ES2048428T3 - Composiciones de ibuprofeno de administracion oral. - Google Patents
Composiciones de ibuprofeno de administracion oral.Info
- Publication number
- ES2048428T3 ES2048428T3 ES90302750T ES90302750T ES2048428T3 ES 2048428 T3 ES2048428 T3 ES 2048428T3 ES 90302750 T ES90302750 T ES 90302750T ES 90302750 T ES90302750 T ES 90302750T ES 2048428 T3 ES2048428 T3 ES 2048428T3
- Authority
- ES
- Spain
- Prior art keywords
- composition
- oral administration
- volume
- weight
- sample
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000000203 mixture Substances 0.000 title abstract 7
- HEFNNWSXXWATRW-UHFFFAOYSA-N Ibuprofen Chemical group CC(C)CC1=CC=C(C(C)C(O)=O)C=C1 HEFNNWSXXWATRW-UHFFFAOYSA-N 0.000 title abstract 3
- 238000013016 damping Methods 0.000 abstract 2
- 229960001680 ibuprofen Drugs 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 239000002253 acid Substances 0.000 abstract 1
- 150000007513 acids Chemical class 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 230000007935 neutral effect Effects 0.000 abstract 1
- 239000000725 suspension Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
Abstract
EL INVENTO CONCIERNE A UNA COMPOSICION IBUPROFEN DE BASE ACUOSA, NEUTRAL DE MUESTRA CONVENIENTE PARA ADMINISTRACION ORAL, QUE COMPRENDE SUSPENDER EL CONTENIDO DE IBUPROFEN DE 0.8 AL 4% DE PESO POR VOLUMEN DE LA COMPOSICION TOTAL, COMPRENDIENDO UNA SUSPENSION PRIMARIA QUE ESTABILIZA LA COMBINACION DE LOS INGREDIENTES QUE COMPRENDEN EL 0.1 AL 2% DE PESO DE LA SUSPENSION QUE ESTABILIZA LA COMBINACION POR VOLUMEN DE LA COMPOSICION TOTAL; LA MUESTRA QUE ENMASCARA LA COMBINACION COMPRENDE DEL 20 AL 70% DE PESO DE LA MUESTRA QUE ENMASCARA LA COMBINACION POR VOLUMEN DE LA COMPOSICION TOTAL; LA COMPOSICION TAMBIEN CONTIENE UNO O MAS ACIDOS AMORTIGUADORES EN UNA CANTIDAD SUFICIENTE PARA AJUSTAR EL PH A 1.5 A 3.5 Y PARA PROVEER UNA CAPACIDAD AMORTIGUADORA DENTRO DEL RANGO DE 0.03 A 0.05 ENTRE EL PH INICIAL Y UN PH QUE ES 1.0 UNIDAD PH MAS ALTA QUE EL PH INICIAL, Y AGUA QS A 100% DE VOLUMEN DE LA COMPOSICION.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/329,624 US4975465A (en) | 1989-03-28 | 1989-03-28 | Orally administrable ibuprofen compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2048428T3 true ES2048428T3 (es) | 1994-03-16 |
Family
ID=23286273
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES90302750T Expired - Lifetime ES2048428T3 (es) | 1989-03-28 | 1990-03-15 | Composiciones de ibuprofeno de administracion oral. |
Country Status (15)
Country | Link |
---|---|
US (1) | US4975465A (es) |
EP (1) | EP0390369B1 (es) |
JP (1) | JP2847134B2 (es) |
KR (1) | KR0143899B1 (es) |
AR (1) | AR245366A1 (es) |
AT (1) | ATE100313T1 (es) |
AU (1) | AU629622B2 (es) |
CA (1) | CA1336819C (es) |
DE (1) | DE69006068T2 (es) |
DK (1) | DK0390369T3 (es) |
ES (1) | ES2048428T3 (es) |
HK (1) | HK68194A (es) |
IE (1) | IE64024B1 (es) |
MX (1) | MX173433B (es) |
NZ (1) | NZ233102A (es) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003047550A1 (es) * | 2001-12-04 | 2003-06-12 | Farmalider, S.A. | Composiciones farmaceuticas liquidas de base acuosa en forma de suspension para la administracion por via oral de ibuprofeno |
Families Citing this family (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5994041A (en) * | 1985-04-06 | 1999-11-30 | Eastman Kodak Company | Process for buffering concentrated aqueous slurries |
NZ234143A (en) * | 1989-06-28 | 1991-10-25 | Mcneil Ppc Inc | Aqueous pharmaceutical suspension formulation for administering substantially insoluble pharmaceutical agents |
