ES2002312A6 - Procedimiento para la preparacion de nuevos 2,5-doaril-tetrahiodrotiofenos y analogos de los mismos, utiles ccomo antagonistas del fap. - Google Patents
Procedimiento para la preparacion de nuevos 2,5-doaril-tetrahiodrotiofenos y analogos de los mismos, utiles ccomo antagonistas del fap.Info
- Publication number
- ES2002312A6 ES2002312A6 ES8601810A ES8601810A ES2002312A6 ES 2002312 A6 ES2002312 A6 ES 2002312A6 ES 8601810 A ES8601810 A ES 8601810A ES 8601810 A ES8601810 A ES 8601810A ES 2002312 A6 ES2002312 A6 ES 2002312A6
- Authority
- ES
- Spain
- Prior art keywords
- substituted
- pyridyl
- cor
- conr
- chem
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/72—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction of compounds containing >C = O groups with the same or other compounds containing >C = O groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/78—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/14—Radicals substituted by singly bound hetero atoms other than halogen
- C07D333/16—Radicals substituted by singly bound hetero atoms other than halogen by oxygen atoms
Abstract
PROCEDIMIENTO PARA LA PREPARACION DE NUEVOS 2,5-DIARIL-TETRAHIDROTIOFENOS Y SUS ANALOGOS, DE FORMULA (I) O SUS SULFOXIDOS Y/O SULFONAS, DONDE R Y R1 INDEPENDIENTEMENTE SON H, ALQUILO INFERIOR, CICLOALQUILO C1-6, HALOALQUILO INFERIOR, HALOGENO, -COOH, -CONR2R3 (DONDE R2 Y R3 SON INDEPENDIENTEMENTE ALQUILO C1-6 Y H), -COOR2, ALQUENILO INFERIOR, ALQUINILO INFERIOR, -COR2, -CH2OR2, -CH2NR2R3, -CH2SR2, FO, -OR2; AR Y AR1 SON IGUALES O DIFERENTES ENTRE SI, Y REPRESENTAN FENILO, PIRRILO, FURILO, PIRIDILO, TIOFENO, CICLOHEXILO O PIRIMIDILO OPCIONALMENTE SUSTITUIDOS. EL PROCEDIMIENTO COMPRENDE TRATAR UN COMPUESTO DE FORMULA (II) (A,B) CON UN AGENTE REDUCTOR Y POSTERIORMENTE CON P2S5 O 2,4-BIS(4-METOXIFENIL)-2,4-DITIOXO-1,3,2,4-DITIADIFOSFETANO. LOS COMPUESTOS OBTENIDOS SON INHIBIDORES DE LEUCOTRIENES Y ANTAGONISTAS DE FAP (FACTOR ACTIVADOR DE PLAQUETAS) Y SON UTILES PARA EL TRATAMIENTO DE TRASTORNOS MEDIADOS POR LEUCOTRIENO Y/O FAP COMO INFLAMACION, TRASTORNOS CARDIOVASCULARES, ASMA, EDEMA PULMONAR,SINDROME DE ANGUSTIA RESPIRATORIA EN ADULTOS, DOLOR Y AGREGACION DE PLAQUETAS.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/776,191 US4757084A (en) | 1984-02-29 | 1985-09-13 | 2,5-diaryl tetrahydrothiophenes and analogs thereof as PAF-antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2002312A6 true ES2002312A6 (es) | 1988-08-01 |
Family
ID=25106726
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES8601810A Expired ES2002312A6 (es) | 1985-09-13 | 1986-09-11 | Procedimiento para la preparacion de nuevos 2,5-doaril-tetrahiodrotiofenos y analogos de los mismos, utiles ccomo antagonistas del fap. |
Country Status (5)
Country | Link |
---|---|
US (1) | US4757084A (es) |
EP (1) | EP0217204A1 (es) |
JP (1) | JPS6267081A (es) |
DK (1) | DK437286A (es) |
ES (1) | ES2002312A6 (es) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5010100A (en) * | 1983-11-14 | 1991-04-23 | Merck & Co. Inc. | Certain 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists |
EP0318066B1 (en) * | 1987-09-22 | 1992-07-29 | Merck & Co. Inc. | Aryl-substituted thiophene 3-ols, derivatives and analogs, as lipoxygenase inhibitors |
US4996203A (en) * | 1987-12-21 | 1991-02-26 | Merck & Co., Inc. | 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists |
US4845236A (en) * | 1988-01-27 | 1989-07-04 | Uniroyal Chemical Company, Inc. | 2-(tetrahydro-2-thienyl)phenols and carbamate derivatives |
EP0365089A3 (en) * | 1988-10-18 | 1991-06-05 | Merck & Co. Inc. | 2-aryl-5(3-methoxy-5-(hydroxypropylsulfonyl)-4-propoxyphenyl) tetrahydrothiophen and analogs |
US4977146A (en) * | 1989-06-08 | 1990-12-11 | Merck & Co., Inc. | 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists |
US5114961A (en) * | 1989-06-08 | 1992-05-19 | Merck & Co., Inc. | 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists |
US5011847A (en) * | 1989-06-08 | 1991-04-30 | Merck & Co., Inc. | 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists |
