12 1992-10-09 S-carboxylmethylcysteinlysinsalt-monohydrat og fremgangsmåde til fremstilling deraf
DE92117267T DE546272T1 (de) 1991-12-12 1992-10-09 5-Carboxymethylcysteine Lysinsalz-Monohydrat und Verfahren zu seiner Herstellung.
ES92117267T ES2049700T3 (es) 1991-12-12 1992-10-09 Sal de la s-carboximetilcisteina lisina monohidratada y procedimiento para su fabricacion.
EP92117267A EP0546272B1 (en) 1991-12-12 1992-10-09 S-carboxymethylcysteine lysine salt monohydrate and a process for the preparation thereof
DE69208605T DE69208605T2 (de) 1991-12-12 1992-10-09 5-Carboxymethylcysteine Lysinsalz-Monohydrat und Verfahren zu seiner Herstellung
JP4352125A JPH05310686A (ja) 1991-12-12 1992-12-10 Ｓ−カルボキシメチルシステインリジンモノハイドレートおよびその調製方法
MX9207225A MX9207225A (es) 1991-12-12 1992-12-11 Monohidrato de sal de s-carboximetilcisteina lisina y proceso para su preparacion.
GR930300083T GR930300083T1 (en) 1991-12-12 1993-10-31 S-carboxymethylcysteine lysine salt monohydrate and a process for the preparation thereof
GR960400981T GR3019589T3 (en) 1991-12-12 1996-04-09 S-carboxymethylcysteine lysine salt monohydrate and a process for the preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ITMI913338A IT1252201B (it) 1991-12-12 1991-12-12 S-carbossimetilcisteina sale di lisina monoidrato e procedimento per la sua preparazione.

Publications (3)

Publication Number Publication Date
ITMI913338A0 ITMI913338A0 (it) 1991-12-12
ITMI913338A1 ITMI913338A1 (it) 1993-06-12
IT1252201B true IT1252201B (it) 1995-06-05

Family

ID=11361322

Family Applications (1)

Application Number Title Priority Date Filing Date
ITMI913338A IT1252201B (it) 1991-12-12 1991-12-12 S-carbossimetilcisteina sale di lisina monoidrato e procedimento per la sua preparazione.

Country Status (9)

Country Link
EP (1) EP0546272B1 (it)
JP (1) JPH05310686A (it)
AT (1) ATE134613T1 (it)
DE (2) DE546272T1 (it)
DK (1) DK0546272T3 (it)
ES (1) ES2049700T3 (it)
GR (2) GR930300083T1 (it)
IT (1) IT1252201B (it)
MX (1) MX9207225A (it)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101851185A (zh) * 2009-10-20 2010-10-06 西华大学 一种福多司坦的制备与纯化方法
CN102863364B (zh) * 2011-07-07 2014-06-25 广州白云山制药股份有限公司广州白云山制药总厂 S-(羧甲基)-半胱氨酸药物化合物及其制备方法和用途
CN102775334B (zh) * 2012-06-12 2013-12-18 宁波市镇海海德生化科技有限公司 L-赖氨酸-s-羧甲基-l-半胱氨酸盐的生产工艺
WO2014005543A1 (zh) * 2012-07-06 2014-01-09 广州白云山制药股份有限公司广州白云山制药总厂 一种s-(羧甲基)-半胱氨酸药物化合物及其制备方法和用途
CN108715582A (zh) * 2018-08-30 2018-10-30 浙江三门恒康制药有限公司 一种赖氨酸羧甲司坦的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2147812A1 (en) * 1971-07-30 1973-03-11 Rech Pharmaceut Scient Hemisalts of s-carboxymethylcysteine - for treating respiratory infections,hepatic and skin disorders atherosclerosis,and
DE2530953C2 (de) * 1975-07-11 1994-07-07 Dr. Madaus & Co, 5000 Köln Verfahren zur Herstellung von röntgenamorphem Aescin, nach diesem Verfahren erhältliches röntgenamorphes Aescin und dieses enthaltende Arzneimittel
IT1130972B (it) * 1980-03-17 1986-06-18 Franco Bolasco Composizioni farmaceutiche ad attivita' mucolitica,broncosecretolitica e antibroncospastica

Also Published As

Publication number Publication date
DE546272T1 (de) 1993-10-14
ATE134613T1 (de) 1996-03-15
ITMI913338A0 (it) 1991-12-12
JPH05310686A (ja) 1993-11-22
DE69208605D1 (de) 1996-04-04
DK0546272T3 (da) 1996-06-10
MX9207225A (es) 1993-07-01
ES2049700T3 (es) 1996-04-16
DE69208605T2 (de) 1996-07-11
GR3019589T3 (en) 1996-07-31
EP0546272B1 (en) 1996-02-28
ES2049700T1 (es) 1994-05-01
GR930300083T1 (en) 1993-10-31
EP0546272A1 (en) 1993-06-16
ITMI913338A1 (it) 1993-06-12

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