ES2012564A6 - Un procedimiento para preparar un glicosido de antraciclina. - Google Patents

Un procedimiento para preparar un glicosido de antraciclina.

Info

Publication number
ES2012564A6
ES2012564A6 ES8803394A ES8803394A ES2012564A6 ES 2012564 A6 ES2012564 A6 ES 2012564A6 ES 8803394 A ES8803394 A ES 8803394A ES 8803394 A ES8803394 A ES 8803394A ES 2012564 A6 ES2012564 A6 ES 2012564A6
Authority
ES
Spain
Prior art keywords
demethoxy
deoxy
amino
anthracycline derivatives
anthracycline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES8803394A
Other languages
English (en)
Inventor
Alberto Bargioti
Maria Grandi
Antonino Suarato
Fernando Giuliani
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Italia SRL
Original Assignee
Farmitalia Carlo Erba SRL
Carlo Erba SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Farmitalia Carlo Erba SRL, Carlo Erba SpA filed Critical Farmitalia Carlo Erba SRL
Publication of ES2012564A6 publication Critical patent/ES2012564A6/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/24—Condensed ring systems having three or more rings
    • C07H15/252—Naphthacene radicals, e.g. daunomycins, adriamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN PROCEDIMIENTO PARA PREPARAR UN GLICOSIDO DE ANTRACICLINA. COMPRENDE: (I) HACER REACCIONAR 4-DESMETOXI-DAUNOMICINONA CON (II) (II) ELIMINAR LOS GRUPOS N-TRIFLUORACETILO DEL COMPUESTO DE FORMULA (III) ASI OBTENIDO DONDE R1 F H Y R2 F CF3 -CO- PARA PRODUCIR (I) EN QUE R1 F H; (III) OPCIONALMENTE, CONVERTIR (I) EN UNA SAL DE ADICION DE ACIDO; (IV) OPCIONALMENTE, BROMAR (I) O SU SAL E HIDROLIZAR EL DERIVADO 14-BROMO PARA OBTENER (I) EN QUE R1 F OH; Y (V) OPCIONALMENTE, TRANSFORMAR ESTE ULTIMO COMPUESTO EN UNA SAL DE ADICION DE ACIDO. APLICACION COMO AGENTES ANTITUMORALES.
ES8803394A 1987-11-10 1988-11-08 Un procedimiento para preparar un glicosido de antraciclina. Expired - Lifetime ES2012564A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8726272A GB2212154B (en) 1987-11-10 1987-11-10 New 4-demethoxy anthracycline derivatives

Publications (1)

Publication Number Publication Date
ES2012564A6 true ES2012564A6 (es) 1990-04-01

Family

ID=10626704

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8803394A Expired - Lifetime ES2012564A6 (es) 1987-11-10 1988-11-08 Un procedimiento para preparar un glicosido de antraciclina.

Country Status (20)

Country Link
US (1) US5045534A (es)
JP (1) JPH01153694A (es)
KR (1) KR890008159A (es)
AU (1) AU2475088A (es)
BE (1) BE1001688A5 (es)
CA (1) CA1312598C (es)
DE (1) DE3837755A1 (es)
DK (2) DK624588A (es)
ES (1) ES2012564A6 (es)
FI (1) FI885063A (es)
FR (1) FR2622889B1 (es)
GB (1) GB2212154B (es)
GR (1) GR880100755A (es)
HU (1) HU199862B (es)
IL (1) IL88311A0 (es)
IT (1) IT1228882B (es)
NL (1) NL8802721A (es)
PT (1) PT88961B (es)
SE (1) SE8804037L (es)
ZA (1) ZA888368B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8818167D0 (en) * 1988-07-29 1988-09-01 Erba Carlo Spa Novel 4-substituted anthracyclinones & process for their preparation
GB9019934D0 (en) * 1990-09-12 1990-10-24 Erba Carlo Spa 2-hydroxy-and 2-acyloxy-4-morpholinyl anthracyclines
GB9028105D0 (en) * 1990-12-27 1991-02-13 Erba Carlo Spa Process for the preparation of substituted benzofuran derivatives
GB9216962D0 (en) * 1992-08-11 1992-09-23 Erba Carlo Spa Therapeutically active naphthalenesulfonic-pyrrolecarboxamido derivatives

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1467383A (en) * 1974-06-12 1977-03-16 Farmaceutici Italia Daunomycin analogues
GB1511559A (en) * 1975-09-26 1978-05-24 Farmaceutici Italia Anthracycline glycosides
GB1511680A (en) * 1975-11-18 1978-05-24 Farmaceutici Italia Daunosaminyl anthracyclinones
DE51280T1 (de) * 1980-11-01 1983-01-20 Farmitalia Carlo Erba S.p.A., 20159 Milano Anthracyclin-glycoside, verfahren zu ihrer herstellung, zwischenprodukte und ihre herstellung und arzneimittel.
AU554416B2 (en) * 1982-05-24 1986-08-21 Farmitalia Carlo Erba S.P.A. Anthracycline glycosides
US4448724A (en) * 1982-12-20 1984-05-15 The Trustees Of The University Of Pennsylvania Synthesis of 4-demethoxydaunomycinone
JPS60115598A (ja) * 1983-11-26 1985-06-22 Sumitomo Chem Co Ltd アンスラサイクリン誘導体
JPS617289A (ja) * 1984-06-22 1986-01-13 Sagami Chem Res Center ３′−ｎ−トリフルオロアセチル−４−デメトキシアドリアマイシン
JPS6150992A (ja) * 1984-08-21 1986-03-13 Sumitomo Chem Co Ltd アンスラサイクリン誘導体とその製法
JPS6178797A (ja) * 1984-09-25 1986-04-22 Sagami Chem Res Center ４−デメトキシアドリアマイシン

Also Published As

Publication number Publication date
KR890008159A (ko) 1989-07-10
GB8726272D0 (en) 1987-12-16
NL8802721A (nl) 1989-06-01
FR2622889B1 (fr) 1994-05-06
DK624588D0 (da) 1988-11-09
AU2475088A (en) 1989-06-29
ZA888368B (en) 1989-09-27
HU199862B (en) 1990-03-28
DK624588A (da) 1989-05-11
SE8804037L (sv) 1989-05-11
FR2622889A1 (fr) 1989-05-12
DE3837755A1 (de) 1989-05-18
US5045534A (en) 1991-09-03
IT8822539A0 (it) 1988-11-07
CA1312598C (en) 1993-01-12
FI885063A0 (fi) 1988-11-03
BE1001688A5 (fr) 1990-02-06
JPH01153694A (ja) 1989-06-15
HUT48639A (en) 1989-06-28
GB2212154A (en) 1989-07-19
SE8804037D0 (sv) 1988-11-08
FI885063A (fi) 1989-05-11
PT88961A (pt) 1989-11-30
DK624688D0 (da) 1988-11-09
PT88961B (pt) 1994-08-31
GB2212154B (en) 1991-03-27
IL88311A0 (en) 1989-06-30
GR880100755A (el) 1994-03-31
IT1228882B (it) 1991-07-09

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Legal Events

Date Code Title Description
SA6 Expiration date (snapshot 920101)

Free format text: 2008-11-08