ES2001866A6 - Un procedimiento para producir derivados de benzotiofeno - Google Patents

Un procedimiento para producir derivados de benzotiofeno

Info

Publication number
ES2001866A6
ES2001866A6 ES8600837A ES8600837A ES2001866A6 ES 2001866 A6 ES2001866 A6 ES 2001866A6 ES 8600837 A ES8600837 A ES 8600837A ES 8600837 A ES8600837 A ES 8600837A ES 2001866 A6 ES2001866 A6 ES 2001866A6
Authority
ES
Spain
Prior art keywords
thiophenes
pharmaceutical compositions
antifungals
dihydrobenzo
useful
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES8600837A
Other languages
English (en)
Inventor
Rane Dinanath Fakir
Pike Russell Edwin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme Corp
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of ES2001866A6 publication Critical patent/ES2001866A6/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA PRODUCIR DERIVADOS DE BENZOTIOFENO DE FORMULA: DONDE X ES HALOGENO, CIANO, NITRO O UN RADICAL ORGANICO, Y ES UN RADICAL ORGANICO, R1 Y R2 SON HIDROGENO, HALOGENO O UN RADICAL ORGANICO, R3 ES UN RADICAL ORGANICO, N ES 1 O 2 Y M ES 1 A 4, EN EL QUE SE CALIENTA, EN UN DISOLVENTE, UN COMPUESTO DE FORMULA DONDE X, Y, N Y M SON COMO ANTES Y R7, R8 Y R9 SON HIDROGENO O UN RADICAL ORGANICO. LA PRODUCCION DE LOS DERIVADOS DE BENZOTIOFENO PUEDE EFECTUARSE POR OTRAS VIAS DE SINTESIS QUE SE DESCRIBEN EN LA MEMORIA. LOS COMPUESTOS OBTENIDOS SON UTILES PARA FORMULAR COMPOSICIONES FARMACEUTICAS CONTRA INFECCIONES FUNGICAS EN HOSPEDANTES SUSCEPTIBLES, TALES COMO SERES HUMANOS.
ES8600837A 1985-08-12 1986-08-04 Un procedimiento para producir derivados de benzotiofeno Expired ES2001866A6 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US06/764,289 US4731364A (en) 1985-08-12 1985-08-12 Dihydrobenzo(B)thiophenes and pharmaceutical compositions thereof useful as antifungals

Publications (1)

Publication Number Publication Date
ES2001866A6 true ES2001866A6 (es) 1988-07-01

Family

ID=25070267

Family Applications (1)

Application Number Title Priority Date Filing Date
ES8600837A Expired ES2001866A6 (es) 1985-08-12 1986-08-04 Un procedimiento para producir derivados de benzotiofeno

Country Status (24)

Country Link
US (1) US4731364A (es)
EP (1) EP0212428B1 (es)
JP (1) JPS6248683A (es)
KR (1) KR900000673B1 (es)
CN (1) CN1022105C (es)
AR (1) AR244224A1 (es)
AT (1) ATE53390T1 (es)
AU (1) AU585381B2 (es)
CA (1) CA1287634C (es)
DE (1) DE3671748D1 (es)
DK (1) DK370886A (es)
ES (1) ES2001866A6 (es)
FI (1) FI95251C (es)
GR (1) GR862058B (es)
HU (1) HU209302B (es)
IE (1) IE59028B1 (es)
IL (1) IL79598A0 (es)
MY (1) MY101809A (es)
NO (1) NO171066C (es)
NZ (1) NZ217081A (es)
OA (1) OA08374A (es)
PH (1) PH23405A (es)
PT (1) PT83151B (es)
ZA (1) ZA865841B (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4695579A (en) * 1984-12-21 1987-09-22 Schering Corporation Antifungal 2-azolylmethyl-3-difluorobenzyloxy-2,3-dihydrofluoro-benzo(B) thiophens
US4943311A (en) * 1988-05-09 1990-07-24 Uniroyal Chemical Company, Inc. Azole derivatives of spiroheterocycles
DE4010797A1 (de) * 1990-04-04 1991-10-10 Hoechst Ag Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4431816A (en) * 1980-12-12 1984-02-14 Schering Corporation 2,3-Dihydro-2-(imidazolylmethyl)benzo(b)thiophenes
US4352808A (en) * 1980-12-12 1982-10-05 Schering Corporation 3-Aralkyloxy-2,3-dihydro-2-(imidazolylmethyl)benzo(b)thiophenes and related derivatives, their use as antimicrobials and pharmaceutical formulations useful therefore
US4468404A (en) * 1980-12-12 1984-08-28 Schering Corporation 3-Aralkyloxy-2,3-dihydro-2-(triazolymethyl)benzo(b)thiophenes
ZA825413B (en) * 1981-08-26 1983-06-29 Pfizer Thromboxane synthetase inhibitors, processes for their production, and pharmaceutical compositions comprising them
US4695579A (en) * 1984-12-21 1987-09-22 Schering Corporation Antifungal 2-azolylmethyl-3-difluorobenzyloxy-2,3-dihydrofluoro-benzo(B) thiophens

Also Published As

Publication number Publication date
AU6085486A (en) 1987-02-19
US4731364A (en) 1988-03-15
GR862058B (en) 1986-12-24
IE59028B1 (en) 1993-12-15
DE3671748D1 (de) 1990-07-12
EP0212428A1 (en) 1987-03-04
IL79598A0 (en) 1986-11-30
MY101809A (en) 1992-01-31
NO171066B (no) 1992-10-12
PH23405A (en) 1989-07-26
NZ217081A (en) 1989-11-28
FI863168A0 (fi) 1986-08-04
NO863140D0 (no) 1986-08-04
EP0212428B1 (en) 1990-06-06
CA1287634C (en) 1991-08-13
ATE53390T1 (de) 1990-06-15
JPS6248683A (ja) 1987-03-03
ZA865841B (en) 1987-03-25
DK370886D0 (da) 1986-08-04
PT83151B (pt) 1989-03-30
KR900000673B1 (ko) 1990-02-02
AR244224A1 (es) 1993-10-29
FI95251B (fi) 1995-09-29
OA08374A (fr) 1988-02-29
KR870002133A (ko) 1987-03-30
NO171066C (no) 1993-01-20
CN1022105C (zh) 1993-09-15
IE862104L (en) 1987-02-12
DK370886A (da) 1987-02-13
HUT44784A (en) 1988-04-28
NO863140L (no) 1987-02-11
FI863168A (fi) 1987-02-13
CN86105964A (zh) 1987-03-11
HU209302B (en) 1994-04-28
PT83151A (en) 1986-09-01
FI95251C (fi) 1996-01-10
AU585381B2 (en) 1989-06-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19981001