ES2014188A6 - Procedimiento de preparar acidos aceticos y sus derivados. - Google Patents
Procedimiento de preparar acidos aceticos y sus derivados.Info
- Publication number
- ES2014188A6 ES2014188A6 ES8902723A ES8902723A ES2014188A6 ES 2014188 A6 ES2014188 A6 ES 2014188A6 ES 8902723 A ES8902723 A ES 8902723A ES 8902723 A ES8902723 A ES 8902723A ES 2014188 A6 ES2014188 A6 ES 2014188A6
- Authority
- ES
- Spain
- Prior art keywords
- trimethylbenzofuranyl
- dihydro
- acetic acids
- acyloxy
- hydroxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- FUWYMDOAFXKROW-UHFFFAOYSA-N 2-(5-hydroxy-4,6,7-trimethyl-2,3-dihydro-1-benzofuran-2-yl)acetic acid Chemical class CC1=C(O)C(C)=C2CC(CC(O)=O)OC2=C1C FUWYMDOAFXKROW-UHFFFAOYSA-N 0.000 title abstract 2
- 235000011054 acetic acid Nutrition 0.000 title abstract 2
- 150000001243 acetic acids Chemical class 0.000 title abstract 2
- 230000002253 anti-ischaemic effect Effects 0.000 title abstract 2
- 150000002148 esters Chemical class 0.000 title abstract 2
- 235000019439 ethyl acetate Nutrition 0.000 title abstract 2
- 239000003814 drug Substances 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
- C07D307/80—Radicals substituted by oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
- C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
- C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/10—Expectorants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8821603A IT1229482B (it) | 1988-08-01 | 1988-08-01 | Acidi (rs) 2 (2,3 diidro 5 idrossi 4,6,7 trimetilbenzofuranil) acetico e 2 (2,3 diidro 5 acilossi 4,6,7 trimetilbenzofuranil) acetici e loro esteri, utili come farmaci mucoregolatori ed antiischemici. |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2014188A6 true ES2014188A6 (es) | 1990-06-16 |
Family
ID=11184201
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES8902723A Expired - Lifetime ES2014188A6 (es) | 1988-08-01 | 1989-08-01 | Procedimiento de preparar acidos aceticos y sus derivados. |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US4999350A (en, 2012) |
| JP (1) | JPH0278675A (en, 2012) |
| KR (1) | KR0129526B1 (en, 2012) |
| CN (1) | CN1034574C (en, 2012) |
| BE (1) | BE1003255A5 (en, 2012) |
| CA (1) | CA1324134C (en, 2012) |
| CH (1) | CH679583A5 (en, 2012) |
| DE (1) | DE3925496A1 (en, 2012) |
| ES (1) | ES2014188A6 (en, 2012) |
| FR (1) | FR2634766A1 (en, 2012) |
| GB (1) | GB2221463B (en, 2012) |
| HK (1) | HK48693A (en, 2012) |
| IT (1) | IT1229482B (en, 2012) |
| SE (1) | SE469652B (en, 2012) |
| SG (1) | SG26693G (en, 2012) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1231341B (it) * | 1989-08-18 | 1991-11-28 | Foscama Biomed Chim Farma | 2,3 diidro 5 ossi 4,6,7 trimetilbenzofurani 2 (rs) sostituiti, utili come farmaci antiossidanti con proprieta' mucoregolatrici e antiischemiche. |
| IT1239946B (it) * | 1990-03-12 | 1993-11-27 | Biomedica Foscama Industria Chimicofarmaceutica | Procedimento per la sintesi degli acidi 5-acilossi e 5-alcossi-2,3-diidro-4,6,7-trimetil-2-(rs)-benzofuranacetici |
| US5240956A (en) * | 1990-11-07 | 1993-08-31 | Cortech, Inc. | Ester inhibitors |
| EP0550292A1 (en) * | 1992-01-02 | 1993-07-07 | Merrell Dow Pharmaceuticals Inc. | Tissue protective tocopherol analogs |
| US5721233A (en) * | 1992-04-06 | 1998-02-24 | Merrell Pharmaceuticals Inc. | Derivatives of 2,3-dihydro benzofuranols |
| US5510373A (en) * | 1992-04-06 | 1996-04-23 | Merrell Pharmaceuticals Inc. | Cardioprotective agents |
