ES2039471T3 - Dispositivo elastico de administracion transdermica, y composiciones y dispositivos que utilizan esteres/eteres de acidos grasos de alcanodioles como potenciadores de la accion percutanea. - Google Patents

Dispositivo elastico de administracion transdermica, y composiciones y dispositivos que utilizan esteres/eteres de acidos grasos de alcanodioles como potenciadores de la accion percutanea.

Info

Publication number
ES2039471T3
ES2039471T3 ES198787402945T ES87402945T ES2039471T3 ES 2039471 T3 ES2039471 T3 ES 2039471T3 ES 198787402945 T ES198787402945 T ES 198787402945T ES 87402945 T ES87402945 T ES 87402945T ES 2039471 T3 ES2039471 T3 ES 2039471T3
Authority
ES
Spain
Prior art keywords
alcanodiols
eters
enhancers
esters
compositions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198787402945T
Other languages
English (en)
Inventor
Gary W. Cleary
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cygnus Therapeutic Systems
Original Assignee
Cygnus Therapeutic Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27365979&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2039471(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Cygnus Therapeutic Systems filed Critical Cygnus Therapeutic Systems
Application granted granted Critical
Publication of ES2039471T3 publication Critical patent/ES2039471T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
    • A61K9/7061—Polyacrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
    • A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
    • A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
    • A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
    • A61K9/7069—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained otherwise than by reactions only involving carbon to carbon unsaturated bonds, e.g. polysiloxane, polyesters, polyurethane, polyethylene oxide

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN MATERIAL COMPUESTO FLEXIBLE, EN ESTADO SOLIDO, PARA ADMINISTRAR TRANSDERMICAMENTE ESTRADIOL, CONSTA DE VARIAS LAMINAS ESTRUCTURALES ESPACIADAS (12, 14, 16) DE UN ELASTOMERO FLEXIBLE, UNA DE LAS CUALES (12) FORMA LA PARTE SUPERIOR DEL MATERIAL COMPUESTO, UNA LAMINA DE POLIMERO HIDROFOBO VISCOELASTICO (13, 15) QUE CONTIENE MONOLAURATO DE PROPILENGLICOL INTERPUESTA ENTRE CADA LAMINA ESTRUCTURAL (12, 14, 16) Y UNA LAMINA ADHESIVA SENSIBLE A LA PRESION (17) QUE PROPORCIONA LA SUPERFICIE BASE DEL MATERIAL COMPUESTO Y CONSTA DE UNA MEZCLA DE UN ADHESIVO SENSIBLE A LA PRESION, ESTRADIOL Y MONOLAURATO DE PROPILENGLICOL.
ES198787402945T 1986-12-22 1987-12-21 Dispositivo elastico de administracion transdermica, y composiciones y dispositivos que utilizan esteres/eteres de acidos grasos de alcanodioles como potenciadores de la accion percutanea. Expired - Lifetime ES2039471T3 (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94535686A 1986-12-22 1986-12-22
US4179387A 1987-04-23 1987-04-23
US7980187A 1987-07-30 1987-07-30

Publications (1)

Publication Number Publication Date
ES2039471T3 true ES2039471T3 (es) 1993-10-01

Family

ID=27365979

Family Applications (2)

Application Number Title Priority Date Filing Date
ES198787402945T Expired - Lifetime ES2039471T3 (es) 1986-12-22 1987-12-21 Dispositivo elastico de administracion transdermica, y composiciones y dispositivos que utilizan esteres/eteres de acidos grasos de alcanodioles como potenciadores de la accion percutanea.
ES92100183T Expired - Lifetime ES2075966T3 (es) 1986-12-22 1987-12-21 Dispositivo de suministro de medicamentos solidos que utilizan esteres de acidos grasos o eteres de alcoholes grasos de alcanodioles como potenciadores de absorcion percutanea.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES92100183T Expired - Lifetime ES2075966T3 (es) 1986-12-22 1987-12-21 Dispositivo de suministro de medicamentos solidos que utilizan esteres de acidos grasos o eteres de alcoholes grasos de alcanodioles como potenciadores de absorcion percutanea.