US5262179A (en) * | 1989-09-13 | 1993-11-16 | Nicholas Kiwi Pty Ltd. | Non-effervescent ibuprofen compositions |
US5605930A (en) * | 1991-10-21 | 1997-02-25 | The United States Of America As Represented By The Department Of Health And Human Services | Compositions and methods for treating and preventing pathologies including cancer |
US5272137A (en) * | 1992-02-14 | 1993-12-21 | Mcneil-Pfc, Inc. | Aqueous pharmaceutical suspension for pharmaceutical actives |
EP0663818A4 (en) * | 1992-09-03 | 1996-04-24 | Ibah Inc | TASTE-COVERING PHARMACEUTICAL SUMMARY AND METHOD FOR PRODUCING THE SAME. |
EP0620001A1 (en) * | 1993-04-16 | 1994-10-19 | McNEIL-PPC, INC. | Aqueous pharmaceutical suspension and process for preparation thereof |
DE4327147C2 (de) * | 1993-08-12 | 1996-12-19 | Klinge Co Chem Pharm Fab | Arzneimittelzusammensetzung, welche neben dem Wirkstoff ein Gemisch aus Gelatine unterschiedlicher Löslichkeit enthält |
FR2713931B1 (fr) * | 1993-12-20 | 1996-04-05 | Laurence Paris | Nouvelles compositions pharmaceutiques liquides à base d'ibuprofène et leur procédé de préparation. |
US5609998A (en) * | 1994-12-29 | 1997-03-11 | Eastman Kodak Company | Process for dispersing concentrated aqueous slurries |
TW442287B (en) * | 1995-06-13 | 2001-06-23 | American Home Produits Corp | Organoleptically acceptable oral pharmaceutical composition comprising the S(+)1,8-diethyl-1-1,3,4,9-tetrahydropyrano[3,4-b] indole-1-acetic acid (Etodolac) |
CA2253260A1 (en) * | 1996-05-02 | 1997-11-13 | Taisho Pharmaceutical Co., Ltd. | Suspension of sparingly water-soluble acidic drug |
GB9625589D0 (en) | 1996-12-10 | 1997-01-29 | Boots Co Plc | Therapeutic agents |
ATE269069T1 (de) | 1998-04-29 | 2004-07-15 | Sumitomo Pharma | Orale zubereitung enthaltend einen biguanid und eine organische säure |
GB0001315D0 (en) * | 2000-01-20 | 2000-03-08 | Novartis Ag | Organic compounds |
DK1411899T3 (da) * | 2001-08-01 | 2009-06-02 | Novartis Ag | Smagsmaskerende sammensætning |
US20040132823A1 (en) * | 2001-11-02 | 2004-07-08 | Leo Pavliv | Pharmaceutical composition of 2-(4-isobutylphenyl) propionic acid |
CN100337630C (zh) * | 2002-03-12 | 2007-09-19 | 布里斯托尔-迈尔斯斯奎布公司 | 可口的口服悬浮液及其制备方法 |
US7300670B2 (en) | 2002-04-03 | 2007-11-27 | Unilab Pharmatech, Ltd. | Oral suspension formulation |
CA2486553C (en) * | 2002-06-17 | 2012-01-10 | Taro Pharmaceuticals U.S.A., Inc. | Ibuprofen suspension |
KR100509432B1 (ko) * | 2002-12-13 | 2005-08-22 | 주식회사 동구제약 | S(+)-이부프로펜을 함유한 시럽제 조성물 및 그의 제조방법 |
FR2850275B1 (fr) | 2003-01-24 | 2005-04-08 | Scherer Technologies Inc R P | Capsules molles a macher contenant une substance active a gout masque |
WO2004069132A2 (de) * | 2003-02-06 | 2004-08-19 | Gebro Pharma Gmbh | Pharmazeutische zubereitungen und verfahren zu deren herstellung |
US20040186180A1 (en) * | 2003-03-21 | 2004-09-23 | Gelotte Cathy K. | Non-steroidal anti-inflammatory drug dosing regimen |
CA2542755A1 (en) * | 2003-10-17 | 2005-04-28 | Medrx Co., Ltd. | Biguanide drug-containing jelly preparation |
US20050095300A1 (en) * | 2003-10-30 | 2005-05-05 | Wynn David W. | Controlled release analgesic suspensions |
GB2407497A (en) * | 2003-10-30 | 2005-05-04 | John Anthony Walters | Method and formulation for the rapid and stable taste-masking of insoluble pharmaceutically active compounds using a surfactant and a hydrocolloid |
US20050095299A1 (en) * | 2003-10-30 | 2005-05-05 | Wynn David W. | Controlled release analgesic suspensions |
US20050266031A1 (en) * | 2004-05-25 | 2005-12-01 | Jay Dickerson | Pharmaceutical suspension composition |
ES2704482T3 (es) * | 2004-11-24 | 2019-03-18 | Meda Pharmaceuticals Inc | Composiciones que comprenden azelastina y sus métodos de uso |
