ES2043294T3 - Procedimiento para preparar derivados de tiofornamida. - Google Patents

Procedimiento para preparar derivados de tiofornamida.

Info

Publication number
ES2043294T3
ES2043294T3 ES90400016T ES90400016T ES2043294T3 ES 2043294 T3 ES2043294 T3 ES 2043294T3 ES 90400016 T ES90400016 T ES 90400016T ES 90400016 T ES90400016 T ES 90400016T ES 2043294 T3 ES2043294 T3 ES 2043294T3
Authority
ES
Spain
Prior art keywords
aryl
alkyl
carbamoyl
represents hydrogen
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES90400016T
Other languages
English (en)
Inventor
Malcolm Norman Palfreyman
Nigel Vicker
Roger John Aitchison Walsh
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
May and Baker Ltd
Original Assignee
May and Baker Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB898900245A external-priority patent/GB8900245D0/en
Priority claimed from GB898900295A external-priority patent/GB8900295D0/en
Application filed by May and Baker Ltd filed Critical May and Baker Ltd
Application granted granted Critical
Publication of ES2043294T3 publication Critical patent/ES2043294T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/12—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D215/14—Radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Pulmonology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Organic Insulating Materials (AREA)
  • Addition Polymer Or Copolymer, Post-Treatments, Or Chemical Modifications (AREA)
  • Separation, Recovery Or Treatment Of Waste Materials Containing Plastics (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Steroid Compounds (AREA)

Abstract

DICHOS DERIVADOS DE FORMULA (I) DONDE: R, ES ALQUIL; A ES UN FENIL OPCIONALMENTE SUSTITUIDO O UN GRUPO HETEROAROMATICO; R1 ES HIDROGENO, ALQUIL, CIANO, CARBOXIL, FORMIL, CARBAMOIL, ALCOXICARBONIL O UN GRUPO DE FORMULA (II): DONDE, R2 ES HIDROGENO, ALQUIL, ALCANOIL, ARIL, ARIL(CH2)N- O ARIL-CO, O JUNTO NITROGENO, DOS GRUPOS R2 PUEDEN SER JUNTOS ALQUILENO; R3 ES HIDROGENO, ALQUIL, ALCANOIL, CARBOXIL, CARBAMOIL, CIANO, ARIL, ARILCO-, ARIL(CH2)N-, O ARIL (CH2)N-CO; R4 ES HIDROGENO, ALQUIL, ARIL, ARIL(CH2)N-, ALQUIL POC. SUST. ALQUENIL, AMINO O CARBAMOL N,N-DISUSTITUIDO POR ALQUILENO; R5 ES ALQUIL, ARIL, O ARIL(CH2)N-, O UN RESIDUO DE ACIDO AMINO; R6 ES ALQUIL, ARIL, O ARIL (CH2)N-, .... ES UN ENLACE SIMPLE O DOBLE, PREVISTO QUE CUANDO R1 ES FORMIL .... ES UN ENLACE DOBLE; Y ES ETILENO, METILENO, O UN ENLACE DIRECTO; Y N ES 1 A 6, Y SALES DEL MISMO CON PROPIEDADES FARMACOLOGICAS
ES90400016T 1989-01-06 1990-01-04 Procedimiento para preparar derivados de tiofornamida. Expired - Lifetime ES2043294T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB898900245A GB8900245D0 (en) 1989-01-06 1989-01-06 New compositions of matter
GB898900295A GB8900295D0 (en) 1989-01-06 1989-01-06 New compositions of matter

Publications (1)

Publication Number Publication Date
ES2043294T3 true ES2043294T3 (es) 1993-12-16

Family

ID=26294807

Family Applications (1)

Application Number Title Priority Date Filing Date
ES90400016T Expired - Lifetime ES2043294T3 (es) 1989-01-06 1990-01-04 Procedimiento para preparar derivados de tiofornamida.

Country Status (16)

Country Link
US (1) US5104883A (es)
EP (1) EP0377532B1 (es)
JP (1) JPH02258760A (es)
KR (1) KR900011727A (es)
AT (1) ATE78814T1 (es)
AU (1) AU4761290A (es)
CA (1) CA2007281A1 (es)
DE (1) DE69000224T2 (es)
DK (1) DK0377532T3 (es)
ES (1) ES2043294T3 (es)
FI (1) FI900056A (es)
GR (1) GR3005616T3 (es)
HU (1) HUT53615A (es)
IL (1) IL92930A0 (es)
OA (1) OA09434A (es)
PT (1) PT92796A (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9000342D0 (en) * 1990-01-08 1990-03-07 May & Baker Ltd New compositions of matter
GB9002879D0 (en) * 1990-02-08 1990-04-04 May & Baker Ltd New compositions of matter
AU661044B2 (en) * 1991-10-14 1995-07-13 Eisai Co. Ltd. Thioformamide derivative

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1056205B (it) * 1970-07-30 1982-01-30 Fujisawa Pharmaceutical Co Composto a paste di derivati tioa cetammidici e loro sali procedimento per il suo ottenimento e composizioni che lo contengono

Also Published As

Publication number Publication date
GR3005616T3 (es) 1993-06-07
DE69000224D1 (en) 1992-09-03
CA2007281A1 (en) 1990-07-06
PT92796A (pt) 1990-07-31
HU900050D0 (en) 1990-03-28
IL92930A0 (en) 1990-09-17
FI900056A (fi) 1990-07-07
DK0377532T3 (da) 1992-09-14
OA09434A (en) 1992-10-15
ATE78814T1 (de) 1992-08-15
EP0377532B1 (en) 1992-07-29
EP0377532A1 (en) 1990-07-11
DE69000224T2 (de) 1993-01-14
AU4761290A (en) 1990-07-12
KR900011727A (ko) 1990-08-02
HUT53615A (en) 1990-11-28
US5104883A (en) 1992-04-14
FI900056A0 (fi) 1990-01-05
JPH02258760A (ja) 1990-10-19

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