Country Status (8)

Country Link
EP (2) EP0272987B1 (es)
JP (2) JPH0816054B2 (es)
AT (1) ATE124256T1 (es)
AU (2) AU601528B2 (es)
CA (1) CA1309021C (es)
DE (2) DE3751383T3 (es)
ES (2) ES2039471T3 (es)
PT (2) PT86426B (es)

Families Citing this family (45)

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US4588580B2 (en) * 1984-07-23 1999-02-16 Alaz Corp Transdermal administration of fentanyl and device therefor
US4818540A (en) * 1985-02-25 1989-04-04 Rutgers, The State University Of New Jersey Transdermal fertility control system and process
US5560922A (en) * 1986-05-30 1996-10-01 Rutgers, The State University Of New Jersey Transdermal absorption dosage unit using a polyacrylate adhesive polymer and process
US4906463A (en) * 1986-12-22 1990-03-06 Cygnus Research Corporation Transdermal drug-delivery composition
AU607172B2 (en) * 1986-12-22 1991-02-28 Cygnus, Inc. Diffusion matrix for transdermal drug administration
AU627163B2 (en) * 1987-11-13 1992-08-20 Landec Labs, Inc. Temperature-controlled active agent dispenser
US4906475A (en) * 1988-02-16 1990-03-06 Paco Pharmaceutical Services Estradiol transdermal delivery system
WO1989007951A1 (en) * 1988-02-26 1989-09-08 Riker Laboratories, Incorporated Transdermal estradiol delivery system
US5223261A (en) * 1988-02-26 1993-06-29 Riker Laboratories, Inc. Transdermal estradiol delivery system
US4994278A (en) * 1988-03-04 1991-02-19 Noven Pharmaceuticals, Inc. Breathable backing
FR2635979B1 (fr) * 1988-09-07 1992-05-29 Lhd Lab Hygiene Dietetique Dispositif auto-adhesif d'administration d'un principe actif par voie percutanee
JPH02233621A (ja) * 1989-03-07 1990-09-17 Nikken Chem Co Ltd 経皮吸収促進剤及びこれを含有する医薬外用製剤
US5053227A (en) * 1989-03-22 1991-10-01 Cygnus Therapeutic Systems Skin permeation enhancer compositions, and methods and transdermal systems associated therewith
US5059426A (en) * 1989-03-22 1991-10-22 Cygnus Therapeutic Systems Skin permeation enhancer compositions, and methods and transdermal systems associated therewith
US4973468A (en) * 1989-03-22 1990-11-27 Cygnus Research Corporation Skin permeation enhancer compositions
US5252335A (en) * 1989-07-12 1993-10-12 Cygnus Therapeutic Systems Transdermal administration of lisuride
US5124157A (en) * 1989-08-18 1992-06-23 Cygnus Therapeutic Systems Method and device for administering dexmedetomidine transdermally
CA2067820A1 (en) * 1989-10-23 1991-04-24 Srinivasan Venkateshwaran Iontophoresis device and method using a rate-controlling membrane
CA2028256A1 (en) * 1989-10-23 1991-04-24 Bahram Farhadieh Multiple layer transdermal drug administration system
US5069909A (en) * 1990-06-20 1991-12-03 Cygnus Therapeutic Systems Transdermal administration of buprenorphine
GB9021674D0 (en) * 1990-10-05 1990-11-21 Ethical Pharma Ltd Transdermal device
TW218849B (es) * 1991-05-17 1994-01-11 Bristol Myers Squibb Co
US5229130A (en) * 1991-12-20 1993-07-20 Cygnus Therapeutics Systems Vegetable oil-based skin permeation enhancer compositions, and associated methods and systems
US5358715A (en) * 1992-09-02 1994-10-25 Cygnus Therapeutic Systems Enhancement of transdermal drug delivery using monoalkyl phosphates and other absorption promoters
IL116539A (en) * 1995-01-06 2002-02-10 Noven Pharma Preparations given through the skin of unstable anti-acid drugs
US6024974A (en) * 1995-01-06 2000-02-15 Noven Pharmaceuticals, Inc. Composition and methods for transdermal delivery of acid labile drugs
US5785991A (en) * 1995-06-07 1998-07-28 Alza Corporation Skin permeation enhancer compositions comprising glycerol monolaurate and lauryl acetate
FR2735024B1 (fr) * 1995-06-08 1997-11-28 Sanofi Sa Dispositif d'administration cutanee d'un produit medicamenteux ou cosmetique.
FR2749586B1 (fr) * 1996-06-11 1998-08-07 Hoechst Marion Roussel Inc Nouveaux dispositifs destines a l'administration transdermique de la trimegestone, leur procede de preparation et leur application a titre de medicaments
CA2367100A1 (en) * 1999-04-01 2000-10-12 Alza Corporation Transdermal drug delivery devices comprising a polyurethane drug reservoir
DE10012908B4 (de) * 2000-03-16 2005-03-17 Lts Lohmann Therapie-Systeme Ag Stabilisierte übersättigte transdermale therapeutische Matrixsysteme und Verfahren zu ihrer Herstellung
US6503894B1 (en) 2000-08-30 2003-01-07 Unimed Pharmaceuticals, Inc. Pharmaceutical composition and method for treating hypogonadism
IT1318705B1 (it) * 2000-09-22 2003-08-27 Gianluigi Ciocca Medicamento transdermico ad alta penetrazione.
US20020119187A1 (en) * 2000-09-29 2002-08-29 Cantor Adam S. Composition for the transdermal delivery of fentanyl
DE10141650C1 (de) 2001-08-24 2002-11-28 Lohmann Therapie Syst Lts Transdermales Therapeutisches System mit Fentanyl bzw. verwandten Substanzen
JP4758101B2 (ja) * 2002-09-13 2011-08-24 久光製薬株式会社 貼付剤
TWI296531B (en) * 2002-10-18 2008-05-11 Hisamitsu Pharmaceutical Co Transdermal adhesive preparations for topical administration of fentanyl
US20050202073A1 (en) * 2004-03-09 2005-09-15 Mylan Technologies, Inc. Transdermal systems containing multilayer adhesive matrices to modify drug delivery
WO2007035939A2 (en) 2005-09-23 2007-03-29 Alza Corporation High enhancer-loading polyacrylate formulation for transdermal applications
US9056061B2 (en) 2005-09-23 2015-06-16 Alza Corporation Transdermal nicotine salt delivery system
DK1937276T3 (da) 2005-10-12 2013-02-11 Besins Healthcare Luxembourg Forbedret testosterongel og fremgangsmåde til anvendelse deraf
EP2295046B1 (de) * 2009-09-14 2012-12-19 Acino AG Transdermales therapeutisches System zur Verabreichung von Fentanyl oder einem Analogstoff davon
EP2599478A1 (de) 2011-11-30 2013-06-05 Acino AG Transdermales therapeutisches System zur Verabreichung von Fentanyl oder einem Analogstoff davon
US20130338122A1 (en) * 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
WO2015138200A1 (en) * 2014-03-11 2015-09-17 Fmc Corporation Controlled release composition and method