US5001123A (en) * | 1989-06-08 | 1991-03-19 | Merck & Co., Inc. | 2,5-diaryl tetrahydrofurans and analogs thereof as PAF antagonists |
GB9204808D0 (en) * | 1992-03-04 | 1992-04-15 | Rhone Poulenc Rorer Ltd | Novel compositions of matter |
US5639782A (en) * | 1992-03-04 | 1997-06-17 | Center For Innovative Technology | Neolignan derivatives as platelet activating factor receptor antagonists and 5-lipoxygenase inhibitors |
US5530141A (en) * | 1992-03-04 | 1996-06-25 | Center For Innovative Technology | 2,4-diaryl-1,3-dithiolanes; 2,4-diaryl-1,3-dioxolanes; 2,4-diaryl-1,3-oxathiolanes; and 2,5-diaryl-1,3-oxathiolanes for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase |
US5434151A (en) * | 1992-08-24 | 1995-07-18 | Cytomed, Inc. | Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase |
US5358938A (en) * | 1992-07-13 | 1994-10-25 | Cytomed, Inc. | Compounds and methods for the treatment of disorders mediated by platelet activating factor or products of 5-lipoxygenase |
US5648486A (en) * | 1992-07-13 | 1997-07-15 | Cytomed, Inc. | Compounds and methods for the treatment of inflammatory and immune disorders |
US5463083A (en) * | 1992-07-13 | 1995-10-31 | Cytomed, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
CA2140034A1 (en) | 1992-07-13 | 1994-01-20 | Xiong Cai | 2,5-diaryl tetrahydro-thiophenes, -furans and analogs for the treatment of inflammatory and immune disorders |
AU5016793A (en) * | 1992-08-20 | 1994-03-15 | Cytomed, Inc | Dual functional anti-inflammatory and immunosuppressive agents |
US6492413B2 (en) | 1993-01-15 | 2002-12-10 | G.D. Searle & Co. | 3.4-diaryl thiophenes and analogs thereof having use as antiinflammatory agents |
US5792776A (en) * | 1994-06-27 | 1998-08-11 | Cytomed, Inc., | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
KR100276570B1 (ko) * | 1994-06-27 | 2001-02-01 | 사이토메드 인코포레이티드 | 심혈관질환염증성질환및면역성질환치료용화합물 |
US5750565A (en) * | 1995-05-25 | 1998-05-12 | Cytomed, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
US5703093A (en) * | 1995-05-31 | 1997-12-30 | Cytomed, Inc. | Compounds and methods for the treatment of cardiovascular, inflammatory and immune disorders |
EP1577289A1 (en) | 2004-03-18 | 2005-09-21 | Revotar Biopharmaceuticals AG | Non-glycosylated/-glycosidic/-peptidic small molecule selectin inhibitors for the treament of inflammatory disorders |
EP1764093A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel aromatic compounds and their use in medical applications |
EP1764096A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel phloroglucinol derivatives having selectin ligand activity |
EP1764095A1 (en) | 2005-09-20 | 2007-03-21 | Revotar Biopharmaceuticals AG | Novel nitrocatechol derivatives having selectin ligand activity |
EP2484655A1 (en) * | 2011-02-04 | 2012-08-08 | Vironova AB | A thionation process and a thionating agent |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2439345A (en) * | 1943-07-13 | 1948-04-06 | Shell Dev | Hydrocarbon-substituted thiacyclopentane-1,1-dioxide |
US3655692A (en) * | 1967-09-11 | 1972-04-11 | Merck & Co Inc | 3-amino-tetrahydrothiophene-3-carboxylic acids |
GB1271082A (en) * | 1968-05-07 | 1972-04-19 | Wyeth John & Brother Ltd | Furan, pyrrole and thiophene derivatives |
NZ211146A (en) * | 1984-02-29 | 1987-10-30 | Merck & Co Inc | 2,5-diaryl-tetrahydrothiophene derivatives and pharmaceutical compositions |
-
1985
- 1985-09-13 US US06/776,191 patent/US4757084A/en not_active Expired - Fee Related
-
1986
- 1986-09-11 ES ES8601810A patent/ES2002312A6/es not_active Expired
- 1986-09-12 DK DK437286A patent/DK437286A/da not_active Application Discontinuation
- 1986-09-12 EP EP86112659A patent/EP0217204A1/en not_active Ceased
- 1986-09-13 JP JP61215064A patent/JPS6267081A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
DK437286D0 (da) | 1986-09-12 |
DK437286A (da) | 1987-03-14 |
EP0217204A1 (en) | 1987-04-08 |
JPS6267081A (ja) | 1987-03-26 |
US4757084A (en) | 1988-07-12 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
SA6 | Expiration date (snapshot 920101) |
Free format text: 2006-09-11 |