ES2045101T3 - Derivados de cianoguanidina, su preparacion y su uso para la sintesis de cimetidina. - Google Patents

Derivados de cianoguanidina, su preparacion y su uso para la sintesis de cimetidina.

Info

Publication number
ES2045101T3
ES2045101T3 ES88301313T ES88301313T ES2045101T3 ES 2045101 T3 ES2045101 T3 ES 2045101T3 ES 88301313 T ES88301313 T ES 88301313T ES 88301313 T ES88301313 T ES 88301313T ES 2045101 T3 ES2045101 T3 ES 2045101T3
Authority
ES
Spain
Prior art keywords
cimetidine
synthesis
preparation
cyanoguanidine
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES88301313T
Other languages
English (en)
Inventor
Hioraki Tan
Keiichi Yokoyama
Noriaki Kihara
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsui Petrochemical Industries Ltd
Original Assignee
Mitsui Petrochemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsui Petrochemical Industries Ltd filed Critical Mitsui Petrochemical Industries Ltd
Application granted granted Critical
Publication of ES2045101T3 publication Critical patent/ES2045101T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/01—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton
    • C07C323/02—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/03—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and halogen atoms, or nitro or nitroso groups bound to the same carbon skeleton having sulfur atoms of thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/64—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms

Abstract

DERIVADOS DE CIANOGUANIDINA DE FORMULA (I), DONDE X E Y SON CLORO O BROMO Y R ES ALQUILO INFERIOR, SON PRECURSORES DE LA SINTESIS DE N-CIANO-N''-METIL N''''-[2-[(5-METIL-1H-IMIDAZOL-4IL) METILTIO]ETIL]GUANIDINA (CIMETIDINA) O SUS HOMOLOGOS. ESTOS DERIVADOS DE CIANOGUANIDINA SE PREPARAN POR HALOGENACION DE OTROS DERIVADOS DE CIANOGUANIDINA.
ES88301313T 1987-02-17 1988-02-17 Derivados de cianoguanidina, su preparacion y su uso para la sintesis de cimetidina. Expired - Lifetime ES2045101T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP62032329A JPH0623181B2 (ja) 1987-02-17 1987-02-17 シアノグアニジン誘導体及びその製造法

Publications (1)

Publication Number Publication Date
ES2045101T3 true ES2045101T3 (es) 1994-01-16

Family

ID=12355901

Family Applications (1)

Application Number Title Priority Date Filing Date
ES88301313T Expired - Lifetime ES2045101T3 (es) 1987-02-17 1988-02-17 Derivados de cianoguanidina, su preparacion y su uso para la sintesis de cimetidina.

Country Status (8)

Country Link
US (1) US4886912A (es)
EP (1) EP0279643B1 (es)
JP (1) JPH0623181B2 (es)
KR (1) KR950011444B1 (es)
CA (1) CA1286319C (es)
DE (1) DE3866374D1 (es)
ES (1) ES2045101T3 (es)
MY (1) MY103208A (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3085768B2 (ja) * 1992-01-28 2000-09-11 株式会社東京自働機械製作所 包装機の耳折り装置
US6362202B1 (en) 1999-03-02 2002-03-26 Sepracor Inc. Methods and compositions using (−) norcisapride in combination with proton pump inhibitors or H2 receptor antagonists
US6353005B1 (en) 1999-03-02 2002-03-05 Sepracor, Inc. Method and compositions using (+) norcisapride in combination with proton pump inhibitors or H2 receptor antagonist
ITBO20000735A1 (it) * 2000-12-21 2002-06-21 Gd Spa Macchine e metodo per l'incarto di prodotti
EP4196793A1 (en) 2020-08-11 2023-06-21 Université de Strasbourg H2 blockers targeting liver macrophages for the prevention and treatment of liver disease and cancer

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4276421A (en) * 1978-11-18 1981-06-30 Societe De Recherches Et De Syntheses Organiques S.A. Cyano-guanidine geometrical isomers
IE55946B1 (en) * 1982-10-08 1991-02-27 Gea Farmaceutisk Fabrik As Thioethercyanoguanidines and their use as intermediates in producing imidazoles

Also Published As

Publication number Publication date
KR880009919A (ko) 1988-10-05
MY103208A (en) 1993-05-29
US4886912A (en) 1989-12-12
EP0279643B1 (en) 1991-11-27
EP0279643A3 (en) 1989-05-31
JPS63201165A (ja) 1988-08-19
DE3866374D1 (de) 1992-01-09
KR950011444B1 (ko) 1995-10-04
CA1286319C (en) 1991-07-16
EP0279643A2 (en) 1988-08-24
JPH0623181B2 (ja) 1994-03-30

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