ES2033361T3 - Un procedimiento para preparar imidazolonas triciclicas cardiotonicas. - Google Patents

Un procedimiento para preparar imidazolonas triciclicas cardiotonicas.

Info

Publication number
ES2033361T3
ES2033361T3 ES198888106634T ES88106634T ES2033361T3 ES 2033361 T3 ES2033361 T3 ES 2033361T3 ES 198888106634 T ES198888106634 T ES 198888106634T ES 88106634 T ES88106634 T ES 88106634T ES 2033361 T3 ES2033361 T3 ES 2033361T3
Authority
ES
Spain
Prior art keywords
imidazolones
tricyclic
procedure
cardiotonic
preparing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES198888106634T
Other languages
English (en)
Inventor
Winton D. Jones
George P. Claxton
Richard A. Schnettler
Richard C. Dage
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2033361T3 publication Critical patent/ES2033361T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

IMIDAZOLONAS TRICICLICAS DE LA ESTRCUTURA (I) DONDE Q ES UN ATOMO DE OXIGENO O AZUFRE DIVALENTE, Y N ES 0 O EL NUMERO ENTERO 1 O 2, UNA SAL DEL MISMO FARMACEUTICAMENTE ACEPTABLE, O UN DERIVADO FUNCIONAL BIOLOGICAMENTE CON UN (C1-C5) ALQUILO O UN SUSTITUYENTE ALCANOILO SOBRE UNO O AMBOS ATOMOS DE NITROGENO DEL ANILLO IMIDAZOL, AUMENTAN LA FUERZA DE CONTRACCION MIOCARDIACA Y SON UTILES COMO CARDIOTONICOS EN EL TRATAMIENTO DE ATAQUES AL CORAZON.
ES198888106634T 1987-05-29 1988-04-26 Un procedimiento para preparar imidazolonas triciclicas cardiotonicas. Expired - Lifetime ES2033361T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/055,666 US4743607A (en) 1987-05-29 1987-05-29 Cardiotonic tricyclic imidazolones

Publications (1)

Publication Number Publication Date
ES2033361T3 true ES2033361T3 (es) 1993-03-16

Family

ID=21999387

Family Applications (1)

Application Number Title Priority Date Filing Date
ES198888106634T Expired - Lifetime ES2033361T3 (es) 1987-05-29 1988-04-26 Un procedimiento para preparar imidazolonas triciclicas cardiotonicas.

Country Status (21)

Country Link
US (1) US4743607A (es)
EP (1) EP0292711B1 (es)
JP (1) JP2657819B2 (es)
KR (1) KR970000044B1 (es)
CN (1) CN1017152B (es)
AR (1) AR243524A1 (es)
AT (1) ATE73454T1 (es)
AU (1) AU602468B2 (es)
CA (1) CA1329807C (es)
DE (1) DE3868978D1 (es)
DK (1) DK253888A (es)
ES (1) ES2033361T3 (es)
FI (1) FI88034C (es)
GR (1) GR3004049T3 (es)
HU (1) HU198049B (es)
IL (1) IL86232A (es)
NO (1) NO167144C (es)
NZ (1) NZ224352A (es)
PH (1) PH24527A (es)
PT (1) PT87441B (es)
ZA (1) ZA883271B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4490543B2 (ja) * 2000-03-07 2010-06-30 日本曹達株式会社 α−アミノケトン類の製造方法
US7723328B2 (en) * 2005-04-15 2010-05-25 The University Of North Carolina At Chapel Hill Methods of facilitating cell survival using neurotrophin mimetics
US20110230479A1 (en) * 2005-04-15 2011-09-22 Longo Frank M Neurotrophin mimetics and uses thereof
US10273219B2 (en) 2009-11-12 2019-04-30 Pharmatrophix, Inc. Crystalline forms of neurotrophin mimetic compounds and their salts
CN104761515B (zh) 2009-11-12 2018-03-09 特罗菲克斯制药股份有限公司 神经营养蛋白模拟化合物及其盐的晶型

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1106962B (it) * 1977-01-17 1985-11-18 Sumitomo Chemical Co Composit derivati del benzossa tiazolone utilizzabili particolarmente come fungicidi
US4532250A (en) * 1983-11-23 1985-07-30 American Hospital Supply Corporation 5-Heteroarylimidazol-2-ones having cardiotonic activity
JPS61215389A (ja) * 1985-03-20 1986-09-25 Kyowa Hakko Kogyo Co Ltd キナゾリン誘導体およびそれを含有する強心剤
US4668686A (en) * 1985-04-25 1987-05-26 Bristol-Myers Company Imidazoquinoline antithrombrogenic cardiotonic agents
US4826986A (en) * 1986-06-16 1989-05-02 Eli Lilly And Company 6-Oxo-trans-octa- and decahydroquinolines
DK146787A (da) * 1987-03-23 1988-09-24 Ferrosan Heterocykliske forbindelser, deres fremstilling og anvendelse

Also Published As

Publication number Publication date
HUT47108A (en) 1989-01-30
CN1030417A (zh) 1989-01-18
NO167144C (no) 1991-10-09
CN1017152B (zh) 1992-06-24
PH24527A (en) 1990-07-18
NO882028L (no) 1988-11-30
ATE73454T1 (de) 1992-03-15
FI882159A (fi) 1988-11-30
CA1329807C (en) 1994-05-24
DK253888D0 (da) 1988-05-09
ZA883271B (en) 1988-12-28
HU198049B (en) 1989-07-28
DK253888A (da) 1988-11-30
EP0292711A1 (en) 1988-11-30
PT87441B (pt) 1992-08-31
KR880013936A (ko) 1988-12-22
NZ224352A (en) 1990-02-26
AR243524A1 (es) 1993-08-31
DE3868978D1 (de) 1992-04-16
PT87441A (pt) 1989-05-31
IL86232A (en) 1992-07-15
JPS63307877A (ja) 1988-12-15
IL86232A0 (en) 1988-11-15
GR3004049T3 (es) 1993-03-31
US4743607A (en) 1988-05-10
JP2657819B2 (ja) 1997-09-30
NO882028D0 (no) 1988-05-09
FI882159A0 (fi) 1988-05-09
EP0292711B1 (en) 1992-03-11
AU1582188A (en) 1988-12-01
AU602468B2 (en) 1990-10-11
FI88034B (fi) 1992-12-15
FI88034C (fi) 1993-03-25
KR970000044B1 (en) 1997-01-04
NO167144B (no) 1991-07-01

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