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US4379454A (en) * 1981-02-17 1983-04-12 Alza Corporation Dosage for coadministering drug and percutaneous absorption enhancer
US4435180A (en) * 1982-05-25 1984-03-06 Alza Corporation Elastomeric active agent delivery system and method of use
JPS5984817A (ja) * 1982-11-08 1984-05-16 Sekisui Chem Co Ltd 薬剤徐放性製剤
JPS59227819A (ja) * 1983-06-09 1984-12-21 Nitto Electric Ind Co Ltd 消炎、鎮痛用貼付製剤
JPS60155113A (ja) * 1984-01-24 1985-08-15 Teika Seiyaku Kk 経皮吸収薬剤
US4588580B2 (en) * 1984-07-23 1999-02-16 Alaz Corp Transdermal administration of fentanyl and device therefor
US4626539A (en) * 1984-08-10 1986-12-02 E. I. Dupont De Nemours And Company Trandermal delivery of opioids
US4568343A (en) * 1984-10-09 1986-02-04 Alza Corporation Skin permeation enhancer compositions
JPS61210024A (ja) * 1985-03-14 1986-09-18 Yamanouchi Pharmaceut Co Ltd 外用塩酸ニカルジピン製剤
JPS61249934A (ja) * 1985-04-27 1986-11-07 Nitto Electric Ind Co Ltd 外皮投与用組成物

Also Published As

Publication number Publication date
EP0272987A3 (en) 1988-08-24
PT86426B (pt) 1994-03-31
JPH0816054B2 (ja) 1996-02-21
PT101320B (pt) 2001-06-29
PT101320A (pt) 1994-07-29
JP2535731B2 (ja) 1996-09-18
DE3785015T2 (de) 1993-10-07
PT86426A (pt) 1989-01-17
AU640383B2 (en) 1993-08-26
DE3751383T3 (de) 2001-07-05
EP0483105A1 (en) 1992-04-29
EP0272987B1 (en) 1993-03-24
DE3785015D1 (de) 1993-04-29
DE3751383D1 (de) 1995-08-03
AU5784590A (en) 1990-11-01
AU601528B2 (en) 1990-09-13
JPH0840937A (ja) 1996-02-13
DE3751383T2 (de) 1996-01-11
EP0483105B1 (en) 1995-06-28
EP0483105B2 (en) 2001-01-17
CA1309021C (en) 1992-10-20
ATE124256T1 (de) 1995-07-15
AU8249887A (en) 1988-06-23
ES2075966T3 (es) 1995-10-16
EP0272987A2 (en) 1988-06-29
JPS63233916A (ja) 1988-09-29

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