| FI944655A0 (fi) * | 1992-04-06 | 1994-10-05 | Merrell Dow Pharma | Uudet 2,3-dihydro-2,2,4,6,7-penta-alkyyli-5-bentsofuranolit |
| TW393475B (en) * | 1992-10-16 | 2000-06-11 | Chugai Pharmaceutical Co Ltd | 4-alkoxyl-2,6-di-t-butyl phenol derivatives |
| IT1289494B1 (it) * | 1996-12-20 | 1998-10-15 | Biomedica Foscana Ind Chimico | Acidi 5-idrossi- e 5-acilossi-2,3-diidro-4,6,7-trimetil-2- benzofuranaceti e loro esteri per il trattamento e la prevenzione |
| IT1320131B1 (it) * | 2000-12-21 | 2003-11-18 | Foscama Biomed Chim Farma | Uso degli acidi 5-idrossi e 5-acilossi-2,3-diidro-4,6,7-trimetil-2-benzofuranacetici e loro esteri come cicatrizzanti delle lesioni |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6065063A (ja) * | 1983-09-20 | 1985-04-13 | Matsunaga Kagaku Kogyo Kk | 難燃化剤 |
| US4537903A (en) * | 1983-10-12 | 1985-08-27 | Merck & Co., Inc. | Substituted cinnamyl-2,3-dihydrobenzofuran and analogs useful as anti-inflammatory agents |
| US4918092A (en) * | 1983-12-21 | 1990-04-17 | Merck Frosst Canada, Inc. | Leukotriene antagonists |
| CA1281325C (en) * | 1984-06-20 | 1991-03-12 | Patrice C. Belanger | Benzofuran derivatives |
| JPS6388173A (ja) * | 1986-09-30 | 1988-04-19 | Kuraray Co Ltd | ２，３−ジヒドロベンゾフラン誘導体 |
| DE3777366D1 (de) * | 1986-12-27 | 1992-04-16 | Takeda Chemical Industries Ltd | 2,3-dihydro-cumaron-derivate, ihre herstellung und verwendung. |
| JP2855340B2 (ja) * | 1988-06-10 | 1999-02-10 | 武田薬品工業株式会社 | ２―置換クマラン誘導体 |
-
1988
- 1988-08-01 IT IT8821603A patent/IT1229482B/it active
-
1989
- 1989-04-13 US US07/337,358 patent/US4999350A/en not_active Expired - Lifetime
- 1989-07-24 CH CH2760/89A patent/CH679583A5/it not_active IP Right Cessation
- 1989-07-26 SE SE8902603A patent/SE469652B/sv not_active IP Right Cessation
- 1989-07-31 JP JP1200164A patent/JPH0278675A/ja active Pending
- 1989-07-31 CA CA000607022A patent/CA1324134C/en not_active Expired - Fee Related
- 1989-08-01 CN CN89107028A patent/CN1034574C/zh not_active Expired - Fee Related
- 1989-08-01 ES ES8902723A patent/ES2014188A6/es not_active Expired - Lifetime
- 1989-08-01 GB GB8917515A patent/GB2221463B/en not_active Expired - Lifetime
- 1989-08-01 FR FR8910354A patent/FR2634766A1/fr active Granted
- 1989-08-01 BE BE8900822A patent/BE1003255A5/fr not_active IP Right Cessation
- 1989-08-01 KR KR1019890011057A patent/KR0129526B1/ko not_active Expired - Fee Related
- 1989-08-01 DE DE3925496A patent/DE3925496A1/de active Granted
-
1990
- 1990-09-17 US US07/583,810 patent/US5041568A/en not_active Expired - Fee Related
-
1993
- 1993-03-11 SG SG266/93A patent/SG26693G/en unknown
- 1993-05-20 HK HK486/93A patent/HK48693A/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DE3925496A1 (de) | 1990-02-22 |
| HK48693A (en) | 1993-05-27 |
| GB2221463B (en) | 1992-03-25 |
| US5041568A (en) | 1991-08-20 |
| SE8902603L (sv) | 1990-02-02 |
| SG26693G (en) | 1993-05-21 |
| CH679583A5 (en, 2012) | 1992-03-13 |
| SE469652B (sv) | 1993-08-16 |
| FR2634766B1 (en, 2012) | 1994-08-19 |
| US4999350A (en) | 1991-03-12 |
| IT1229482B (it) | 1991-09-03 |
| KR0129526B1 (ko) | 1998-04-09 |
| CA1324134C (en) | 1993-11-09 |
| DE3925496C2 (en, 2012) | 1992-04-30 |
| GB2221463A (en) | 1990-02-07 |
| FR2634766A1 (fr) | 1990-02-02 |
| IT8821603A0 (it) | 1988-08-01 |
| GB8917515D0 (en) | 1989-09-13 |
| CN1034574C (zh) | 1997-04-16 |
| CN1042354A (zh) | 1990-05-23 |
| BE1003255A5 (fr) | 1992-02-11 |
| KR900003145A (ko) | 1990-03-23 |
| JPH0278675A (ja) | 1990-03-19 |
| SE8902603D0 (sv) | 1989-07-26 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19981001 |