US8394415B2 (en) | 2006-11-21 | 2013-03-12 | Mcneil-Ppc, Inc | Modified release analgesic suspensions |
US9833510B2 (en) * | 2007-06-12 | 2017-12-05 | Johnson & Johnson Consumer Inc. | Modified release solid or semi-solid dosage forms |
US8362083B2 (en) * | 2008-01-15 | 2013-01-29 | C.B. Fleet Company Inc. | Taste-masked docusate compositions |
GB201006218D0 (en) * | 2010-04-14 | 2010-06-02 | Ayanda As | Composition |
US9452135B2 (en) | 2012-03-20 | 2016-09-27 | Particle Dynamics International, Llc | Gelling agent-based dosage form |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4145440A (en) * | 1977-08-18 | 1979-03-20 | The Upjohn Company | Liquid suspension of an aluminum salt of ibuprofen |
US4361580A (en) * | 1980-06-20 | 1982-11-30 | The Upjohn Manufacturing Company | Aluminum ibuprofen pharmaceutical suspensions |
US4631580A (en) * | 1984-11-09 | 1986-12-23 | John Taube | Video-stereoscopic-image-producing system |
GB8609566D0 (en) * | 1986-04-18 | 1986-05-21 | Boots Co Plc | Analgesic method |
US4788220A (en) * | 1987-07-08 | 1988-11-29 | American Home Products Corporation (Del.) | Pediatric ibuprofen compositions |
-
1989
- 1989-03-28 US US07/329,624 patent/US4975465A/en not_active Expired - Lifetime
- 1989-07-12 CA CA000605461A patent/CA1336819C/en not_active Expired - Lifetime
-
1990
- 1990-03-15 EP EP90302750A patent/EP0390369B1/en not_active Expired - Lifetime
- 1990-03-15 DE DE90302750T patent/DE69006068T2/de not_active Expired - Lifetime
- 1990-03-15 ES ES90302750T patent/ES2048428T3/es not_active Expired - Lifetime
- 1990-03-15 AT AT90302750T patent/ATE100313T1/de not_active IP Right Cessation
- 1990-03-15 DK DK90302750.6T patent/DK0390369T3/da active
- 1990-03-27 JP JP2078586A patent/JP2847134B2/ja not_active Expired - Lifetime
- 1990-03-27 MX MX020055A patent/MX173433B/es unknown
- 1990-03-27 KR KR1019900004086A patent/KR0143899B1/ko not_active IP Right Cessation
- 1990-03-27 NZ NZ233102A patent/NZ233102A/xx unknown
- 1990-03-27 IE IE111990A patent/IE64024B1/en not_active IP Right Cessation
- 1990-03-27 AR AR90316469A patent/AR245366A1/es active
- 1990-03-27 AU AU52269/90A patent/AU629622B2/en not_active Expired
-
1994
- 1994-07-14 HK HK68194A patent/HK68194A/xx not_active IP Right Cessation
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2003047550A1 (es) * | 2001-12-04 | 2003-06-12 | Farmalider, S.A. | Composiciones farmaceuticas liquidas de base acuosa en forma de suspension para la administracion por via oral de ibuprofeno |
ES2197781A1 (es) * | 2001-12-04 | 2004-01-01 | Farmalider Sa | Composiciones farmaceuticas liquidas de base acuosa en forma de suspension para la administracion por via oral de ibuprofeno. |
Also Published As
Publication number | Publication date |
---|---|
IE901119L (en) | 1990-09-28 |
HK68194A (en) | 1994-07-22 |
US4975465A (en) | 1990-12-04 |
AU629622B2 (en) | 1992-10-08 |
EP0390369A3 (en) | 1991-05-15 |
CA1336819C (en) | 1995-08-29 |
AU5226990A (en) | 1990-10-04 |
EP0390369A2 (en) | 1990-10-03 |
KR900013952A (ko) | 1990-10-22 |
ATE100313T1 (de) | 1994-02-15 |
IE64024B1 (en) | 1995-06-28 |
KR0143899B1 (ko) | 1998-07-15 |
AR245366A1 (es) | 1994-01-31 |
MX173433B (es) | 1994-03-03 |
EP0390369B1 (en) | 1994-01-19 |
DE69006068D1 (de) | 1994-03-03 |
JPH02286615A (ja) | 1990-11-26 |
DK0390369T3 (da) | 1994-04-11 |
JP2847134B2 (ja) | 1999-01-13 |
NZ233102A (en) | 1991-08-27 |
DE69006068T2 (de) | 1994-05-11 |
MX20055A (es) | 1993-10-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG2A | Definitive protection |
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