ES2035053T3 - Un aparato para monitorizar la concentracion de glucosa en un fluido corporal. - Google Patents
Un aparato para monitorizar la concentracion de glucosa en un fluido corporal.Info
- Publication number
- ES2035053T3 ES2035053T3 ES198787304539T ES87304539T ES2035053T3 ES 2035053 T3 ES2035053 T3 ES 2035053T3 ES 198787304539 T ES198787304539 T ES 198787304539T ES 87304539 T ES87304539 T ES 87304539T ES 2035053 T3 ES2035053 T3 ES 2035053T3
- Authority
- ES
- Spain
- Prior art keywords
- conjugate
- glucose
- body fluid
- emission
- monitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M21/00—Bioreactors or fermenters specially adapted for specific uses
- C12M21/18—Apparatus specially designed for the use of free, immobilized or carrier-bound enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M23/00—Constructional details, e.g. recesses, hinges
- C12M23/20—Material Coatings
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/54—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving glucose or galactose
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N2021/6484—Optical fibres
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
- G01N2021/7706—Reagent provision
- G01N2021/772—Tip coated light guide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N2021/7769—Measurement method of reaction-produced change in sensor
- G01N2021/7786—Fluorescence
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/80—Fluorescent dyes, e.g. rhodamine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/805—Optical property
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S436/00—Chemistry: analytical and immunological testing
- Y10S436/904—Oxidation - reduction indicators
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
- Y10T436/144444—Glucose
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/20—Oxygen containing
- Y10T436/207497—Molecular oxygen
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/20—Oxygen containing
- Y10T436/207497—Molecular oxygen
- Y10T436/209163—Dissolved or trace oxygen or oxygen content of a sealed environment
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Analytical Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biomedical Technology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Sustainable Development (AREA)
- Clinical Laboratory Science (AREA)
- Plasma & Fusion (AREA)
- Biophysics (AREA)
- Emergency Medicine (AREA)
- Optics & Photonics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Abstract
UN METODO PARA DETECTAR SI EL NIVEL DE GLUCOSA EN UN FLUIDO CORPORAL DIFIERE CON RELACION A UN NIVEL DE REFERENCIA Y QUE COMPRENDE: (A) PONER EN CONTACTO UN FLUIDO CORPORAL QUE CONTIENE GLUCOSA CON UN PRIMER SOPORTE SOLIDO QUE TIENE INMOVILIZADO UN PRIMER CONJUGADO QUE COMPRENDE GLUCOSA-OXIDASA ACTIVA Y UN COLORANTE FLUORESCENTE CUYA EMISION DE FLUORESCENCIA ES SENSIBLE A LA REDUCCION DE OXIGENO, Y CON UN SEGUNDO SOPORTE SOLIDO QUE TIENE INMOVILIZADO UN SEGUNDO MATERIAL QUE COMPRENDE EL MISMO COLORANTE FLUORESCENTE ANTES MENCIONADO DONDE DICHA GLUCOSA ES OXIDADA POR OXIGENO EN DICHO FLUIDO EN EL PRIMER COMJUGADO; (B) APLICAR LUZ DE EXCITACION AL PRIMER CONJUGADO Y AL SEGUNDO MATERIAL; (C) DETECTAR LA EMISION FLUORESCENTE DEL PRIMER CONJUGADO Y DEL SEGUNDO MATERIAL; (D) COMPARAR LAS INTENSIDADES DE EMISION DEL PRIMER CONJUGADO Y DEL SEGUNDO MATERIAL, Y (E) DETERMINAR QUE EXISTE UN DIFERENTE NIVEL DE GLUCOSA EN DICHO FLUIDO SI LA INTENSIDAD DE EMISION DEL PRIMER CONJUGADO ES DIFERENTE DE LAINTENSIDAD DE EMISION DEL SEGUNDO MATERIAL. SE DESCRIBEN LOS COMPONENTES Y DISPOSITIVOS DEL APARATO PARA MONITORIZAR LA CONCENTRACION DE GLUCOSA EN UN FLUIDO CORPORAL DE ACUERDO CON EL METODO DESCRITO.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/878,560 US4981779A (en) | 1986-06-26 | 1986-06-26 | Apparatus for monitoring glucose |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2035053T3 true ES2035053T3 (es) | 1993-04-16 |
Family
ID=25372281
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES198787304539T Expired - Lifetime ES2035053T3 (es) | 1986-06-26 | 1987-05-21 | Un aparato para monitorizar la concentracion de glucosa en un fluido corporal. |
Country Status (11)
Country | Link |
---|---|
US (1) | US4981779A (es) |
EP (1) | EP0251475B1 (es) |
JP (1) | JPH06104080B2 (es) |
AU (1) | AU608510B2 (es) |
BR (1) | BR8702607A (es) |
CA (1) | CA1300395C (es) |
DE (1) | DE3781605T2 (es) |
ES (1) | ES2035053T3 (es) |
GR (1) | GR3005651T3 (es) |
MX (1) | MX170234B (es) |
NZ (1) | NZ219926A (es) |
Families Citing this family (99)
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US5341805A (en) * | 1993-04-06 | 1994-08-30 | Cedars-Sinai Medical Center | Glucose fluorescence monitor and method |
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-
1986
- 1986-06-26 US US06/878,560 patent/US4981779A/en not_active Expired - Fee Related
-
1987
- 1987-04-03 CA CA000533792A patent/CA1300395C/en not_active Expired - Lifetime
- 1987-04-08 AU AU71187/87A patent/AU608510B2/en not_active Expired
- 1987-04-09 NZ NZ219926A patent/NZ219926A/en unknown
- 1987-05-21 DE DE8787304539T patent/DE3781605T2/de not_active Expired - Lifetime
- 1987-05-21 ES ES198787304539T patent/ES2035053T3/es not_active Expired - Lifetime
- 1987-05-21 BR BR8702607A patent/BR8702607A/pt not_active Application Discontinuation
- 1987-05-21 EP EP87304539A patent/EP0251475B1/en not_active Expired - Lifetime
- 1987-05-29 JP JP62134743A patent/JPH06104080B2/ja not_active Expired - Lifetime
- 1987-06-05 MX MX006806A patent/MX170234B/es unknown
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1992
- 1992-09-10 GR GR920401925T patent/GR3005651T3/el unknown
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AU608510B2 (en) | 1991-04-11 |
DE3781605T2 (de) | 1993-02-18 |
DE3781605D1 (de) | 1992-10-15 |
EP0251475A1 (en) | 1988-01-07 |
CA1300395C (en) | 1992-05-12 |
AU7118787A (en) | 1988-01-07 |
GR3005651T3 (es) | 1993-06-07 |
MX170234B (es) | 1993-08-12 |
BR8702607A (pt) | 1988-02-23 |
US4981779A (en) | 1991-01-01 |
JPS637799A (ja) | 1988-01-13 |
NZ219926A (en) | 1990-04-26 |
JPH06104080B2 (ja) | 1994-12-21 |
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